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Q9JII9 (CXCR3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-X-C chemokine receptor type 3

Short name=CXC-R3
Short name=CXCR-3
Alternative name(s):
Interferon-inducible protein 10 receptor
Short name=IP-10 receptor
CD_antigen=CD183
Gene names
Name:Cxcr3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length367 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response By similarity.

Subunit structure

Homomer. Forms heteromers with ACKR4 By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Post-translational modification

Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding By similarity.

N-glycosylated By similarity.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
   Biological processAngiogenesis
Chemotaxis
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMDisulfide bond
Glycoprotein
Sulfation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from sequence or structural similarity. Source: UniProtKB

T cell chemotaxis

Inferred from mutant phenotype PubMed 21038468. Source: RGD

angiogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

calcium-mediated signaling

Inferred from direct assay Ref.1. Source: RGD

chemokine (C-C motif) ligand 11 production

Inferred from sequence or structural similarity. Source: UniProtKB

chemokine-mediated signaling pathway

Inferred from direct assay Ref.1. Source: GOC

inflammatory response

Inferred from electronic annotation. Source: InterPro

negative regulation of angiogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of endothelial cell proliferation

Inferred from electronic annotation. Source: Ensembl

negative regulation of execution phase of apoptosis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of angiogenesis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cAMP metabolic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of cAMP-mediated signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell proliferation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of chemotaxis

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of cytosolic calcium ion concentration

Inferred from direct assay Ref.1. Source: RGD

positive regulation of execution phase of apoptosis

Inferred from electronic annotation. Source: Ensembl

positive regulation of release of sequestered calcium ion into cytosol

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of leukocyte migration

Inferred from electronic annotation. Source: InterPro

sensory perception of pain

Non-traceable author statement PubMed 15341587. Source: RGD

   Cellular_componentexternal side of plasma membrane

Inferred from direct assay PubMed 16434036. Source: RGD

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from direct assay Ref.1. Source: RGD

   Molecular_functionC-X-C chemokine binding

Inferred from sequence or structural similarity. Source: UniProtKB

C-X-C chemokine receptor activity

Inferred from physical interaction Ref.1. Source: RGD

chemokine receptor activity

Inferred from direct assay Ref.1. Source: RGD

receptor activity

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 367367C-X-C chemokine receptor type 3
PRO_0000069348

Regions

Topological domain1 – 5656Extracellular Potential
Transmembrane57 – 7721Helical; Name=1; Potential
Topological domain78 – 8912Cytoplasmic Potential
Transmembrane90 – 11021Helical; Name=2; Potential
Topological domain111 – 12515Extracellular Potential
Transmembrane126 – 14621Helical; Name=3; Potential
Topological domain147 – 16822Cytoplasmic Potential
Transmembrane169 – 18921Helical; Name=4; Potential
Topological domain190 – 22233Extracellular Potential
Transmembrane223 – 24321Helical; Name=5; Potential
Topological domain244 – 25512Cytoplasmic Potential
Transmembrane256 – 27621Helical; Name=6; Potential
Topological domain277 – 30024Extracellular Potential
Transmembrane301 – 32121Helical; Name=7; Potential
Topological domain322 – 36746Cytoplasmic Potential

Amino acid modifications

Modified residue271Sulfotyrosine By similarity
Modified residue291Sulfotyrosine By similarity
Glycosylation221N-linked (GlcNAc...) Potential
Glycosylation321N-linked (GlcNAc...) Potential
Glycosylation1981N-linked (GlcNAc...) Potential
Disulfide bond123 ↔ 202 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JII9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: F67C0362EDDBFCB7

FASTA36740,935
        10         20         30         40         50         60 
MYLEVSERQV LDASDIAFLL ENSTSPYDYG ENESDFSDSP PCPQDFSLNF DRTFLPVLYS 

        70         80         90        100        110        120 
LLFLLGLLGN GAVAAVLLSQ RTALSSTDTF LLHLAVADVL LVLTLPLWAV DAAAQWVFGS 

       130        140        150        160        170        180 
GLCKVAGALF NINFYAGAFL LACISFDRYL SIVHATQIYR RDPWVRVALT CIVVWGLCVL 

       190        200        210        220        230        240 
FALPDFIFLS ASHDQRLNAT HCQYNFPQVG RTALRVLQLV AGFLMPLLVM AYCYAHILAV 

       250        260        270        280        290        300 
LLVSRGQRRF RAMRLVVVVV VAFAVCWTPY HLVVLVDILM DVGVLARNCG RESHVDVAKS 

       310        320        330        340        350        360 
VTSGMGYMHC CLNPLLYAFV GVKFKEQMWM LLMRLGRSDQ RGPQRQPSSS RRESSWSETT 


EASYLGL 

« Hide

References

« Hide 'large scale' references
[1]"Identification and molecular characterization of rat CXCR3: receptor expression and interferon-inducible protein-10 binding are increased in focal stroke."
Wang X., Li X., Schmidt D.B., Foley J.J., Barone F.C., Ames R.S., Sarau H.M.
Mol. Pharmacol. 57:1190-1198(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Spleen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF223642 mRNA. Translation: AAF76982.1.
BC091136 mRNA. Translation: AAH91136.1.
RefSeqNP_445867.1. NM_053415.1.
UniGeneRn.24787.

3D structure databases

ProteinModelPortalQ9JII9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000004406.

Chemistry

BindingDBQ9JII9.
ChEMBLCHEMBL1075172.
GuidetoPHARMACOLOGY70.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9JII9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000004406; ENSRNOP00000004406; ENSRNOG00000003305.
GeneID84475.
KEGGrno:84475.
UCSCRGD:621528. rat.

Organism-specific databases

CTD2833.
RGD621528. Cxcr3.

Phylogenomic databases

eggNOGNOG150428.
GeneTreeENSGT00730000110292.
HOGENOMHOG000234122.
HOVERGENHBG106917.
InParanoidQ9JII9.
KOK04188.
OMAAYCYARI.
OrthoDBEOG7F5126.
PhylomeDBQ9JII9.
TreeFamTF330966.

Gene expression databases

GenevestigatorQ9JII9.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR004070. Chemokine_CXCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF27. PTHR24227:SF27. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00657. CCCHEMOKINER.
PR01532. CXCCHMKINER3.
PR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio616974.
PROQ9JII9.

Entry information

Entry nameCXCR3_RAT
AccessionPrimary (citable) accession number: Q9JII9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries