ID KCMB4_MOUSE Reviewed; 210 AA. AC Q9JIN6; Q149I1; DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 27-MAR-2024, entry version 134. DE RecName: Full=Calcium-activated potassium channel subunit beta-4; DE AltName: Full=BK channel subunit beta-4; DE Short=BKbeta4; DE AltName: Full=Calcium-activated potassium channel, subfamily M subunit beta-4; DE AltName: Full=Charybdotoxin receptor subunit beta-4; DE AltName: Full=K(VCA)beta-4; DE AltName: Full=Maxi K channel subunit beta-4; DE AltName: Full=Slo-beta-4; GN Name=Kcnmb4; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], AND INTERACTION WITH KCNMA1. RC STRAIN=BALB/cJ; TISSUE=Brain; RX PubMed=10804197; DOI=10.1523/jneurosci.20-10-03563.2000; RA Weiger T.M., Holmqvist M.H., Levitan I.B., Clark F.T., Sprague S., RA Huang W.-J., Ge P., Wang C., Lawson D., Jurman M.E., Glucksmann M.A., RA Silos-Santiago I., DiStefano P.S., Curtis R.; RT "A novel nervous system beta subunit that downregulates human large RT conductance calcium-dependent potassium channels."; RL J. Neurosci. 20:3563-3570(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP INTERACTION WITH FMR1. RX PubMed=25561520; DOI=10.1073/pnas.1423094112; RA Myrick L.K., Deng P.Y., Hashimoto H., Oh Y.M., Cho Y., Poidevin M.J., RA Suhl J.A., Visootsak J., Cavalli V., Jin P., Cheng X., Warren S.T., RA Klyachko V.A.; RT "Independent role for presynaptic FMRP revealed by an FMR1 missense RT mutation associated with intellectual disability and seizures."; RL Proc. Natl. Acad. Sci. U.S.A. 112:949-956(2015). CC -!- FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1 CC (maxiK) channel. Modulates the calcium sensitivity and gating kinetics CC of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases CC the gating kinetics and calcium sensitivity of the KCNMA1 channel, but CC with fast deactivation kinetics. May decrease KCNMA1 channel openings CC at low calcium concentrations but increases channel openings at high CC calcium concentrations. Makes KCNMA1 channel resistant to 100 nM CC charybdotoxin (CTX) toxin concentrations (By similarity). CC {ECO:0000250}. CC -!- SUBUNIT: Interacts with KCNMA1 tetramer (PubMed:10804197). There are CC probably 4 molecules of KCMNB4 per KCNMA1 tetramer (PubMed:10804197). CC Interacts with FMR1 (via N-terminus) (PubMed:25561520). CC {ECO:0000269|PubMed:10804197, ECO:0000269|PubMed:25561520}. CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane CC protein {ECO:0000250}. CC -!- DOMAIN: Resistance to charybdotoxin (CTX) toxin is mediated by the CC extracellular domain. {ECO:0000250}. CC -!- PTM: Phosphorylated. Phosphorylation modulates its effect on KCNMA1 CC activation kinetics (By similarity). {ECO:0000250}. CC -!- PTM: N-glycosylated. A highly glycosylated form is promoted by KCNMA1. CC Glycosylation, which is not required for the interaction with KCNMA1 CC and subcellular location, increases protection against charybdotoxin CC (By similarity). {ECO:0000250}. CC -!- SIMILARITY: Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB4 CC subfamily. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF215892; AAF75597.1; -; mRNA. DR EMBL; BC117779; AAI17780.1; -; mRNA. DR CCDS; CCDS24184.1; -. DR RefSeq; NP_067427.1; NM_021452.1. DR AlphaFoldDB; Q9JIN6; -. DR SMR; Q9JIN6; -. DR BioGRID; 208440; 1. DR IntAct; Q9JIN6; 1. DR STRING; 10090.ENSMUSP00000065384; -. DR TCDB; 8.A.14.1.1; the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family. DR GlyCosmos; Q9JIN6; 2 sites, No reported glycans. DR GlyGen; Q9JIN6; 2 sites. DR PhosphoSitePlus; Q9JIN6; -. DR SwissPalm; Q9JIN6; -. DR PaxDb; 10090-ENSMUSP00000065384; -. DR ProteomicsDB; 269255; -. DR ABCD; Q9JIN6; 1 sequenced antibody. DR Antibodypedia; 29474; 206 antibodies from 30 providers. DR DNASU; 58802; -. DR Ensembl; ENSMUST00000068233.11; ENSMUSP00000065384.5; ENSMUSG00000054934.11. DR GeneID; 58802; -. DR KEGG; mmu:58802; -. DR UCSC; uc007hbw.1; mouse. DR AGR; MGI:1913272; -. DR CTD; 27345; -. DR MGI; MGI:1913272; Kcnmb4. DR VEuPathDB; HostDB:ENSMUSG00000054934; -. DR eggNOG; ENOG502QR4Z; Eukaryota. DR GeneTree; ENSGT00950000183039; -. DR HOGENOM; CLU_085739_0_0_1; -. DR InParanoid; Q9JIN6; -. DR OMA; PDDVLWQ; -. DR OrthoDB; 3976732at2759; -. DR PhylomeDB; Q9JIN6; -. DR TreeFam; TF328589; -. DR Reactome; R-MMU-1296052; Ca2+ activated K+ channels. DR BioGRID-ORCS; 58802; 2 hits in 78 CRISPR screens. DR ChiTaRS; Kcnmb4; mouse. DR PRO; PR:Q9JIN6; -. DR Proteomes; UP000000589; Chromosome 10. DR RNAct; Q9JIN6; Protein. DR Bgee; ENSMUSG00000054934; Expressed in primary motor cortex and 226 other cell types or tissues. DR GO; GO:0005886; C:plasma membrane; ISS:UniProtKB. DR GO; GO:0008076; C:voltage-gated potassium channel complex; IGI:MGI. DR GO; GO:0015269; F:calcium-activated potassium channel activity; IGI:MGI. DR GO; GO:0005267; F:potassium channel activity; ISS:MGI. DR GO; GO:0015459; F:potassium channel regulator activity; IBA:GO_Central. DR GO; GO:0099508; F:voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential; ISO:MGI. DR GO; GO:0001508; P:action potential; ISS:UniProtKB. DR GO; GO:0005513; P:detection of calcium ion; ISS:UniProtKB. DR GO; GO:0019228; P:neuronal action potential; ISS:UniProtKB. DR GO; GO:0006813; P:potassium ion transport; ISS:UniProtKB. DR InterPro; IPR003930; K_chnl_Ca-activ_BK_bsu. DR PANTHER; PTHR10258; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA; 1. DR PANTHER; PTHR10258:SF3; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-4; 1. DR Pfam; PF03185; CaKB; 1. DR Genevisible; Q9JIN6; MM. PE 1: Evidence at protein level; KW Glycoprotein; Ion channel; Ion transport; Membrane; Phosphoprotein; KW Reference proteome; Transmembrane; Transmembrane helix; Transport. FT CHAIN 1..210 FT /note="Calcium-activated potassium channel subunit beta-4" FT /id="PRO_0000187056" FT TOPO_DOM 1..19 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT TRANSMEM 20..40 FT /note="Helical; Name=1" FT /evidence="ECO:0000255" FT TOPO_DOM 41..167 FT /note="Extracellular" FT /evidence="ECO:0000255" FT TRANSMEM 168..188 FT /note="Helical; Name=2" FT /evidence="ECO:0000255" FT TOPO_DOM 189..210 FT /note="Cytoplasmic" FT /evidence="ECO:0000255" FT CARBOHYD 53 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000250" FT CARBOHYD 90 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000250" SQ SEQUENCE 210 AA; 23857 MW; 11C73DD2C2C6F1D4 CRC64; MAKLRVSYEY TEAEDKSIRL GLFLIVSGIL SLFIFGFCWL SPALQDLQAT AANCTVLSVQ QIGEVFECTF TCGTDCRGTS QYPCVQVYVN NSESNSRALL HSDQHQLLTN PKCSYIPPCK RENQKNSESV MNWQQYWKDE IGSQPFTCYF NQHQRPEDVL LQRTHDEIAL LHCFLWPVVA FVVGVLIVVL TICAKSLAVK AEAMKKRKFS //