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Protein

Frizzled-2

Gene

Fzd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

GO - Molecular functioni

GO - Biological processi

  • canonical Wnt signaling pathway Source: MGI
  • cell-cell signaling Source: MGI
  • cochlea morphogenesis Source: MGI
  • epithelial cell differentiation Source: MGI
  • hard palate development Source: MGI
  • inner ear receptor cell development Source: MGI
  • membranous septum morphogenesis Source: MGI
  • muscular septum morphogenesis Source: MGI
  • outflow tract morphogenesis Source: MGI
  • planar cell polarity pathway involved in neural tube closure Source: MGI
  • positive regulation of cGMP metabolic process Source: MGI
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: MGI
  • positive regulation of transcription, DNA-templated Source: MGI
  • sensory perception of smell Source: MGI
  • ventricular septum morphogenesis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiR-MMU-4086398. Ca2+ pathway.
R-MMU-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.
R-MMU-5140745. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled-2
Short name:
Fz-2
Short name:
mFz2
Alternative name(s):
Frizzled-10
Short name:
Fz-10
Short name:
mFz10
Gene namesi
Name:Fzd2
Synonyms:Fzd10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1888513. Fzd2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 252224ExtracellularSequence analysisAdd
BLAST
Transmembranei253 – 27321Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini274 – 28411CytoplasmicSequence analysisAdd
BLAST
Transmembranei285 – 30521Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini306 – 33227ExtracellularSequence analysisAdd
BLAST
Transmembranei333 – 35321Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini354 – 37522CytoplasmicSequence analysisAdd
BLAST
Transmembranei376 – 39621Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini397 – 41923ExtracellularSequence analysisAdd
BLAST
Transmembranei420 – 44021Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini441 – 46626CytoplasmicSequence analysisAdd
BLAST
Transmembranei467 – 48721Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini488 – 52437ExtracellularSequence analysisAdd
BLAST
Transmembranei525 – 54521Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini546 – 57025CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 570542Frizzled-2PRO_0000012979Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi44 ↔ 105PROSITE-ProRule annotation
Disulfide bondi52 ↔ 98PROSITE-ProRule annotation
Glycosylationi58 – 581N-linked (GlcNAc...)Sequence analysis
Disulfide bondi89 ↔ 126PROSITE-ProRule annotation
Disulfide bondi115 ↔ 155PROSITE-ProRule annotation
Disulfide bondi119 ↔ 143PROSITE-ProRule annotation
Glycosylationi159 – 1591N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9JIP6.
PaxDbiQ9JIP6.
PRIDEiQ9JIP6.

PTM databases

PhosphoSiteiQ9JIP6.

Expressioni

Tissue specificityi

Expressed in embryonic and adult heart, lung, chondrocytes and brain. Also expressed in the developing gastrointestinal tract (strongest in foregut), much weaker expression in the adult. No expression in fetal liver and adult spleen. Up-regulated in esophageal squamous cell carcinomas.

Gene expression databases

BgeeiQ9JIP6.
CleanExiMM_FZD10.
MM_FZD2.
GenevisibleiQ9JIP6. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ9JIP6. 1 interaction.
MINTiMINT-1779244.
STRINGi10090.ENSMUSP00000091463.

Structurei

3D structure databases

ProteinModelPortaliQ9JIP6.
SMRiQ9JIP6. Positions 44-150, 240-561.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 158120FZPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi548 – 5536Lys-Thr-X-X-X-Trp motif, mediates interaction with the PDZ domain of Dvl family membersBy similarity
Motifi568 – 5703PDZ-binding

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi186 – 1927Poly-Gly

Domaini

Lys-Thr-X-X-X-Trp motif interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.By similarity
The FZ domain is involved in binding with Wnt ligands.By similarity

