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Protein

72 kDa inositol polyphosphate 5-phosphatase

Gene

Inpp5e

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2, and phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate. Specific for lipid substrates, inactive towards water soluble inositol phosphates.1 Publication

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.1 Publication

GO - Molecular functioni

  • phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Source: MGI

GO - Biological processi

  • inositol phosphate dephosphorylation Source: MGI
  • phosphatidylinositol dephosphorylation Source: MGI
  • phosphatidylinositol metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.3.36. 3474.
ReactomeiR-MMU-1660514. Synthesis of PIPs at the Golgi membrane.
R-MMU-5624958. ARL13B-mediated ciliary trafficking of INPP5E.

Names & Taxonomyi

Protein namesi
Recommended name:
72 kDa inositol polyphosphate 5-phosphatase (EC:3.1.3.361 Publication)
Alternative name(s):
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase
Phosphatidylinositol polyphosphate 5-phosphatase type IV
Gene namesi
Name:Inpp5e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1927753. Inpp5e.

Subcellular locationi

GO - Cellular componenti

  • axoneme Source: UniProtKB
  • Golgi cisterna membrane Source: UniProtKB-SubCell
  • Golgi membrane Source: MGI
  • plasma membrane Source: UniProtKB-SubCell
  • ruffle Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Cilium, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002097481 – 64472 kDa inositol polyphosphate 5-phosphataseBy similarityAdd BLAST644
PropeptideiPRO_0000431689645 – 647Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei103PhosphoserineCombined sources1
Modified residuei197PhosphothreonineCombined sources1
Modified residuei245PhosphoserineBy similarity1
Modified residuei259PhosphoserineCombined sources1
Modified residuei644Cysteine methyl esterBy similarity1
Lipidationi644S-farnesyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Proteomic databases

MaxQBiQ9JII1.
PaxDbiQ9JII1.
PRIDEiQ9JII1.

PTM databases

iPTMnetiQ9JII1.
PhosphoSitePlusiQ9JII1.

Expressioni

Tissue specificityi

Highly expressed in testis, in pachytene and diplotene spermatocytes, but not in more mature elongating spermatids. Detected in neurons throughout the brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000026925.
CleanExiMM_INPP5E.
ExpressionAtlasiQ9JII1. baseline and differential.
GenevisibleiQ9JII1. MM.

Interactioni

Subunit structurei

Interacts (when prenylated) with PDE6D; this is important for normal location in cilia.By similarity

Protein-protein interaction databases

BioGridi211076. 2 interactors.
STRINGi10090.ENSMUSP00000119485.

Structurei

3D structure databases

ProteinModelPortaliQ9JII1.
SMRiQ9JII1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati52 – 5514
Repeati76 – 7924
Repeati240 – 24334

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni52 – 2433 X 4 AA repeats of P-X-X-PAdd BLAST192

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi96 – 101Poly-Arg6

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0565. Eukaryota.
COG5411. LUCA.
GeneTreeiENSGT00760000119075.
HOGENOMiHOG000231541.
HOVERGENiHBG052132.
InParanoidiQ9JII1.
KOiK20278.
OMAiSCSPPCL.
OrthoDBiEOG091G05DT.
PhylomeDBiQ9JII1.
TreeFamiTF323475.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SMARTiSM00128. IPPc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JII1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPSKSACLRH TEAPGQLEGR MLQGQPPNTE KKLIPTPGFL PASDSQGSET
60 70 80 90 100
NPMPPFSIPA KTSNQNPQTK ANLITPQPPI RPKLERTLSL DDKGWRRRRF
110 120 130 140 150
RGSQEDLTVQ NGASPCRGSL QDSVAQSPAY SRPLPCLSTS LQEIPKSRRA
160 170 180 190 200
TGSEGGSPSL WSDCLSGMIS TSLDLLHRDA ASGGPPSRLA SLHASHTPPA
210 220 230 240 250
MDLSIASSSL RTANKVDPEH TDYKLRMQTR LVRAHSNLGP SRPRSPLAGD
260 270 280 290 300
DHSIHSARSF SLLAPIRTKD IRSRSYLEGS LLASGALLGA EELARYFPDR
310 320 330 340 350
NMALFVATWN MQGQKELPAS LDEFLLPTEA DYTQDLYVIG IQEGCSDRRE
360 370 380 390 400
WETRLQETLG PQYVLLSSAA HGVLYMSLFI RRDLIWFCSE VEYSTVTTRI
410 420 430 440 450
VSQIKTKGAL GVSFTFFGTS FLFITSHFTS GDGKVAERLL DYSRTIQALA
460 470 480 490 500
LPRNVPDTNP YRSSAGDVTT RFDEVFWFGD FNFRLSGGRV AVEAFLKQKP
510 520 530 540 550
EVDVLALLQH DQLTREMKKG SIFRGFEEAE IHFLPSYKFD IGKDTYDSTS
560 570 580 590 600
KQRTPSYTDR VLYKSRHKGD ICPMKYSSCP GIKTSDHRPV YGLFQVKVRP
610 620 630 640
GRDNIPLAAG KFDRELYLIG IKRRISKEIQ RQEALKSQSS SAVCTVS
Length:647
Mass (Da):71,915
Last modified:October 1, 2000 - v1
Checksum:i4BBE3A39DB7ECB0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226683 mRNA. Translation: AAF86957.1.
AK080075 mRNA. Translation: BAC37823.1.
AK154097 mRNA. Translation: BAE32374.1.
AK170786 mRNA. Translation: BAE42028.1.
BC052717 mRNA. Translation: AAH52717.1.
BC080295 mRNA. Translation: AAH80295.1.
CCDSiCCDS15805.1.
RefSeqiNP_001277366.1. NM_001290437.1.
NP_149125.1. NM_033134.3.
UniGeneiMm.330070.

Genome annotation databases

EnsembliENSMUST00000145701; ENSMUSP00000119485; ENSMUSG00000026925.
GeneIDi64436.
KEGGimmu:64436.
UCSCiuc008ivf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF226683 mRNA. Translation: AAF86957.1.
AK080075 mRNA. Translation: BAC37823.1.
AK154097 mRNA. Translation: BAE32374.1.
AK170786 mRNA. Translation: BAE42028.1.
BC052717 mRNA. Translation: AAH52717.1.
BC080295 mRNA. Translation: AAH80295.1.
CCDSiCCDS15805.1.
RefSeqiNP_001277366.1. NM_001290437.1.
NP_149125.1. NM_033134.3.
UniGeneiMm.330070.

3D structure databases

ProteinModelPortaliQ9JII1.
SMRiQ9JII1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211076. 2 interactors.
STRINGi10090.ENSMUSP00000119485.

PTM databases

iPTMnetiQ9JII1.
PhosphoSitePlusiQ9JII1.

Proteomic databases

MaxQBiQ9JII1.
PaxDbiQ9JII1.
PRIDEiQ9JII1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000145701; ENSMUSP00000119485; ENSMUSG00000026925.
GeneIDi64436.
KEGGimmu:64436.
UCSCiuc008ivf.2. mouse.

Organism-specific databases

CTDi56623.
MGIiMGI:1927753. Inpp5e.

Phylogenomic databases

eggNOGiKOG0565. Eukaryota.
COG5411. LUCA.
GeneTreeiENSGT00760000119075.
HOGENOMiHOG000231541.
HOVERGENiHBG052132.
InParanoidiQ9JII1.
KOiK20278.
OMAiSCSPPCL.
OrthoDBiEOG091G05DT.
PhylomeDBiQ9JII1.
TreeFamiTF323475.

Enzyme and pathway databases

BRENDAi3.1.3.36. 3474.
ReactomeiR-MMU-1660514. Synthesis of PIPs at the Golgi membrane.
R-MMU-5624958. ARL13B-mediated ciliary trafficking of INPP5E.

Miscellaneous databases

PROiQ9JII1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026925.
CleanExiMM_INPP5E.
ExpressionAtlasiQ9JII1. baseline and differential.
GenevisibleiQ9JII1. MM.

Family and domain databases

Gene3Di3.60.10.10. 1 hit.
InterProiIPR005135. Endo/exonuclease/phosphatase.
IPR000300. IPPc.
[Graphical view]
PfamiPF03372. Exo_endo_phos. 1 hit.
[Graphical view]
SMARTiSM00128. IPPc. 1 hit.
[Graphical view]
SUPFAMiSSF56219. SSF56219. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiINP5E_MOUSE
AccessioniPrimary (citable) accession number: Q9JII1
Secondary accession number(s): Q3TCC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.