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Q9JIL2

- CCL28_MOUSE

UniProt

Q9JIL2 - CCL28_MOUSE

Protein

C-C motif chemokine 28

Gene

Ccl28

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Chemotactic for resting CD4, CD8 T-cells and eosinophils By similarity. Binds to CCR10 and induces calcium mobilization in a dose-dependent manner.By similarity

    GO - Molecular functioni

    1. chemokine activity Source: MGI

    GO - Biological processi

    1. cell chemotaxis Source: GOC
    2. immune response Source: InterPro
    3. positive regulation of cytosolic calcium ion concentration Source: MGI
    4. response to nutrient Source: Ensembl

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 28
    Alternative name(s):
    Small-inducible cytokine A28
    Gene namesi
    Name:Ccl28
    Synonyms:Scya28
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1861731. Ccl28.

    Subcellular locationi

    Secreted By similarity

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 130114C-C motif chemokine 28PRO_0000005243Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi30 ↔ 58By similarity
    Disulfide bondi31 ↔ 73By similarity
    Glycosylationi78 – 781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ9JIL2.

    PTM databases

    PhosphoSiteiQ9JIL2.

    Expressioni

    Tissue specificityi

    Mainly expressed in testis, epithelial cells of normal colon, kidney, Peyer patches, lymph nodes. Also found in lower levels in brain, spleen and lung.

    Gene expression databases

    BgeeiQ9JIL2.
    CleanExiMM_CCL28.
    GenevestigatoriQ9JIL2.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9JIL2. 1 interaction.
    MINTiMINT-6629031.
    STRINGi10090.ENSMUSP00000096847.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JIL2.
    SMRiQ9JIL2. Positions 23-94.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG41057.
    GeneTreeiENSGT00530000063923.
    HOGENOMiHOG000036970.
    HOVERGENiHBG101413.
    InParanoidiQ9JIL2.
    KOiK05513.
    OMAiTHRHEAS.
    OrthoDBiEOG70W3G4.
    PhylomeDBiQ9JIL2.
    TreeFamiTF337014.

    Family and domain databases

    InterProiIPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JIL2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQQAGLTLMA VAVCVAFQTS EAILPMASSC CTEVSHHVSG RLLERVSSCS    50
    IQRADGDCDL AAVILHVKRR RICISPHNRT LKQWMRASEV KKNGRENVCS 100
    GKKQPSRKDR KGHTTRKHRT RGTHRHEASR 130
    Length:130
    Mass (Da):14,570
    Last modified:October 1, 2000 - v1
    Checksum:i6F3B909A4F97F013
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF220238 mRNA. Translation: AAF87206.1.
    BC055864 mRNA. Translation: AAH55864.1.
    CCDSiCCDS56900.1.
    RefSeqiNP_064675.1. NM_020279.3.
    UniGeneiMm.143745.

    Genome annotation databases

    EnsembliENSMUST00000099241; ENSMUSP00000096847; ENSMUSG00000074715.
    GeneIDi56838.
    KEGGimmu:56838.
    UCSCiuc007sal.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF220238 mRNA. Translation: AAF87206.1 .
    BC055864 mRNA. Translation: AAH55864.1 .
    CCDSi CCDS56900.1.
    RefSeqi NP_064675.1. NM_020279.3.
    UniGenei Mm.143745.

    3D structure databases

    ProteinModelPortali Q9JIL2.
    SMRi Q9JIL2. Positions 23-94.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9JIL2. 1 interaction.
    MINTi MINT-6629031.
    STRINGi 10090.ENSMUSP00000096847.

    PTM databases

    PhosphoSitei Q9JIL2.

    Proteomic databases

    PRIDEi Q9JIL2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000099241 ; ENSMUSP00000096847 ; ENSMUSG00000074715 .
    GeneIDi 56838.
    KEGGi mmu:56838.
    UCSCi uc007sal.1. mouse.

    Organism-specific databases

    CTDi 56477.
    MGIi MGI:1861731. Ccl28.

    Phylogenomic databases

    eggNOGi NOG41057.
    GeneTreei ENSGT00530000063923.
    HOGENOMi HOG000036970.
    HOVERGENi HBG101413.
    InParanoidi Q9JIL2.
    KOi K05513.
    OMAi THRHEAS.
    OrthoDBi EOG70W3G4.
    PhylomeDBi Q9JIL2.
    TreeFami TF337014.

    Miscellaneous databases

    NextBioi 313383.
    PROi Q9JIL2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JIL2.
    CleanExi MM_CCL28.
    Genevestigatori Q9JIL2.

    Family and domain databases

    InterProi IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], RECEPTOR INTERACTION.
      Tissue: Kidney.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Kidney.

    Entry informationi

    Entry nameiCCL28_MOUSE
    AccessioniPrimary (citable) accession number: Q9JIL2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 104 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3