Solute carrier family 15 member 1 - Mus musculus (Mouse)

Contribute

Send feedback

Read comments (?) or add your own

Q9JIP7 (S15A1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 68. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Solute carrier family 15 member 1

Alternative name(s):
Intestinal H(+)/peptide cotransporter
Oligopeptide transporter, small intestine isoform
Peptide transporter 1
Proton-coupled dipeptide cotransporter

Gene names

Name:	Slc15a1
Synonyms:	Pept1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	709 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Sequence similarities	Belongs to the PTR2/POT transporter (TC 2.A.17) family. [View classification]

Ontologies

Keywords
Biological process	Peptide transport Protein transport Symport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from direct assay Ref.1. Source: MGI
Molecular function	proton-dependent oligopeptide secondary active transmembrane transporter activity Inferred from direct assay Ref.1. Source: MGI symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 709

709

Solute carrier family 15 member 1

PRO_0000064305

Regions

Transmembrane

1 – 21

Helical; Potential

Topological domain

22 – 53

Extracellular Potential

Transmembrane

54 – 74

Helical; Potential

Topological domain

75 – 82

Cytoplasmic Potential

Transmembrane

83 – 103

Helical; Potential

Topological domain

104 – 118

Extracellular Potential

Transmembrane

119 – 139

Helical; Potential

Topological domain

140 – 161

Cytoplasmic Potential

Transmembrane

162 – 182

Helical; Potential

Topological domain

183 – 198

Extracellular Potential

Transmembrane

199 – 219

Helical; Potential

Topological domain

220 – 276

Cytoplasmic Potential

Transmembrane

277 – 297

Helical; Potential

Topological domain

298 – 327

Extracellular Potential

Transmembrane

328 – 348

Helical; Potential

Topological domain

349 – 361

Cytoplasmic Potential

Transmembrane

362 – 382

Helical; Potential

Topological domain

383 – 585

203

Extracellular Potential

Transmembrane

586 – 606

Helical; Potential

Topological domain

607 – 620

Cytoplasmic Potential

Transmembrane

621 – 641

Helical; Potential

Topological domain

642 – 646

Extracellular Potential

Transmembrane

647 – 667

Helical; Potential

Topological domain

668 – 709

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

406

N-linked (GlcNAc...) Potential

Glycosylation

439

N-linked (GlcNAc...) Ref.3

Glycosylation

515

N-linked (GlcNAc...) Ref.3

Glycosylation

532

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

287

Y → F in AAF81666. Ref.1

Sequence conflict

295

A → G in AAF81666. Ref.1

Sequence conflict

318

I → N in AAF81666. Ref.1

Sequence conflict

333 – 339

IVIMVPI → NVNNGPN in AAF81666. Ref.1

Sequence conflict

346 – 347

PL → RS in AAF81666. Ref.1

Sequence conflict

462

T → N in AAF81666. Ref.1

Sequence conflict

467

N → E in AAF81666. Ref.1

Sequence conflict

478

L → P in AAF81666. Ref.1

Sequence conflict

501

I → N in AAF81666. Ref.1

Sequence conflict

510 – 511

NV → KF in AAF81666. Ref.1

Sequence conflict

520 – 522

QFF → KFL in AAF81666. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q9JIP7 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 7DF0D0F9068CD046
Show »

FASTA

709

78,560

        10         20         30         40         50         60 
MGMSKSRGCF GYPLSIFFIV VNEFCERFSY YGMRALLVLY FRNFLGWDDN LSTAIYHTFV 

        70         80         90        100        110        120 
ALCYLTPILG ALIADSWLGK FKTIVSLSIV YTIGQAVISV SSINDLTDHD HNGSPDSLPV 

       130        140        150        160        170        180 
HVALSMVGLA LIALGTGGIK PCVSAFGGDQ FEEGQEKQRN RFFSIFYLAI NGGSLLSTII 

