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Protein

Double-strand break repair protein MRE11A

Gene

Mre11a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.By similarity

Cofactori

Mn2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291Proton donorBy similarity

GO - Molecular functioni

GO - Biological processi

  • double-strand break repair Source: InterPro
  • heart development Source: RGD
  • intra-S DNA damage checkpoint Source: GO_Central
  • meiotic cell cycle Source: UniProtKB-KW
  • negative regulation of viral entry into host cell Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Exonuclease, Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA repair, Meiosis

Keywords - Ligandi

Manganese

Names & Taxonomyi

Protein namesi
Recommended name:
Double-strand break repair protein MRE11A
Alternative name(s):
Meiotic recombination 11 homolog 1
Short name:
MRE11 homolog 1
Meiotic recombination 11 homolog A
Short name:
MRE11 homolog A
Gene namesi
Name:Mre11a
Synonyms:Mre11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69263. Mre11a.

Subcellular locationi

  • Nucleus By similarity
  • Chromosometelomere By similarity

  • Note: Localizes to discrete nuclear foci after treatment with genotoxic agents.By similarity

GO - Cellular componenti

  • chromosome, telomeric region Source: UniProtKB-SubCell
  • condensed nuclear chromosome Source: RGD
  • Mre11 complex Source: InterPro
  • nuclear chromatin Source: RGD
  • nucleoplasm Source: RGD
  • nucleus Source: RGD
  • perinuclear region of cytoplasm Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 706705Double-strand break repair protein MRE11APRO_0000138675Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei2 – 21PhosphoserineBy similarity
Modified residuei275 – 2751PhosphoserineBy similarity
Modified residuei618 – 6181PhosphoserineBy similarity
Modified residuei640 – 6401PhosphoserineBy similarity
Modified residuei648 – 6481PhosphoserineBy similarity
Modified residuei676 – 6761PhosphoserineBy similarity
Modified residuei686 – 6861PhosphoserineCombined sources
Modified residuei699 – 6991PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9JIM0.
PRIDEiQ9JIM0.

PTM databases

iPTMnetiQ9JIM0.
PhosphoSiteiQ9JIM0.

Interactioni

Subunit structurei

Component of the MRN complex composed of two heterodimers RAD50/MRE11A associated with a single NBN. Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11A and NBN. Found in a complex with TERF2. Interacts with DCLRE1C/Artemis and DCLRE1B/Apollo. Interacts with ATF2. Interacts with EXD2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012940.

Structurei

3D structure databases

ProteinModelPortaliQ9JIM0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MRE11/RAD32 family.Curated

Phylogenomic databases

eggNOGiKOG2310. Eukaryota.
COG0420. LUCA.
HOGENOMiHOG000216581.
HOVERGENiHBG052508.
InParanoidiQ9JIM0.
KOiK10865.
PhylomeDBiQ9JIM0.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR003701. Mre11.
IPR007281. Mre11_DNA-bd.
[Graphical view]
PANTHERiPTHR10139:SF1. PTHR10139:SF1. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
PF04152. Mre11_DNA_bind. 1 hit.
[Graphical view]
PIRSFiPIRSF000882. DSB_repair_MRE11. 1 hit.
SMARTiSM01347. Mre11_DNA_bind. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 2 hits.
TIGRFAMsiTIGR00583. mre11. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JIM0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPTDPLDDE DTFKILVATD IHLGFMEKDA VRGNDTFVTF DEILRLALEN
60 70 80 90 100
EVDFILLGGD LFHENKPSRK TLHSCLELLR KYCMGDRPVQ FEIISDQSVN
110 120 130 140 150
FGFSKFPWVN YRDGNLNISI PVFSIHGNHD DPTGADALCA LDVLSCAGFV
160 170 180 190 200
NHFGRSMSVE KVDISPVLLQ KGSTKLALYG LGSIPDERLY RMFVNKKVTM
210 220 230 240 250
LRPKEDENSW FNLFVIHQNR SKHGSTNFIP EQFLDDFIDL VIWGHEHECK
260 270 280 290 300
IGPTRNEQQL FYVSQPGSSV VTALSPGETV KKHVGLLRVK GRKMNMQKLP
310 320 330 340 350
LRTVRQFFME DVVLANHPSL FNPDNPKVTQ AIQSFCLEKI EEMLDSAERE
360 370 380 390 400
RLGNPQQPEK PLIRLRVDYS GGFEPFNVLR FSQKFVDRVA NPKDVIHFFR
410 420 430 440 450
HREQKGKTGE EINFGKLIIK PASEGTTLRV EDLVKQYFQT AEKNVQLSLL
460 470 480 490 500
TERGMGEAVQ EFVDKEEKDA IEELVKYQLE KTQRFLKERH IDALEDKIDE
510 520 530 540 550
EVRRFRESRQ RNTNEEDDEV REAMSRARAL RSQSENAASA FSADDLSFDI
560 570 580 590 600
TEQTADDSDD SQSAVPSRGR GRGRGRRGGR GQSTAPRGGS QRGRDTGLGI
610 620 630 640 650
STRGRSSKAT ASTSRNMSII DAFRSTRQQP SRNVATKNYS ETIEVDESDD
660 670 680 690 700
DDSFPTSSRA DQRWSGTAPS KRMSQSQTAK GVDFESDEDD DDDPFMSGSC

PRRNRR
Length:706
Mass (Da):80,122
Last modified:October 1, 2000 - v1
Checksum:i0183A41BC015FDA0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218574 mRNA. Translation: AAF91227.1.
RefSeqiNP_071615.1. NM_022279.1.
UniGeneiRn.209040.

Genome annotation databases

GeneIDi64046.
KEGGirno:64046.
UCSCiRGD:69263. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218574 mRNA. Translation: AAF91227.1.
RefSeqiNP_071615.1. NM_022279.1.
UniGeneiRn.209040.

3D structure databases

ProteinModelPortaliQ9JIM0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012940.

PTM databases

iPTMnetiQ9JIM0.
PhosphoSiteiQ9JIM0.

Proteomic databases

PaxDbiQ9JIM0.
PRIDEiQ9JIM0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi64046.
KEGGirno:64046.
UCSCiRGD:69263. rat.

Organism-specific databases

CTDi4361.
RGDi69263. Mre11a.

Phylogenomic databases

eggNOGiKOG2310. Eukaryota.
COG0420. LUCA.
HOGENOMiHOG000216581.
HOVERGENiHBG052508.
InParanoidiQ9JIM0.
KOiK10865.
PhylomeDBiQ9JIM0.

Miscellaneous databases

PROiQ9JIM0.

Family and domain databases

Gene3Di3.60.21.10. 2 hits.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
IPR003701. Mre11.
IPR007281. Mre11_DNA-bd.
[Graphical view]
PANTHERiPTHR10139:SF1. PTHR10139:SF1. 1 hit.
PfamiPF00149. Metallophos. 1 hit.
PF04152. Mre11_DNA_bind. 1 hit.
[Graphical view]
PIRSFiPIRSF000882. DSB_repair_MRE11. 1 hit.
SMARTiSM01347. Mre11_DNA_bind. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 2 hits.
TIGRFAMsiTIGR00583. mre11. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMRE11_RAT
AccessioniPrimary (citable) accession number: Q9JIM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.