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Q9JIQ8 (TMPS2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transmembrane protease serine 2

EC=3.4.21.-
Alternative name(s):
Epitheliasin
Plasmic transmembrane protein X
Gene names
Name:Tmprss2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length490 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Cell membrane; Single-pass type II membrane protein By similarity.

Transmembrane protease serine 2 catalytic chain: Secreted By similarity. Note: Activated by cleavage and secreted By similarity.

Tissue specificity

Expressed mainly in prostate and kidney. Ref.1

Sequence similarities

Belongs to the peptidase S1 family.

Contains 1 LDL-receptor class A domain.

Contains 1 peptidase S1 domain.

Contains 1 SRCR domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 253253Transmembrane protease serine 2 non-catalytic chain
PRO_0000027857
Chain254 – 490237Transmembrane protease serine 2 catalytic chain
PRO_0000027858

Regions

Topological domain1 – 8383Cytoplasmic Potential
Transmembrane84 – 10421Helical; Signal-anchor for type II membrane protein; Potential
Topological domain105 – 490386Extracellular Potential
Domain111 – 14939LDL-receptor class A
Domain150 – 24293SRCR
Domain254 – 487234Peptidase S1

Sites

Active site2941Charge relay system By similarity
Active site3431Charge relay system By similarity
Active site4391Charge relay system By similarity
Site253 – 2542Cleavage Potential

Amino acid modifications

Glycosylation1111N-linked (GlcNAc...) Potential
Glycosylation2121N-linked (GlcNAc...) Potential
Glycosylation4741N-linked (GlcNAc...) Potential
Disulfide bond112 ↔ 125 By similarity
Disulfide bond119 ↔ 138 By similarity
Disulfide bond132 ↔ 147 By similarity
Disulfide bond171 ↔ 230 By similarity
Disulfide bond184 ↔ 240 By similarity
Disulfide bond243 ↔ 363Interchain (between non-catalytic and catalytic chains) By similarity
Disulfide bond279 ↔ 295 By similarity
Disulfide bond408 ↔ 424 By similarity
Disulfide bond435 ↔ 463 By similarity

Experimental info

Sequence conflict751L → P in AAF97867. Ref.1
Sequence conflict751L → P in AAF64186. Ref.2
Sequence conflict751L → P in AAF21308. Ref.3
Sequence conflict751L → P in AAH38393. Ref.4
Sequence conflict1221S → L in AAF21308. Ref.3
Sequence conflict1781S → N in AAF21308. Ref.3
Sequence conflict3021S → G in AAF97867. Ref.1
Sequence conflict3021S → G in AAF64186. Ref.2
Sequence conflict3021S → G in AAF21308. Ref.3
Sequence conflict3021S → G in AAH38393. Ref.4
Sequence conflict3201Y → H in AAF97867. Ref.1
Sequence conflict4741N → D in AAF97867. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9JIQ8 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: 54650B028417665A

FASTA49053,526
        10         20         30         40         50         60 
MALNSGSPPG IGPCYENHGY QSEHICPPRP PVAPNGYNLY PAQYYPSPVP QYAPRITTQA 

        70         80         90        100        110        120 
STSVIHTHPK SSGALCTSKS KKSLCLALAL GTVLTGAAVA AVLLWRFWDS NCSTSEMECG 

       130        140        150        160        170        180 
SSGTCISSSL WCDGVAHCPN GEDENRCVRL YGQSFILQVY SSQRKAWYPV CQDDWSESYG 

       190        200        210        220        230        240 
RAACKDMGYK NNFYSSQGIP DQSGATSFMK LNVSSGNVDL YKKLYHSDSC SSRMVVSLRC 

       250        260        270        280        290        300 
IECGVRSVKR QSRIVGGLNA SPGDWPWQVS LHVQGVHVCG GSIITPEWIV TAAHCVEEPL 

       310        320        330        340        350        360 
SSPRYWTAFA GILRQSLMFY GSRHQVEKVI SHPNYDSKTK NNDIALMKLQ TPLAFNDLVK 

       370        380        390        400        410        420 
PVCLPNPGMM LDLDQECWIS GWGATYEKGK TSDVLNAAMV PLIEPSKCNS KYIYNNLITP 

       430        440        450        460        470        480 
AMICAGFLQG SVDSCQGDSG GPLVTLKNGI WWLIGDTSWG SGCAKALRPG VYGNVTVFTD 

       490 
WIYQQMRANS 

« Hide

References

« Hide 'large scale' references
[1]"Expression of transmembrane serine protease TMPRSS2 in mouse and human tissues."
Vaarala M.H., Porvari K.S., Kellokumpu S., Kyllonen A.P., Vihko P.T.
J. Pathol. 193:134-140(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: BALB/c.
[2]"Putative transmembrane protease X."
Han J., Kim S.
Submitted (MAR-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning, genomic organization, chromosomal assignment and expression of a novel mosaic serine proteinase: epitheliasin."
Jacquinet E.J., Rao N.V., Rao G.V., Hoidal J.R.
FEBS Lett. 468:93-100(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: 129.
Tissue: Mammary gland.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF199362 mRNA. Translation: AAF97867.1.
AF243500 mRNA. Translation: AAF64186.1.
AF113596 mRNA. Translation: AAF21308.1.
BC038393 mRNA. Translation: AAH38393.1.
BC054348 mRNA. Translation: AAH54348.1.
RefSeqNP_056590.2. NM_015775.2.
XP_006523127.1. XM_006523064.1.
XP_006523128.1. XM_006523065.1.
UniGeneMm.276145.

3D structure databases

ProteinModelPortalQ9JIQ8.
SMRQ9JIQ8. Positions 157-490.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSS01.247.

PTM databases

PhosphoSiteQ9JIQ8.

Proteomic databases

PRIDEQ9JIQ8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000000395; ENSMUSP00000000395; ENSMUSG00000000385.
GeneID50528.
KEGGmmu:50528.
UCSCuc008adl.1. mouse.

Organism-specific databases

CTD7113.
MGIMGI:1354381. Tmprss2.

Phylogenomic databases

eggNOGCOG5640.
GeneTreeENSGT00730000110467.
HOGENOMHOG000251822.
HOVERGENHBG013304.
InParanoidQ7TN04.
KOK09633.
OMAKSWHPVC.
OrthoDBEOG75B84T.
TreeFamTF351678.

Gene expression databases

BgeeQ9JIQ8.
CleanExMM_TMPRSS2.
GenevestigatorQ9JIQ8.

Family and domain databases

Gene3D3.10.250.10. 1 hit.
4.10.400.10. 1 hit.
InterProIPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR001190. SRCR.
IPR017448. SRCR-like_dom.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamPF00057. Ldl_recept_a. 1 hit.
PF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSPR00722. CHYMOTRYPSIN.
SMARTSM00192. LDLa. 1 hit.
SM00202. SR. 1 hit.
SM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMSSF50494. SSF50494. 1 hit.
SSF56487. SSF56487. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEPS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS50287. SRCR_2. 1 hit.
PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio307534.
PROQ9JIQ8.
SOURCESearch...

Entry information

Entry nameTMPS2_MOUSE
AccessionPrimary (citable) accession number: Q9JIQ8
Secondary accession number(s): Q7TN04, Q9JKC4, Q9QY82
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot