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Q9JIP3 (I17RB_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Interleukin-17 receptor B

Short name=IL-17 receptor B
Short name=IL-17RB
Alternative name(s):
IL-17 receptor homolog 1
Short name=IL-17ER
Short name=IL-17Rh1
Short name=IL17Rh1
Interleukin-17B receptor
Short name=IL-17B receptor
Gene names
Name:Il17rb
Synonyms:Evi27, Il17br
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length499 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the proinflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells.

Subunit structure

Interacts with DAZAP2 By similarity.

Subcellular location

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Isoform 2: Secreted.

Tissue specificity

Liver and testis. Expressed at lower level in kidney and lung. Expressed in selected T-cell, B-cell and myeloid cell lines.

Miscellaneous

Evi27 is a common site of retroviral integration in Bxh2 murine myeloid leukemias, localized near the Il17rb gene. Proviral integrations result in increased expression of Il17rb on the cell surface.

Sequence similarities

Contains 1 SEFIR domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9JIP3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9JIP3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     163-218: LNHVMKYKKQ...ILIQRDTTLG → TRENTEVTSG...SLFHDFVKLT
     219-499: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 By similarity
Chain18 – 499482Interleukin-17 receptor B
PRO_0000011033

Regions

Topological domain18 – 286269Extracellular Potential
Transmembrane287 – 30721Helical; Potential
Topological domain308 – 499192Cytoplasmic Potential
Domain328 – 474147SEFIR

Amino acid modifications

Glycosylation671N-linked (GlcNAc...) Potential
Glycosylation1031N-linked (GlcNAc...) Potential
Glycosylation1561N-linked (GlcNAc...) Potential
Glycosylation1971N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence163 – 21856LNHVM…DTTLG → TRENTEVTSGVFPAAKHQAL RISAPFPLQFPPGPEDSVIL PPQPLASLFHDFVKLT in isoform 2.
VSP_001742
Alternative sequence219 – 499281Missing in isoform 2.
VSP_001743

Secondary structure

............................ 499
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: C66440430E3C31F3

FASTA49955,617
        10         20         30         40         50         60 
MLLVLLILAA SCRSALPREP TIQCGSETGP SPEWMVQHTL TPGDLRDLQV ELVKTSVAAE 

        70         80         90        100        110        120 
EFSILMNISW ILRADASIRL LKATKICVSG KNNMNSYSCV RCNYTEAFQS QTRPSGGKWT 

       130        140        150        160        170        180 
FSYVGFPVEL STLYLISAHN IPNANMNEDS PSLSVNFTSP GCLNHVMKYK KQCTEAGSLW 

       190        200        210        220        230        240 
DPDITACKKN EKMVEVNFTT NPLGNRYTIL IQRDTTLGFS RVLENKLMRT SVAIPVTEES 

       250        260        270        280        290        300 
EGAVVQLTPY LHTCGNDCIR REGTVVLCSE TSAPIPPDDN RRMLGGWLPL FLVLLVAVWV 

       310        320        330        340        350        360 
LAAGIYLTWR QGRSTKTSFP ISTMLLPLIK VLVVYPSEIC FHHTVCRFTD FLQNYCRSEV 

       370        380        390        400        410        420 
ILEKWQKKKI AEMGPVQWLT TQKQAADKVV FLLPSDVPTL CDSACGHNEG SARENSQDLF 

       430        440        450        460        470        480 
PLAFNLFCSD FSSQTHLHKY LVVYLGGADL KGDYNALSVC PQYHLMKDAT AFHTELLKAT 

       490 
QSMSVKKRSQ ACHDSCSPL 

« Hide

Isoform 2 [UniParc].

Checksum: E17C154C824E1F0B
Show »

FASTA21823,855

References

« Hide 'large scale' references
[1]"Evi27 encodes a novel membrane protein with homology to the IL17 receptor."
Tian E., Sawyer J.R., Largaespada D.A., Jenkins N.A., Copeland N.G., Shaughnessy J.D. Jr.
Oncogene 19:2098-2109(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: FVB/N.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF208108 mRNA. Translation: AAF86049.1.
AF208109 mRNA. Translation: AAF86050.1.
BC026546 mRNA. Translation: AAH26546.1.
RefSeqNP_062529.2. NM_019583.3.
UniGeneMm.269363.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3VBCX-ray1.80A325-486[»]
ProteinModelPortalQ9JIP3.
SMRQ9JIP3. Positions 13-265, 325-481.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid206146. 2 interactions.
IntActQ9JIP3. 1 interaction.
STRING10090.ENSMUSP00000016110.

PTM databases

PhosphoSiteQ9JIP3.

Proteomic databases

PRIDEQ9JIP3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000016110; ENSMUSP00000016110; ENSMUSG00000015966. [Q9JIP3-1]
GeneID50905.
KEGGmmu:50905.
UCSCuc007sun.1. mouse. [Q9JIP3-1]

Organism-specific databases

CTD55540.
MGIMGI:1355292. Il17rb.

Phylogenomic databases

eggNOGNOG47257.
GeneTreeENSGT00530000063782.
HOGENOMHOG000112985.
HOVERGENHBG052063.
KOK05165.

Gene expression databases

ArrayExpressQ9JIP3.
BgeeQ9JIP3.
CleanExMM_IL17RB.
GenevestigatorQ9JIP3.

Family and domain databases

InterProIPR013568. SEFIR.
[Graphical view]
PfamPF08357. SEFIR. 1 hit.
[Graphical view]
PROSITEPS51534. SEFIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio307877.
PROQ9JIP3.
SOURCESearch...

Entry information

Entry nameI17RB_MOUSE
AccessionPrimary (citable) accession number: Q9JIP3
Secondary accession number(s): Q9JIP2
Entry history
Integrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot