Reviewed, UniProtKB/Swiss-Prot Q9JIM3 (RAD26_MOUSE)

Names and origin

Protein names

Recommended name:
    Putative DNA repair and recombination protein RAD26-like
    EC=3.6.1.-

Gene names

Name:

Rad26l

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	699 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the SNF2/RAD54 helicase family. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain.
Sequence caution	The sequence AAH32964.1 differs from that shown. Reason: Frameshift at position 281.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Ligand	ATP-binding DNA-binding Nucleotide-binding
Molecular function	Helicase Hydrolase
Gene Ontology (GO)
Biological process	DNA repair Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATP-dependent helicase activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9JIM3-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9JIM3-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-116: Missing.
     117-156: TINRYLRDYQ...DDMGLGKTIQ → MPGSRPTCRA...PRSPAQTPAK
     583-699: Missing.

Isoform 3 (identifier: Q9JIM3-3)

The sequence of this isoform differs from the canonical sequence as follows:
     261-273: SLEWSAIIVDEAH → RQTFCSSHHEHAS
     274-699: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 699	699	Putative DNA repair and recombination protein RAD26-like		PRO_0000326087
Regions
	Domain	134 – 319	186	Helicase ATP-binding
	Domain	510 – 660	151	Helicase C-terminal
	Nucleotide binding	147 – 154	8	ATP By similarity
	Motif	270 – 273	4	DEAH box
Natural variations
	Alternative sequence	1 – 116	116	Missing in isoform 2.		VSP_032545
	Alternative sequence	117 – 156	40	TINRY…GKTIQ → MPGSRPTCRALLAAESGGAA GCLPLARWTSPPRSPAQTPA K in isoform 2.		VSP_032546
	Alternative sequence	261 – 273	13	SLEWS…VDEAH → RQTFCSSHHEHAS in isoform 3.		VSP_032547
	Alternative sequence	274 – 699	426	Missing in isoform 3.		VSP_032548
	Alternative sequence	583 – 699	117	Missing in isoform 2.		VSP_032549
Experimental info
	Sequence conflict	18	1	C → M in BAC38652. Ref.1
	Sequence conflict	86	1	K → E in AAF73858. Ref.3
	Sequence conflict	301	1	V → I in AAF73858. Ref.3
	Sequence conflict	453	1	V → I in AAF73858. Ref.3
	Sequence conflict	453	1	V → I in AAH32964. Ref.4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: 0BA3912C697A7A39	FASTA	699	79,899
	10 20 30 40 50 60 MDISAPQSRA DSRKDRWCPG ERCLAPSLDN KKLCEASIKS ITVDGNGKPF AVVLYPDFQE 70 80 90 100 110 120 KTIPLQRLQE VKSTKDYSRS LIFDDKDLEK PYFPDRKIPS LASAFQLSED GDSIPYTINR 130 140 150 160 170 180 YLRDYQREGA QFLYRHYIEG RGCILGDDMG LGKTIQVISF LAAVLHKKGT REDIENNMPE 190 200 210 220 230 240 FLLKSMKKKP PSTAKKMFLI VAPLSVLYNW KDELDTWGYF RVTVLHGSKK DNELLRLKQR 250 260 270 280 290 300 KCEIALTTYE TLRLCLEELN SLEWSAIIVD EAHRIKNPKA RVTEVMKAVK CKVRIGLTGT 310 320 330 340 350 360 VLQNNMKELW CVMDWAVPGL LGSRIHFKKQ FSDPVEHGQR HTATKRELAT GRKAMHRLAK 370 380 390 400 410 420 KMSGWFLRRT KTLIKGQLPK KEDRMVYCSL TDFQKAVYQT VLETEDVALI LTSSQPCTCG 430 440 450 460 470 480 SGQKRRKCCY KTNSRGDTVR TLCLSYLTVL QKVANHVALL QAASTSKHQE TVIKRICDRV 490 500 510 520 530 540 FSRFPDFVQK SKDAAFETLS DPKYSGKMKV LQQLLNHFRK QRDKVLLFSF STKLLDVLQQ 550 560 570 580 590 600 YCMASGLDYR RLDGSTKSEE RLKIVKEFNS SQDVNICLVS TMAGGLGLNF VGANVVILFD 610 620 630 640 650 660 PTWNPANDLQ AVDRAYRIGQ CRDVKVLRLI SLGTVEEIMY LRQVYKQQLH CVVVGSENAK 670 680 690 RYFEAVQGSK EHRGELFGVH NLFKLRSQGS CLTRDILEV
	Isoform 2. Checksum: 741071999B26B78D	FASTA	467	53,069
