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Q9JIP3

- I17RB_MOUSE

UniProt

Q9JIP3 - I17RB_MOUSE

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Protein

Interleukin-17 receptor B

Gene

Il17rb

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.

GO - Molecular functioni

  1. cytokine receptor activity Source: MGI

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-17 receptor B
Short name:
IL-17 receptor B
Short name:
IL-17RB
Alternative name(s):
IL-17 receptor homolog 1
Short name:
IL-17ER
Short name:
IL-17Rh1
Short name:
IL17Rh1
Interleukin-17B receptor
Short name:
IL-17B receptor
Gene namesi
Name:Il17rb
Synonyms:Evi27, Il17br
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 14

Organism-specific databases

MGIiMGI:1355292. Il17rb.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 286269ExtracellularSequence AnalysisAdd
BLAST
Transmembranei287 – 30721HelicalSequence AnalysisAdd
BLAST
Topological domaini308 – 499192CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. cytoplasm Source: MGI
  3. extracellular region Source: UniProtKB-KW
  4. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717By similarityAdd
BLAST
Chaini18 – 499482Interleukin-17 receptor BPRO_0000011033Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi67 – 671N-linked (GlcNAc...)Sequence Analysis
Glycosylationi103 – 1031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi156 – 1561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9JIP3.

PTM databases

PhosphoSiteiQ9JIP3.

Expressioni

Tissue specificityi

Liver and testis. Expressed at lower level in kidney and lung. Expressed in selected T-cell, B-cell and myeloid cell lines.

Gene expression databases

BgeeiQ9JIP3.
CleanExiMM_IL17RB.
ExpressionAtlasiQ9JIP3. baseline and differential.
GenevestigatoriQ9JIP3.

Interactioni

Subunit structurei

Interacts with DAZAP2.By similarity

Protein-protein interaction databases

BioGridi206146. 2 interactions.
IntActiQ9JIP3. 1 interaction.
STRINGi10090.ENSMUSP00000016110.

Structurei

Secondary structure

1
499
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi329 – 3346Combined sources
Helixi339 – 3413Combined sources
Helixi342 – 35413Combined sources
Beta strandi358 – 3625Combined sources
Helixi363 – 3653Combined sources
Helixi367 – 3737Combined sources
Helixi375 – 38511Combined sources
Beta strandi387 – 3937Combined sources
Helixi419 – 4279Combined sources
Helixi428 – 4303Combined sources
Beta strandi434 – 4363Combined sources
Beta strandi440 – 4445Combined sources
Helixi455 – 4595Combined sources
Beta strandi462 – 4643Combined sources
Turni465 – 4684Combined sources
Helixi469 – 47810Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3VBCX-ray1.80A325-486[»]
ProteinModelPortaliQ9JIP3.
SMRiQ9JIP3. Positions 13-265, 325-481.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini328 – 474147SEFIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 SEFIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG47257.
GeneTreeiENSGT00530000063782.
HOGENOMiHOG000112985.
HOVERGENiHBG052063.
InParanoidiQ9JIP3.
KOiK05165.

Family and domain databases

InterProiIPR013568. SEFIR.
[Graphical view]
PfamiPF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEiPS51534. SEFIR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9JIP3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLVLLILAA SCRSALPREP TIQCGSETGP SPEWMVQHTL TPGDLRDLQV
60 70 80 90 100
ELVKTSVAAE EFSILMNISW ILRADASIRL LKATKICVSG KNNMNSYSCV
110 120 130 140 150
RCNYTEAFQS QTRPSGGKWT FSYVGFPVEL STLYLISAHN IPNANMNEDS
160 170 180 190 200
PSLSVNFTSP GCLNHVMKYK KQCTEAGSLW DPDITACKKN EKMVEVNFTT
210 220 230 240 250
NPLGNRYTIL IQRDTTLGFS RVLENKLMRT SVAIPVTEES EGAVVQLTPY
260 270 280 290 300
LHTCGNDCIR REGTVVLCSE TSAPIPPDDN RRMLGGWLPL FLVLLVAVWV
310 320 330 340 350
LAAGIYLTWR QGRSTKTSFP ISTMLLPLIK VLVVYPSEIC FHHTVCRFTD
360 370 380 390 400
FLQNYCRSEV ILEKWQKKKI AEMGPVQWLT TQKQAADKVV FLLPSDVPTL
410 420 430 440 450
CDSACGHNEG SARENSQDLF PLAFNLFCSD FSSQTHLHKY LVVYLGGADL
460 470 480 490
KGDYNALSVC PQYHLMKDAT AFHTELLKAT QSMSVKKRSQ ACHDSCSPL
Length:499
Mass (Da):55,617
Last modified:October 1, 2000 - v1
Checksum:iC66440430E3C31F3
GO
Isoform 2 (identifier: Q9JIP3-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     163-218: LNHVMKYKKQ...ILIQRDTTLG → TRENTEVTSG...SLFHDFVKLT
     219-499: Missing.

