Transmembrane protease serine 2 - Mus musculus (Mouse)

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Q9JIQ8 (TMPS2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 119. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Transmembrane protease serine 2
EC=3.4.21.-

Alternative name(s):
Epitheliasin
Plasmic transmembrane protein X

Cleaved into the following 2 chains:

Transmembrane protease serine 2 non-catalytic chain
Transmembrane protease serine 2 catalytic chain

Gene names

Name:

Tmprss2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location

Cell membrane; Single-pass type II membrane protein By similarity.

Transmembrane protease serine 2 catalytic chain: Secreted By similarity. Note: Activated by cleavage and secreted By similarity.

Tissue specificity

Expressed mainly in prostate and kidney. Ref.1

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 LDL-receptor class A domain.

Contains 1 peptidase S1 domain.

Contains 1 SRCR domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Domain	Signal-anchor Transmembrane Transmembrane helix
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	scavenger receptor activity Inferred from electronic annotation. Source: InterPro serine-type endopeptidase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 253

253

Transmembrane protease serine 2 non-catalytic chain

PRO_0000027857

Chain

254 – 490

237

Transmembrane protease serine 2 catalytic chain

PRO_0000027858

Regions

Topological domain

1 – 83

Cytoplasmic Potential

Transmembrane

84 – 104

Helical; Signal-anchor for type II membrane protein; Potential

Topological domain

105 – 490

386

Extracellular Potential

Domain

111 – 149

LDL-receptor class A

Domain

150 – 242

SRCR

Domain

254 – 487

234

Peptidase S1

Sites

Active site

294

Charge relay system By similarity

Active site

343

Charge relay system By similarity

Active site

439

Charge relay system By similarity

Site

253 – 254

Cleavage Potential

Amino acid modifications

Glycosylation

111

N-linked (GlcNAc...) Potential

Glycosylation

212

N-linked (GlcNAc...) Potential

Glycosylation

474

N-linked (GlcNAc...) Potential

Disulfide bond

112 ↔ 125

By similarity

Disulfide bond

119 ↔ 138

By similarity

Disulfide bond

132 ↔ 147

By similarity

Disulfide bond

171 ↔ 230

By similarity

Disulfide bond

184 ↔ 240

By similarity

Disulfide bond

243 ↔ 363

Interchain (between non-catalytic and catalytic chains) By similarity

Disulfide bond

279 ↔ 295

By similarity

Disulfide bond

408 ↔ 424

By similarity

Disulfide bond

435 ↔ 463

By similarity

Experimental info

Sequence conflict

L → P in AAF97867. Ref.1

Sequence conflict

L → P in AAF64186. Ref.2

Sequence conflict

L → P in AAF21308. Ref.3

Sequence conflict

L → P in AAH38393. Ref.4

Sequence conflict

122

S → L in AAF21308. Ref.3

Sequence conflict

178

S → N in AAF21308. Ref.3

Sequence conflict

302

S → G in AAF97867. Ref.1

Sequence conflict

302

S → G in AAF64186. Ref.2

Sequence conflict

302

S → G in AAF21308. Ref.3

Sequence conflict

302

S → G in AAH38393. Ref.4

Sequence conflict

320

Y → H in AAF97867. Ref.1

Sequence conflict

474

N → D in AAF97867. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q9JIQ8 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 54650B028417665A
Show »

FASTA

490

53,526

        10         20         30         40         50         60 
MALNSGSPPG IGPCYENHGY QSEHICPPRP PVAPNGYNLY PAQYYPSPVP QYAPRITTQA 

        70         80         90        100        110        120 
STSVIHTHPK SSGALCTSKS KKSLCLALAL GTVLTGAAVA AVLLWRFWDS NCSTSEMECG 

       130        140        150        160        170        180 
SSGTCISSSL WCDGVAHCPN GEDENRCVRL YGQSFILQVY SSQRKAWYPV CQDDWSESYG 

       190        200        210        220        230        240 
RAACKDMGYK NNFYSSQGIP DQSGATSFMK LNVSSGNVDL YKKLYHSDSC SSRMVVSLRC 

       250        260        270        280        290        300 
IECGVRSVKR QSRIVGGLNA SPGDWPWQVS LHVQGVHVCG GSIITPEWIV TAAHCVEEPL 

