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Protein

Solute carrier family 15 member 1

Gene

Slc15a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • oligopeptide transport Source: MGI
  • protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-427975. Proton/oligopeptide cotransporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 1
Alternative name(s):
Intestinal H(+)/peptide cotransporter
Oligopeptide transporter, small intestine isoform
Peptide transporter 1
Proton-coupled dipeptide cotransporter
Gene namesi
Name:Slc15a1
Synonyms:Pept1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:1861376. Slc15a1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1 – 21HelicalSequence analysisAdd BLAST21
Topological domaini22 – 53ExtracellularSequence analysisAdd BLAST32
Transmembranei54 – 74HelicalSequence analysisAdd BLAST21
Topological domaini75 – 82CytoplasmicSequence analysis8
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Topological domaini104 – 118ExtracellularSequence analysisAdd BLAST15
Transmembranei119 – 139HelicalSequence analysisAdd BLAST21
Topological domaini140 – 161CytoplasmicSequence analysisAdd BLAST22
Transmembranei162 – 182HelicalSequence analysisAdd BLAST21
Topological domaini183 – 198ExtracellularSequence analysisAdd BLAST16
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 276CytoplasmicSequence analysisAdd BLAST57
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Topological domaini298 – 327ExtracellularSequence analysisAdd BLAST30
Transmembranei328 – 348HelicalSequence analysisAdd BLAST21
Topological domaini349 – 361CytoplasmicSequence analysisAdd BLAST13
Transmembranei362 – 382HelicalSequence analysisAdd BLAST21
Topological domaini383 – 585ExtracellularSequence analysisAdd BLAST203
Transmembranei586 – 606HelicalSequence analysisAdd BLAST21
Topological domaini607 – 620CytoplasmicSequence analysisAdd BLAST14
Transmembranei621 – 641HelicalSequence analysisAdd BLAST21
Topological domaini642 – 646ExtracellularSequence analysis5
Transmembranei647 – 667HelicalSequence analysisAdd BLAST21
Topological domaini668 – 709CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

  • brush border Source: UniProtKB
  • integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2073714.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000643051 – 709Solute carrier family 15 member 1Add BLAST709

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Glycosylationi406N-linked (GlcNAc...)Sequence analysis1
Glycosylationi439N-linked (GlcNAc...)1 Publication1
Glycosylationi515N-linked (GlcNAc...)1 Publication1
Glycosylationi532N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9JIP7.
PaxDbiQ9JIP7.
PRIDEiQ9JIP7.

PTM databases

PhosphoSitePlusiQ9JIP7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000025557.
GenevisibleiQ9JIP7. MM.

Interactioni

Protein-protein interaction databases

IntActiQ9JIP7. 1 interactor.
STRINGi10090.ENSMUSP00000085728.

Chemistry databases

BindingDBiQ9JIP7.

Structurei

Secondary structure

1709
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi393 – 401Combined sources9
Beta strandi403 – 405Combined sources3
Beta strandi407 – 411Combined sources5
Beta strandi414 – 418Combined sources5
Beta strandi428 – 431Combined sources4
Helixi432 – 434Combined sources3
Beta strandi439 – 444Combined sources6
Beta strandi448 – 450Combined sources3
Beta strandi459 – 466Combined sources8
Turni467 – 469Combined sources3
Beta strandi470 – 480Combined sources11
Beta strandi487 – 493Combined sources7
Beta strandi495 – 497Combined sources3
Beta strandi499 – 503Combined sources5
Beta strandi506 – 511Combined sources6
Beta strandi520 – 522Combined sources3
Beta strandi528 – 532Combined sources5
Beta strandi534 – 536Combined sources3
Beta strandi543 – 545Combined sources3
Beta strandi554 – 561Combined sources8
Beta strandi565 – 574Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5A9DX-ray2.10A/B391-579[»]
ProteinModelPortaliQ9JIP7.
SMRiQ9JIP7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000285186.
HOVERGENiHBG052962.
InParanoidiQ9JIP7.
KOiK14206.
OMAiAYTYVIR.
OrthoDBiEOG091G0M1S.
TreeFamiTF330897.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JIP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMSKSRGCF GYPLSIFFIV VNEFCERFSY YGMRALLVLY FRNFLGWDDN
60 70 80 90 100
LSTAIYHTFV ALCYLTPILG ALIADSWLGK FKTIVSLSIV YTIGQAVISV
110 120 130 140 150
SSINDLTDHD HNGSPDSLPV HVALSMVGLA LIALGTGGIK PCVSAFGGDQ
160 170 180 190 200
FEEGQEKQRN RFFSIFYLAI NGGSLLSTII TPILRVQQCG IHSQQACYPL
210 220 230 240 250
AFGVPAALMA VALIVFVLGS GMYKKFQPQG NIMGKVAKCI GFAIKNRFRH
260 270 280 290 300
RSKAYPKREH WLDWAKEKYD ERLISQIKMV TKVMFLYIPL PMFWALFDQQ
310 320 330 340 350
GSRWTLQATT MNGKIGAIEI QPDQMQTVNA ILIVIMVPIV DAVVYPLIAK
360 370 380 390 400
CGFNFTSLKK MTVGMFLASM AFVVAAIVQV EIDKTLPVFP GGNQVQIKVL
410 420 430 440 450
NIGNNNMTVH FPGNSVTLAQ MSQTDTFMTF DIDKLTSINI SSSGSPGVTT
460 470 480 490 500
VAHDFEQGHR HTLLVWNPSQ YRVVKDGLNQ KPEKGENGIR FVNTLNEMVT
510 520 530 540 550
IKMSGKVYEN VTSHNASGYQ FFPSGEKQYT INTTAVAPTC LTDFKSSNLD
560 570 580 590 600
FGSAYTYVIR RASDGCLEVK EFEDIPPNTV NMALQIPQYF LLTCGEVVFS
610 620 630 640 650
VTGLEFSYSQ APSNMKSVLQ AGWLLTVAVG NIIVLIVAGA GHFPKQWAEY
660 670 680 690 700
ILFASLLLVV CVIFAIMARF YTYINPAEIE AQFDEDEKKK GIGKENPYSS

