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Q9JIN6

- KCMB4_MOUSE

UniProt

Q9JIN6 - KCMB4_MOUSE

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Protein

Calcium-activated potassium channel subunit beta-4

Gene

Kcnmb4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations (By similarity).By similarity

GO - Molecular functioni

  1. calcium-activated potassium channel activity Source: UniProtKB
  2. potassium channel activity Source: MGI

GO - Biological processi

  1. action potential Source: UniProtKB
  2. detection of calcium ion Source: UniProtKB
  3. neuronal action potential Source: UniProtKB
  4. potassium ion transmembrane transport Source: GOC
  5. potassium ion transport Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_199092. Ca2+ activated K+ channels.

Protein family/group databases

TCDBi8.A.14.1.1. the ca(2+)-activated k(+) channel auxiliary subunit slowpoke- (slo) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-activated potassium channel subunit beta-4
Alternative name(s):
BK channel subunit beta-4
Short name:
BKbeta4
Calcium-activated potassium channel, subfamily M subunit beta-4
Charybdotoxin receptor subunit beta-4
K(VCA)beta-4
Maxi K channel subunit beta-4
Slo-beta-4
Gene namesi
Name:Kcnmb4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1913272. Kcnmb4.

Subcellular locationi

Membrane By similarity; Multi-pass membrane protein By similarity

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. voltage-gated potassium channel complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Calcium-activated potassium channel subunit beta-4PRO_0000187056Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi53 – 531N-linked (GlcNAc...)By similarity
Glycosylationi90 – 901N-linked (GlcNAc...)By similarity

Post-translational modificationi

Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics (By similarity).By similarity
N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEiQ9JIN6.

PTM databases

PhosphoSiteiQ9JIN6.

Expressioni

Gene expression databases

BgeeiQ9JIN6.
ExpressionAtlasiQ9JIN6. baseline and differential.
GenevestigatoriQ9JIN6.

Interactioni

Subunit structurei

Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer.1 Publication

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini41 – 167127ExtracellularSequence AnalysisAdd
BLAST
Topological domaini189 – 21022CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei20 – 4021Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei168 – 18821Helical; Name=2Sequence AnalysisAdd
BLAST

Family & Domainsi

Domaini

Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG83271.
GeneTreeiENSGT00390000015997.
HOGENOMiHOG000113205.
HOVERGENiHBG052224.
InParanoidiQ9JIN6.
KOiK04941.
OMAiYVPPCER.
OrthoDBiEOG77WWDC.
PhylomeDBiQ9JIN6.
TreeFamiTF328589.

Family and domain databases

InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
[Graphical view]
PANTHERiPTHR10258. PTHR10258. 1 hit.
PfamiPF03185. CaKB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JIN6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKLRVSYEY TEAEDKSIRL GLFLIVSGIL SLFIFGFCWL SPALQDLQAT
60 70 80 90 100
AANCTVLSVQ QIGEVFECTF TCGTDCRGTS QYPCVQVYVN NSESNSRALL
110 120 130 140 150
HSDQHQLLTN PKCSYIPPCK RENQKNSESV MNWQQYWKDE IGSQPFTCYF
160 170 180 190 200
NQHQRPEDVL LQRTHDEIAL LHCFLWPVVA FVVGVLIVVL TICAKSLAVK
210
AEAMKKRKFS
Length:210
Mass (Da):23,857
Last modified:October 1, 2000 - v1
Checksum:i11C73DD2C2C6F1D4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF215892 mRNA. Translation: AAF75597.1.
BC117779 mRNA. Translation: AAI17780.1.
CCDSiCCDS24184.1.
RefSeqiNP_067427.1. NM_021452.1.
UniGeneiMm.440652.

Genome annotation databases

EnsembliENSMUST00000068233; ENSMUSP00000065384; ENSMUSG00000054934.
GeneIDi58802.
KEGGimmu:58802.
UCSCiuc007hbw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF215892 mRNA. Translation: AAF75597.1 .
BC117779 mRNA. Translation: AAI17780.1 .
CCDSi CCDS24184.1.
RefSeqi NP_067427.1. NM_021452.1.
UniGenei Mm.440652.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein family/group databases

TCDBi 8.A.14.1.1. the ca(2+)-activated k(+) channel auxiliary subunit slowpoke- (slo) family.

PTM databases

PhosphoSitei Q9JIN6.

Proteomic databases

PRIDEi Q9JIN6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000068233 ; ENSMUSP00000065384 ; ENSMUSG00000054934 .
GeneIDi 58802.
KEGGi mmu:58802.
UCSCi uc007hbw.1. mouse.

Organism-specific databases

CTDi 27345.
MGIi MGI:1913272. Kcnmb4.

Phylogenomic databases

eggNOGi NOG83271.
GeneTreei ENSGT00390000015997.
HOGENOMi HOG000113205.
HOVERGENi HBG052224.
InParanoidi Q9JIN6.
KOi K04941.
OMAi YVPPCER.
OrthoDBi EOG77WWDC.
PhylomeDBi Q9JIN6.
TreeFami TF328589.

Enzyme and pathway databases

Reactomei REACT_199092. Ca2+ activated K+ channels.

Miscellaneous databases

ChiTaRSi KCNMB4. mouse.
NextBioi 314378.
PROi Q9JIN6.
SOURCEi Search...

Gene expression databases

Bgeei Q9JIN6.
ExpressionAtlasi Q9JIN6. baseline and differential.
Genevestigatori Q9JIN6.

Family and domain databases

InterProi IPR003930. K_chnl_Ca-activ_BK_bsu.
[Graphical view ]
PANTHERi PTHR10258. PTHR10258. 1 hit.
Pfami PF03185. CaKB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels."
    Weiger T.M., Holmqvist M.H., Levitan I.B., Clark F.T., Sprague S., Huang W.-J., Ge P., Wang C., Lawson D., Jurman M.E., Glucksmann M.A., Silos-Santiago I., DiStefano P.S., Curtis R.
    J. Neurosci. 20:3563-3570(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH KCNMA1.
    Strain: BALB/c.
    Tissue: Brain.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiKCMB4_MOUSE
AccessioniPrimary (citable) accession number: Q9JIN6
Secondary accession number(s): Q149I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3