       190        200        210        220        230        240 
TPILRVQQCG IHSQQACYPL AFGVPAALMA VALIVFVLGS GMYKKFQPQG NIMGKVAKCI 

       250        260        270        280        290        300 
GFAIKNRFRH RSKAYPKREH WLDWAKEKYD ERLISQIKMV TKVMFLYIPL PMFWALFDQQ 

       310        320        330        340        350        360 
GSRWTLQATT MNGKIGAIEI QPDQMQTVNA ILIVIMVPIV DAVVYPLIAK CGFNFTSLKK 

       370        380        390        400        410        420 
MTVGMFLASM AFVVAAIVQV EIDKTLPVFP GGNQVQIKVL NIGNNNMTVH FPGNSVTLAQ 

       430        440        450        460        470        480 
MSQTDTFMTF DIDKLTSINI SSSGSPGVTT VAHDFEQGHR HTLLVWNPSQ YRVVKDGLNQ 

       490        500        510        520        530        540 
KPEKGENGIR FVNTLNEMVT IKMSGKVYEN VTSHNASGYQ FFPSGEKQYT INTTAVAPTC 

       550        560        570        580        590        600 
LTDFKSSNLD FGSAYTYVIR RASDGCLEVK EFEDIPPNTV NMALQIPQYF LLTCGEVVFS 

       610        620        630        640        650        660 
VTGLEFSYSQ APSNMKSVLQ AGWLLTVAVG NIIVLIVAGA GHFPKQWAEY ILFASLLLVV 

       670        680        690        700 
CVIFAIMARF YTYINPAEIE AQFDEDEKKK GIGKENPYSS LEPVSQTNM

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"cDNA structure, genomic organization, and promoter analysis of the mouse intestinal peptide transporter PEPT1." Fei Y.-J., Sugawara M., Liu J.-C., Li H.W., Ganapathy V., Ganapathy M.E., Leibach F.H. Biochim. Biophys. Acta 1492:145-154(2000) [PubMed: 11004485] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: 129/SvJ.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6.
[3]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed: 19349973] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-439 AND ASN-515, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF205540 mRNA. Translation: AAF81666.1. AC126253 Genomic DNA. No translation available. AC154618 Genomic DNA. No translation available.
IPI	IPI00120907.
RefSeq	NP_444309.2. NM_053079.2.
UniGene	Mm.155618.
3D structure databases
ProteinModelPortal	Q9JIP7.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9JIP7. 1 interaction.
STRING	Q9JIP7.
PTM databases
PhosphoSite	Q9JIP7.
Proteomic databases
PRIDE	Q9JIP7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000088386; ENSMUSP00000085728; ENSMUSG00000025557.
GeneID	56643.
KEGG	mmu:56643.
Organism-specific databases
CTD	6564.
MGI	MGI:1861376. Slc15a1.
Phylogenomic databases
GeneTree	ENSGT00530000062961.
HOGENOM	HBG447142.
HOVERGEN	HBG052962.
InParanoid	Q9JIP7.
OrthoDB	EOG4W6NVM.
PhylomeDB	Q9JIP7.
Gene expression databases
ArrayExpress	Q9JIP7.
Bgee	Q9JIP7.
Genevestigator	Q9JIP7.
GermOnline	ENSMUSG00000025557. Mus musculus.
Family and domain databases
InterPro	IPR016196. MFS_dom_general_subst_transpt. IPR000109. Oligopeptide_transporter. IPR004768. Pep_H_symport. IPR018456. PTR2_symporter_CS. [Graphical view]
KO	K14206.
Pfam	PF00854. PTR2. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMs	TIGR00926. 2A1704. 1 hit.
PROSITE	PS01022. PTR2_1. 1 hit. PS01023. PTR2_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

S15A1_MOUSE

Accession

Primary (citable) accession number: Q9JIP7
Secondary accession number(s): E9QMX3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2005
Last sequence update:	July 27, 2011
Last modified:	December 14, 2011
This is version 68 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents