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Protein

RIMS-binding protein 2

Gene

Rimbp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B.By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
RIMS-binding protein 2
Short name:
RIM-BP2
Gene namesi
Name:Rimbp2
Synonyms:Rbp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708533. Rimbp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10491049RIMS-binding protein 2PRO_0000221385Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei701 – 7011PhosphoserineCombined sources
Modified residuei709 – 7091PhosphoserineCombined sources
Cross-linki724 – 724Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei832 – 8321PhosphoserineCombined sources
Modified residuei839 – 8391PhosphoserineCombined sources
Modified residuei841 – 8411PhosphothreonineCombined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ9JIR1.
PRIDEiQ9JIR1.

PTM databases

PhosphoSiteiQ9JIR1.

Interactioni

Subunit structurei

Interacts with CACNA1D and CACNA1B, and potentially with other Ca2+ channel alpha-1 isoforms (By similarity). Interacts with RIMS1 and RIMS2.By similarity1 Publication

Protein-protein interaction databases

IntActiQ9JIR1. 2 interactions.
STRINGi10116.ENSRNOP00000059643.

Structurei

3D structure databases

ProteinModelPortaliQ9JIR1.
SMRiQ9JIR1. Positions 159-241, 474-590, 839-924, 955-1017.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini164 – 23168SH3 1PROSITE-ProRule annotationAdd
BLAST
Domaini294 – 38794Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini390 – 47182Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini486 – 587102Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini848 – 91669SH3 2PROSITE-ProRule annotationAdd
BLAST
Domaini952 – 101968SH3 3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi579 – 66082Pro-richAdd
BLAST

Domaini

The SH3 domains mediate binding to a proline-rich motif in RIMS1, RIMS2, CACNA1D and CACNA1B.By similarity

Sequence similaritiesi

Belongs to the RIMBP family.Curated
Contains 3 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 3 SH3 domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, SH3 domain

Phylogenomic databases

eggNOGiKOG3632. Eukaryota.
ENOG410XZ8W. LUCA.
HOGENOMiHOG000139176.
HOVERGENiHBG079131.
InParanoidiQ9JIR1.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00060. FN3. 3 hits.
SM00326. SH3. 3 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF50044. SSF50044. 3 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50002. SH3. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JIR1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MREAAERRQQ LELEHEQALA ILNAKQQEIQ LLQQSKVREL EEKCRVQSEQ
60 70 80 90 100
FNLLSRDLEK FRQHAGSIDL LGSNSVALLD VPLAPGKPFS QYMNGLATSI
110 120 130 140 150
HKGHEGPTGH YSVIGDYIPL SGDKLESPCV KPSFLLRSSS PRCRFESEMD
160 170 180 190 200
DDRSSNKSKH SSSGKVHLCV ARYSYNPFDG PNENPEAELP LTAGKYLYVY
210 220 230 240 250
GDMDEDGFYE GELLDGQRGL VPSNFVDFIQ DNESRFAGTL GSEQDQNFLN
260 270 280 290 300
HSGISLERDS ILHLHSPTQV DSGITDNGGG TLDVNIDDIG EDIVPYPRKI
310 320 330 340 350
TLIKQLAKSV IVGWEPPAVP PGWGTVSSYN VLVDKETRMS LALGRRTKAL
360 370 380 390 400
IEKLNTAACT YRISVQCVTS RGNSDELQCT LLVGKDVVVA PSQLRVDNIT
410 420 430 440 450
QISAQLSWLP TNSNYSHIIF LNEEELDIVK AARYKYQFFN LRPNMAYKVK
460 470 480 490 500
VLAQPHQMPW QLPLEQREKD EACVEFSTLP AGPPAPPQDV TVQAGATTAS
510 520 530 540 550
VQVSWKPPAL TPTGLSNGAN VTGYGVYAKG QRVAEVIAPT ANGAAVELVR
560 570 580 590 600
LRSLEAKAVS VRTLSAQGES MDSALAAIPP DLLVPPAPHP RTAPPPKPLT
610 620 630 640 650
SDMDTKDLGP HVKVDESWEQ SRPPGPAHGH MLEPPDMHST GPGRRSPSPS
660 670 680 690 700
RILPQPQGAP VSTTVAKAMA REAAQRVAET SKLEKRSLFL EQSSAGPYAN
710 720 730 740 750
SDEEDGYASP EVKRRGTSVD DFLKGSELGQ QPHCCHGDEY HTESSRGSDL
760 770 780 790 800
SDIMEEDEEE LYSEMQLEDG GRRRPSGTSH NALKILGNSA LMGRGDRMEH
810 820 830 840 850
VSRRYSHSGG GPQRHRPMAP SIDEYTGRDH LSPDFYDESE TDPGAEELPA
860 870 880 890 900
RIFVALFDYD PLTMSPNPDA AEEELPFKEG QIIKVYGDKD ADGFYRGETC
910 920 930 940 950
ARLGLIPCNM VSEIHADDEE MMDQLLRQGF LPLNTPVEKI ERSRRSGRGH
960 970 980 990 1000
SVPTRRMVAL YDYDPRESSP NVDVEAELLF CTGDIITVFG EIDEDGFYYG
1010 1020 1030 1040
ELNGQKGLVP SNFLEEVPDD VEVHLSDAPP HYSHDPPMRT KAKRVSQPP
Length:1,049
Mass (Da):115,614
Last modified:January 16, 2004 - v2
Checksum:i079C513375146B6B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03082106 Genomic DNA. No translation available.
AABR03082706 Genomic DNA. No translation available.
AABR03082432 Genomic DNA. No translation available.
AF199336 mRNA. Translation: AAF81658.1.
UniGeneiRn.50806.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR03082106 Genomic DNA. No translation available.
AABR03082706 Genomic DNA. No translation available.
AABR03082432 Genomic DNA. No translation available.
AF199336 mRNA. Translation: AAF81658.1.
UniGeneiRn.50806.

3D structure databases

ProteinModelPortaliQ9JIR1.
SMRiQ9JIR1. Positions 159-241, 474-590, 839-924, 955-1017.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JIR1. 2 interactions.
STRINGi10116.ENSRNOP00000059643.

PTM databases

PhosphoSiteiQ9JIR1.

Proteomic databases

PaxDbiQ9JIR1.
PRIDEiQ9JIR1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi708533. Rimbp2.

Phylogenomic databases

eggNOGiKOG3632. Eukaryota.
ENOG410XZ8W. LUCA.
HOGENOMiHOG000139176.
HOVERGENiHBG079131.
InParanoidiQ9JIR1.

Miscellaneous databases

PROiQ9JIR1.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR011511. SH3_2.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF07653. SH3_2. 1 hit.
PF14604. SH3_9. 2 hits.
[Graphical view]
PRINTSiPR00452. SH3DOMAIN.
SMARTiSM00060. FN3. 3 hits.
SM00326. SH3. 3 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
SSF50044. SSF50044. 3 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50002. SH3. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The RIM/NIM family of neuronal C2 domain proteins. Interactions with Rab3 and a new class of Src homology 3 domain proteins."
    Wang Y., Sugita S., Suedhof T.C.
    J. Biol. Chem. 275:20033-20044(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 785-1049, INTERACTION WITH RIMS1 AND RIMS2.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-701; SER-709; SER-832; SER-839 AND THR-841, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRIMB2_RAT
AccessioniPrimary (citable) accession number: Q9JIR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: November 11, 2015
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.