	10 20 30 40 50 60 MPGSRPTCRA LLAAESGGAA GCLPLARWTS PPRSPAQTPA KVISFLAAVL HKKGTREDIE 70 80 90 100 110 120 NNMPEFLLKS MKKKPPSTAK KMFLIVAPLS VLYNWKDELD TWGYFRVTVL HGSKKDNELL 130 140 150 160 170 180 RLKQRKCEIA LTTYETLRLC LEELNSLEWS AIIVDEAHRI KNPKARVTEV MKAVKCKVRI 190 200 210 220 230 240 GLTGTVLQNN MKELWCVMDW AVPGLLGSRI HFKKQFSDPV EHGQRHTATK RELATGRKAM 250 260 270 280 290 300 HRLAKKMSGW FLRRTKTLIK GQLPKKEDRM VYCSLTDFQK AVYQTVLETE DVALILTSSQ 310 320 330 340 350 360 PCTCGSGQKR RKCCYKTNSR GDTVRTLCLS YLTVLQKVAN HVALLQAAST SKHQETVIKR 370 380 390 400 410 420 ICDRVFSRFP DFVQKSKDAA FETLSDPKYS GKMKVLQQLL NHFRKQRDKV LLFSFSTKLL 430 440 450 460 DVLQQYCMAS GLDYRRLDGS TKSEERLKIV KEFNSSQDVN ICLVSTM
	Isoform 3. Checksum: AC88934DF0E97D6C	FASTA	273	31,463
	10 20 30 40 50 60 MDISAPQSRA DSRKDRWCPG ERCLAPSLDN KKLCEASIKS ITVDGNGKPF AVVLYPDFQE 70 80 90 100 110 120 KTIPLQRLQE VKSTKDYSRS LIFDDKDLEK PYFPDRKIPS LASAFQLSED GDSIPYTINR 130 140 150 160 170 180 YLRDYQREGA QFLYRHYIEG RGCILGDDMG LGKTIQVISF LAAVLHKKGT REDIENNMPE 190 200 210 220 230 240 FLLKSMKKKP PSTAKKMFLI VAPLSVLYNW KDELDTWGYF RVTVLHGSKK DNELLRLKQR 250 260 270 KCEIALTTYE TLRLCLEELN RQTFCSSHHE HAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y. Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Strain: C57BL/6J. Tissue: Kidney.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed: 19468303] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"Characterization of the mammalian Rad26L gene encoding a putative repair and recombination helicase." Ramirez M.H., Shannon M.E., Thelen M.P. Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-699 (ISOFORM 1).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 280-699 (ISOFORM 1). Strain: C57BL/6J. Tissue: Mammary gland.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AK002307 mRNA. Translation: BAB22002.1. AK082850 mRNA. Translation: BAC38652.1. AC154248 Genomic DNA. No translation available. AF217319 mRNA. Translation: AAF73858.1. BC032964 mRNA. Translation: AAH32964.1. Frameshift.
IPI	IPI00403243. IPI00754737. IPI00857027.
RefSeq	NP_075996.2.
UniGene	Mm.186610
3D structure databases
HSSP	HSSP built from PDB template 1Z63 based on UniProtKB Q97XQ5.
ModBase	Search...
Proteomic databases
PRIDE	Q9JIM3.
Genome annotation databases
Ensembl	ENSMUST00000021925; ENSMUSP00000021925; ENSMUSG00000021470; Mus musculus. [Genome view] ENSMUST00000067821; ENSMUSP00000069488; ENSMUSG00000021470; Mus musculus. [Genome view] ENSMUST00000109778; ENSMUSP00000105400; ENSMUSG00000021470; Mus musculus. [Genome view]
GeneID	76251.
UCSC	uc007qyc.1. mouse.
Organism-specific databases
MGI	MGI:1923501. 0610007P08Rik.
Phylogenomic databases
HOVERGEN	Q9JIM3.
OMA	FLYGHYI
Gene expression databases
ArrayExpress	Q9JIM3.
Bgee	Q9JIM3.
CleanEx	MM_0610007P08RIK.
Genevestigator	Q9JIM3.
Family and domain databases
InterPro	IPR014001. DEAD-like_N. IPR001650. DNA/RNA_helicase_C. IPR002464. DNA/RNA_helicase_DEAH_CS. IPR014021. Helicase_SF1/SF2_ATP-bd. IPR000330. SNF2_N. [Graphical view]
Pfam	PF00271. Helicase_C. 1 hit. PF00176. SNF2_N. 1 hit. [Graphical view]
SMART	SM00487. DEXDc. 1 hit. SM00490. HELICc. 1 hit. [Graphical view]
PROSITE	PS00690. DEAH_ATP_HELICASE. 1 hit. PS51192. HELICASE_ATP_BIND_1. 1 hit. PS51194. HELICASE_CTER. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	344851.
SOURCE	Search...

Entry information

Entry name

RAD26_MOUSE

Accession

Primary (citable) accession number: Q9JIM3
Secondary accession number(s): Q8BIV4, Q8K267, Q9DD01

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 18, 2008
Last sequence update:	March 18, 2008
Last modified:	November 24, 2009
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)