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Q9JIP7 (S15A1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Solute carrier family 15 member 1
Alternative name(s):
Intestinal H(+)/peptide cotransporter
Oligopeptide transporter, small intestine isoform
Peptide transporter 1
Proton-coupled dipeptide cotransporter
Gene names
Name:Slc15a1
Synonyms:Pept1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length709 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides. May constitute a major route for the absorption of protein digestion end-products By similarity.

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the PTR2/POT transporter (TC 2.A.17) family. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 709709Solute carrier family 15 member 1
PRO_0000064305

Regions

Transmembrane1 – 2121Helical; Potential
Topological domain22 – 5332Extracellular Potential
Transmembrane54 – 7421Helical; Potential
Topological domain75 – 828Cytoplasmic Potential
Transmembrane83 – 10321Helical; Potential
Topological domain104 – 11815Extracellular Potential
Transmembrane119 – 13921Helical; Potential
Topological domain140 – 16122Cytoplasmic Potential
Transmembrane162 – 18221Helical; Potential
Topological domain183 – 19816Extracellular Potential
Transmembrane199 – 21921Helical; Potential
Topological domain220 – 27657Cytoplasmic Potential
Transmembrane277 – 29721Helical; Potential
Topological domain298 – 32730Extracellular Potential
Transmembrane328 – 34821Helical; Potential
Topological domain349 – 36113Cytoplasmic Potential
Transmembrane362 – 38221Helical; Potential
Topological domain383 – 585203Extracellular Potential
Transmembrane586 – 60621Helical; Potential
Topological domain607 – 62014Cytoplasmic Potential
Transmembrane621 – 64121Helical; Potential
Topological domain642 – 6465Extracellular Potential
Transmembrane647 – 66721Helical; Potential
Topological domain668 – 70942Cytoplasmic Potential

Amino acid modifications

Glycosylation501N-linked (GlcNAc...) Potential
Glycosylation4061N-linked (GlcNAc...) Potential
Glycosylation4391N-linked (GlcNAc...) Ref.3
Glycosylation5151N-linked (GlcNAc...) Ref.3
Glycosylation5321N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2871Y → F in AAF81666. Ref.1
Sequence conflict2951A → G in AAF81666. Ref.1
Sequence conflict3181I → N in AAF81666. Ref.1
Sequence conflict333 – 3397IVIMVPI → NVNNGPN in AAF81666. Ref.1
Sequence conflict346 – 3472PL → RS in AAF81666. Ref.1
Sequence conflict4621T → N in AAF81666. Ref.1
Sequence conflict4671N → E in AAF81666. Ref.1
Sequence conflict4781L → P in AAF81666. Ref.1
Sequence conflict5011I → N in AAF81666. Ref.1
Sequence conflict510 – 5112NV → KF in AAF81666. Ref.1
Sequence conflict520 – 5223QFF → KFL in AAF81666. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9JIP7 [UniParc].

Last modified July 27, 2011. Version 2.
Checksum: 7DF0D0F9068CD046

FASTA70978,560
        10         20         30         40         50         60 
MGMSKSRGCF GYPLSIFFIV VNEFCERFSY YGMRALLVLY FRNFLGWDDN LSTAIYHTFV 

        70         80         90        100        110        120 
ALCYLTPILG ALIADSWLGK FKTIVSLSIV YTIGQAVISV SSINDLTDHD HNGSPDSLPV 

       130        140        150        160        170        180 
HVALSMVGLA LIALGTGGIK PCVSAFGGDQ FEEGQEKQRN RFFSIFYLAI NGGSLLSTII 

       190        200        210        220        230        240 
TPILRVQQCG IHSQQACYPL AFGVPAALMA VALIVFVLGS GMYKKFQPQG NIMGKVAKCI 

       250        260        270        280        290        300 
GFAIKNRFRH RSKAYPKREH WLDWAKEKYD ERLISQIKMV TKVMFLYIPL PMFWALFDQQ 

