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Protein

Calcium-activated potassium channel subunit beta-4

Gene

Kcnmb4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-1296052. Ca2+ activated K+ channels.

Protein family/group databases

TCDBi8.A.14.1.1. the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-activated potassium channel subunit beta-4
Alternative name(s):
BK channel subunit beta-4
Short name:
BKbeta4
Calcium-activated potassium channel, subfamily M subunit beta-4
Charybdotoxin receptor subunit beta-4
K(VCA)beta-4
Maxi K channel subunit beta-4
Slo-beta-4
Gene namesi
Name:Kcnmb4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1913272. Kcnmb4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 19CytoplasmicSequence analysisAdd BLAST19
Transmembranei20 – 40Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini41 – 167ExtracellularSequence analysisAdd BLAST127
Transmembranei168 – 188Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini189 – 210CytoplasmicSequence analysisAdd BLAST22

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001870561 – 210Calcium-activated potassium channel subunit beta-4Add BLAST210

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...)By similarity1
Glycosylationi90N-linked (GlcNAc...)By similarity1

Post-translational modificationi

Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics (By similarity).By similarity
N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JIN6.
PRIDEiQ9JIN6.

PTM databases

PhosphoSitePlusiQ9JIN6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000054934.
ExpressionAtlasiQ9JIN6. baseline and differential.
GenevisibleiQ9JIN6. MM.

Interactioni

Subunit structurei

Interacts with KCNMA1 tetramer (PubMed:10804197). There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer (PubMed:10804197). Interacts with FMR1 (via N-terminus) (PubMed:25561520).2 Publications

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065384.

Structurei

3D structure databases

ProteinModelPortaliQ9JIN6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJVB. Eukaryota.
ENOG410XSTD. LUCA.
GeneTreeiENSGT00390000015997.
HOGENOMiHOG000113205.
HOVERGENiHBG052224.
InParanoidiQ9JIN6.
KOiK04941.
OMAiPPCERDN.
OrthoDBiEOG091G0MVO.
PhylomeDBiQ9JIN6.
TreeFamiTF328589.

Family and domain databases

InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
[Graphical view]
PANTHERiPTHR10258. PTHR10258. 1 hit.
PfamiPF03185. CaKB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JIN6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLRVSYEY TEAEDKSIRL GLFLIVSGIL SLFIFGFCWL SPALQDLQAT
60 70 80 90 100
AANCTVLSVQ QIGEVFECTF TCGTDCRGTS QYPCVQVYVN NSESNSRALL
110 120 130 140 150
HSDQHQLLTN PKCSYIPPCK RENQKNSESV MNWQQYWKDE IGSQPFTCYF
160 170 180 190 200
NQHQRPEDVL LQRTHDEIAL LHCFLWPVVA FVVGVLIVVL TICAKSLAVK
210
AEAMKKRKFS
Length:210
Mass (Da):23,857
Last modified:October 1, 2000 - v1
Checksum:i11C73DD2C2C6F1D4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215892 mRNA. Translation: AAF75597.1.
BC117779 mRNA. Translation: AAI17780.1.
CCDSiCCDS24184.1.
RefSeqiNP_067427.1. NM_021452.1.
UniGeneiMm.440652.

Genome annotation databases

EnsembliENSMUST00000068233; ENSMUSP00000065384; ENSMUSG00000054934.
GeneIDi58802.
KEGGimmu:58802.
UCSCiuc007hbw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF215892 mRNA. Translation: AAF75597.1.
BC117779 mRNA. Translation: AAI17780.1.
CCDSiCCDS24184.1.
RefSeqiNP_067427.1. NM_021452.1.
UniGeneiMm.440652.

3D structure databases

ProteinModelPortaliQ9JIN6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065384.

Protein family/group databases

TCDBi8.A.14.1.1. the ca(2+)-activated k(+) channel auxiliary subunit slowpoke-Beta (sloBeta) family.

PTM databases

PhosphoSitePlusiQ9JIN6.

Proteomic databases

PaxDbiQ9JIN6.
PRIDEiQ9JIN6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068233; ENSMUSP00000065384; ENSMUSG00000054934.
GeneIDi58802.
KEGGimmu:58802.
UCSCiuc007hbw.1. mouse.

Organism-specific databases

CTDi27345.
MGIiMGI:1913272. Kcnmb4.

Phylogenomic databases

eggNOGiENOG410IJVB. Eukaryota.
ENOG410XSTD. LUCA.
GeneTreeiENSGT00390000015997.
HOGENOMiHOG000113205.
HOVERGENiHBG052224.
InParanoidiQ9JIN6.
KOiK04941.
OMAiPPCERDN.
OrthoDBiEOG091G0MVO.
PhylomeDBiQ9JIN6.
TreeFamiTF328589.

Enzyme and pathway databases

ReactomeiR-MMU-1296052. Ca2+ activated K+ channels.

Miscellaneous databases

PROiQ9JIN6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054934.
ExpressionAtlasiQ9JIN6. baseline and differential.
GenevisibleiQ9JIN6. MM.

Family and domain databases

InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
[Graphical view]
PANTHERiPTHR10258. PTHR10258. 1 hit.
PfamiPF03185. CaKB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKCMB4_MOUSE
AccessioniPrimary (citable) accession number: Q9JIN6
Secondary accession number(s): Q149I1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.