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Q9JIP0

- TRPV5_RAT

UniProt

Q9JIP0 - TRPV5_RAT

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Protein

Transient receptor potential cation channel subfamily V member 5

Gene

Trpv5

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Constitutively active calcium selective cation channel thought to be involved in Ca2+ reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca2+-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).By similarity

Enzyme regulationi

Activated by WNK3.By similarity

GO - Molecular functioni

  1. calcium channel activity Source: UniProtKB

GO - Biological processi

  1. calcium ion transport Source: UniProtKB
  2. calcium ion transport into cytosol Source: RGD
  3. protein tetramerization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Calmodulin-binding

Enzyme and pathway databases

ReactomeiREACT_198388. TRP channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily V member 5
Short name:
TrpV5
Alternative name(s):
Calcium transporter 2
Short name:
CaT2
Epithelial calcium channel 1
Short name:
ECaC1
Osm-9-like TRP channel 3
Short name:
OTRPC3
Gene namesi
Name:Trpv5
Synonyms:Cat2, Ecac, Ecac1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi620636. Trpv5.

Subcellular locationi

Apical cell membrane By similarity; Multi-pass membrane protein By similarity
Note: Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells. The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3 (By similarity).By similarity

GO - Cellular componenti

  1. apical plasma membrane Source: RGD
  2. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 723723Transient receptor potential cation channel subfamily V member 5PRO_0000215353Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi351 – 3511N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9JIP0.

Expressioni

Tissue specificityi

Exclusively expressed in kidney.1 Publication

Gene expression databases

GenevestigatoriQ9JIP0.

Interactioni

Subunit structurei

Homotetramer and probably heterotetramer with TRPV6. Interacts with TRPV6. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020975.

Structurei

3D structure databases

ProteinModelPortaliQ9JIP0.
SMRiQ9JIP0. Positions 38-259.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 320320CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini342 – 38039ExtracellularSequence AnalysisAdd
BLAST
Topological domaini402 – 41211CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini434 – 4418ExtracellularSequence Analysis
Topological domaini463 – 48523CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini571 – 723153CytoplasmicSequence AnalysisAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei517 – 53721Pore-formingCuratedAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei321 – 34121HelicalSequence AnalysisAdd
BLAST
Transmembranei381 – 40121HelicalSequence AnalysisAdd
BLAST
Transmembranei413 – 43321HelicalSequence AnalysisAdd
BLAST
Transmembranei442 – 46221HelicalSequence AnalysisAdd
BLAST
Transmembranei486 – 50621HelicalSequence AnalysisAdd
BLAST
Transmembranei550 – 57021HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati72 – 10130ANK 1Add
BLAST
Repeati110 – 13930ANK 2Add
BLAST
Repeati156 – 18530ANK 3Add
BLAST
Repeati232 – 26130ANK 4Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni591 – 5955Interaction with S100A10By similarity
Regioni643 – 6464Involved in Ca(2+)-dependent inactivationBy similarity
Regioni693 – 72331Involved in Ca(2+)-dependent inactivationBy similarityAdd
BLAST

Sequence similaritiesi

Contains 4 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG278734.
GeneTreeiENSGT00550000074425.
HOGENOMiHOG000234397.
HOVERGENiHBG061442.
InParanoidiQ9JIP0.
KOiK04974.
OMAiLCEPFVG.
OrthoDBiEOG70087C.
PhylomeDBiQ9JIP0.
TreeFamiTF314711.

Family and domain databases

Gene3Di1.25.40.20. 2 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR008346. TRPV5.
IPR008344. TRPV5/TRPV6.
[Graphical view]
PANTHERiPTHR10582:SF11. PTHR10582:SF11. 1 hit.
PfamiPF12796. Ank_2. 2 hits.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
PR01765. ECACCHANNEL.
PR01767. ECACCHANNEL2.
SMARTiSM00248. ANK. 4 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
TIGRFAMsiTIGR00870. trp. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9JIP0-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVKKPWIQL QKRLNWWVRE QDWNQHVDQL HMLQQKSIWE SPLLRAAKEN
60 70 80 90 100
DMCTLKRLQH DQNCDFRQRG ALGETALHVA ALYDNLDAAI MLMETAPYLV
110 120 130 140 150
TESTLCEPFV GQTALHIAIM NQNVNLVRAL LARGASASAR ATGSAFHRSS
160 170 180 190 200
HNLIYYGEHP LSFAACVGSE EIVRLLIEHG ADIRAQDSLG NTVLHILVLQ
210 220 230 240 250
PNKTFACQMY NLLLSHDGGD HLKSLELVPN NQGLTPFKLA GVEGNTVMFQ
260 270 280 290 300
HLMQKRKHIQ WSLGPLTSSI YDLTEIDSWG EDLSFLELVV SSKKKEARQI
310 320 330 340 350
LEQTPVKELV SLKWKKYGQP YFCLLGMLYI FYMICFTTCC VYRPLKFRDA
360 370 380 390 400
NRTHVRDNTV LEQKPLQEAY VTYQDKVRLV GELVTVIGAV VILLIEIPDI
410 420 430 440 450
FRVGASRYFG HTVLGGPFHV IIITYASLVL LIMVMRLTSM NGEVVPISMA
460 470 480 490 500
LVLGWCSVMY FSRGFQMLGP FTIMIQKMIF GDLLRFCWLM AMVILGFASA
510 520 530 540 550
FYIIFQTEDP ESLGEFSDYP TAMFSTFELF LTIIDGPANY SVDLPFMYHL
560 570 580 590 600
TYFAFAIIAT LLMLNLFIAM MGDTHWRVAQ ERDELWRAQV VATTVMLERK
610 620 630 640 650
MPRFLWPRSG ICGCEYGLGD RWFLRVEHHQ EQNPYRVLRY VEAFKSSDKE
660 670 680 690 700
EVQEQLSEKQ PSGTETGTLA RGSVVLQTPP LSRTTSLSSN SHRGWEILRR
710 720
NTLGHLNLGQ DLGEGDGEEI YHF
Length:723
Mass (Da):82,454
Last modified:October 1, 2000 - v1
Checksum:iF41FCF2F2B431A25
GO
Isoform 2 (identifier: Q9JIP0-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-296: Missing.

