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Protein

Cadherin-related family member 5

Gene

Cdhr5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli. Thereby, controls the packing of microvilli at the apical membrane of epithelial cells. Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC. This complex plays a central role in microvilli and epithelial brush border differentiation.1 Publication

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
  • cell adhesion molecule binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Cadherin-related family member 5Curated
Alternative name(s):
GP1001 Publication
Mu-protocadherin1 Publication
Gene namesi
Name:Cdhr5Imported
Synonyms:MucdhlImported, MupcdhImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620504. Cdhr5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 671643ExtracellularSequence analysisAdd
BLAST
Transmembranei672 – 69221HelicalSequence analysisAdd
BLAST
Topological domaini693 – 862170CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • brush border membrane Source: UniProtKB
  • coated pit Source: RGD
  • extracellular exosome Source: Ensembl
  • integral component of membrane Source: UniProtKB
  • microvillus membrane Source: UniProtKB
  • spanning component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence analysisAdd
BLAST
Chaini29 – 862834Cadherin-related family member 5PRO_0000004014Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Curated
Glycosylationi45 – 451N-linked (GlcNAc...)Curated
Glycosylationi135 – 1351N-linked (GlcNAc...)Curated
Glycosylationi173 – 1731N-linked (GlcNAc...)Curated
Glycosylationi201 – 2011N-linked (GlcNAc...)Curated
Glycosylationi311 – 3111N-linked (GlcNAc...)Curated
Glycosylationi408 – 4081N-linked (GlcNAc...)Curated
Glycosylationi438 – 4381N-linked (GlcNAc...)Curated
Glycosylationi479 – 4791N-linked (GlcNAc...)Curated
Modified residuei729 – 7291PhosphoserineCombined sources
Modified residuei751 – 7511PhosphoserineBy similarity
Modified residuei755 – 7551PhosphoserineBy similarity
Modified residuei758 – 7581PhosphothreonineBy similarity
Modified residuei766 – 7661PhosphoserineBy similarity
Modified residuei783 – 7831PhosphoserineBy similarity
Modified residuei825 – 8251PhosphothreonineBy similarity
Modified residuei832 – 8321PhosphoserineBy similarity
Modified residuei834 – 8341PhosphoserineBy similarity
Modified residuei836 – 8361PhosphoserineBy similarity

Post-translational modificationi

N- and O-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ9JIK1.
PRIDEiQ9JIK1.

PTM databases

iPTMnetiQ9JIK1.

Expressioni

Tissue specificityi

Expressed predominantly in kidney. Also detected in lung and small intestine.1 Publication

Developmental stagei

At embryonic day 19, both maternal and embryonic kidneys express isoform 1 almost exclusively. In the postpartum female and neonate, expression of isoform 2 increases.1 Publication

Gene expression databases

ExpressionAtlasiQ9JIK1. baseline and differential.
GenevisibleiQ9JIK1. RN.

Interactioni

Subunit structurei

Part of the IMAC/intermicrovillar adhesion complex/intermicrovillar tip-link complex composed of ANKS4B, MYO7B, USH1C, CDHR2 and CDHR5. Interacts (via cytoplasmic domain) with USH1C and MYO7B; required for proper localization of CDHR5 to microvilli tips and its function in brush border differentiation.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044906.

Structurei

3D structure databases

ProteinModelPortaliQ9JIK1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini40 – 12788Cadherin 1PROSITE-ProRule annotationCuratedAdd
BLAST
Domaini128 – 240113Cadherin 2PROSITE-ProRule annotationCuratedAdd
BLAST
Domaini252 – 357106Cadherin 3PROSITE-ProRule annotationCuratedAdd
BLAST
Domaini358 – 462105Cadherin 4PROSITE-ProRule annotationCuratedAdd
BLAST
Repeati545 – 575311CuratedAdd
BLAST
Repeati576 – 606312CuratedAdd
BLAST
Repeati607 – 636303CuratedAdd
BLAST
Repeati637 – 648124; truncatedAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni545 – 6481044 X 31 AA approximate tandem repeatsAdd
BLAST
Regioni693 – 862170Mediates interaction with USH1C and MYO7B and is required for proper localization to microvilli tips and function in microvilli organizationBy similarityAdd
BLAST

Sequence similaritiesi

Contains 4 cadherin domains.PROSITE-ProRule annotationCurated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00390000001008.
HOVERGENiHBG052536.
InParanoidiQ9JIK1.
KOiK16505.
PhylomeDBiQ9JIK1.
TreeFamiTF350567.