       310        320        330        340        350        360 
SSPRYWTAFA GILRQSLMFY GSRHQVEKVI SHPNYDSKTK NNDIALMKLQ TPLAFNDLVK 

       370        380        390        400        410        420 
PVCLPNPGMM LDLDQECWIS GWGATYEKGK TSDVLNAAMV PLIEPSKCNS KYIYNNLITP 

       430        440        450        460        470        480 
AMICAGFLQG SVDSCQGDSG GPLVTLKNGI WWLIGDTSWG SGCAKALRPG VYGNVTVFTD 

       490 
WIYQQMRANS

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues." Vaarala M.H., Porvari K.S., Kellokumpu S., Kyllonen A.P., Vihko P.T. J. Pathol. 193:134-140(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Strain: BALB/c.
[2]	"Putative transmembrane protease X." Han J., Kim S. Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning, genomic organization, chromosomal assignment and expression of a novel mosaic serine proteinase: epitheliasin." Jacquinet E.J., Rao N.V., Rao G.V., Hoidal J.R. FEBS Lett. 468:93-100(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: 129. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF199362 mRNA. Translation: AAF97867.1. AF243500 mRNA. Translation: AAF64186.1. AF113596 mRNA. Translation: AAF21308.1. BC038393 mRNA. Translation: AAH38393.1. BC054348 mRNA. Translation: AAH54348.1.
IPI	IPI00310496.
RefSeq	NP_056590.2. NM_015775.2.
UniGene	Mm.276145.
3D structure databases
ProteinModelPortal	Q9JIQ8.
SMR	Q9JIQ8. Positions 157-490.
ModBase	Search...
Protein family/group databases
MEROPS	S01.247.
PTM databases
PhosphoSite	Q9JIQ8.
Proteomic databases
PRIDE	Q9JIQ8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000000395; ENSMUSP00000000395; ENSMUSG00000000385.
GeneID	50528.
KEGG	mmu:50528.
Organism-specific databases
CTD	7113.
MGI	MGI:1354381. Tmprss2.
Phylogenomic databases
eggNOG	COG5640.
GeneTree	ENSGT00700000104118.
HOGENOM	HOG000251822.
HOVERGEN	HBG013304.
InParanoid	Q7TN04.
KO	K09633.
OMA	FYSSQGI.
OrthoDB	EOG4J6RQN.
Gene expression databases
Bgee	Q9JIQ8.
CleanEx	MM_TMPRSS2.
Genevestigator	Q9JIQ8.
GermOnline	ENSMUSG00000000385. Mus musculus.
Family and domain databases
Gene3D	4.10.400.10. 1 hit.
InterPro	IPR023415. LDLR_class-A_CS. IPR002172. LDrepeatLR_classA_rpt. IPR001254. Peptidase_S1. IPR018114. Peptidase_S1_AS. IPR001314. Peptidase_S1A. IPR001190. Srcr_rcpt. IPR017448. Srcr_rcpt-rel. IPR009003. Trypsin-like_Pept_dom. [Graphical view]
Pfam	PF00057. Ldl_recept_a. 1 hit. PF00530. SRCR. 1 hit. PF00089. Trypsin. 1 hit. [Graphical view]
PRINTS	PR00722. CHYMOTRYPSIN.
SMART	SM00192. LDLa. 1 hit. SM00202. SR. 1 hit. SM00020. Tryp_SPc. 1 hit. [Graphical view]
SUPFAM	SSF57424. LDL_rcpt_classA_cys-rich. 1 hit. SSF50494. Pept_Ser_Cys. 1 hit. SSF56487. Srcr_receptor. 1 hit.
PROSITE	PS01209. LDLRA_1. 1 hit. PS50068. LDLRA_2. 1 hit. PS00420. SRCR_1. False negative. PS50287. SRCR_2. 1 hit. PS50240. TRYPSIN_DOM. 1 hit. PS00134. TRYPSIN_HIS. 1 hit. PS00135. TRYPSIN_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	307534.
SOURCE	Search...

Entry information

Entry name

TMPS2_MOUSE

Accession

Primary (citable) accession number: Q9JIQ8
Secondary accession number(s): Q7TN04, Q9JKC4, Q9QY82

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 119 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Cleaved into the following 2 chains:

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents