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Protein

C-X-C chemokine receptor type 3

Gene

Cxcr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity).By similarity

GO - Molecular functioni

  • C-X-C chemokine binding Source: UniProtKB
  • C-X-C chemokine receptor activity Source: RGD
  • receptor activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Angiogenesis, Chemotaxis

Enzyme and pathway databases

ReactomeiR-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 3
Short name:
CXC-R3
Short name:
CXCR-3
Alternative name(s):
Interferon-inducible protein 10 receptor
Short name:
IP-10 receptor
CD_antigen: CD183
Gene namesi
Name:Cxcr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi621528. Cxcr3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 56ExtracellularSequence analysisAdd BLAST56
Transmembranei57 – 77Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini78 – 89CytoplasmicSequence analysisAdd BLAST12
Transmembranei90 – 110Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini111 – 125ExtracellularSequence analysisAdd BLAST15
Transmembranei126 – 146Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini147 – 168CytoplasmicSequence analysisAdd BLAST22
Transmembranei169 – 189Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini190 – 222ExtracellularSequence analysisAdd BLAST33
Transmembranei223 – 243Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini244 – 255CytoplasmicSequence analysisAdd BLAST12
Transmembranei256 – 276Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini277 – 300ExtracellularSequence analysisAdd BLAST24
Transmembranei301 – 321Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini322 – 367CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

  • external side of plasma membrane Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: GOC
  • plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1075172.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693481 – 367C-X-C chemokine receptor type 3Add BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi22N-linked (GlcNAc...)Sequence analysis1
Modified residuei27SulfotyrosineBy similarity1
Modified residuei29SulfotyrosineBy similarity1
Glycosylationi32N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi123 ↔ 202PROSITE-ProRule annotation
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding.By similarity
N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

Proteomic databases

PaxDbiQ9JII9.

PTM databases

PhosphoSitePlusiQ9JII9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000003305.
ExpressionAtlasiQ9JII9. baseline and differential.
GenevisibleiQ9JII9. RN.

Interactioni

Subunit structurei

Homomer. Forms heteromers with ACKR4 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004406.

Chemistry databases

BindingDBiQ9JII9.

Structurei

3D structure databases

ProteinModelPortaliQ9JII9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE41. Eukaryota.
ENOG410YWPA. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ9JII9.
KOiK04188.
OMAiAYCYARI.
OrthoDBiEOG091G0EDT.
PhylomeDBiQ9JII9.
TreeFamiTF330966.

Family and domain databases

InterProiIPR004070. Chemokine_CXCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01532. CXCCHMKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JII9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLEVSERQV LDASDIAFLL ENSTSPYDYG ENESDFSDSP PCPQDFSLNF
60 70 80 90 100
DRTFLPVLYS LLFLLGLLGN GAVAAVLLSQ RTALSSTDTF LLHLAVADVL
110 120 130 140 150
LVLTLPLWAV DAAAQWVFGS GLCKVAGALF NINFYAGAFL LACISFDRYL
160 170 180 190 200
SIVHATQIYR RDPWVRVALT CIVVWGLCVL FALPDFIFLS ASHDQRLNAT
210 220 230 240 250
HCQYNFPQVG RTALRVLQLV AGFLMPLLVM AYCYAHILAV LLVSRGQRRF
260 270 280 290 300
RAMRLVVVVV VAFAVCWTPY HLVVLVDILM DVGVLARNCG RESHVDVAKS
310 320 330 340 350
VTSGMGYMHC CLNPLLYAFV GVKFKEQMWM LLMRLGRSDQ RGPQRQPSSS
360
RRESSWSETT EASYLGL
Length:367
Mass (Da):40,935
Last modified:October 1, 2000 - v1
Checksum:iF67C0362EDDBFCB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF223642 mRNA. Translation: AAF76982.1.
BC091136 mRNA. Translation: AAH91136.1.
RefSeqiNP_445867.1. NM_053415.1.
UniGeneiRn.24787.

Genome annotation databases

EnsembliENSRNOT00000004406; ENSRNOP00000004406; ENSRNOG00000003305.
GeneIDi84475.
KEGGirno:84475.
UCSCiRGD:621528. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF223642 mRNA. Translation: AAF76982.1.
BC091136 mRNA. Translation: AAH91136.1.
RefSeqiNP_445867.1. NM_053415.1.
UniGeneiRn.24787.

3D structure databases

ProteinModelPortaliQ9JII9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004406.

Chemistry databases

BindingDBiQ9JII9.
ChEMBLiCHEMBL1075172.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ9JII9.

Proteomic databases

PaxDbiQ9JII9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004406; ENSRNOP00000004406; ENSRNOG00000003305.
GeneIDi84475.
KEGGirno:84475.
UCSCiRGD:621528. rat.

Organism-specific databases

CTDi2833.
RGDi621528. Cxcr3.

Phylogenomic databases

eggNOGiENOG410IE41. Eukaryota.
ENOG410YWPA. LUCA.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ9JII9.
KOiK04188.
OMAiAYCYARI.
OrthoDBiEOG091G0EDT.
PhylomeDBiQ9JII9.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiR-RNO-380108. Chemokine receptors bind chemokines.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ9JII9.

Gene expression databases

BgeeiENSRNOG00000003305.
ExpressionAtlasiQ9JII9. baseline and differential.
GenevisibleiQ9JII9. RN.

Family and domain databases

InterProiIPR004070. Chemokine_CXCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01532. CXCCHMKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXCR3_RAT
AccessioniPrimary (citable) accession number: Q9JII9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.