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Protein

Solute carrier family 15 member 1

Gene

Slc15a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products (By similarity).By similarity

GO - Molecular functioni

  1. proton-dependent oligopeptide secondary active transmembrane transporter activity Source: MGI
  2. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. oligopeptide transmembrane transport Source: GOC
  2. oligopeptide transport Source: MGI
  3. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Peptide transport, Protein transport, Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_246374. Proton/oligonucleotide cotransporters.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 15 member 1
Alternative name(s):
Intestinal H(+)/peptide cotransporter
Oligopeptide transporter, small intestine isoform
Peptide transporter 1
Proton-coupled dipeptide cotransporter
Gene namesi
Name:Slc15a1
Synonyms:Pept1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1861376. Slc15a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121HelicalSequence AnalysisAdd
BLAST
Topological domaini22 – 5332ExtracellularSequence AnalysisAdd
BLAST
Transmembranei54 – 7421HelicalSequence AnalysisAdd
BLAST
Topological domaini75 – 828CytoplasmicSequence Analysis
Transmembranei83 – 10321HelicalSequence AnalysisAdd
BLAST
Topological domaini104 – 11815ExtracellularSequence AnalysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence AnalysisAdd
BLAST
Topological domaini140 – 16122CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence AnalysisAdd
BLAST
Topological domaini183 – 19816ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 21921HelicalSequence AnalysisAdd
BLAST
Topological domaini220 – 27657CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei277 – 29721HelicalSequence AnalysisAdd
BLAST
Topological domaini298 – 32730ExtracellularSequence AnalysisAdd
BLAST
Transmembranei328 – 34821HelicalSequence AnalysisAdd
BLAST
Topological domaini349 – 36113CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei362 – 38221HelicalSequence AnalysisAdd
BLAST
Topological domaini383 – 585203ExtracellularSequence AnalysisAdd
BLAST
Transmembranei586 – 60621HelicalSequence AnalysisAdd
BLAST
Topological domaini607 – 62014CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei621 – 64121HelicalSequence AnalysisAdd
BLAST
Topological domaini642 – 6465ExtracellularSequence Analysis
Transmembranei647 – 66721HelicalSequence AnalysisAdd
BLAST
Topological domaini668 – 70942CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 709709Solute carrier family 15 member 1PRO_0000064305Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi406 – 4061N-linked (GlcNAc...)Sequence Analysis
Glycosylationi439 – 4391N-linked (GlcNAc...)1 Publication
Glycosylationi515 – 5151N-linked (GlcNAc...)1 Publication
Glycosylationi532 – 5321N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9JIP7.
PaxDbiQ9JIP7.
PRIDEiQ9JIP7.

PTM databases

PhosphoSiteiQ9JIP7.

Expressioni

Gene expression databases

BgeeiQ9JIP7.
GenevestigatoriQ9JIP7.

Interactioni

Protein-protein interaction databases

IntActiQ9JIP7. 1 interaction.
STRINGi10090.ENSMUSP00000085728.

Structurei

3D structure databases

ProteinModelPortaliQ9JIP7.
SMRiQ9JIP7. Positions 7-374, 585-636.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG3104.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000285186.
HOVERGENiHBG052962.
InParanoidiQ9JIP7.
KOiK14206.
OMAiILRVQQC.
OrthoDBiEOG7M3J0R.
TreeFamiTF330897.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 1 hit.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JIP7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMSKSRGCF GYPLSIFFIV VNEFCERFSY YGMRALLVLY FRNFLGWDDN
60 70 80 90 100
LSTAIYHTFV ALCYLTPILG ALIADSWLGK FKTIVSLSIV YTIGQAVISV
110 120 130 140 150
SSINDLTDHD HNGSPDSLPV HVALSMVGLA LIALGTGGIK PCVSAFGGDQ
160 170 180 190 200
FEEGQEKQRN RFFSIFYLAI NGGSLLSTII TPILRVQQCG IHSQQACYPL
210 220 230 240 250
AFGVPAALMA VALIVFVLGS GMYKKFQPQG NIMGKVAKCI GFAIKNRFRH
260 270 280 290 300
RSKAYPKREH WLDWAKEKYD ERLISQIKMV TKVMFLYIPL PMFWALFDQQ
310 320 330 340 350
GSRWTLQATT MNGKIGAIEI QPDQMQTVNA ILIVIMVPIV DAVVYPLIAK
360 370 380 390 400
CGFNFTSLKK MTVGMFLASM AFVVAAIVQV EIDKTLPVFP GGNQVQIKVL
410 420 430 440 450
NIGNNNMTVH FPGNSVTLAQ MSQTDTFMTF DIDKLTSINI SSSGSPGVTT
460 470 480 490 500
VAHDFEQGHR HTLLVWNPSQ YRVVKDGLNQ KPEKGENGIR FVNTLNEMVT
510 520 530 540 550
IKMSGKVYEN VTSHNASGYQ FFPSGEKQYT INTTAVAPTC LTDFKSSNLD
560 570 580 590 600
FGSAYTYVIR RASDGCLEVK EFEDIPPNTV NMALQIPQYF LLTCGEVVFS
610 620 630 640 650
VTGLEFSYSQ APSNMKSVLQ AGWLLTVAVG NIIVLIVAGA GHFPKQWAEY
660 670 680 690 700
ILFASLLLVV CVIFAIMARF YTYINPAEIE AQFDEDEKKK GIGKENPYSS

LEPVSQTNM
Length:709
Mass (Da):78,560
Last modified:July 27, 2011 - v2
Checksum:i7DF0D0F9068CD046
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti287 – 2871Y → F in AAF81666 (PubMed:11004485).Curated
Sequence conflicti295 – 2951A → G in AAF81666 (PubMed:11004485).Curated
Sequence conflicti318 – 3181I → N in AAF81666 (PubMed:11004485).Curated
Sequence conflicti333 – 3397IVIMVPI → NVNNGPN in AAF81666 (PubMed:11004485).Curated
Sequence conflicti346 – 3472PL → RS in AAF81666 (PubMed:11004485).Curated
Sequence conflicti462 – 4621T → N in AAF81666 (PubMed:11004485).Curated
Sequence conflicti467 – 4671N → E in AAF81666 (PubMed:11004485).Curated
Sequence conflicti478 – 4781L → P in AAF81666 (PubMed:11004485).Curated
Sequence conflicti501 – 5011I → N in AAF81666 (PubMed:11004485).Curated
Sequence conflicti510 – 5112NV → KF in AAF81666 (PubMed:11004485).Curated
Sequence conflicti520 – 5223QFF → KFL in AAF81666 (PubMed:11004485).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205540 mRNA. Translation: AAF81666.1.
AC126253 Genomic DNA. No translation available.
AC154618 Genomic DNA. No translation available.
CCDSiCCDS37017.1.
RefSeqiNP_444309.2. NM_053079.2.
UniGeneiMm.155618.

Genome annotation databases

EnsembliENSMUST00000088386; ENSMUSP00000085728; ENSMUSG00000025557.
GeneIDi56643.
KEGGimmu:56643.
UCSCiuc007vad.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF205540 mRNA. Translation: AAF81666.1.
AC126253 Genomic DNA. No translation available.
AC154618 Genomic DNA. No translation available.
CCDSiCCDS37017.1.
RefSeqiNP_444309.2. NM_053079.2.
UniGeneiMm.155618.

3D structure databases

ProteinModelPortaliQ9JIP7.
SMRiQ9JIP7. Positions 7-374, 585-636.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JIP7. 1 interaction.
STRINGi10090.ENSMUSP00000085728.

Chemistry

ChEMBLiCHEMBL2073714.

PTM databases

PhosphoSiteiQ9JIP7.

Proteomic databases

MaxQBiQ9JIP7.
PaxDbiQ9JIP7.
PRIDEiQ9JIP7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000088386; ENSMUSP00000085728; ENSMUSG00000025557.
GeneIDi56643.
KEGGimmu:56643.
UCSCiuc007vad.1. mouse.

Organism-specific databases

CTDi6564.
MGIiMGI:1861376. Slc15a1.

Phylogenomic databases

eggNOGiCOG3104.
GeneTreeiENSGT00530000062961.
HOGENOMiHOG000285186.
HOVERGENiHBG052962.
InParanoidiQ9JIP7.
KOiK14206.
OMAiILRVQQC.
OrthoDBiEOG7M3J0R.
TreeFamiTF330897.

Enzyme and pathway databases

ReactomeiREACT_246374. Proton/oligonucleotide cotransporters.

Miscellaneous databases

NextBioi313093.
PROiQ9JIP7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JIP7.
GenevestigatoriQ9JIP7.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERiPTHR11654. PTHR11654. 1 hit.
PfamiPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00926. 2A1704. 1 hit.
PROSITEiPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA structure, genomic organization, and promoter analysis of the mouse intestinal peptide transporter PEPT1."
    Fei Y.-J., Sugawara M., Liu J.-C., Li H.W., Ganapathy V., Ganapathy M.E., Leibach F.H.
    Biochim. Biophys. Acta 1492:145-154(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/SvJ.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-439 AND ASN-515.

Entry informationi

Entry nameiS15A1_MOUSE
AccessioniPrimary (citable) accession number: Q9JIP7
Secondary accession number(s): E9QMX3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 27, 2011
Last modified: January 7, 2015
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.