Family and domain databases

Gene3Di2.60.40.60. 2 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR030326. Mucdhl.
[Graphical view]
PANTHERiPTHR24027:SF313. PTHR24027:SF313. 1 hit.
SMARTiSM00112. CA. 3 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 2 hits.
PROSITEiPS00232. CADHERIN_1. 1 hit.
PS50268. CADHERIN_2. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9JIK1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGAPALLWPP LLLPLLTVLF GHLPGTLAQA QVCSANQTVF TMNENTTVSG
60 70 80 90 100
PLADIFVPED QYVTLGQLST PNAFKVEGNK LFLIVTPDYE ENSLLEAVLE
110 120 130 140 150
CKRGDTLVTQ FRVFVAVLDI NDNAPEFPFT IKEYNVSEDT RVNTIVIPET
160 170 180 190 200
ELKATDADKD DILVYTLQEV TPNASKFFSL VGINSPALKL DQTLDYYKSP
210 220 230 240 250
NMTFRLLARD TREENVIPSH TATATVVLNV LPADLRTPWF LPCSFTDDYF
260 270 280 290 300
CIQAQYHTVI PTGHKLPSPL ILSPGPIYAV DGDQAINQPI VYSIMMGNTD
310 320 330 340 350
DTFIINKDDG NLTMAKSIPS PMTFTLVVRA EQADMARYSV TQAVVEARDV
360 370 380 390 400
TGNPLQFSQS LYFGTVVLGS EAGTAVKDKT FPSEILRIQA QYLGFPDLNS
410 420 430 440 450
AVTYQVTNSS EFIMNKDILL TTVPMETERT IRIEVEANNT VTKDIATTIV
460 470 480 490 500
EIQVSEREPP STESPTPPEA GGTTGPSSNT TLETPSTSGT SQGPATTSSG
510 520 530 540 550
GSAGPFPPAG TTLSPLTSAP TVPGGSPTLG ISTSPQTATP GGDATQTPKP
560 570 580 590 600
GTSQPMVPTP GASTSSQPAT PSGSSTQTPK PGTSQPMVPT PGASTSSQPA
610 620 630 640 650
TPSGSSTQTP RPGTSQPMVP TPGASTSSQP ATPSGSTQTP KPGTSQPTTT
660 670 680 690 700
GPISGVGELG DGQRFSTVDM AVLGGVLGAL LLLALIFLII LIHKHYRHRF
710 720 730 740 750
TCCSGKAKEP QPSGYDNLTF LPDNKAKWSP TSNRKPEPGP EPVQPPLRPP
760 770 780 790 800
SPMSSSPTPP SSMPPSPQPK ASGSPKTVQA GDSPSAVRSI LTKERRPEGE
810 820 830 840 850
GGYKAVWFGK DIGAEADVVV LNEPTADVDS ASASGSEGSD DDDDPDQKKS
860
LRLGAVADNT YV
Length:862
Mass (Da):90,976
Last modified:October 1, 2000 - v1
Checksum:i302E302503A9C375
GO
Isoform 21 Publication (identifier: Q9JIK1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     464-655: Missing.

Show »
Length:670
Mass (Da):72,993
Checksum:i19E653A7928CF848
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei464 – 655192Missing in isoform 2. 1 PublicationVSP_050688Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF221952 mRNA. Translation: AAF70456.1.
BC098904 mRNA. Translation: AAH98904.1.
RefSeqiNP_612534.1. NM_138525.1. [Q9JIK1-1]
UniGeneiRn.18860.

Genome annotation databases

EnsembliENSRNOT00000044238; ENSRNOP00000044906; ENSRNOG00000017762. [Q9JIK1-1]
GeneIDi171554.
KEGGirno:171554.
UCSCiRGD:620504. rat. [Q9JIK1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF221952 mRNA. Translation: AAF70456.1.
BC098904 mRNA. Translation: AAH98904.1.
RefSeqiNP_612534.1. NM_138525.1. [Q9JIK1-1]
UniGeneiRn.18860.

3D structure databases

ProteinModelPortaliQ9JIK1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000044906.

PTM databases

iPTMnetiQ9JIK1.

Proteomic databases

PaxDbiQ9JIK1.
PRIDEiQ9JIK1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000044238; ENSRNOP00000044906; ENSRNOG00000017762. [Q9JIK1-1]
GeneIDi171554.
KEGGirno:171554.
UCSCiRGD:620504. rat. [Q9JIK1-1]

Organism-specific databases

CTDi53841.
RGDi620504. Cdhr5.

Phylogenomic databases

eggNOGiKOG3594. Eukaryota.
ENOG410XQHI. LUCA.
GeneTreeiENSGT00390000001008.
HOVERGENiHBG052536.
InParanoidiQ9JIK1.
KOiK16505.
PhylomeDBiQ9JIK1.
TreeFamiTF350567.

Miscellaneous databases

PROiQ9JIK1.

Gene expression databases

ExpressionAtlasiQ9JIK1. baseline and differential.
GenevisibleiQ9JIK1. RN.

Family and domain databases

Gene3Di2.60.40.60. 2 hits.
InterProiIPR002126. Cadherin.
IPR015919. Cadherin-like.
IPR020894. Cadherin_CS.
IPR030326. Mucdhl.
[Graphical view]
PANTHERiPTHR24027:SF313. PTHR24027:SF313. 1 hit.
SMARTiSM00112. CA. 3 hits.
[Graphical view]
SUPFAMiSSF49313. SSF49313. 2 hits.
PROSITEiPS00232. CADHERIN_1. 1 hit.
PS50268. CADHERIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "mu-protocadherin, a novel developmentally regulated protocadherin with mucin-like domains."
    Goldberg M., Peshkovsky C., Shifteh A., Al-Awqati Q.
    J. Biol. Chem. 275:24622-24629(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), PROTEIN SEQUENCE OF 132-145; 176-198; 265-280; 416-438 AND 708-722, FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, GLYCOSYLATION.
    Strain: Sprague-DawleyImported.
    Tissue: Kidney1 Publication.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-729, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCDHR5_RAT
AccessioniPrimary (citable) accession number: Q9JIK1
Secondary accession number(s): Q4FZY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.