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Protein

28S ribosomal protein S34, mitochondrial

Gene

Mrps34

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Required for mitochondrial translation, plays a role in maintaining the stability of the small ribosomal subunit and the 12S rRNA that are required for mitoribosome formation.1 Publication

GO - Molecular functioni

GO - Biological processi

  • mitochondrial translation Source: UniProtKB

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-5389840. Mitochondrial translation elongation.
R-MMU-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S34, mitochondrial
Short name:
MRP-S34
Short name:
S34mt
Alternative name(s):
T-complex expressed gene 2 protein
Gene namesi
Name:Mrps34
Synonyms:Tce2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1930188. Mrps34.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: UniProtKB
  • ribosome Source: UniProtKB-KW

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi68L → P: Decreases protein expression. Decreases mitochodrial ribosomal subunits and translationally competent mitoribosomes. Mutant mice show heart hypertrophy and liver steatosis. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000877312 – 21828S ribosomal protein S34, mitochondrialAdd BLAST217

Proteomic databases

EPDiQ9JIK9.
MaxQBiQ9JIK9.
PaxDbiQ9JIK9.
PeptideAtlasiQ9JIK9.
PRIDEiQ9JIK9.

PTM databases

iPTMnetiQ9JIK9.
PhosphoSitePlusiQ9JIK9.

Expressioni

Tissue specificityi

Widely expressed (at protein liver).1 Publication

Gene expression databases

BgeeiENSMUSG00000038880.
CleanExiMM_MRPS34.
GenevisibleiQ9JIK9. MM.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

IntActiQ9JIK9. 2 interactors.
MINTiMINT-1849242.
STRINGi10090.ENSMUSP00000045111.

Structurei

3D structure databases

ProteinModelPortaliQ9JIK9.
SMRiQ9JIK9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IGV1. Eukaryota.
ENOG4111FKH. LUCA.
GeneTreeiENSGT00390000008964.
HOGENOMiHOG000154216.
HOVERGENiHBG036130.
InParanoidiQ9JIK9.
KOiK17412.
OMAiHDEPCYW.
OrthoDBiEOG091G0IHL.
PhylomeDBiQ9JIK9.
TreeFamiTF320386.

Family and domain databases

InterProiView protein in InterPro
IPR032053. MRP-S34.
PfamiView protein in Pfam
PF16053. MRP-S34. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JIK9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKKVRPRL IAELARRVRA LREQRNQPRD SQLYALDYET LTRPHSGRRL
60 70 80 90 100
PVRAWADVRR ESRLLQLLAR LPLFGLGRLV TRKSWLWQHD EPCYWRLTRV
110 120 130 140 150
RPDYTAQNLD HGRAWGILTF KGKSEDTARE IEQVMYHDWR LVPKHEEEAF
160 170 180 190 200
TAFTAKPEDR LNSVPYPPLL RAMILAERQK NGDTSVQEPL LNLERTRMRP
210
WDYPAKQETK GRAKGTPV
Length:218
Mass (Da):25,827
Last modified:October 1, 2000 - v1
Checksum:i1C8D03A1F13BD85B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5K → E in BAB24970 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF220294 Genomic DNA. Translation: AAF69478.1.
AK002285 mRNA. Translation: BAB21988.1.
AK004049 mRNA. Translation: BAB23142.1.
AK007337 mRNA. Translation: BAB24970.1.
AK019922 mRNA. No translation available.
BC024336 mRNA. Translation: AAH24336.1.
CCDSiCCDS28502.1.
RefSeqiNP_075749.1. NM_023260.1.
UniGeneiMm.328851.

Genome annotation databases

EnsembliENSMUST00000043907; ENSMUSP00000045111; ENSMUSG00000038880.
ENSMUST00000154236; ENSMUSP00000120985; ENSMUSG00000038880.
GeneIDi79044.
KEGGimmu:79044.
UCSCiuc008ayy.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRT34_MOUSE
AccessioniPrimary (citable) accession number: Q9JIK9
Secondary accession number(s): Q9D2B0, Q9D957
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 1, 2000
Last modified: May 10, 2017
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families