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Protein

DAZ-associated protein 1

Gene

Dazap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein, which may be required during spermatogenesis.By similarity

GO - Molecular functioni

  • poly(G) binding Source: Ensembl
  • poly(U) RNA binding Source: Ensembl
  • RNA binding Source: MGI
  • RNA stem-loop binding Source: MGI

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • cell proliferation Source: MGI
  • maternal placenta development Source: MGI
  • positive regulation of mRNA splicing, via spliceosome Source: MGI
  • spermatogenesis Source: MGI

Keywordsi

Molecular functionDevelopmental protein, RNA-binding
Biological processDifferentiation, Spermatogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
DAZ-associated protein 1
Alternative name(s):
Deleted in azoospermia-associated protein 1
Gene namesi
Name:Dazap1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1917498 Dazap1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815661 – 406DAZ-associated protein 1Add BLAST406

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei150N6-acetyllysineBy similarity1
Modified residuei253Omega-N-methylarginineCombined sources1

Post-translational modificationi

Acetylation at Lys-150 is predominantly observed in the nuclear fraction, and may regulate nucleocytoplasmic transport.By similarity

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiQ9JII5
PRIDEiQ9JII5

2D gel databases

REPRODUCTION-2DPAGEQ9JII5

PTM databases

iPTMnetiQ9JII5
PhosphoSitePlusiQ9JII5
SwissPalmiQ9JII5

Expressioni

Tissue specificityi

Mainly expressed in testis. Expressed at much lower level in liver, heart and brain. Also expressed in ovary. Expressed throughout testes development, in both the prenatal and postnatal periods.1 Publication

Developmental stagei

First expressed in midpachytene spermatocytes in stage VII tubules.

Gene expression databases

BgeeiENSMUSG00000069565
CleanExiMM_DAZAP1
ExpressionAtlasiQ9JII5 baseline and differential
GenevisibleiQ9JII5 MM

Interactioni

Subunit structurei

Interacts with DAZ and DAZL.By similarity

Protein-protein interaction databases

IntActiQ9JII5, 1 interactor
MINTiQ9JII5
STRINGi10090.ENSMUSP00000089958

Structurei

3D structure databases

ProteinModelPortaliQ9JII5
SMRiQ9JII5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 97RRM 1PROSITE-ProRule annotationAdd BLAST88
Domaini113 – 190RRM 2PROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi222 – 384Pro-richAdd BLAST163

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4205 Eukaryota
ENOG410YA8Z LUCA
GeneTreeiENSGT00900000140835
HOGENOMiHOG000234441
HOVERGENiHBG002295
InParanoidiQ9JII5
KOiK14411
OrthoDBiEOG091G1CPI

Family and domain databases

CDDicd12574 RRM1_DAZAP1, 1 hit
cd12327 RRM2_DAZAP1, 1 hit
Gene3Di3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR034134 DAZAP1_RRM1
IPR034131 DAZAP1_RRM2
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 2 hits
SMARTiView protein in SMART
SM00360 RRM, 2 hits
SUPFAMiSSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JII5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNSAGADEIG KLFVGGLDWS TTQETLRSYF SQYGEVVDCV IMKDKTTNQS
60 70 80 90 100
RGFGFVKFKD PNCVGTVLAS RPHTLDGRNI DPKPCTPRGM QPERTRPKEG
110 120 130 140 150
WQKGPRSDSS KSNKIFVGGI PHNCGETELR EYFKKFGVVT EVVMIYDAEK
160 170 180 190 200
QRPRGFGFIT FEDEQSVDQA VNMHFHDIMG KKVEVKRAEP RDSKNQAPGQ
210 220 230 240 250
PGASQWGSRV APSAANGWAG QPPPTWQQGY GPQGMWVPAG QAIGGYGPPP
260 270 280 290 300
AGRGAPPPPP PFTSYIVSTP PGGFPPPQGF PQGYGAPPQF SFGYGPPPPP
310 320 330 340 350
PDQFAPPGVP PPPATPGAAP LAFPPPPSQA APDMSKPPTA QPDFPYGQYG
360 370 380 390 400
YGQDLSGFGQ GFSDPSQQPP SYGGPSVPGS GGPPAGGSGF GRGQNHNVQG

FHPYRR
Length:406
Mass (Da):43,214
Last modified:March 1, 2004 - v2
Checksum:iB0C71A7AED2F50D7
GO
Isoform 2 (identifier: Q9JII5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     102-102: Missing.

Note: No experimental confirmation available.
Show »
Length:405
Mass (Da):43,086
Checksum:i4CE8B2223B0A9391
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti241Q → R in AAF81071 (PubMed:11604102).Curated1
Sequence conflicti358F → L in AAF81071 (PubMed:11604102).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009443102Missing in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF225910 mRNA Translation: AAF81071.1
BC049355 mRNA Translation: AAH49355.1
CCDSiCCDS35977.1 [Q9JII5-2]
CCDS48626.1 [Q9JII5-1]
RefSeqiNP_001116076.1, NM_001122604.1 [Q9JII5-1]
NP_001116077.1, NM_001122605.1
NP_573451.2, NM_133188.2 [Q9JII5-2]
UniGeneiMm.148693

Genome annotation databases

EnsembliENSMUST00000092305; ENSMUSP00000089958; ENSMUSG00000069565 [Q9JII5-1]
ENSMUST00000105362; ENSMUSP00000101001; ENSMUSG00000069565 [Q9JII5-2]
GeneIDi70248
KEGGimmu:70248
UCSCiuc007gcl.2 mouse [Q9JII5-2]
uc007gcm.2 mouse [Q9JII5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiDAZP1_MOUSE
AccessioniPrimary (citable) accession number: Q9JII5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: March 1, 2004
Last modified: April 25, 2018
This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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