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Q9JII9

- CXCR3_RAT

UniProt

Q9JII9 - CXCR3_RAT

Protein

C-X-C chemokine receptor type 3

Gene

Cxcr3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response By similarity.By similarity

    GO - Molecular functioni

    1. chemokine receptor activity Source: RGD
    2. C-X-C chemokine binding Source: UniProtKB
    3. C-X-C chemokine receptor activity Source: RGD
    4. receptor activity Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: UniProtKB-KW
    2. calcium-mediated signaling Source: RGD
    3. chemokine (C-C motif) ligand 11 production Source: UniProtKB
    4. chemokine-mediated signaling pathway Source: GOC
    5. G-protein coupled receptor signaling pathway Source: UniProtKB
    6. inflammatory response Source: InterPro
    7. negative regulation of angiogenesis Source: Ensembl
    8. negative regulation of endothelial cell proliferation Source: Ensembl
    9. negative regulation of execution phase of apoptosis Source: UniProtKB
    10. positive regulation of angiogenesis Source: UniProtKB
    11. positive regulation of cAMP-mediated signaling Source: Ensembl
    12. positive regulation of cAMP metabolic process Source: Ensembl
    13. positive regulation of cell proliferation Source: UniProtKB
    14. positive regulation of chemotaxis Source: UniProtKB
    15. positive regulation of cytosolic calcium ion concentration Source: RGD
    16. positive regulation of execution phase of apoptosis Source: Ensembl
    17. positive regulation of release of sequestered calcium ion into cytosol Source: UniProtKB
    18. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    19. regulation of leukocyte migration Source: InterPro
    20. sensory perception of pain Source: RGD
    21. T cell chemotaxis Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Biological processi

    Angiogenesis, Chemotaxis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-X-C chemokine receptor type 3
    Short name:
    CXC-R3
    Short name:
    CXCR-3
    Alternative name(s):
    Interferon-inducible protein 10 receptor
    Short name:
    IP-10 receptor
    CD_antigen: CD183
    Gene namesi
    Name:Cxcr3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome X

    Organism-specific databases

    RGDi621528. Cxcr3.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. external side of plasma membrane Source: RGD
    2. integral component of membrane Source: UniProtKB-KW
    3. plasma membrane Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 367367C-X-C chemokine receptor type 3PRO_0000069348Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi22 – 221N-linked (GlcNAc...)Sequence Analysis
    Modified residuei27 – 271SulfotyrosineBy similarity
    Modified residuei29 – 291SulfotyrosineBy similarity
    Glycosylationi32 – 321N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi123 ↔ 202PROSITE-ProRule annotation
    Glycosylationi198 – 1981N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Sulfation on Tyr-27 and Tyr-29 is essential for CXCL10 binding.By similarity
    N-glycosylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Sulfation

    PTM databases

    PhosphoSiteiQ9JII9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9JII9.

    Interactioni

    Subunit structurei

    Homomer. Forms heteromers with ACKR4 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000004406.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JII9.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5656ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini78 – 8912CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini111 – 12515ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini147 – 16822CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini190 – 22233ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini244 – 25512CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini277 – 30024ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini322 – 36746CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei57 – 7721Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei90 – 11021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei126 – 14621Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei169 – 18921Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei223 – 24321Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei256 – 27621Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei301 – 32121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG150428.
    GeneTreeiENSGT00730000110292.
    HOGENOMiHOG000234122.
    HOVERGENiHBG106917.
    InParanoidiQ9JII9.
    KOiK04188.
    OMAiAYCYARI.
    OrthoDBiEOG7F5126.
    PhylomeDBiQ9JII9.
    TreeFamiTF330966.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR004070. Chemokine_CXCR3.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view]
    PANTHERiPTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF27. PTHR24227:SF27. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00657. CCCHEMOKINER.
    PR01532. CXCCHMKINER3.
    PR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JII9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYLEVSERQV LDASDIAFLL ENSTSPYDYG ENESDFSDSP PCPQDFSLNF    50
    DRTFLPVLYS LLFLLGLLGN GAVAAVLLSQ RTALSSTDTF LLHLAVADVL 100
    LVLTLPLWAV DAAAQWVFGS GLCKVAGALF NINFYAGAFL LACISFDRYL 150
    SIVHATQIYR RDPWVRVALT CIVVWGLCVL FALPDFIFLS ASHDQRLNAT 200
    HCQYNFPQVG RTALRVLQLV AGFLMPLLVM AYCYAHILAV LLVSRGQRRF 250
    RAMRLVVVVV VAFAVCWTPY HLVVLVDILM DVGVLARNCG RESHVDVAKS 300
    VTSGMGYMHC CLNPLLYAFV GVKFKEQMWM LLMRLGRSDQ RGPQRQPSSS 350
    RRESSWSETT EASYLGL 367
    Length:367
    Mass (Da):40,935
    Last modified:October 1, 2000 - v1
    Checksum:iF67C0362EDDBFCB7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF223642 mRNA. Translation: AAF76982.1.
    BC091136 mRNA. Translation: AAH91136.1.
    RefSeqiNP_445867.1. NM_053415.1.
    UniGeneiRn.24787.

    Genome annotation databases

    EnsembliENSRNOT00000004406; ENSRNOP00000004406; ENSRNOG00000003305.
    GeneIDi84475.
    KEGGirno:84475.
    UCSCiRGD:621528. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF223642 mRNA. Translation: AAF76982.1 .
    BC091136 mRNA. Translation: AAH91136.1 .
    RefSeqi NP_445867.1. NM_053415.1.
    UniGenei Rn.24787.

    3D structure databases

    ProteinModelPortali Q9JII9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000004406.

    Chemistry

    BindingDBi Q9JII9.
    ChEMBLi CHEMBL1075172.
    GuidetoPHARMACOLOGYi 70.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9JII9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000004406 ; ENSRNOP00000004406 ; ENSRNOG00000003305 .
    GeneIDi 84475.
    KEGGi rno:84475.
    UCSCi RGD:621528. rat.

    Organism-specific databases

    CTDi 2833.
    RGDi 621528. Cxcr3.

    Phylogenomic databases

    eggNOGi NOG150428.
    GeneTreei ENSGT00730000110292.
    HOGENOMi HOG000234122.
    HOVERGENi HBG106917.
    InParanoidi Q9JII9.
    KOi K04188.
    OMAi AYCYARI.
    OrthoDBi EOG7F5126.
    PhylomeDBi Q9JII9.
    TreeFami TF330966.

    Miscellaneous databases

    NextBioi 616974.
    PROi Q9JII9.

    Gene expression databases

    Genevestigatori Q9JII9.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR004070. Chemokine_CXCR3.
    IPR000355. Chemokine_rcpt.
    IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    [Graphical view ]
    PANTHERi PTHR24227. PTHR24227. 1 hit.
    PTHR24227:SF27. PTHR24227:SF27. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00657. CCCHEMOKINER.
    PR01532. CXCCHMKINER3.
    PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and molecular characterization of rat CXCR3: receptor expression and interferon-inducible protein-10 binding are increased in focal stroke."
      Wang X., Li X., Schmidt D.B., Foley J.J., Barone F.C., Ames R.S., Sarau H.M.
      Mol. Pharmacol. 57:1190-1198(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Spleen.

    Entry informationi

    Entry nameiCXCR3_RAT
    AccessioniPrimary (citable) accession number: Q9JII9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3