LEPVSQTNM
Length:709
Mass (Da):78,560
Last modified:July 27, 2011 - v2
Checksum:i7DF0D0F9068CD046
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti287Y → F in AAF81666 (PubMed:11004485).Curated1
Sequence conflicti295A → G in AAF81666 (PubMed:11004485).Curated1
Sequence conflicti318I → N in AAF81666 (PubMed:11004485).Curated1
Sequence conflicti333 – 339IVIMVPI → NVNNGPN in AAF81666 (PubMed:11004485).Curated7
Sequence conflicti346 – 347PL → RS in AAF81666 (PubMed:11004485).Curated2
Sequence conflicti462T → N in AAF81666 (PubMed:11004485).Curated1
Sequence conflicti467N → E in AAF81666 (PubMed:11004485).Curated1
Sequence conflicti478L → P in AAF81666 (PubMed:11004485).Curated1
Sequence conflicti501I → N in AAF81666 (PubMed:11004485).Curated1
Sequence conflicti510 – 511NV → KF in AAF81666 (PubMed:11004485).Curated2
Sequence conflicti520 – 522QFF → KFL in AAF81666 (PubMed:11004485).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205540 mRNA. Translation: AAF81666.1.
AC126253 Genomic DNA. No translation available.
AC154618 Genomic DNA. No translation available.
CCDSiCCDS37017.1.
RefSeqiNP_444309.2. NM_053079.2.
UniGeneiMm.155618.

Genome annotation databases

EnsembliENSMUST00000088386; ENSMUSP00000085728; ENSMUSG00000025557.
GeneIDi56643.
KEGGimmu:56643.
UCSCiuc007vad.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205540 mRNA. Translation: AAF81666.1.
AC126253 Genomic DNA. No translation available.
AC154618 Genomic DNA. No translation available.
CCDSiCCDS37017.1.
RefSeqiNP_444309.2. NM_053079.2.
UniGeneiMm.155618.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5A9DX-ray2.10A/B391-579[»]
ProteinModelPortaliQ9JIP7.
SMRiQ9JIP7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JIP7. 1 interactor.
STRINGi10090.ENSMUSP00000085728.

Chemistry databases

BindingDBiQ9JIP7.
ChEMBLiCHEMBL2073714.

PTM databases

PhosphoSitePlusiQ9JIP7.

Proteomic databases

MaxQBiQ9JIP7.
PaxDbiQ9JIP7.
PRIDEiQ9JIP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088386; ENSMUSP00000085728; ENSMUSG00000025557.
GeneIDi56643.
KEGGimmu:56643.
UCSCiuc007vad.1. mouse.

Organism-specific databases

CTDi6564.
MGIiMGI:1861376. Slc15a1.

Phylogenomic databases

eggNOGiKOG1237. Eukaryota.
COG3104. LUCA.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000285186.
HOVERGENiHBG052962.
InParanoidiQ9JIP7.
KOiK14206.
OMAiAYTYVIR.
OrthoDBiEOG091G0M1S.
TreeFamiTF330897.

Enzyme and pathway databases

ReactomeiR-MMU-427975. Proton/oligopeptide cotransporters.

Miscellaneous databases

PROiQ9JIP7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025557.
GenevisibleiQ9JIP7. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 2 hits.
PfamiPF00854. PTR2. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS15A1_MOUSE
AccessioniPrimary (citable) accession number: Q9JIP7
Secondary accession number(s): E9QMX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.