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Protein

C-C motif chemokine 28

Gene

Ccl28

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic for resting CD4, CD8 T-cells and eosinophils (By similarity). Binds to CCR10 and induces calcium mobilization in a dose-dependent manner.By similarity

GO - Molecular functioni

  1. chemokine activity Source: MGI

GO - Biological processi

  1. cell chemotaxis Source: MGI
  2. immune response Source: InterPro
  3. negative regulation of leukocyte tethering or rolling Source: MGI
  4. positive regulation of cell-matrix adhesion Source: MGI
  5. positive regulation of cytosolic calcium ion concentration Source: MGI
  6. response to nutrient Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_230248. Chemokine receptors bind chemokines.
REACT_250376. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 28
Alternative name(s):
Small-inducible cytokine A28
Gene namesi
Name:Ccl28
Synonyms:Scya28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1861731. Ccl28.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
  2. extracellular vesicular exosome Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 130114C-C motif chemokine 28PRO_0000005243Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 58By similarity
Disulfide bondi31 ↔ 73By similarity
Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ9JIL2.

PTM databases

PhosphoSiteiQ9JIL2.

Expressioni

Tissue specificityi

Mainly expressed in testis, epithelial cells of normal colon, kidney, Peyer patches, lymph nodes. Also found in lower levels in brain, spleen and lung.

Gene expression databases

BgeeiQ9JIL2.
CleanExiMM_CCL28.
GenevestigatoriQ9JIL2.

Interactioni

Protein-protein interaction databases

IntActiQ9JIL2. 1 interaction.
MINTiMINT-6629031.
STRINGi10090.ENSMUSP00000096847.

Structurei

3D structure databases

ProteinModelPortaliQ9JIL2.
SMRiQ9JIL2. Positions 23-94.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG41057.
GeneTreeiENSGT00530000063923.
HOGENOMiHOG000036970.
HOVERGENiHBG101413.
InParanoidiQ9JIL2.
KOiK05513.
OMAiGNICHKK.
OrthoDBiEOG70W3G4.
PhylomeDBiQ9JIL2.
TreeFamiTF337014.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JIL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQAGLTLMA VAVCVAFQTS EAILPMASSC CTEVSHHVSG RLLERVSSCS
60 70 80 90 100
IQRADGDCDL AAVILHVKRR RICISPHNRT LKQWMRASEV KKNGRENVCS
110 120 130
GKKQPSRKDR KGHTTRKHRT RGTHRHEASR
Length:130
Mass (Da):14,570
Last modified:October 1, 2000 - v1
Checksum:i6F3B909A4F97F013
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220238 mRNA. Translation: AAF87206.1.
BC055864 mRNA. Translation: AAH55864.1.
CCDSiCCDS56900.1.
RefSeqiNP_064675.1. NM_020279.3.
UniGeneiMm.143745.

Genome annotation databases

EnsembliENSMUST00000099241; ENSMUSP00000096847; ENSMUSG00000074715.
GeneIDi56838.
KEGGimmu:56838.
UCSCiuc007sal.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220238 mRNA. Translation: AAF87206.1.
BC055864 mRNA. Translation: AAH55864.1.
CCDSiCCDS56900.1.
RefSeqiNP_064675.1. NM_020279.3.
UniGeneiMm.143745.

3D structure databases

ProteinModelPortaliQ9JIL2.
SMRiQ9JIL2. Positions 23-94.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JIL2. 1 interaction.
MINTiMINT-6629031.
STRINGi10090.ENSMUSP00000096847.

PTM databases

PhosphoSiteiQ9JIL2.

Proteomic databases

PRIDEiQ9JIL2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099241; ENSMUSP00000096847; ENSMUSG00000074715.
GeneIDi56838.
KEGGimmu:56838.
UCSCiuc007sal.1. mouse.

Organism-specific databases

CTDi56477.
MGIiMGI:1861731. Ccl28.

Phylogenomic databases

eggNOGiNOG41057.
GeneTreeiENSGT00530000063923.
HOGENOMiHOG000036970.
HOVERGENiHBG101413.
InParanoidiQ9JIL2.
KOiK05513.
OMAiGNICHKK.
OrthoDBiEOG70W3G4.
PhylomeDBiQ9JIL2.
TreeFamiTF337014.

Enzyme and pathway databases

ReactomeiREACT_230248. Chemokine receptors bind chemokines.
REACT_250376. G alpha (i) signalling events.

Miscellaneous databases

NextBioi313383.
PROiQ9JIL2.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JIL2.
CleanExiMM_CCL28.
GenevestigatoriQ9JIL2.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], RECEPTOR INTERACTION.
    Tissue: Kidney.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Kidney.

Entry informationi

Entry nameiCCL28_MOUSE
AccessioniPrimary (citable) accession number: Q9JIL2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: February 4, 2015
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.