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Q9JIM4

- DUS12_RAT

UniProt

Q9JIM4 - DUS12_RAT

Protein

Dual specificity protein phosphatase 12

Gene

Dusp12

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Seems to dephosphorylate glucokinase.1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei114 – 1141Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. kinase binding Source: RGD
    2. metal ion binding Source: UniProtKB-KW
    3. phosphoprotein phosphatase activity Source: RGD
    4. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    5. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. positive regulation of glucokinase activity Source: RGD
    2. protein dephosphorylation Source: RGD

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 12 (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    Glucokinase-associated dual specificity phosphatase
    Short name:
    GKAP
    Gene namesi
    Name:Dusp12
    Synonyms:Gkap
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 13

    Organism-specific databases

    RGDi68375. Dusp12.

    Subcellular locationi

    Cytoplasm 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: RGD
    2. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 339339Dual specificity protein phosphatase 12PRO_0000260313Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Expressioni

    Gene expression databases

    GenevestigatoriQ9JIM4.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000004179.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JIM4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini87 – 16175Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    GeneTreeiENSGT00740000115610.
    HOGENOMiHOG000243638.
    HOVERGENiHBG051421.
    InParanoidiQ9JIM4.
    KOiK14819.
    OMAiKITHILT.
    OrthoDBiEOG7Z95MG.
    PhylomeDBiQ9JIM4.
    TreeFamiTF105123.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR016278. DUSP12.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000941. DUSP12. 1 hit.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JIM4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLEVQSSNHG CERQAPTTSP ASSAGHAVEV RPGLYLGGAA AVAGPDYLRE    50
    AGITAVLTVD SEPAFPAGAG FEGLQSLFVP ALDKPETDLL SHLDRCVAFI 100
    GQARSEGRAV LVHCHAGVSR SVAVVTAFIM KTEQLTFEKA YENLQTIKPE 150
    AKMNEGFEWQ LKLYEAMGHE VHTSSAVYKQ YRLQKVTEKY PELRNLPREL 200
    FAVDPTTVSQ GLKDDILYKC RKCRRSLFRR SSILDHSEGS GPVAFAHKRT 250
    GLSSVLTTGN QAQCTSYFIE PVQWMESALL GVMDGQLLCP KCSAKLGSFN 300
    WYGEQCSCGR WITPAFQIHK NRVDEVKTLP ALGSQTKKP 339
    Length:339
    Mass (Da):37,196
    Last modified:October 1, 2000 - v1
    Checksum:iF2E41DE35F0E2C00
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF217233 mRNA. Translation: AAF87971.1.
    RefSeqiNP_071584.1. NM_022248.1.
    UniGeneiRn.52231.

    Genome annotation databases

    EnsembliENSRNOT00000004179; ENSRNOP00000004179; ENSRNOG00000003100.
    GeneIDi64014.
    KEGGirno:64014.
    UCSCiRGD:68375. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF217233 mRNA. Translation: AAF87971.1 .
    RefSeqi NP_071584.1. NM_022248.1.
    UniGenei Rn.52231.

    3D structure databases

    ProteinModelPortali Q9JIM4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000004179.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000004179 ; ENSRNOP00000004179 ; ENSRNOG00000003100 .
    GeneIDi 64014.
    KEGGi rno:64014.
    UCSCi RGD:68375. rat.

    Organism-specific databases

    CTDi 11266.
    RGDi 68375. Dusp12.

    Phylogenomic databases

    eggNOGi COG2453.
    GeneTreei ENSGT00740000115610.
    HOGENOMi HOG000243638.
    HOVERGENi HBG051421.
    InParanoidi Q9JIM4.
    KOi K14819.
    OMAi KITHILT.
    OrthoDBi EOG7Z95MG.
    PhylomeDBi Q9JIM4.
    TreeFami TF105123.

    Miscellaneous databases

    NextBioi 612590.
    PROi Q9JIM4.

    Gene expression databases

    Genevestigatori Q9JIM4.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR016278. DUSP12.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000941. DUSP12. 1 hit.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel cytosolic dual specificity phosphatase, interacting with glucokinase, increases glucose phosphorylation rate."
      Munoz-Alonso M.J., Guillemain G., Kassis N., Girard J., Burnol A.-F., Leturque A.
      J. Biol. Chem. 275:32406-32412(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiDUS12_RAT
    AccessioniPrimary (citable) accession number: Q9JIM4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3