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Q9JIL2 (CCL28_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 28
Alternative name(s):
Small-inducible cytokine A28
Gene names
Name:Ccl28
Synonyms:Scya28
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length130 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Chemotactic for resting CD4, CD8 T-cells and eosinophils By similarity. Binds to CCR10 and induces calcium mobilization in a dose-dependent manner.

Subcellular location

Secreted By similarity.

Tissue specificity

Mainly expressed in testis, epithelial cells of normal colon, kidney, Peyer patches, lymph nodes. Also found in lower levels in brain, spleen and lung.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 130114C-C motif chemokine 28
PRO_0000005243

Amino acid modifications

Glycosylation781N-linked (GlcNAc...) Potential
Disulfide bond30 ↔ 58 By similarity
Disulfide bond31 ↔ 73 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JIL2 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 6F3B909A4F97F013

FASTA13014,570
        10         20         30         40         50         60 
MQQAGLTLMA VAVCVAFQTS EAILPMASSC CTEVSHHVSG RLLERVSSCS IQRADGDCDL 

        70         80         90        100        110        120 
AAVILHVKRR RICISPHNRT LKQWMRASEV KKNGRENVCS GKKQPSRKDR KGHTTRKHRT 

       130 
RGTHRHEASR 

« Hide

References

« Hide 'large scale' references
[1]"Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2)."
Wang W., Soto H., Oldham E.R., Buchanan M.E., Homey B., Catron D., Jenkins N., Copeland N.G., Gilbert D.J., Nguyen N., Abrams J., Kershenovich D., Smith K., McClanahan T., Vicari A.P., Zlotnik A.
J. Biol. Chem. 275:22313-22323(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], RECEPTOR INTERACTION.
Tissue: Kidney.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF220238 mRNA. Translation: AAF87206.1.
BC055864 mRNA. Translation: AAH55864.1.
CCDSCCDS56900.1.
RefSeqNP_064675.1. NM_020279.3.
UniGeneMm.143745.

3D structure databases

ProteinModelPortalQ9JIL2.
SMRQ9JIL2. Positions 23-94.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9JIL2. 1 interaction.
MINTMINT-6629031.
STRING10090.ENSMUSP00000096847.

PTM databases

PhosphoSiteQ9JIL2.

Proteomic databases

PRIDEQ9JIL2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000099241; ENSMUSP00000096847; ENSMUSG00000074715.
GeneID56838.
KEGGmmu:56838.
UCSCuc007sal.1. mouse.

Organism-specific databases

CTD56477.
MGIMGI:1861731. Ccl28.

Phylogenomic databases

eggNOGNOG41057.
GeneTreeENSGT00530000063923.
HOGENOMHOG000036970.
HOVERGENHBG101413.
InParanoidQ9JIL2.
KOK05513.
OMATHRHEAS.
OrthoDBEOG70W3G4.
PhylomeDBQ9JIL2.
TreeFamTF337014.

Gene expression databases

BgeeQ9JIL2.
CleanExMM_CCL28.
GenevestigatorQ9JIL2.

Family and domain databases

InterProIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
ProtoNetSearch...

Other

NextBio313383.
PROQ9JIL2.
SOURCESearch...

Entry information

Entry nameCCL28_MOUSE
AccessionPrimary (citable) accession number: Q9JIL2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot