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Protein

Tubby-related protein 4

Gene

Tulp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation
UniPathwayiUPA00143

Names & Taxonomyi

Protein namesi
Recommended name:
Tubby-related protein 4
Alternative name(s):
Tubby superfamily protein
Tubby-like protein 4
Gene namesi
Name:Tulp4
Synonyms:Tusp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1916092 Tulp4

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001864731 – 1547Tubby-related protein 4Add BLAST1547

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei577PhosphoserineBy similarity1
Modified residuei949Asymmetric dimethylarginineCombined sources1
Modified residuei954Asymmetric dimethylarginineCombined sources1
Modified residuei1347PhosphoserineBy similarity1
Modified residuei1378PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

EPDiQ9JIL5
MaxQBiQ9JIL5
PaxDbiQ9JIL5
PRIDEiQ9JIL5

PTM databases

iPTMnetiQ9JIL5
PhosphoSitePlusiQ9JIL5

Expressioni

Gene expression databases

BgeeiENSMUSG00000034377
CleanExiMM_TULP4
ExpressionAtlasiQ9JIL5 baseline and differential
GenevisibleiQ9JIL5 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000049248

Structurei

3D structure databases

ProteinModelPortaliQ9JIL5
SMRiQ9JIL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati80 – 119WD 1Add BLAST40
Repeati123 – 162WD 2Add BLAST40
Repeati165 – 204WD 3Add BLAST40
Domaini364 – 414SOCS boxPROSITE-ProRule annotationAdd BLAST51

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1436 – 1547TUBAdd BLAST112

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Belongs to the TUB family.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG2503 Eukaryota
ENOG410YEKG LUCA
GeneTreeiENSGT00610000085970
HOGENOMiHOG000060128
HOVERGENiHBG057880
InParanoidiQ9JIL5
OMAiPYPGTIP
OrthoDBiEOG091G0YBE
PhylomeDBiQ9JIL5
TreeFamiTF314076

Family and domain databases

Gene3Di2.130.10.10, 1 hit
3.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001496 SOCS_box
IPR025659 Tubby-like_C
IPR000007 Tubby_C
IPR008983 Tumour_necrosis_fac-like_dom
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF01167 Tub, 1 hit
SMARTiView protein in SMART
SM00969 SOCS_box, 1 hit
SM00320 WD40, 2 hits
SUPFAMiSSF49842 SSF49842, 1 hit
SSF50978 SSF50978, 2 hits
SSF54518 SSF54518, 2 hits
PROSITEiView protein in PROSITE
PS50225 SOCS, 1 hit
PS50082 WD_REPEATS_2, 1 hit
PS50294 WD_REPEATS_REGION, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JIL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYAAVEHGPV LCSDSNILCL SWKGRVPKSE KEKPVCRRRY YEEGWLATGN
60 70 80 90 100
GRGVVGVTFT SSHCRRDRST PQRINFNLRG HNSEVVLVRW NEPYQKLATC
110 120 130 140 150
DADGGIFVWI QYEGRWSVEL VNDRGAQVSD FTWSHDGTQA LISYRDGFVL
160 170 180 190 200
VGSVSGQRHW SSEINLESQI TCGIWTPDDQ QVLFGTADGQ VIVMDCHGRM
210 220 230 240 250
LAHVLLHESD GILSMSWNYP IFLVEDSSES DTDSDDYSPP QDGPAAYPIP
260 270 280 290 300
VQNTKPLLTV SFTSGDISLM NNYDDLSPTV IRSGLKEVVA QWCTQGDLLA
310 320 330 340 350
VAGMEQQAQL SELPNGPLLK SAMVKFYNVR GEHIFTLDTL VQRPIISICW
360 370 380 390 400
GHRDSRLLMA SGPALYVVRV EHRVSSLQLL CQQAIASTLR EDKDVNKLTL
410 420 430 440 450
PPRLCSYLST AFIPTIKPPI PDPNNMRDFV SYPSAGNERL HCTMKRTEDD
460 470 480 490 500
PEVGGPCYTL YLEYLGGLVP ILKGRRISKL RPEFVIMDPR TDSKSDEIYG
510 520 530 540 550
NSLISTVIDS CNCSDSSDIE LSDDWAAKKS PKISRSSKSP KLPRISIEAR
560 570 580 590 600
KSPKLPRAAQ EISRSPRLPM RKPSMGSPSL TRREFPFEDI TQHNYLAQVT
610 620 630 640 650
SNIWGTKFKI VGLAAFLPTN LGAVIYKTSL LHLQPRQMTI YLPEVRKISM
660 670 680 690 700
DYINLPVFNP NVFSEDEDDL PVTGASGVPE NNPPCTVNIP IAPIHSSAQA
710 720 730 740 750
LSPTQSIGLV QSLLANQNVQ LDVLTNQTTA VGSAEHAGDA ATQYPVSSRY
760 770 780 790 800
SNPGQVIFGG VEMGRIIQNP PQLPLPPPPP PPPQAPMQLS AVDHGDRDHE
810 820 830 840 850
HLQKSAKALR PVPQLAAEGD AVVFSAPQEV QVAKMNPPPP YPGTIPAAPT
860 870 880 890 900
TAAPPPPLPP PQPPVDVCLK KGDFSLYPTA AHYQPPLGYE RITTFDSSGN
910 920 930 940 950
VEEVCRPRTR MLCSQNTYTL PGPGSSATLR LTATEKKVPQ PCTSATLNRL
960 970 980 990 1000
TVPRYSIPTG DPPPYPEIAS QLAQGRSAAQ RLDNSLIHAT LRRNNREVAL
1010 1020 1030 1040 1050
KMAQLADSSR APLQPLAKPK GGAAGAVAQL PARPPPALYT CSQCSGAGPS
1060 1070 1080 1090 1100
SQSGAALAHA ISTSPLASQS SYNLLSPPDT SRDRTDYVNS AFTEDEALSQ
1110 1120 1130 1140 1150
HCQLEKPLRH PPLPEAAVTM KRPPPYQWDP MLGEDVWVPQ ERTAQPTVPN
1160 1170 1180 1190 1200
PLKLSPLMLG QGQHLDVARV PFVPPKSPSS PTATFPTGYG MGMPYPGSYN
1210 1220 1230 1240 1250
NPSLPGVQAP CSPKDALSQA QFAQQESAVV LQPAYPPSLS YCTLPPTYPG
1260 1270 1280 1290 1300
SSTCSSVQLP PIALHPWNSY STCPPMQNTQ GTLPPKPHLV VEKPLVSPPP
1310 1320 1330 1340 1350
AELQSHMGTE VMVETADNFQ EVLSLTESPV PQRTEKFGKK NRKRLDSRAE
1360 1370 1380 1390 1400
EGSVQAITEG KVKKDARTLS DFNSLISSPR LGREKKKVKS QKDQLKSKKL
1410 1420 1430 1440 1450
NKTNEFQDSS ESEPELFISG DELMNQSQGS KKGWKSKRSL RTASELEEFK
1460 1470 1480 1490 1500
CRKASEKEDG RLGSQGFVYV MANKQPLWNE ATQVYQLDFG GRVTQESAKN
1510 1520 1530 1540
FQIELEGRQV MQFGRIDGNA YILDFQYPFS AVQAFAVALA NVTQRLK
Length:1,547
Mass (Da):169,638
Last modified:October 1, 2000 - v1
Checksum:i8B7CA7A250884423
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1420G → R in BAC30348 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF219945 mRNA Translation: AAF87974.1
AK039439 mRNA Translation: BAC30348.1
BC008557 mRNA Translation: AAH08557.1
BC138024 mRNA Translation: AAI38025.1
BC138025 mRNA Translation: AAI38026.1
CCDSiCCDS28370.1
RefSeqiNP_473381.1, NM_054040.3
XP_006523314.1, XM_006523251.3
UniGeneiMm.449307
Mm.482119
Mm.486644

Genome annotation databases

EnsembliENSMUST00000039655; ENSMUSP00000049248; ENSMUSG00000034377
GeneIDi68842
KEGGimmu:68842
UCSCiuc008agf.2 mouse

Similar proteinsi

Entry informationi

Entry nameiTULP4_MOUSE
AccessioniPrimary (citable) accession number: Q9JIL5
Secondary accession number(s): B2RQP8, Q8CA75, Q922C2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health