Show »
Length:218
Mass (Da):23,855
Checksum:iE17C154C824E1F0B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei163 – 21856LNHVM…DTTLG → TRENTEVTSGVFPAAKHQAL RISAPFPLQFPPGPEDSVIL PPQPLASLFHDFVKLT in isoform 2. 1 PublicationVSP_001742Add
BLAST
Alternative sequencei219 – 499281Missing in isoform 2. 1 PublicationVSP_001743Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208108 mRNA. Translation: AAF86049.1.
AF208109 mRNA. Translation: AAF86050.1.
BC026546 mRNA. Translation: AAH26546.1.
CCDSiCCDS36845.1. [Q9JIP3-1]
RefSeqiNP_062529.2. NM_019583.3. [Q9JIP3-1]
UniGeneiMm.269363.

Genome annotation databases

EnsembliENSMUST00000016110; ENSMUSP00000016110; ENSMUSG00000015966. [Q9JIP3-1]
GeneIDi50905.
KEGGimmu:50905.
UCSCiuc007sun.1. mouse. [Q9JIP3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF208108 mRNA. Translation: AAF86049.1 .
AF208109 mRNA. Translation: AAF86050.1 .
BC026546 mRNA. Translation: AAH26546.1 .
CCDSi CCDS36845.1. [Q9JIP3-1 ]
RefSeqi NP_062529.2. NM_019583.3. [Q9JIP3-1 ]
UniGenei Mm.269363.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3VBC X-ray 1.80 A 325-486 [» ]
ProteinModelPortali Q9JIP3.
SMRi Q9JIP3. Positions 13-265, 325-481.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 206146. 2 interactions.
IntActi Q9JIP3. 1 interaction.
STRINGi 10090.ENSMUSP00000016110.

PTM databases

PhosphoSitei Q9JIP3.

Proteomic databases

PRIDEi Q9JIP3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000016110 ; ENSMUSP00000016110 ; ENSMUSG00000015966 . [Q9JIP3-1 ]
GeneIDi 50905.
KEGGi mmu:50905.
UCSCi uc007sun.1. mouse. [Q9JIP3-1 ]

Organism-specific databases

CTDi 55540.
MGIi MGI:1355292. Il17rb.

Phylogenomic databases

eggNOGi NOG47257.
GeneTreei ENSGT00530000063782.
HOGENOMi HOG000112985.
HOVERGENi HBG052063.
InParanoidi Q9JIP3.
KOi K05165.

Miscellaneous databases

NextBioi 307877.
PROi Q9JIP3.
SOURCEi Search...

Gene expression databases

Bgeei Q9JIP3.
CleanExi MM_IL17RB.
ExpressionAtlasi Q9JIP3. baseline and differential.
Genevestigatori Q9JIP3.

Family and domain databases

InterProi IPR013568. SEFIR.
[Graphical view ]
Pfami PF08357. SEFIR. 1 hit.
[Graphical view ]
PROSITEi PS51534. SEFIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evi27 encodes a novel membrane protein with homology to the IL17 receptor."
    Tian E., Sawyer J.R., Largaespada D.A., Jenkins N.A., Copeland N.G., Shaughnessy J.D. Jr.
    Oncogene 19:2098-2109(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiI17RB_MOUSE
AccessioniPrimary (citable) accession number: Q9JIP3
Secondary accession number(s): Q9JIP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Evi27 is a common site of retroviral integration in Bxh2 murine myeloid leukemias, localized near the Il17rb gene. Proviral integrations result in increased expression of Il17rb on the cell surface.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3