Sequence similaritiesi

Contains 1 FZ (frizzled) domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000233237.
HOVERGENiHBG006977.
InParanoidiQ9JIP6.
KOiK02235.
OMAiCENFPRH.
OrthoDBiEOG7M3J01.
PhylomeDBiQ9JIP6.
TreeFamiTF317907.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026550. FZD2.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF34. PTHR11309:SF34. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JIP6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRARSALPRS ALPRLLLPLL LLPAAGPAQF HGEKGISIPD HGFCQPISIP
60 70 80 90 100
LCTDIAYNQT IMPNLLGHTN QEDAGLEVHQ FYPLVKVQCS PELRFFLCSM
110 120 130 140 150
YAPVCTVLEQ AIPPCRSICE RARQGCEALM NKFGFQWPER LRCEHFPRHG
160 170 180 190 200
AEQICVGQNH SEDGAPALLT TAPPSGLQPG AGGTPGGPGG GGSPPRYATL
210 220 230 240 250
EHPFHCPRVL KVPSYLSYKF LGERDCAAPC EPARPDGSMF FSQEETRFAR
260 270 280 290 300
LWILTWSVLC CASTFFTVTT YLVDMQRFRY PERPIIFLSG CYTMVSVAYI
310 320 330 340 350
AGFVLQERVV CNERFSEDGY RTVVQGTKKE GCTILFMMLY FFSMASSIWW
360 370 380 390 400
VILSLTWFLA AGMKWGHEAI EANSQYFHLA AWAVPAVKTI TILAMGQIDG
410 420 430 440 450
DLLSGVCFVG LNSLDPLRGF VLAPLFVYLF IGTSFLLAGF VSLFRIRTIM
460 470 480 490 500
KHDGTKTEKL ERLMVRIGVF SVLYTVPATI VIACYFYEQA FREHWERSWV
510 520 530 540 550
SQHCKSLAIP CPAHYTPRMS PDFTVYMIKY LMTLIVGITS GFWIWSGKTL
560 570
HSWRKFYTRL TNSRHGETTV
Length:570
Mass (Da):64,059
Last modified:October 1, 2000 - v1
Checksum:i79EE7F71D10FC51A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti307 – 3071E → K in AAD28286 (Ref. 3) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF206321 mRNA. Translation: AAF74056.1.
AF206322 mRNA. Translation: AAF74057.1.
BC049774 mRNA. Translation: AAH49774.2.
BC055727 mRNA. Translation: AAH55727.1.
AF139183 mRNA. Translation: AAD28286.1.
CCDSiCCDS25501.1.
RefSeqiNP_065256.1. NM_020510.2.
UniGeneiMm.36416.

Genome annotation databases

EnsembliENSMUST00000057893; ENSMUSP00000091463; ENSMUSG00000050288.
GeneIDi57265.
KEGGimmu:57265.
UCSCiuc011yft.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF206321 mRNA. Translation: AAF74056.1.
AF206322 mRNA. Translation: AAF74057.1.
BC049774 mRNA. Translation: AAH49774.2.
BC055727 mRNA. Translation: AAH55727.1.
AF139183 mRNA. Translation: AAD28286.1.
CCDSiCCDS25501.1.
RefSeqiNP_065256.1. NM_020510.2.
UniGeneiMm.36416.

3D structure databases

ProteinModelPortaliQ9JIP6.
SMRiQ9JIP6. Positions 44-150, 240-561.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JIP6. 1 interaction.
MINTiMINT-1779244.
STRINGi10090.ENSMUSP00000091463.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9JIP6.

Proteomic databases

MaxQBiQ9JIP6.
PaxDbiQ9JIP6.
PRIDEiQ9JIP6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057893; ENSMUSP00000091463; ENSMUSG00000050288.
GeneIDi57265.
KEGGimmu:57265.
UCSCiuc011yft.1. mouse.

Organism-specific databases

CTDi2535.
MGIiMGI:1888513. Fzd2.

Phylogenomic databases

eggNOGiKOG3577. Eukaryota.
ENOG410XRC8. LUCA.
GeneTreeiENSGT00760000118864.
HOGENOMiHOG000233237.
HOVERGENiHBG006977.
InParanoidiQ9JIP6.
KOiK02235.
OMAiCENFPRH.
OrthoDBiEOG7M3J01.
PhylomeDBiQ9JIP6.
TreeFamiTF317907.

Enzyme and pathway databases

ReactomeiR-MMU-4086398. Ca2+ pathway.
R-MMU-4641262. Disassembly of the destruction complex and recruitment of AXIN to the membrane.
R-MMU-5140745. WNT5A-dependent internalization of FZD2, FZD5 and ROR2.

Miscellaneous databases

ChiTaRSiFzd2. mouse.
NextBioi313595.
PROiQ9JIP6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JIP6.
CleanExiMM_FZD10.
MM_FZD2.
GenevisibleiQ9JIP6. MM.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiIPR000539. Frizzled.
IPR015526. Frizzled/SFRP.
IPR020067. Frizzled_dom.
IPR026550. FZD2.
IPR017981. GPCR_2-like.
[Graphical view]
PANTHERiPTHR11309. PTHR11309. 1 hit.
PTHR11309:SF34. PTHR11309:SF34. 1 hit.
PfamiPF01534. Frizzled. 1 hit.
PF01392. Fz. 1 hit.
[Graphical view]
PRINTSiPR00489. FRIZZLED.
SMARTiSM00063. FRI. 1 hit.
SM01330. Frizzled. 1 hit.
[Graphical view]
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiPS50038. FZ. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and expression of a novel frizzled gene isolated from the developing mouse gut."
    Malik T.H., Shivdasani R.A.
    Biochem. J. 349:829-834(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: ICR.
    Tissue: Fetal intestine.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain and Limb.
  3. "Characterization of the wnt signaling cascade in the TRAMP transgenic mouse model of prostate cancer."
    Johnson M.A., Greenberg N.M.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 172-312.
    Strain: C57BL/6J.
    Tissue: Prostate.

Entry informationi

Entry nameiFZD2_MOUSE
AccessioniPrimary (citable) accession number: Q9JIP6
Secondary accession number(s): Q810M0, Q9JIP5, Q9WUJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2001
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.