Show »
Length:674
Mass (Da):76,691
Checksum:i692B148D08FE9BA3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti290 – 2901V → L in BAA99541. 1 PublicationCurated
Sequence conflicti295 – 2951K → I in BAA99541. 1 PublicationCurated
Sequence conflicti331 – 3311F → S in BAA99541. 1 PublicationCurated
Sequence conflicti488 – 4881W → R in BAA99541. 1 PublicationCurated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei248 – 29649Missing in isoform 2. 1 PublicationVSP_013438Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF209196 mRNA. Translation: AAF86309.1.
AB032019 mRNA. Translation: BAA99541.1.
AY762624 mRNA. Translation: AAV31121.1.
RefSeqiNP_446239.2. NM_053787.2.
UniGeneiRn.137513.

Genome annotation databases

EnsembliENSRNOT00000020975; ENSRNOP00000020975; ENSRNOG00000015394. [Q9JIP0-1]
ENSRNOT00000051687; ENSRNOP00000046276; ENSRNOG00000015394. [Q9JIP0-2]
GeneIDi116469.
KEGGirno:116469.
UCSCiRGD:620636. rat. [Q9JIP0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF209196 mRNA. Translation: AAF86309.1 .
AB032019 mRNA. Translation: BAA99541.1 .
AY762624 mRNA. Translation: AAV31121.1 .
RefSeqi NP_446239.2. NM_053787.2.
UniGenei Rn.137513.

3D structure databases

ProteinModelPortali Q9JIP0.
SMRi Q9JIP0. Positions 38-259.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000020975.

Proteomic databases

PRIDEi Q9JIP0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000020975 ; ENSRNOP00000020975 ; ENSRNOG00000015394 . [Q9JIP0-1 ]
ENSRNOT00000051687 ; ENSRNOP00000046276 ; ENSRNOG00000015394 . [Q9JIP0-2 ]
GeneIDi 116469.
KEGGi rno:116469.
UCSCi RGD:620636. rat. [Q9JIP0-1 ]

Organism-specific databases

CTDi 56302.
RGDi 620636. Trpv5.

Phylogenomic databases

eggNOGi NOG278734.
GeneTreei ENSGT00550000074425.
HOGENOMi HOG000234397.
HOVERGENi HBG061442.
InParanoidi Q9JIP0.
KOi K04974.
OMAi LCEPFVG.
OrthoDBi EOG70087C.
PhylomeDBi Q9JIP0.
TreeFami TF314711.

Enzyme and pathway databases

Reactomei REACT_198388. TRP channels.

Miscellaneous databases

NextBioi 619014.
PROi Q9JIP0.

Gene expression databases

Genevestigatori Q9JIP0.

Family and domain databases

Gene3Di 1.25.40.20. 2 hits.
InterProi IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR004729. TRP_channel.
IPR008346. TRPV5.
IPR008344. TRPV5/TRPV6.
[Graphical view ]
PANTHERi PTHR10582:SF11. PTHR10582:SF11. 1 hit.
Pfami PF12796. Ank_2. 2 hits.
PF00520. Ion_trans. 1 hit.
[Graphical view ]
PRINTSi PR01415. ANKYRIN.
PR01765. ECACCHANNEL.
PR01767. ECACCHANNEL2.
SMARTi SM00248. ANK. 4 hits.
[Graphical view ]
SUPFAMi SSF48403. SSF48403. 1 hit.
TIGRFAMsi TIGR00870. trp. 1 hit.
PROSITEi PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A rat kidney-specific calcium transporter in the distal nephron."
    Peng J.-B., Chen X.-Z., Berger U.V., Vassilev P.M., Brown E.M., Hediger M.A.
    J. Biol. Chem. 275:28186-28194(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Strain: CD1 Charles River.
    Tissue: Kidney cortex.
  2. Ishibashi K., Suzuki M., Imai M.
    Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  3. "A variant of the TrpV5 calcium channel from rat."
    Nehrke K., Sherman T., Bushinsky D.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiTRPV5_RAT
AccessioniPrimary (citable) accession number: Q9JIP0
Secondary accession number(s): Q5UC98, Q9JJL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3