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Protein

C-X-C chemokine receptor type 3

Gene

Cxcr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response (By similarity).By similarity

GO - Molecular functioni

  1. chemokine receptor activity Source: RGD
  2. C-X-C chemokine binding Source: UniProtKB
  3. C-X-C chemokine receptor activity Source: RGD
  4. receptor activity Source: UniProtKB

GO - Biological processi

  1. angiogenesis Source: UniProtKB-KW
  2. calcium-mediated signaling Source: RGD
  3. chemokine (C-C motif) ligand 11 production Source: UniProtKB
  4. chemokine-mediated signaling pathway Source: GOC
  5. G-protein coupled receptor signaling pathway Source: UniProtKB
  6. inflammatory response Source: InterPro
  7. negative regulation of angiogenesis Source: Ensembl
  8. negative regulation of endothelial cell proliferation Source: Ensembl
  9. negative regulation of execution phase of apoptosis Source: UniProtKB
  10. positive regulation of angiogenesis Source: UniProtKB
  11. positive regulation of cAMP-mediated signaling Source: Ensembl
  12. positive regulation of cAMP metabolic process Source: Ensembl
  13. positive regulation of cell proliferation Source: UniProtKB
  14. positive regulation of chemotaxis Source: UniProtKB
  15. positive regulation of cytosolic calcium ion concentration Source: RGD
  16. positive regulation of execution phase of apoptosis Source: Ensembl
  17. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
  18. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  19. regulation of leukocyte migration Source: InterPro
  20. sensory perception of pain Source: RGD
  21. T cell chemotaxis Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Biological processi

Angiogenesis, Chemotaxis

Enzyme and pathway databases

ReactomeiREACT_233455. G alpha (i) signalling events.
REACT_263785. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-X-C chemokine receptor type 3
Short name:
CXC-R3
Short name:
CXCR-3
Alternative name(s):
Interferon-inducible protein 10 receptor
Short name:
IP-10 receptor
CD_antigen: CD183
Gene namesi
Name:Cxcr3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome X

Organism-specific databases

RGDi621528. Cxcr3.

Subcellular locationi

Cell membrane By similarity; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5656ExtracellularSequence AnalysisAdd
BLAST
Transmembranei57 – 7721Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini78 – 8912CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei90 – 11021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini111 – 12515ExtracellularSequence AnalysisAdd
BLAST
Transmembranei126 – 14621Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini147 – 16822CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei169 – 18921Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini190 – 22233ExtracellularSequence AnalysisAdd
BLAST
Transmembranei223 – 24321Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini244 – 25512CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei256 – 27621Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini277 – 30024ExtracellularSequence AnalysisAdd
BLAST
Transmembranei301 – 32121Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini322 – 36746CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: RGD
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 367367C-X-C chemokine receptor type 3PRO_0000069348Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
Modified residuei27 – 271SulfotyrosineBy similarity
Modified residuei29 – 291SulfotyrosineBy similarity
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi123 ↔ 202PROSITE-ProRule annotation
Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding.By similarity
N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Sulfation

PTM databases

PhosphoSiteiQ9JII9.

Expressioni

Gene expression databases

GenevestigatoriQ9JII9.

Interactioni

Subunit structurei

Homomer. Forms heteromers with ACKR4 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004406.

Structurei

3D structure databases

ProteinModelPortaliQ9JII9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG150428.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ9JII9.
KOiK04188.
OMAiAYCYARI.
OrthoDBiEOG7F5126.
PhylomeDBiQ9JII9.
TreeFamiTF330966.

Family and domain databases

InterProiIPR004070. Chemokine_CXCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF27. PTHR24227:SF27. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01532. CXCCHMKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JII9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYLEVSERQV LDASDIAFLL ENSTSPYDYG ENESDFSDSP PCPQDFSLNF
60 70 80 90 100
DRTFLPVLYS LLFLLGLLGN GAVAAVLLSQ RTALSSTDTF LLHLAVADVL
110 120 130 140 150
LVLTLPLWAV DAAAQWVFGS GLCKVAGALF NINFYAGAFL LACISFDRYL
160 170 180 190 200
SIVHATQIYR RDPWVRVALT CIVVWGLCVL FALPDFIFLS ASHDQRLNAT
210 220 230 240 250
HCQYNFPQVG RTALRVLQLV AGFLMPLLVM AYCYAHILAV LLVSRGQRRF
260 270 280 290 300
RAMRLVVVVV VAFAVCWTPY HLVVLVDILM DVGVLARNCG RESHVDVAKS
310 320 330 340 350
VTSGMGYMHC CLNPLLYAFV GVKFKEQMWM LLMRLGRSDQ RGPQRQPSSS
360
RRESSWSETT EASYLGL
Length:367
Mass (Da):40,935
Last modified:October 1, 2000 - v1
Checksum:iF67C0362EDDBFCB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF223642 mRNA. Translation: AAF76982.1.
BC091136 mRNA. Translation: AAH91136.1.
RefSeqiNP_445867.1. NM_053415.1.
UniGeneiRn.24787.

Genome annotation databases

EnsembliENSRNOT00000004406; ENSRNOP00000004406; ENSRNOG00000003305.
GeneIDi84475.
KEGGirno:84475.
UCSCiRGD:621528. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF223642 mRNA. Translation: AAF76982.1.
BC091136 mRNA. Translation: AAH91136.1.
RefSeqiNP_445867.1. NM_053415.1.
UniGeneiRn.24787.

3D structure databases

ProteinModelPortaliQ9JII9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000004406.

Chemistry

BindingDBiQ9JII9.
ChEMBLiCHEMBL1075172.
GuidetoPHARMACOLOGYi70.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ9JII9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000004406; ENSRNOP00000004406; ENSRNOG00000003305.
GeneIDi84475.
KEGGirno:84475.
UCSCiRGD:621528. rat.

Organism-specific databases

CTDi2833.
RGDi621528. Cxcr3.

Phylogenomic databases

eggNOGiNOG150428.
GeneTreeiENSGT00760000118785.
HOGENOMiHOG000234122.
HOVERGENiHBG106917.
InParanoidiQ9JII9.
KOiK04188.
OMAiAYCYARI.
OrthoDBiEOG7F5126.
PhylomeDBiQ9JII9.
TreeFamiTF330966.

Enzyme and pathway databases

ReactomeiREACT_233455. G alpha (i) signalling events.
REACT_263785. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi616974.
PROiQ9JII9.

Gene expression databases

GenevestigatoriQ9JII9.

Family and domain databases

InterProiIPR004070. Chemokine_CXCR3.
IPR000355. Chemokine_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PANTHERiPTHR24227. PTHR24227. 1 hit.
PTHR24227:SF27. PTHR24227:SF27. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00657. CCCHEMOKINER.
PR01532. CXCCHMKINER3.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and molecular characterization of rat CXCR3: receptor expression and interferon-inducible protein-10 binding are increased in focal stroke."
    Wang X., Li X., Schmidt D.B., Foley J.J., Barone F.C., Ames R.S., Sarau H.M.
    Mol. Pharmacol. 57:1190-1198(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Spleen.

Entry informationi

Entry nameiCXCR3_RAT
AccessioniPrimary (citable) accession number: Q9JII9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.