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Protein

Diablo homolog, mitochondrial

Gene

Diablo

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases (By similarity).By similarity1 Publication

GO - Biological processi

  • activation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
  • activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c Source: MGI
  • intrinsic apoptotic signaling pathway Source: UniProtKB
  • intrinsic apoptotic signaling pathway in response to oxidative stress Source: MGI
  • neuron apoptotic process Source: MGI
  • positive regulation of apoptotic process Source: UniProtKB

Keywordsi

Biological processApoptosis

Enzyme and pathway databases

ReactomeiR-MMU-111457 Release of apoptotic factors from the mitochondria
R-MMU-111463 SMAC binds to IAPs
R-MMU-111464 SMAC-mediated dissociation of IAP:caspase complexes

Names & Taxonomyi

Protein namesi
Recommended name:
Diablo homolog, mitochondrial
Alternative name(s):
Direct IAP-binding protein with low pI
Second mitochondria-derived activator of caspase
Short name:
Smac
Gene namesi
Name:Diablo
Synonyms:Smac
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1913843 Diablo

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 53MitochondrionBy similarityAdd BLAST53
ChainiPRO_000002107354 – 237Diablo homolog, mitochondrialAdd BLAST184

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei222PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated by BIRC7/livin.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ9JIQ3
MaxQBiQ9JIQ3
PaxDbiQ9JIQ3
PeptideAtlasiQ9JIQ3
PRIDEiQ9JIQ3

PTM databases

iPTMnetiQ9JIQ3
PhosphoSitePlusiQ9JIQ3

Expressioni

Tissue specificityi

Highest expression found in heart, liver, kidney and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000029433
CleanExiMM_DIABLO
ExpressionAtlasiQ9JIQ3 baseline and differential
GenevisibleiQ9JIQ3 MM

Interactioni

Subunit structurei

Homodimer. Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Interacts with the monomeric and dimeric form of BIRC5/survivin (By similarity). Interacts with BEX3.By similarity1 Publication

Protein-protein interaction databases

BioGridi211579, 2 interactors
IntActiQ9JIQ3, 2 interactors
MINTiQ9JIQ3
STRINGi10090.ENSMUSP00000107214

Structurei

3D structure databases

ProteinModelPortaliQ9JIQ3
SMRiQ9JIQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi54 – 58IAP-bindingSequence analysis5

Domaini

The mature N-terminus mediates interaction with XIAP/BIRC4.By similarity

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IHTM Eukaryota
ENOG4111KJ0 LUCA
GeneTreeiENSGT00390000007237
HOGENOMiHOG000217916
HOVERGENiHBG051315
InParanoidiQ9JIQ3
KOiK10522
OMAiYAKAVHT
OrthoDBiEOG091G0L3E
PhylomeDBiQ9JIQ3
TreeFamiTF102048

Family and domain databases

InterProiView protein in InterPro
IPR009062 Smac/DIABLO-like_sf
IPR015142 Smac_DIABLO
PANTHERiPTHR32247 PTHR32247, 1 hit
PfamiView protein in Pfam
PF09057 Smac_DIABLO, 1 hit
SUPFAMiSSF46984 SSF46984, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JIQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALRSWVTR SVCSLFRYRQ RFPVLANSKK RCFSELIKPW HKTVLTGFGM
60 70 80 90 100
TLCAVPIAQK SEPQSLSNEA LMRRAVSLVT DSTSTFLSQT TYALIEAITE
110 120 130 140 150
YTKAVYTLVS LYRQYTSLLG KMNSQEEDEV WQVIIGARVE MTSKQQEYLK
160 170 180 190 200
LETTWMTAVG LSEMAAEAAY QTGADQASIT ARNHIQLVKS QVQEVRQLSQ
210 220 230
KAETKLAEAQ TKELHQKAQE VSDEGADQEE EAYLRED
Length:237
Mass (Da):26,820
Last modified:October 3, 2012 - v2
Checksum:i6961A7E76C780AC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64Q → H in AAF82190 (PubMed:10929712).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF203914 mRNA Translation: AAF82190.1
AK012760 mRNA Translation: BAB28450.1
AK002887 mRNA No translation available.
AK077198 mRNA Translation: BAC36676.1
AK133194 mRNA Translation: BAE21552.1
AC157931 Genomic DNA No translation available.
CCDSiCCDS39270.1
RefSeqiNP_075721.3, NM_023232.3
UniGeneiMm.46716

Genome annotation databases

EnsembliENSMUST00000111587; ENSMUSP00000107214; ENSMUSG00000029433
ENSMUST00000125652; ENSMUSP00000115045; ENSMUSG00000029433
GeneIDi66593
KEGGimmu:66593
UCSCiuc008znx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDBLOH_MOUSE
AccessioniPrimary (citable) accession number: Q9JIQ3
Secondary accession number(s): Q542V8, Q9CZD1, Q9DCD3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 3, 2012
Last modified: May 23, 2018
This is version 143 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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