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Protein

C-C motif chemokine 28

Gene

Ccl28

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Chemotactic for resting CD4, CD8 T-cells and eosinophils (By similarity). Binds to CCR10 and induces calcium mobilization in a dose-dependent manner.By similarity

GO - Molecular functioni

  • chemokine activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-380108. Chemokine receptors bind chemokines.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 28
Alternative name(s):
Small-inducible cytokine A28
Gene namesi
Name:Ccl28
Synonyms:Scya28
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:1861731. Ccl28.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000000524317 – 130C-C motif chemokine 28Add BLAST114

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 58By similarity
Disulfide bondi31 ↔ 73By similarity
Glycosylationi78N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JIL2.
PRIDEiQ9JIL2.

PTM databases

PhosphoSitePlusiQ9JIL2.

Expressioni

Tissue specificityi

Mainly expressed in testis, epithelial cells of normal colon, kidney, Peyer patches, lymph nodes. Also found in lower levels in brain, spleen and lung.

Gene expression databases

BgeeiENSMUSG00000074715.
CleanExiMM_CCL28.
GenevisibleiQ9JIL2. MM.

Interactioni

GO - Molecular functioni

  • chemokine activity Source: UniProtKB

Protein-protein interaction databases

IntActiQ9JIL2. 1 interactor.
MINTiMINT-6629031.
STRINGi10090.ENSMUSP00000096847.

Structurei

3D structure databases

ProteinModelPortaliQ9JIL2.
SMRiQ9JIL2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410JBTP. Eukaryota.
ENOG411138S. LUCA.
GeneTreeiENSGT00530000063923.
HOGENOMiHOG000036970.
HOVERGENiHBG101413.
InParanoidiQ9JIL2.
KOiK05513.
OMAiGNICHKK.
OrthoDBiEOG091G0U3F.
PhylomeDBiQ9JIL2.
TreeFamiTF337014.

Family and domain databases

InterProiView protein in InterPro
IPR001811. Chemokine_IL8-like_dom.
IPR036048. Interleukin_8-like_sf.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JIL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQAGLTLMA VAVCVAFQTS EAILPMASSC CTEVSHHVSG RLLERVSSCS
60 70 80 90 100
IQRADGDCDL AAVILHVKRR RICISPHNRT LKQWMRASEV KKNGRENVCS
110 120 130
GKKQPSRKDR KGHTTRKHRT RGTHRHEASR
Length:130
Mass (Da):14,570
Last modified:October 1, 2000 - v1
Checksum:i6F3B909A4F97F013
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220238 mRNA. Translation: AAF87206.1.
BC055864 mRNA. Translation: AAH55864.1.
CCDSiCCDS56900.1.
RefSeqiNP_064675.1. NM_020279.3.
UniGeneiMm.143745.

Genome annotation databases

EnsembliENSMUST00000099241; ENSMUSP00000096847; ENSMUSG00000074715.
GeneIDi56838.
KEGGimmu:56838.
UCSCiuc007sal.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiCCL28_MOUSE
AccessioniPrimary (citable) accession number: Q9JIL2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: October 25, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families