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Q9JIM4

- DUS12_RAT

UniProt

Q9JIM4 - DUS12_RAT

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Protein

Dual specificity protein phosphatase 12

Gene

Dusp12

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Seems to dephosphorylate glucokinase.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Binds 2 zinc ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei114 – 1141Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. kinase binding Source: RGD
  2. metal ion binding Source: UniProtKB-KW
  3. phosphoprotein phosphatase activity Source: RGD
  4. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
  5. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. positive regulation of glucokinase activity Source: RGD
  2. protein dephosphorylation Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 12 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Glucokinase-associated dual specificity phosphatase
Short name:
GKAP
Gene namesi
Name:Dusp12
Synonyms:Gkap
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 13

Organism-specific databases

RGDi68375. Dusp12.

Subcellular locationi

Cytoplasm 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 339339Dual specificity protein phosphatase 12PRO_0000260313Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Expressioni

Gene expression databases

GenevestigatoriQ9JIM4.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004179.

Structurei

3D structure databases

ProteinModelPortaliQ9JIM4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini87 – 16175Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
GeneTreeiENSGT00740000115610.
HOGENOMiHOG000243638.
HOVERGENiHBG051421.
InParanoidiQ9JIM4.
KOiK14819.
OMAiKITHILT.
OrthoDBiEOG7Z95MG.
PhylomeDBiQ9JIM4.
TreeFamiTF105123.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR016278. DUSP12.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PIRSFiPIRSF000941. DUSP12. 1 hit.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JIM4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLEVQSSNHG CERQAPTTSP ASSAGHAVEV RPGLYLGGAA AVAGPDYLRE
60 70 80 90 100
AGITAVLTVD SEPAFPAGAG FEGLQSLFVP ALDKPETDLL SHLDRCVAFI
110 120 130 140 150
GQARSEGRAV LVHCHAGVSR SVAVVTAFIM KTEQLTFEKA YENLQTIKPE
160 170 180 190 200
AKMNEGFEWQ LKLYEAMGHE VHTSSAVYKQ YRLQKVTEKY PELRNLPREL
210 220 230 240 250
FAVDPTTVSQ GLKDDILYKC RKCRRSLFRR SSILDHSEGS GPVAFAHKRT
260 270 280 290 300
GLSSVLTTGN QAQCTSYFIE PVQWMESALL GVMDGQLLCP KCSAKLGSFN
310 320 330
WYGEQCSCGR WITPAFQIHK NRVDEVKTLP ALGSQTKKP
Length:339
Mass (Da):37,196
Last modified:October 1, 2000 - v1
Checksum:iF2E41DE35F0E2C00
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF217233 mRNA. Translation: AAF87971.1.
RefSeqiNP_071584.1. NM_022248.1.
UniGeneiRn.52231.

Genome annotation databases

EnsembliENSRNOT00000004179; ENSRNOP00000004179; ENSRNOG00000003100.
GeneIDi64014.
KEGGirno:64014.
UCSCiRGD:68375. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF217233 mRNA. Translation: AAF87971.1 .
RefSeqi NP_071584.1. NM_022248.1.
UniGenei Rn.52231.

3D structure databases

ProteinModelPortali Q9JIM4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000004179.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000004179 ; ENSRNOP00000004179 ; ENSRNOG00000003100 .
GeneIDi 64014.
KEGGi rno:64014.
UCSCi RGD:68375. rat.

Organism-specific databases

CTDi 11266.
RGDi 68375. Dusp12.

Phylogenomic databases

eggNOGi COG2453.
GeneTreei ENSGT00740000115610.
HOGENOMi HOG000243638.
HOVERGENi HBG051421.
InParanoidi Q9JIM4.
KOi K14819.
OMAi KITHILT.
OrthoDBi EOG7Z95MG.
PhylomeDBi Q9JIM4.
TreeFami TF105123.

Miscellaneous databases

NextBioi 612590.
PROi Q9JIM4.

Gene expression databases

Genevestigatori Q9JIM4.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR016278. DUSP12.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
[Graphical view ]
PIRSFi PIRSF000941. DUSP12. 1 hit.
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel cytosolic dual specificity phosphatase, interacting with glucokinase, increases glucose phosphorylation rate."
    Munoz-Alonso M.J., Guillemain G., Kassis N., Girard J., Burnol A.-F., Leturque A.
    J. Biol. Chem. 275:32406-32412(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiDUS12_RAT
AccessioniPrimary (citable) accession number: Q9JIM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3