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Protein

G-protein coupled receptor family C group 5 member D

Gene

Gprc5d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: MGI
  • hair cycle Source: UniProtKB
  • keratinization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor family C group 5 member D
Gene namesi
Name:Gprc5d
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:1935037. Gprc5d.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2727ExtracellularSequence analysisAdd
BLAST
Transmembranei28 – 4821Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini49 – 6315CytoplasmicSequence analysisAdd
BLAST
Transmembranei64 – 8421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini85 – 939ExtracellularSequence analysis
Transmembranei94 – 11421Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini115 – 12410CytoplasmicSequence analysis
Transmembranei125 – 14521Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini146 – 16722ExtracellularSequence analysisAdd
BLAST
Transmembranei168 – 18821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini189 – 20416CytoplasmicSequence analysisAdd
BLAST
Transmembranei205 – 22521Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini226 – 23914ExtracellularSequence analysisAdd
BLAST
Transmembranei240 – 26021Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini261 – 34484CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 344344G-protein coupled receptor family C group 5 member DPRO_0000206898Add
BLAST

Proteomic databases

PaxDbiQ9JIL6.
PRIDEiQ9JIL6.

PTM databases

PhosphoSiteiQ9JIL6.

Expressioni

Gene expression databases

BgeeiQ9JIL6.
ExpressionAtlasiQ9JIL6. baseline and differential.
GenevisibleiQ9JIL6. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032327.

Structurei

3D structure databases

ProteinModelPortaliQ9JIL6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK8H. Eukaryota.
ENOG411157H. LUCA.
GeneTreeiENSGT00520000055551.
HOGENOMiHOG000116197.
HOVERGENiHBG049967.
InParanoidiQ9JIL6.
KOiK04621.
OMAiLVTNAWV.
OrthoDBiEOG7RRF79.
PhylomeDBiQ9JIL6.
TreeFamiTF321410.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JIL6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYEDCVKSTE DYYLFCDNEG PWAIVLESLA VIGIVVTILL LLAFLFLMRK
60 70 80 90 100
VQDCSQWNVL PTQFLFLLAV LGLFGLTFAF IIQLNHQTAP VRYFLFGVLF
110 120 130 140 150
AICFSCLLAH ASNLVKLVRG RVSFCWTTIL FIAIGVSLLQ TIIAIEYVTL
160 170 180 190 200
IMTRGLMFEH MTPYQLNVDF VCLLIYVLFL MALTFFVSKA TFCGPCENWK
210 220 230 240 250
QHGRLIFATV LVSIIIWVVW ISMLLRGNPQ LQRQPHWDDA VICIGLVTNA
260 270 280 290 300
WVFLLIYIIP ELSILYRSCR QECPTQGNVC QVPVYQRSFR MDTQEPTRAR
310 320 330 340
DSDGAQEDVA LTAYGTPIQL QSADPSREYL IPSATLSPQQ DAGL
Length:344
Mass (Da):39,056
Last modified:April 13, 2004 - v2
Checksum:iCBBC1B6A3F683764
GO
Isoform 2 (identifier: Q9JIL6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     299-300: AR → EC
     301-344: Missing.

Show »
Length:300
Mass (Da):34,488
Checksum:iD9423064260A4C59
GO

Sequence cautioni

The sequence BAC20266.1 differs from that shown. Reason: Frameshift at position 23. Curated
The sequence BAC20267.1 differs from that shown. Reason: Frameshift at position 23. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241I → C (Ref. 3) Curated
Sequence conflicti234 – 2352QP → HA in BAC20266 (Ref. 3) Curated
Sequence conflicti234 – 2352QP → HA in BAC20267 (Ref. 3) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei299 – 3002AR → EC in isoform 2. 3 PublicationsVSP_010009
Alternative sequencei301 – 34444Missing in isoform 2. 3 PublicationsVSP_010010Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218809 mRNA. Translation: AAF72880.1.
AB099816 mRNA. Translation: BAC79168.1.
AB025221 mRNA. Translation: BAC20266.1. Frameshift.
AB025222 mRNA. Translation: BAC20267.1. Frameshift.
CCDSiCCDS39680.1. [Q9JIL6-2]
CCDS57462.1. [Q9JIL6-1]
RefSeqiNP_001192325.1. NM_001205396.1. [Q9JIL6-1]
NP_444348.1. NM_053118.1. [Q9JIL6-2]
XP_006506869.1. XM_006506806.2. [Q9JIL6-1]
UniGeneiMm.49902.

Genome annotation databases

EnsembliENSMUST00000032327; ENSMUSP00000032327; ENSMUSG00000030205. [Q9JIL6-1]
ENSMUST00000111922; ENSMUSP00000107553; ENSMUSG00000030205. [Q9JIL6-2]
GeneIDi93746.
KEGGimmu:93746.
UCSCiuc009elg.1. mouse. [Q9JIL6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF218809 mRNA. Translation: AAF72880.1.
AB099816 mRNA. Translation: BAC79168.1.
AB025221 mRNA. Translation: BAC20266.1. Frameshift.
AB025222 mRNA. Translation: BAC20267.1. Frameshift.
CCDSiCCDS39680.1. [Q9JIL6-2]
CCDS57462.1. [Q9JIL6-1]
RefSeqiNP_001192325.1. NM_001205396.1. [Q9JIL6-1]
NP_444348.1. NM_053118.1. [Q9JIL6-2]
XP_006506869.1. XM_006506806.2. [Q9JIL6-1]
UniGeneiMm.49902.

3D structure databases

ProteinModelPortaliQ9JIL6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032327.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9JIL6.

Proteomic databases

PaxDbiQ9JIL6.
PRIDEiQ9JIL6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032327; ENSMUSP00000032327; ENSMUSG00000030205. [Q9JIL6-1]
ENSMUST00000111922; ENSMUSP00000107553; ENSMUSG00000030205. [Q9JIL6-2]
GeneIDi93746.
KEGGimmu:93746.
UCSCiuc009elg.1. mouse. [Q9JIL6-1]

Organism-specific databases

CTDi55507.
MGIiMGI:1935037. Gprc5d.

Phylogenomic databases

eggNOGiENOG410IK8H. Eukaryota.
ENOG411157H. LUCA.
GeneTreeiENSGT00520000055551.
HOGENOMiHOG000116197.
HOVERGENiHBG049967.
InParanoidiQ9JIL6.
KOiK04621.
OMAiLVTNAWV.
OrthoDBiEOG7RRF79.
PhylomeDBiQ9JIL6.
TreeFamiTF321410.

Miscellaneous databases

NextBioi351609.
PROiQ9JIL6.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JIL6.
ExpressionAtlasiQ9JIL6. baseline and differential.
GenevisibleiQ9JIL6. MM.

Family and domain databases

InterProiIPR017978. GPCR_3_C.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D."
    Braeuner-Osborne H., Jensen A.A., Sheppard P.O., Brodin B., Krogsgaard-Larsen P., O'Hara P.
    Biochim. Biophys. Acta 1518:237-248(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
  2. "Characterization of GPRC5D, a member of RAIG family in hard keratinized structures."
    Inoue S., Nanbu T., Shimomura T.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Skin.
  3. "Molecular cloning of new putative G protein-coupled receptors from skin."
    Ishibashi K.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-344 (ISOFORMS 1 AND 2).
    Tissue: Skin.

Entry informationi

Entry nameiGPC5D_MOUSE
AccessioniPrimary (citable) accession number: Q9JIL6
Secondary accession number(s): Q8CJI0, Q8CJI1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: April 13, 2004
Last modified: March 16, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.