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Q9JIP0

- TRPV5_RAT

UniProt

Q9JIP0 - TRPV5_RAT

Protein

Transient receptor potential cation channel subfamily V member 5

Gene

Trpv5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Constitutively active calcium selective cation channel thought to be involved in Ca2+ reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca2+-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating By similarity.By similarity

    Enzyme regulationi

    Activated by WNK3.By similarity

    GO - Molecular functioni

    1. calcium channel activity Source: UniProtKB

    GO - Biological processi

    1. calcium ion transport Source: UniProtKB
    2. calcium ion transport into cytosol Source: RGD
    3. protein tetramerization Source: UniProtKB

    Keywords - Molecular functioni

    Calcium channel, Ion channel

    Keywords - Biological processi

    Calcium transport, Ion transport, Transport

    Keywords - Ligandi

    Calcium, Calmodulin-binding

    Enzyme and pathway databases

    ReactomeiREACT_198388. TRP channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transient receptor potential cation channel subfamily V member 5
    Short name:
    TrpV5
    Alternative name(s):
    Calcium transporter 2
    Short name:
    CaT2
    Epithelial calcium channel 1
    Short name:
    ECaC1
    Osm-9-like TRP channel 3
    Short name:
    OTRPC3
    Gene namesi
    Name:Trpv5
    Synonyms:Cat2, Ecac, Ecac1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi620636. Trpv5.

    Subcellular locationi

    Apical cell membrane By similarity; Multi-pass membrane protein By similarity
    Note: Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells. The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3 By similarity.By similarity

    GO - Cellular componenti

    1. apical plasma membrane Source: RGD
    2. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 723723Transient receptor potential cation channel subfamily V member 5PRO_0000215353Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi351 – 3511N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9JIP0.

    Expressioni

    Tissue specificityi

    Exclusively expressed in kidney.1 Publication

    Gene expression databases

    GenevestigatoriQ9JIP0.

    Interactioni

    Subunit structurei

    Homotetramer and probably heterotetramer with TRPV6. Interacts with TRPV6. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000020975.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JIP0.
    SMRiQ9JIP0. Positions 38-259.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 320320CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini342 – 38039ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini402 – 41211CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini434 – 4418ExtracellularSequence Analysis
    Topological domaini463 – 48523CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini571 – 723153CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei517 – 53721Pore-formingCuratedAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei321 – 34121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei381 – 40121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei413 – 43321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei442 – 46221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei486 – 50621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei550 – 57021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati72 – 10130ANK 1Add
    BLAST
    Repeati110 – 13930ANK 2Add
    BLAST
    Repeati156 – 18530ANK 3Add
    BLAST
    Repeati232 – 26130ANK 4Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni591 – 5955Interaction with S100A10By similarity
    Regioni643 – 6464Involved in Ca(2+)-dependent inactivationBy similarity
    Regioni693 – 72331Involved in Ca(2+)-dependent inactivationBy similarityAdd
    BLAST

    Sequence similaritiesi

    Contains 4 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG278734.
    GeneTreeiENSGT00550000074425.
    HOGENOMiHOG000234397.
    HOVERGENiHBG061442.
    InParanoidiQ9JIP0.
    KOiK04974.
    OMAiLCEPFVG.
    OrthoDBiEOG70087C.
    PhylomeDBiQ9JIP0.
    TreeFamiTF314711.

    Family and domain databases

    Gene3Di1.25.40.20. 2 hits.
    InterProiIPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR008346. TRPV5.
    IPR008344. TRPV5/TRPV6.
    [Graphical view]
    PANTHERiPTHR10582:SF11. PTHR10582:SF11. 1 hit.
    PfamiPF12796. Ank_2. 2 hits.
    PF00520. Ion_trans. 1 hit.
    [Graphical view]
    PRINTSiPR01415. ANKYRIN.
    PR01765. ECACCHANNEL.
    PR01767. ECACCHANNEL2.
    SMARTiSM00248. ANK. 4 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    TIGRFAMsiTIGR00870. trp. 1 hit.
    PROSITEiPS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9JIP0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGVKKPWIQL QKRLNWWVRE QDWNQHVDQL HMLQQKSIWE SPLLRAAKEN    50
    DMCTLKRLQH DQNCDFRQRG ALGETALHVA ALYDNLDAAI MLMETAPYLV 100
    TESTLCEPFV GQTALHIAIM NQNVNLVRAL LARGASASAR ATGSAFHRSS 150
    HNLIYYGEHP LSFAACVGSE EIVRLLIEHG ADIRAQDSLG NTVLHILVLQ 200
    PNKTFACQMY NLLLSHDGGD HLKSLELVPN NQGLTPFKLA GVEGNTVMFQ 250
    HLMQKRKHIQ WSLGPLTSSI YDLTEIDSWG EDLSFLELVV SSKKKEARQI 300
    LEQTPVKELV SLKWKKYGQP YFCLLGMLYI FYMICFTTCC VYRPLKFRDA 350
    NRTHVRDNTV LEQKPLQEAY VTYQDKVRLV GELVTVIGAV VILLIEIPDI 400
    FRVGASRYFG HTVLGGPFHV IIITYASLVL LIMVMRLTSM NGEVVPISMA 450
    LVLGWCSVMY FSRGFQMLGP FTIMIQKMIF GDLLRFCWLM AMVILGFASA 500
    FYIIFQTEDP ESLGEFSDYP TAMFSTFELF LTIIDGPANY SVDLPFMYHL 550
    TYFAFAIIAT LLMLNLFIAM MGDTHWRVAQ ERDELWRAQV VATTVMLERK 600
    MPRFLWPRSG ICGCEYGLGD RWFLRVEHHQ EQNPYRVLRY VEAFKSSDKE 650
    EVQEQLSEKQ PSGTETGTLA RGSVVLQTPP LSRTTSLSSN SHRGWEILRR 700
    NTLGHLNLGQ DLGEGDGEEI YHF 723
    Length:723
    Mass (Da):82,454
    Last modified:October 1, 2000 - v1
    Checksum:iF41FCF2F2B431A25
    GO
    Isoform 2 (identifier: Q9JIP0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         248-296: Missing.

    Show »
    Length:674
    Mass (Da):76,691
    Checksum:i692B148D08FE9BA3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti290 – 2901V → L in BAA99541. 1 PublicationCurated
    Sequence conflicti295 – 2951K → I in BAA99541. 1 PublicationCurated
    Sequence conflicti331 – 3311F → S in BAA99541. 1 PublicationCurated
    Sequence conflicti488 – 4881W → R in BAA99541. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei248 – 29649Missing in isoform 2. 1 PublicationVSP_013438Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF209196 mRNA. Translation: AAF86309.1.
    AB032019 mRNA. Translation: BAA99541.1.
    AY762624 mRNA. Translation: AAV31121.1.
    RefSeqiNP_446239.2. NM_053787.2.
    UniGeneiRn.137513.

    Genome annotation databases

    EnsembliENSRNOT00000020975; ENSRNOP00000020975; ENSRNOG00000015394. [Q9JIP0-1]
    ENSRNOT00000051687; ENSRNOP00000046276; ENSRNOG00000015394. [Q9JIP0-2]
    GeneIDi116469.
    KEGGirno:116469.
    UCSCiRGD:620636. rat. [Q9JIP0-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF209196 mRNA. Translation: AAF86309.1 .
    AB032019 mRNA. Translation: BAA99541.1 .
    AY762624 mRNA. Translation: AAV31121.1 .
    RefSeqi NP_446239.2. NM_053787.2.
    UniGenei Rn.137513.

    3D structure databases

    ProteinModelPortali Q9JIP0.
    SMRi Q9JIP0. Positions 38-259.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000020975.

    Proteomic databases

    PRIDEi Q9JIP0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000020975 ; ENSRNOP00000020975 ; ENSRNOG00000015394 . [Q9JIP0-1 ]
    ENSRNOT00000051687 ; ENSRNOP00000046276 ; ENSRNOG00000015394 . [Q9JIP0-2 ]
    GeneIDi 116469.
    KEGGi rno:116469.
    UCSCi RGD:620636. rat. [Q9JIP0-1 ]

    Organism-specific databases

    CTDi 56302.
    RGDi 620636. Trpv5.

    Phylogenomic databases

    eggNOGi NOG278734.
    GeneTreei ENSGT00550000074425.
    HOGENOMi HOG000234397.
    HOVERGENi HBG061442.
    InParanoidi Q9JIP0.
    KOi K04974.
    OMAi LCEPFVG.
    OrthoDBi EOG70087C.
    PhylomeDBi Q9JIP0.
    TreeFami TF314711.

    Enzyme and pathway databases

    Reactomei REACT_198388. TRP channels.

    Miscellaneous databases

    NextBioi 619014.
    PROi Q9JIP0.

    Gene expression databases

    Genevestigatori Q9JIP0.

    Family and domain databases

    Gene3Di 1.25.40.20. 2 hits.
    InterProi IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    IPR005821. Ion_trans_dom.
    IPR004729. TRP_channel.
    IPR008346. TRPV5.
    IPR008344. TRPV5/TRPV6.
    [Graphical view ]
    PANTHERi PTHR10582:SF11. PTHR10582:SF11. 1 hit.
    Pfami PF12796. Ank_2. 2 hits.
    PF00520. Ion_trans. 1 hit.
    [Graphical view ]
    PRINTSi PR01415. ANKYRIN.
    PR01765. ECACCHANNEL.
    PR01767. ECACCHANNEL2.
    SMARTi SM00248. ANK. 4 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    TIGRFAMsi TIGR00870. trp. 1 hit.
    PROSITEi PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A rat kidney-specific calcium transporter in the distal nephron."
      Peng J.-B., Chen X.-Z., Berger U.V., Vassilev P.M., Brown E.M., Hediger M.A.
      J. Biol. Chem. 275:28186-28194(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
      Strain: CD1 Charles River.
      Tissue: Kidney cortex.
    2. Ishibashi K., Suzuki M., Imai M.
      Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Kidney.
    3. "A variant of the TrpV5 calcium channel from rat."
      Nehrke K., Sherman T., Bushinsky D.
      Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiTRPV5_RAT
    AccessioniPrimary (citable) accession number: Q9JIP0
    Secondary accession number(s): Q5UC98, Q9JJL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3