Q9JII9 (CXCR3_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-X-C chemokine receptor type 3
Short name=CXC-R3
Short name=CXCR-3

Alternative name(s):
Interferon-inducible protein 10 receptor
Short name=IP-10 receptor
CD_antigen=CD183

Gene names

Name:

Cxcr3

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	367 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for CXCL9, CXCL10 and CXCL11 By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity.
Post-translational modification	Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding By similarity. N-glycosylated By similarity.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein Sulfation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	T cell chemotaxis Inferred from mutant phenotype PubMed 21038468. Source: RGD calcium-mediated signaling Inferred from direct assay Ref.1. Source: RGD elevation of cytosolic calcium ion concentration Inferred from direct assay Ref.1. Source: RGD sensory perception of pain Non-traceable author statement PubMed 15341587. Source: RGD
Cellular_component	external side of plasma membrane Inferred from direct assay PubMed 16434036. Source: RGD integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	C-X-C chemokine receptor activity Inferred from physical interaction Ref.1. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 367	367	C-X-C chemokine receptor type 3		PRO_0000069348
Regions
	Topological domain	1 – 56	56	Extracellular Potential
	Transmembrane	57 – 77	21	Helical; Name=1; Potential
	Topological domain	78 – 89	12	Cytoplasmic Potential
	Transmembrane	90 – 110	21	Helical; Name=2; Potential
	Topological domain	111 – 125	15	Extracellular Potential
	Transmembrane	126 – 146	21	Helical; Name=3; Potential
	Topological domain	147 – 168	22	Cytoplasmic Potential
	Transmembrane	169 – 189	21	Helical; Name=4; Potential
	Topological domain	190 – 222	33	Extracellular Potential
	Transmembrane	223 – 243	21	Helical; Name=5; Potential
	Topological domain	244 – 255	12	Cytoplasmic Potential
	Transmembrane	256 – 276	21	Helical; Name=6; Potential
	Topological domain	277 – 300	24	Extracellular Potential
	Transmembrane	301 – 321	21	Helical; Name=7; Potential
	Topological domain	322 – 367	46	Cytoplasmic Potential
Amino acid modifications
	Modified residue	27	1	Sulfotyrosine By similarity
	Modified residue	29	1	Sulfotyrosine By similarity
	Glycosylation	22	1	N-linked (GlcNAc...) Potential
	Glycosylation	32	1	N-linked (GlcNAc...) Potential
	Glycosylation	198	1	N-linked (GlcNAc...) Potential
	Disulfide bond	123 ↔ 202		By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9JII9 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: F67C0362EDDBFCB7	FASTA	367	40,935
	10 20 30 40 50 60 MYLEVSERQV LDASDIAFLL ENSTSPYDYG ENESDFSDSP PCPQDFSLNF DRTFLPVLYS 70 80 90 100 110 120 LLFLLGLLGN GAVAAVLLSQ RTALSSTDTF LLHLAVADVL LVLTLPLWAV DAAAQWVFGS 130 140 150 160 170 180 GLCKVAGALF NINFYAGAFL LACISFDRYL SIVHATQIYR RDPWVRVALT CIVVWGLCVL 190 200 210 220 230 240 FALPDFIFLS ASHDQRLNAT HCQYNFPQVG RTALRVLQLV AGFLMPLLVM AYCYAHILAV 250 260 270 280 290 300 LLVSRGQRRF RAMRLVVVVV VAFAVCWTPY HLVVLVDILM DVGVLARNCG RESHVDVAKS 310 320 330 340 350 360 VTSGMGYMHC CLNPLLYAFV GVKFKEQMWM LLMRLGRSDQ RGPQRQPSSS RRESSWSETT EASYLGL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and molecular characterization of rat CXCR3: receptor expression and interferon-inducible protein-10 binding are increased in focal stroke." Wang X., Li X., Schmidt D.B., Foley J.J., Barone F.C., Ames R.S., Sarau H.M. Mol. Pharmacol. 57:1190-1198(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Spleen.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF223642 mRNA. Translation: AAF76982.1. BC091136 mRNA. Translation: AAH91136.1.
IPI	IPI00200582.
RefSeq	NP_445867.1. NM_053415.1.
UniGene	Rn.24787.
3D structure databases
ProteinModelPortal	Q9JII9.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000004406.
Protein family/group databases
GPCRDB	Search...
PTM databases
PhosphoSite	Q9JII9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000004406; ENSRNOP00000004406; ENSRNOG00000003305.
GeneID	84475.
KEGG	rno:84475.
UCSC	RGD:621528. rat.
Organism-specific databases
CTD	2833.
RGD	621528. Cxcr3.
Phylogenomic databases
eggNOG	NOG150428.
GeneTree	ENSGT00640000091250.
HOGENOM	HOG000234122.
HOVERGEN	HBG106917.
InParanoid	Q9JII9.
KO	K04188.
OMA	AYCYARI.
OrthoDB	EOG4J6RRW.
Gene expression databases
Genevestigator	Q9JII9.
GermOnline	ENSRNOG00000003305. Rattus norvegicus.
Family and domain databases
InterPro	IPR004070. Chemokine_CXCR3. IPR000355. Chemokine_rcpt. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. [Graphical view]
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00657. CCCHEMOKINER. PR01532. CXCCHMKINER3. PR00237. GPCRRHODOPSN.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. 1 hit. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9JII9.
ChEMBL	CHEMBL1075172.
NextBio	616974.

Entry information

Entry name

CXCR3_RAT

Accession

Primary (citable) accession number: Q9JII9

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 27, 2005
Last sequence update:	October 1, 2000
Last modified:	April 3, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program