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Protein

Frizzled-2

Gene

Fzd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

GO - Molecular functioni

GO - Biological processi

  • canonical Wnt signaling pathway Source: MGI
  • cell-cell signaling Source: MGI
  • cochlea morphogenesis Source: MGI
  • epithelial cell differentiation Source: MGI
  • hard palate development Source: MGI
  • inner ear receptor cell development Source: MGI
  • membranous septum morphogenesis Source: MGI
  • muscular septum morphogenesis Source: MGI
  • outflow tract morphogenesis Source: MGI
  • planar cell polarity pathway involved in neural tube closure Source: MGI
  • positive regulation of cGMP metabolic process Source: MGI
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • sensory perception of smell Source: MGI
  • ventricular septum morphogenesis Source: MGI

Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer
Biological processWnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-4086398. Ca2+ pathway.
R-MMU-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.
R-MMU-5140745. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-2
Short name:
Fz-2
Short name:
mFz2
Alternative name(s):
Frizzled-10
Short name:
Fz-10
Short name:
mFz10
Gene namesi
Name:Fzd2
Synonyms:Fzd10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1888513. Fzd2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 252ExtracellularSequence analysisAdd BLAST224
Transmembranei253 – 273Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini274 – 284CytoplasmicSequence analysisAdd BLAST11
Transmembranei285 – 305Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini306 – 332ExtracellularSequence analysisAdd BLAST27
Transmembranei333 – 353Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini354 – 375CytoplasmicSequence analysisAdd BLAST22
Transmembranei376 – 396Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini397 – 419ExtracellularSequence analysisAdd BLAST23
Transmembranei420 – 440Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini441 – 466CytoplasmicSequence analysisAdd BLAST26
Transmembranei467 – 487Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini488 – 524ExtracellularSequence analysisAdd BLAST37
Transmembranei525 – 545Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini546 – 570CytoplasmicSequence analysisAdd BLAST25

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001297929 – 570Frizzled-2Add BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi44 ↔ 105PROSITE-ProRule annotation
Disulfide bondi52 ↔ 98PROSITE-ProRule annotation
Glycosylationi58N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi89 ↔ 126PROSITE-ProRule annotation
Disulfide bondi115 ↔ 155PROSITE-ProRule annotation
Disulfide bondi119 ↔ 143PROSITE-ProRule annotation
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9JIP6.
PaxDbiQ9JIP6.
PeptideAtlasiQ9JIP6.
PRIDEiQ9JIP6.

PTM databases

PhosphoSitePlusiQ9JIP6.

Expressioni

Tissue specificityi

Expressed in embryonic and adult heart, lung, chondrocytes and brain. Also expressed in the developing gastrointestinal tract (strongest in foregut), much weaker expression in the adult. No expression in fetal liver and adult spleen. Up-regulated in esophageal squamous cell carcinomas.

Gene expression databases

BgeeiENSMUSG00000050288.
CleanExiMM_FZD10.
MM_FZD2.
GenevisibleiQ9JIP6. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9JIP6. 1 interactor.
MINTiMINT-1779244.
STRINGi10090.ENSMUSP00000091463.

Structurei

3D structure databases

ProteinModelPortaliQ9JIP6.
SMRiQ9JIP6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 158FZPROSITE-ProRule annotationAdd BLAST120

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi548 – 553Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity6
Motifi568 – 570PDZ-binding3

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi186 – 192Poly-Gly7

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000233237.
HOVERGENiHBG006977.
InParanoidiQ9JIP6.
KOiK02235.
OMAiKDCAAPC.
OrthoDBiEOG091G0N5M.
PhylomeDBiQ9JIP6.
TreeFamiTF317907.

Family and domain databases

InterProiView protein in InterPro
IPR015526. Frizzled/SFRP.
IPR000539. Frizzled/Smoothened_TM.
IPR020067. Frizzled_dom.
IPR026550. FZD2.
IPR017981. GPCR_2-like.
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF103. PTHR11309:SF103. 1 hit.
PfamiView protein in Pfam
PF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
PRINTSiPR00489. FRIZZLED.
SMARTiView protein in SMART
SM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiView protein in PROSITE
PS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JIP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRARSALPRS ALPRLLLPLL LLPAAGPAQF HGEKGISIPD HGFCQPISIP
60 70 80 90 100
LCTDIAYNQT IMPNLLGHTN QEDAGLEVHQ FYPLVKVQCS PELRFFLCSM
110 120 130 140 150
YAPVCTVLEQ AIPPCRSICE RARQGCEALM NKFGFQWPER LRCEHFPRHG
160 170 180 190 200
AEQICVGQNH SEDGAPALLT TAPPSGLQPG AGGTPGGPGG GGSPPRYATL
210 220 230 240 250
EHPFHCPRVL KVPSYLSYKF LGERDCAAPC EPARPDGSMF FSQEETRFAR
260 270 280 290 300
LWILTWSVLC CASTFFTVTT YLVDMQRFRY PERPIIFLSG CYTMVSVAYI
310 320 330 340 350
AGFVLQERVV CNERFSEDGY RTVVQGTKKE GCTILFMMLY FFSMASSIWW
360 370 380 390 400
VILSLTWFLA AGMKWGHEAI EANSQYFHLA AWAVPAVKTI TILAMGQIDG
410 420 430 440 450
DLLSGVCFVG LNSLDPLRGF VLAPLFVYLF IGTSFLLAGF VSLFRIRTIM
460 470 480 490 500
KHDGTKTEKL ERLMVRIGVF SVLYTVPATI VIACYFYEQA FREHWERSWV
510 520 530 540 550
SQHCKSLAIP CPAHYTPRMS PDFTVYMIKY LMTLIVGITS GFWIWSGKTL
560 570
HSWRKFYTRL TNSRHGETTV
Length:570
Mass (Da):64,059
Last modified:October 1, 2000 - v1
Checksum:i79EE7F71D10FC51A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti307E → K in AAD28286 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF206321 mRNA. Translation: AAF74056.1.
AF206322 mRNA. Translation: AAF74057.1.
BC049774 mRNA. Translation: AAH49774.2.
BC055727 mRNA. Translation: AAH55727.1.
AF139183 mRNA. Translation: AAD28286.1.
CCDSiCCDS25501.1.
RefSeqiNP_065256.1. NM_020510.2.
UniGeneiMm.36416.

Genome annotation databases

EnsembliENSMUST00000057893; ENSMUSP00000091463; ENSMUSG00000050288.
GeneIDi57265.
KEGGimmu:57265.
UCSCiuc011yft.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiFZD2_MOUSE
AccessioniPrimary (citable) accession number: Q9JIP6
Secondary accession number(s): Q810M0, Q9JIP5, Q9WUJ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families