       310        320        330        340        350        360 
GSRWTLQATT MNGKIGAIEI QPDQMQTVNA ILIVIMVPIV DAVVYPLIAK CGFNFTSLKK 

       370        380        390        400        410        420 
MTVGMFLASM AFVVAAIVQV EIDKTLPVFP GGNQVQIKVL NIGNNNMTVH FPGNSVTLAQ 

       430        440        450        460        470        480 
MSQTDTFMTF DIDKLTSINI SSSGSPGVTT VAHDFEQGHR HTLLVWNPSQ YRVVKDGLNQ 

       490        500        510        520        530        540 
KPEKGENGIR FVNTLNEMVT IKMSGKVYEN VTSHNASGYQ FFPSGEKQYT INTTAVAPTC 

       550        560        570        580        590        600 
LTDFKSSNLD FGSAYTYVIR RASDGCLEVK EFEDIPPNTV NMALQIPQYF LLTCGEVVFS 

       610        620        630        640        650        660 
VTGLEFSYSQ APSNMKSVLQ AGWLLTVAVG NIIVLIVAGA GHFPKQWAEY ILFASLLLVV 

       670        680        690        700 
CVIFAIMARF YTYINPAEIE AQFDEDEKKK GIGKENPYSS LEPVSQTNM 

« Hide

References

« Hide 'large scale' references
[1]"cDNA structure, genomic organization, and promoter analysis of the mouse intestinal peptide transporter PEPT1."
Fei Y.-J., Sugawara M., Liu J.-C., Li H.W., Ganapathy V., Ganapathy M.E., Leibach F.H.
Biochim. Biophys. Acta 1492:145-154(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: 129/SvJ.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-439 AND ASN-515.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF205540 mRNA. Translation: AAF81666.1.
AC126253 Genomic DNA. No translation available.
AC154618 Genomic DNA. No translation available.
CCDSCCDS37017.1.
RefSeqNP_444309.2. NM_053079.2.
UniGeneMm.155618.

3D structure databases

ProteinModelPortalQ9JIP7.
SMRQ9JIP7. Positions 585-636.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9JIP7. 1 interaction.
STRING10090.ENSMUSP00000085728.

Chemistry

ChEMBLCHEMBL2073714.

PTM databases

PhosphoSiteQ9JIP7.

Proteomic databases

MaxQBQ9JIP7.
PaxDbQ9JIP7.
PRIDEQ9JIP7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000088386; ENSMUSP00000085728; ENSMUSG00000025557.
GeneID56643.
KEGGmmu:56643.
UCSCuc007vad.1. mouse.

Organism-specific databases

CTD6564.
MGIMGI:1861376. Slc15a1.

Phylogenomic databases

eggNOGCOG3104.
GeneTreeENSGT00530000062961.
HOGENOMHOG000285186.
HOVERGENHBG052962.
InParanoidQ9JIP7.
KOK14206.
OMALVWAPNH.
OrthoDBEOG7M3J0R.
TreeFamTF330897.

Gene expression databases

BgeeQ9JIP7.
GenevestigatorQ9JIP7.

Family and domain databases

InterProIPR016196. MFS_dom_general_subst_transpt.
IPR004768. Oligopep_transport.
IPR000109. POT_fam.
IPR018456. PTR2_symporter_CS.
[Graphical view]
PANTHERPTHR11654. PTHR11654. 1 hit.
PfamPF00854. PTR2. 1 hit.
[Graphical view]
SUPFAMSSF103473. SSF103473. 2 hits.
TIGRFAMsTIGR00926. 2A1704. 1 hit.
PROSITEPS01022. PTR2_1. 1 hit.
PS01023. PTR2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio313093.
PROQ9JIP7.
SOURCESearch...

Entry information

Entry nameS15A1_MOUSE
AccessionPrimary (citable) accession number: Q9JIP7
Secondary accession number(s): E9QMX3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 27, 2011
Last modified: July 9, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot