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Protein

Transient receptor potential cation channel subfamily V member 5

Gene

Trpv5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Constitutively active calcium selective cation channel thought to be involved in Ca2+ reabsorption in kidney and intestine (PubMed:10875938). Required for normal Ca2+ reabsorption in the kidney distal convoluted tubules (By similarity). The channel is activated by low internal calcium level and the current exhibits an inward rectification (By similarity). A Ca2+-dependent feedback regulation includes fast channel inactivation and slow current decay (By similarity). Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity).By similarity1 Publication

Enzyme regulationi

Activated by WNK3.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi535Calcium; shared with neighboring subunitsBy similarity1

GO - Molecular functioni

  • calcium channel activity Source: RGD
  • calmodulin binding Source: UniProtKB-KW
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionCalcium channel, Calmodulin-binding, Ion channel
Biological processCalcium transport, Ion transport, Transport
LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-RNO-3295583 TRP channels

Names & Taxonomyi

Protein namesi
Recommended name:
Transient receptor potential cation channel subfamily V member 5
Short name:
TrpV5
Alternative name(s):
Calcium transporter 21 Publication
Short name:
CaT21 Publication
Epithelial calcium channel 1
Short name:
ECaC1
Osm-9-like TRP channel 3
Short name:
OTRPC3
Gene namesi
Name:Trpv5
Synonyms:Cat2, Ecac, Ecac1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi620636 Trpv5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 320CytoplasmicBy similarityAdd BLAST320
Transmembranei321 – 341HelicalBy similarityAdd BLAST21
Topological domaini342 – 378ExtracellularBy similarityAdd BLAST37
Transmembranei379 – 401HelicalBy similarityAdd BLAST23
Topological domaini402 – 412CytoplasmicBy similarityAdd BLAST11
Transmembranei413 – 435HelicalBy similarityAdd BLAST23
Topological domaini436 – 441ExtracellularBy similarity6
Transmembranei442 – 462HelicalBy similarityAdd BLAST21
Topological domaini463 – 485CytoplasmicBy similarityAdd BLAST23
Transmembranei486 – 506HelicalBy similarityAdd BLAST21
Intramembranei517 – 537Pore-formingBy similarityAdd BLAST21
Transmembranei550 – 570HelicalBy similarityAdd BLAST21
Topological domaini571 – 723CytoplasmicBy similarityAdd BLAST153

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002153531 – 723Transient receptor potential cation channel subfamily V member 5Add BLAST723

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi351N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei678PhosphothreonineBy similarity1
Modified residuei682PhosphoserineBy similarity1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JIP0
PRIDEiQ9JIP0

Expressioni

Tissue specificityi

Detected in kidney (at protein level). Detected in kidney.1 Publication

Gene expression databases

BgeeiENSRNOG00000015394
GenevisibleiQ9JIP0 RN

Interactioni

Subunit structurei

Homotetramer and probably heterotetramer with TRPV6. Interacts with TRPV6 (By similarity). Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020975

Structurei

3D structure databases

ProteinModelPortaliQ9JIP0
SMRiQ9JIP0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati72 – 101ANK 1Sequence analysisAdd BLAST30
Repeati110 – 139ANK 2Sequence analysisAdd BLAST30
Repeati156 – 185ANK 3Sequence analysisAdd BLAST30
Repeati189 – 222ANK 4Sequence analysisAdd BLAST34
Repeati232 – 261ANK 5Sequence analysisAdd BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni591 – 595Interaction with S100A10By similarity5
Regioni643 – 646Involved in Ca(2+)-dependent inactivationBy similarity4
Regioni693 – 723Involved in Ca(2+)-dependent inactivationBy similarityAdd BLAST31

Sequence similaritiesi

Keywords - Domaini

ANK repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3676 Eukaryota
ENOG4110DG4 LUCA
GeneTreeiENSGT00550000074425
HOGENOMiHOG000234397
HOVERGENiHBG061442
InParanoidiQ9JIP0
KOiK04974
OMAiYFGQTVL
OrthoDBiEOG091G0314
PhylomeDBiQ9JIP0
TreeFamiTF314711

Family and domain databases

CDDicd00204 ANK, 2 hits
Gene3Di1.25.40.202 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR005821 Ion_trans_dom
IPR004729 TRP_channel
IPR024862 TRPV
IPR008346 TRPV5
IPR008344 TRPV5/TRPV6
PANTHERiPTHR10582 PTHR10582, 1 hit
PTHR10582:SF11 PTHR10582:SF11, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF00520 Ion_trans, 1 hit
PRINTSiPR01415 ANKYRIN
PR01765 ECACCHANNEL
PR01767 ECACCHANNEL2
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
TIGRFAMsiTIGR00870 trp, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JIP0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVKKPWIQL QKRLNWWVRE QDWNQHVDQL HMLQQKSIWE SPLLRAAKEN
60 70 80 90 100
DMCTLKRLQH DQNCDFRQRG ALGETALHVA ALYDNLDAAI MLMETAPYLV
110 120 130 140 150
TESTLCEPFV GQTALHIAIM NQNVNLVRAL LARGASASAR ATGSAFHRSS
160 170 180 190 200
HNLIYYGEHP LSFAACVGSE EIVRLLIEHG ADIRAQDSLG NTVLHILVLQ
210 220 230 240 250
PNKTFACQMY NLLLSHDGGD HLKSLELVPN NQGLTPFKLA GVEGNTVMFQ
260 270 280 290 300
HLMQKRKHIQ WSLGPLTSSI YDLTEIDSWG EDLSFLELVV SSKKKEARQI
310 320 330 340 350
LEQTPVKELV SLKWKKYGQP YFCLLGMLYI FYMICFTTCC VYRPLKFRDA
360 370 380 390 400
NRTHVRDNTV LEQKPLQEAY VTYQDKVRLV GELVTVIGAV VILLIEIPDI
410 420 430 440 450
FRVGASRYFG HTVLGGPFHV IIITYASLVL LIMVMRLTSM NGEVVPISMA
460 470 480 490 500
LVLGWCSVMY FSRGFQMLGP FTIMIQKMIF GDLLRFCWLM AMVILGFASA
510 520 530 540 550
FYIIFQTEDP ESLGEFSDYP TAMFSTFELF LTIIDGPANY SVDLPFMYHL
560 570 580 590 600
TYFAFAIIAT LLMLNLFIAM MGDTHWRVAQ ERDELWRAQV VATTVMLERK
610 620 630 640 650
MPRFLWPRSG ICGCEYGLGD RWFLRVEHHQ EQNPYRVLRY VEAFKSSDKE
660 670 680 690 700
EVQEQLSEKQ PSGTETGTLA RGSVVLQTPP LSRTTSLSSN SHRGWEILRR
710 720
NTLGHLNLGQ DLGEGDGEEI YHF
Length:723
Mass (Da):82,454
Last modified:October 1, 2000 - v1
Checksum:iF41FCF2F2B431A25
GO
Isoform 2 (identifier: Q9JIP0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     248-296: Missing.

Show »
Length:674
Mass (Da):76,691
Checksum:i692B148D08FE9BA3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti290V → L in BAA99541 (Ref. 2) Curated1
Sequence conflicti295K → I in BAA99541 (Ref. 2) Curated1
Sequence conflicti331F → S in BAA99541 (Ref. 2) Curated1
Sequence conflicti488W → R in BAA99541 (Ref. 2) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013438248 – 296Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF209196 mRNA Translation: AAF86309.1
AB032019 mRNA Translation: BAA99541.1
AY762624 mRNA Translation: AAV31121.1
RefSeqiNP_446239.2, NM_053787.2
UniGeneiRn.137513

Genome annotation databases

EnsembliENSRNOT00000020975; ENSRNOP00000020975; ENSRNOG00000015394 [Q9JIP0-1]
ENSRNOT00000051687; ENSRNOP00000046276; ENSRNOG00000015394 [Q9JIP0-2]
GeneIDi116469
KEGGirno:116469
UCSCiRGD:620636 rat [Q9JIP0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTRPV5_RAT
AccessioniPrimary (citable) accession number: Q9JIP0
Secondary accession number(s): Q5UC98, Q9JJL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome