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Protein

Tubby-related protein 4

Gene

Tulp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Tubby-related protein 4
Alternative name(s):
Tubby superfamily protein
Tubby-like protein 4
Gene namesi
Name:Tulp4
Synonyms:Tusp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1916092. Tulp4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001864731 – 1547Tubby-related protein 4Add BLAST1547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei577PhosphoserineBy similarity1
Modified residuei949Asymmetric dimethylarginineCombined sources1
Modified residuei954Asymmetric dimethylarginineCombined sources1
Modified residuei1347PhosphoserineBy similarity1
Modified residuei1378PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9JIL5.
MaxQBiQ9JIL5.
PaxDbiQ9JIL5.
PRIDEiQ9JIL5.

PTM databases

iPTMnetiQ9JIL5.
PhosphoSitePlusiQ9JIL5.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034377.
CleanExiMM_TULP4.
ExpressionAtlasiQ9JIL5. baseline and differential.
GenevisibleiQ9JIL5. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049248.

Structurei

3D structure databases

ProteinModelPortaliQ9JIL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati80 – 119WD 1Add BLAST40
Repeati123 – 162WD 2Add BLAST40
Repeati165 – 204WD 3Add BLAST40
Domaini364 – 414SOCS boxPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1436 – 1547TUBAdd BLAST112

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Belongs to the TUB family.Curated
Contains 1 SOCS box domain.PROSITE-ProRule annotation
Contains 3 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2503. Eukaryota.
ENOG410YEKG. LUCA.
GeneTreeiENSGT00610000085970.
HOGENOMiHOG000060128.
HOVERGENiHBG057880.
InParanoidiQ9JIL5.
OMAiDFSLYPT.
OrthoDBiEOG091G0YBE.
PhylomeDBiQ9JIL5.
TreeFamiTF314076.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
3.20.90.10. 3 hits.
InterProiIPR001496. SOCS_box.
IPR000007. Tubby_C.
IPR025659. Tubby_C-like.
IPR008983. Tumour_necrosis_fac-like_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF01167. Tub. 1 hit.
[Graphical view]
SMARTiSM00969. SOCS_box. 1 hit.
SM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
SSF50978. SSF50978. 2 hits.
SSF54518. SSF54518. 2 hits.
PROSITEiPS50225. SOCS. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JIL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYAAVEHGPV LCSDSNILCL SWKGRVPKSE KEKPVCRRRY YEEGWLATGN
60 70 80 90 100
GRGVVGVTFT SSHCRRDRST PQRINFNLRG HNSEVVLVRW NEPYQKLATC
110 120 130 140 150
DADGGIFVWI QYEGRWSVEL VNDRGAQVSD FTWSHDGTQA LISYRDGFVL
160 170 180 190 200
VGSVSGQRHW SSEINLESQI TCGIWTPDDQ QVLFGTADGQ VIVMDCHGRM
210 220 230 240 250
LAHVLLHESD GILSMSWNYP IFLVEDSSES DTDSDDYSPP QDGPAAYPIP
260 270 280 290 300
VQNTKPLLTV SFTSGDISLM NNYDDLSPTV IRSGLKEVVA QWCTQGDLLA
310 320 330 340 350
VAGMEQQAQL SELPNGPLLK SAMVKFYNVR GEHIFTLDTL VQRPIISICW
360 370 380 390 400
GHRDSRLLMA SGPALYVVRV EHRVSSLQLL CQQAIASTLR EDKDVNKLTL
410 420 430 440 450
PPRLCSYLST AFIPTIKPPI PDPNNMRDFV SYPSAGNERL HCTMKRTEDD
460 470 480 490 500
PEVGGPCYTL YLEYLGGLVP ILKGRRISKL RPEFVIMDPR TDSKSDEIYG
510 520 530 540 550
NSLISTVIDS CNCSDSSDIE LSDDWAAKKS PKISRSSKSP KLPRISIEAR
560 570 580 590 600
KSPKLPRAAQ EISRSPRLPM RKPSMGSPSL TRREFPFEDI TQHNYLAQVT
610 620 630 640 650
SNIWGTKFKI VGLAAFLPTN LGAVIYKTSL LHLQPRQMTI YLPEVRKISM
660 670 680 690 700
DYINLPVFNP NVFSEDEDDL PVTGASGVPE NNPPCTVNIP IAPIHSSAQA
710 720 730 740 750
LSPTQSIGLV QSLLANQNVQ LDVLTNQTTA VGSAEHAGDA ATQYPVSSRY
760 770 780 790 800
SNPGQVIFGG VEMGRIIQNP PQLPLPPPPP PPPQAPMQLS AVDHGDRDHE
810 820 830 840 850
HLQKSAKALR PVPQLAAEGD AVVFSAPQEV QVAKMNPPPP YPGTIPAAPT
860 870 880 890 900
TAAPPPPLPP PQPPVDVCLK KGDFSLYPTA AHYQPPLGYE RITTFDSSGN
910 920 930 940 950
VEEVCRPRTR MLCSQNTYTL PGPGSSATLR LTATEKKVPQ PCTSATLNRL
960 970 980 990 1000
TVPRYSIPTG DPPPYPEIAS QLAQGRSAAQ RLDNSLIHAT LRRNNREVAL
1010 1020 1030 1040 1050
KMAQLADSSR APLQPLAKPK GGAAGAVAQL PARPPPALYT CSQCSGAGPS
1060 1070 1080 1090 1100
SQSGAALAHA ISTSPLASQS SYNLLSPPDT SRDRTDYVNS AFTEDEALSQ
1110 1120 1130 1140 1150
HCQLEKPLRH PPLPEAAVTM KRPPPYQWDP MLGEDVWVPQ ERTAQPTVPN
1160 1170 1180 1190 1200
PLKLSPLMLG QGQHLDVARV PFVPPKSPSS PTATFPTGYG MGMPYPGSYN
1210 1220 1230 1240 1250
NPSLPGVQAP CSPKDALSQA QFAQQESAVV LQPAYPPSLS YCTLPPTYPG
1260 1270 1280 1290 1300
SSTCSSVQLP PIALHPWNSY STCPPMQNTQ GTLPPKPHLV VEKPLVSPPP
1310 1320 1330 1340 1350
AELQSHMGTE VMVETADNFQ EVLSLTESPV PQRTEKFGKK NRKRLDSRAE
1360 1370 1380 1390 1400
EGSVQAITEG KVKKDARTLS DFNSLISSPR LGREKKKVKS QKDQLKSKKL
1410 1420 1430 1440 1450
NKTNEFQDSS ESEPELFISG DELMNQSQGS KKGWKSKRSL RTASELEEFK
1460 1470 1480 1490 1500
CRKASEKEDG RLGSQGFVYV MANKQPLWNE ATQVYQLDFG GRVTQESAKN
1510 1520 1530 1540
FQIELEGRQV MQFGRIDGNA YILDFQYPFS AVQAFAVALA NVTQRLK
Length:1,547
Mass (Da):169,638
Last modified:October 1, 2000 - v1
Checksum:i8B7CA7A250884423
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1420G → R in BAC30348 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF219945 mRNA. Translation: AAF87974.1.
AK039439 mRNA. Translation: BAC30348.1.
BC008557 mRNA. Translation: AAH08557.1.
BC138024 mRNA. Translation: AAI38025.1.
BC138025 mRNA. Translation: AAI38026.1.
CCDSiCCDS28370.1.
RefSeqiNP_473381.1. NM_054040.3.
XP_006523314.1. XM_006523251.3.
UniGeneiMm.449307.
Mm.482119.
Mm.486644.

Genome annotation databases

EnsembliENSMUST00000039655; ENSMUSP00000049248; ENSMUSG00000034377.
GeneIDi68842.
KEGGimmu:68842.
UCSCiuc008agf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF219945 mRNA. Translation: AAF87974.1.
AK039439 mRNA. Translation: BAC30348.1.
BC008557 mRNA. Translation: AAH08557.1.
BC138024 mRNA. Translation: AAI38025.1.
BC138025 mRNA. Translation: AAI38026.1.
CCDSiCCDS28370.1.
RefSeqiNP_473381.1. NM_054040.3.
XP_006523314.1. XM_006523251.3.
UniGeneiMm.449307.
Mm.482119.
Mm.486644.

3D structure databases

ProteinModelPortaliQ9JIL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049248.

PTM databases

iPTMnetiQ9JIL5.
PhosphoSitePlusiQ9JIL5.

Proteomic databases

EPDiQ9JIL5.
MaxQBiQ9JIL5.
PaxDbiQ9JIL5.
PRIDEiQ9JIL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000039655; ENSMUSP00000049248; ENSMUSG00000034377.
GeneIDi68842.
KEGGimmu:68842.
UCSCiuc008agf.2. mouse.

Organism-specific databases

CTDi56995.
MGIiMGI:1916092. Tulp4.

Phylogenomic databases

eggNOGiKOG2503. Eukaryota.
ENOG410YEKG. LUCA.
GeneTreeiENSGT00610000085970.
HOGENOMiHOG000060128.
HOVERGENiHBG057880.
InParanoidiQ9JIL5.
OMAiDFSLYPT.
OrthoDBiEOG091G0YBE.
PhylomeDBiQ9JIL5.
TreeFamiTF314076.

Enzyme and pathway databases

UniPathwayiUPA00143.

Miscellaneous databases

ChiTaRSiTulp4. mouse.
PROiQ9JIL5.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034377.
CleanExiMM_TULP4.
ExpressionAtlasiQ9JIL5. baseline and differential.
GenevisibleiQ9JIL5. MM.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
3.20.90.10. 3 hits.
InterProiIPR001496. SOCS_box.
IPR000007. Tubby_C.
IPR025659. Tubby_C-like.
IPR008983. Tumour_necrosis_fac-like_dom.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF01167. Tub. 1 hit.
[Graphical view]
SMARTiSM00969. SOCS_box. 1 hit.
SM00320. WD40. 2 hits.
[Graphical view]
SUPFAMiSSF49842. SSF49842. 1 hit.
SSF50978. SSF50978. 2 hits.
SSF54518. SSF54518. 2 hits.
PROSITEiPS50225. SOCS. 1 hit.
PS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTULP4_MOUSE
AccessioniPrimary (citable) accession number: Q9JIL5
Secondary accession number(s): B2RQP8, Q8CA75, Q922C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.