Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9JIN6

- KCMB4_MOUSE

UniProt

Q9JIN6 - KCMB4_MOUSE

Protein

Calcium-activated potassium channel subunit beta-4

Gene

Kcnmb4

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations By similarity.By similarity

    GO - Molecular functioni

    1. calcium-activated potassium channel activity Source: UniProtKB
    2. potassium channel activity Source: MGI

    GO - Biological processi

    1. action potential Source: UniProtKB
    2. detection of calcium ion Source: UniProtKB
    3. neuronal action potential Source: UniProtKB
    4. potassium ion transmembrane transport Source: GOC
    5. potassium ion transport Source: UniProtKB

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_199092. Ca2+ activated K+ channels.

    Protein family/group databases

    TCDBi8.A.14.1.1. the ca(2+)-activated k(+) channel auxiliary subunit slowpoke- (slo) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-activated potassium channel subunit beta-4
    Alternative name(s):
    BK channel subunit beta-4
    Short name:
    BKbeta4
    Calcium-activated potassium channel, subfamily M subunit beta-4
    Charybdotoxin receptor subunit beta-4
    K(VCA)beta-4
    Maxi K channel subunit beta-4
    Slo-beta-4
    Gene namesi
    Name:Kcnmb4
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1913272. Kcnmb4.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. voltage-gated potassium channel complex Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 210210Calcium-activated potassium channel subunit beta-4PRO_0000187056Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi53 – 531N-linked (GlcNAc...)By similarity
    Glycosylationi90 – 901N-linked (GlcNAc...)By similarity

    Post-translational modificationi

    Phosphorylated. Phosphorylation modulates its effect on KCNMA1 activation kinetics By similarity.By similarity
    N-glycosylated. A highly glycosylated form is promoted by KCNMA1. Glycosylation, which is not required for the interaction with KCNMA1 and subcellular location, increases protection against charybdotoxin By similarity.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    PRIDEiQ9JIN6.

    PTM databases

    PhosphoSiteiQ9JIN6.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9JIN6.
    BgeeiQ9JIN6.
    GenevestigatoriQ9JIN6.

    Interactioni

    Subunit structurei

    Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer.1 Publication

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1919CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini41 – 167127ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini189 – 21022CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei20 – 4021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei168 – 18821Helical; Name=2Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domaini

    Resistance to charybdotoxin (CTX) toxin is mediated by the extracellular domain.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG83271.
    GeneTreeiENSGT00390000015997.
    HOGENOMiHOG000113205.
    HOVERGENiHBG052224.
    InParanoidiQ149I1.
    KOiK04941.
    OMAiYVPPCER.
    OrthoDBiEOG77WWDC.
    PhylomeDBiQ9JIN6.
    TreeFamiTF328589.

    Family and domain databases

    InterProiIPR003930. K_chnl_Ca-activ_BK_bsu.
    [Graphical view]
    PANTHERiPTHR10258. PTHR10258. 1 hit.
    PfamiPF03185. CaKB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JIN6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKLRVSYEY TEAEDKSIRL GLFLIVSGIL SLFIFGFCWL SPALQDLQAT    50
    AANCTVLSVQ QIGEVFECTF TCGTDCRGTS QYPCVQVYVN NSESNSRALL 100
    HSDQHQLLTN PKCSYIPPCK RENQKNSESV MNWQQYWKDE IGSQPFTCYF 150
    NQHQRPEDVL LQRTHDEIAL LHCFLWPVVA FVVGVLIVVL TICAKSLAVK 200
    AEAMKKRKFS 210
    Length:210
    Mass (Da):23,857
    Last modified:October 1, 2000 - v1
    Checksum:i11C73DD2C2C6F1D4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF215892 mRNA. Translation: AAF75597.1.
    BC117779 mRNA. Translation: AAI17780.1.
    CCDSiCCDS24184.1.
    RefSeqiNP_067427.1. NM_021452.1.
    UniGeneiMm.440652.

    Genome annotation databases

    EnsembliENSMUST00000068233; ENSMUSP00000065384; ENSMUSG00000054934.
    GeneIDi58802.
    KEGGimmu:58802.
    UCSCiuc007hbw.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF215892 mRNA. Translation: AAF75597.1 .
    BC117779 mRNA. Translation: AAI17780.1 .
    CCDSi CCDS24184.1.
    RefSeqi NP_067427.1. NM_021452.1.
    UniGenei Mm.440652.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    TCDBi 8.A.14.1.1. the ca(2+)-activated k(+) channel auxiliary subunit slowpoke- (slo) family.

    PTM databases

    PhosphoSitei Q9JIN6.

    Proteomic databases

    PRIDEi Q9JIN6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000068233 ; ENSMUSP00000065384 ; ENSMUSG00000054934 .
    GeneIDi 58802.
    KEGGi mmu:58802.
    UCSCi uc007hbw.1. mouse.

    Organism-specific databases

    CTDi 27345.
    MGIi MGI:1913272. Kcnmb4.

    Phylogenomic databases

    eggNOGi NOG83271.
    GeneTreei ENSGT00390000015997.
    HOGENOMi HOG000113205.
    HOVERGENi HBG052224.
    InParanoidi Q149I1.
    KOi K04941.
    OMAi YVPPCER.
    OrthoDBi EOG77WWDC.
    PhylomeDBi Q9JIN6.
    TreeFami TF328589.

    Enzyme and pathway databases

    Reactomei REACT_199092. Ca2+ activated K+ channels.

    Miscellaneous databases

    ChiTaRSi KCNMB4. mouse.
    NextBioi 314378.
    PROi Q9JIN6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JIN6.
    Bgeei Q9JIN6.
    Genevestigatori Q9JIN6.

    Family and domain databases

    InterProi IPR003930. K_chnl_Ca-activ_BK_bsu.
    [Graphical view ]
    PANTHERi PTHR10258. PTHR10258. 1 hit.
    Pfami PF03185. CaKB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel nervous system beta subunit that downregulates human large conductance calcium-dependent potassium channels."
      Weiger T.M., Holmqvist M.H., Levitan I.B., Clark F.T., Sprague S., Huang W.-J., Ge P., Wang C., Lawson D., Jurman M.E., Glucksmann M.A., Silos-Santiago I., DiStefano P.S., Curtis R.
      J. Neurosci. 20:3563-3570(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH KCNMA1.
      Strain: BALB/c.
      Tissue: Brain.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiKCMB4_MOUSE
    AccessioniPrimary (citable) accession number: Q9JIN6
    Secondary accession number(s): Q149I1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 13, 2004
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3