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Q9JIP7

- S15A1_MOUSE

UniProt

Q9JIP7 - S15A1_MOUSE

Protein

Solute carrier family 15 member 1

Gene

Slc15a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products By similarity.By similarity

    GO - Molecular functioni

    1. proton-dependent oligopeptide secondary active transmembrane transporter activity Source: MGI
    2. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. oligopeptide transmembrane transport Source: GOC
    2. oligopeptide transport Source: MGI
    3. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Peptide transport, Protein transport, Symport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 15 member 1
    Alternative name(s):
    Intestinal H(+)/peptide cotransporter
    Oligopeptide transporter, small intestine isoform
    Peptide transporter 1
    Proton-coupled dipeptide cotransporter
    Gene namesi
    Name:Slc15a1
    Synonyms:Pept1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 14

    Organism-specific databases

    MGIiMGI:1861376. Slc15a1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 709709Solute carrier family 15 member 1PRO_0000064305Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi439 – 4391N-linked (GlcNAc...)1 Publication
    Glycosylationi515 – 5151N-linked (GlcNAc...)1 Publication
    Glycosylationi532 – 5321N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9JIP7.
    PaxDbiQ9JIP7.
    PRIDEiQ9JIP7.

    PTM databases

    PhosphoSiteiQ9JIP7.

    Expressioni

    Gene expression databases

    BgeeiQ9JIP7.
    GenevestigatoriQ9JIP7.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9JIP7. 1 interaction.
    STRINGi10090.ENSMUSP00000085728.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JIP7.
    SMRiQ9JIP7. Positions 585-636.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 5332ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini75 – 828CytoplasmicSequence Analysis
    Topological domaini104 – 11815ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini140 – 16122CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini183 – 19816ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini220 – 27657CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini298 – 32730ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini349 – 36113CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini383 – 585203ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini607 – 62014CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini642 – 6465ExtracellularSequence Analysis
    Topological domaini668 – 70942CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1 – 2121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei54 – 7421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei83 – 10321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei119 – 13921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei162 – 18221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei199 – 21921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei277 – 29721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei328 – 34821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei362 – 38221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei586 – 60621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei621 – 64121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei647 – 66721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3104.
    GeneTreeiENSGT00530000062961.
    HOGENOMiHOG000285186.
    HOVERGENiHBG052962.
    InParanoidiQ9JIP7.
    KOiK14206.
    OMAiLVWAPNH.
    OrthoDBiEOG7M3J0R.
    TreeFamiTF330897.

    Family and domain databases

    InterProiIPR016196. MFS_dom_general_subst_transpt.
    IPR004768. Oligopep_transport.
    IPR000109. POT_fam.
    IPR018456. PTR2_symporter_CS.
    [Graphical view]
    PANTHERiPTHR11654. PTHR11654. 1 hit.
    PfamiPF00854. PTR2. 1 hit.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.
    TIGRFAMsiTIGR00926. 2A1704. 1 hit.
    PROSITEiPS01022. PTR2_1. 1 hit.
    PS01023. PTR2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JIP7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGMSKSRGCF GYPLSIFFIV VNEFCERFSY YGMRALLVLY FRNFLGWDDN    50
    LSTAIYHTFV ALCYLTPILG ALIADSWLGK FKTIVSLSIV YTIGQAVISV 100
    SSINDLTDHD HNGSPDSLPV HVALSMVGLA LIALGTGGIK PCVSAFGGDQ 150
    FEEGQEKQRN RFFSIFYLAI NGGSLLSTII TPILRVQQCG IHSQQACYPL 200
    AFGVPAALMA VALIVFVLGS GMYKKFQPQG NIMGKVAKCI GFAIKNRFRH 250
    RSKAYPKREH WLDWAKEKYD ERLISQIKMV TKVMFLYIPL PMFWALFDQQ 300
    GSRWTLQATT MNGKIGAIEI QPDQMQTVNA ILIVIMVPIV DAVVYPLIAK 350
    CGFNFTSLKK MTVGMFLASM AFVVAAIVQV EIDKTLPVFP GGNQVQIKVL 400
    NIGNNNMTVH FPGNSVTLAQ MSQTDTFMTF DIDKLTSINI SSSGSPGVTT 450
    VAHDFEQGHR HTLLVWNPSQ YRVVKDGLNQ KPEKGENGIR FVNTLNEMVT 500
    IKMSGKVYEN VTSHNASGYQ FFPSGEKQYT INTTAVAPTC LTDFKSSNLD 550
    FGSAYTYVIR RASDGCLEVK EFEDIPPNTV NMALQIPQYF LLTCGEVVFS 600
    VTGLEFSYSQ APSNMKSVLQ AGWLLTVAVG NIIVLIVAGA GHFPKQWAEY 650
    ILFASLLLVV CVIFAIMARF YTYINPAEIE AQFDEDEKKK GIGKENPYSS 700
    LEPVSQTNM 709
    Length:709
    Mass (Da):78,560
    Last modified:July 27, 2011 - v2
    Checksum:i7DF0D0F9068CD046
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti287 – 2871Y → F in AAF81666. (PubMed:11004485)Curated
    Sequence conflicti295 – 2951A → G in AAF81666. (PubMed:11004485)Curated
    Sequence conflicti318 – 3181I → N in AAF81666. (PubMed:11004485)Curated
    Sequence conflicti333 – 3397IVIMVPI → NVNNGPN in AAF81666. (PubMed:11004485)Curated
    Sequence conflicti346 – 3472PL → RS in AAF81666. (PubMed:11004485)Curated
    Sequence conflicti462 – 4621T → N in AAF81666. (PubMed:11004485)Curated
    Sequence conflicti467 – 4671N → E in AAF81666. (PubMed:11004485)Curated
    Sequence conflicti478 – 4781L → P in AAF81666. (PubMed:11004485)Curated
    Sequence conflicti501 – 5011I → N in AAF81666. (PubMed:11004485)Curated
    Sequence conflicti510 – 5112NV → KF in AAF81666. (PubMed:11004485)Curated
    Sequence conflicti520 – 5223QFF → KFL in AAF81666. (PubMed:11004485)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF205540 mRNA. Translation: AAF81666.1.
    AC126253 Genomic DNA. No translation available.
    AC154618 Genomic DNA. No translation available.
    CCDSiCCDS37017.1.
    RefSeqiNP_444309.2. NM_053079.2.
    UniGeneiMm.155618.

    Genome annotation databases

    EnsembliENSMUST00000088386; ENSMUSP00000085728; ENSMUSG00000025557.
    GeneIDi56643.
    KEGGimmu:56643.
    UCSCiuc007vad.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF205540 mRNA. Translation: AAF81666.1 .
    AC126253 Genomic DNA. No translation available.
    AC154618 Genomic DNA. No translation available.
    CCDSi CCDS37017.1.
    RefSeqi NP_444309.2. NM_053079.2.
    UniGenei Mm.155618.

    3D structure databases

    ProteinModelPortali Q9JIP7.
    SMRi Q9JIP7. Positions 585-636.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9JIP7. 1 interaction.
    STRINGi 10090.ENSMUSP00000085728.

    Chemistry

    ChEMBLi CHEMBL2073714.

    PTM databases

    PhosphoSitei Q9JIP7.

    Proteomic databases

    MaxQBi Q9JIP7.
    PaxDbi Q9JIP7.
    PRIDEi Q9JIP7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000088386 ; ENSMUSP00000085728 ; ENSMUSG00000025557 .
    GeneIDi 56643.
    KEGGi mmu:56643.
    UCSCi uc007vad.1. mouse.

    Organism-specific databases

    CTDi 6564.
    MGIi MGI:1861376. Slc15a1.

    Phylogenomic databases

    eggNOGi COG3104.
    GeneTreei ENSGT00530000062961.
    HOGENOMi HOG000285186.
    HOVERGENi HBG052962.
    InParanoidi Q9JIP7.
    KOi K14206.
    OMAi LVWAPNH.
    OrthoDBi EOG7M3J0R.
    TreeFami TF330897.

    Miscellaneous databases

    NextBioi 313093.
    PROi Q9JIP7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JIP7.
    Genevestigatori Q9JIP7.

    Family and domain databases

    InterProi IPR016196. MFS_dom_general_subst_transpt.
    IPR004768. Oligopep_transport.
    IPR000109. POT_fam.
    IPR018456. PTR2_symporter_CS.
    [Graphical view ]
    PANTHERi PTHR11654. PTHR11654. 1 hit.
    Pfami PF00854. PTR2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    TIGRFAMsi TIGR00926. 2A1704. 1 hit.
    PROSITEi PS01022. PTR2_1. 1 hit.
    PS01023. PTR2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA structure, genomic organization, and promoter analysis of the mouse intestinal peptide transporter PEPT1."
      Fei Y.-J., Sugawara M., Liu J.-C., Li H.W., Ganapathy V., Ganapathy M.E., Leibach F.H.
      Biochim. Biophys. Acta 1492:145-154(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: 129/SvJ.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-439 AND ASN-515.

    Entry informationi

    Entry nameiS15A1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JIP7
    Secondary accession number(s): E9QMX3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3