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Q9JIG7

- CCD22_MOUSE

UniProt

Q9JIG7 - CCD22_MOUSE

Protein

Coiled-coil domain-containing protein 22

Gene

Ccdc22

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Coiled-coil domain-containing protein 22
    Gene namesi
    Name:Ccdc22
    Synonyms:DXImx40e
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1859608. Ccdc22.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 627627Coiled-coil domain-containing protein 22PRO_0000076200Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei410 – 4101PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9JIG7.
    PaxDbiQ9JIG7.
    PRIDEiQ9JIG7.

    PTM databases

    PhosphoSiteiQ9JIG7.

    Expressioni

    Gene expression databases

    BgeeiQ9JIG7.
    CleanExiMM_CCDC22.
    GenevestigatoriQ9JIG7.

    Interactioni

    Subunit structurei

    Interacts with CPNE1 and CPNE4.1 Publication

    Protein-protein interaction databases

    BioGridi207701. 2 interactions.
    IntActiQ9JIG7. 6 interactions.
    MINTiMINT-1865494.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JIG7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili448 – 53588Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CCDC22 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG253647.
    GeneTreeiENSGT00390000003809.
    HOGENOMiHOG000039965.
    HOVERGENiHBG053063.
    InParanoidiB1AVA1.
    OMAiECRQSEL.
    OrthoDBiEOG7QNVKR.
    PhylomeDBiQ9JIG7.
    TreeFamiTF325575.

    Family and domain databases

    InterProiIPR008530. DUF812.
    [Graphical view]
    PANTHERiPTHR15668. PTHR15668. 1 hit.
    PfamiPF05667. DUF812. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JIG7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEEADRILIH SLRQAGTAVP PEVQTLRAFT TELVVEAVVR CLRVINPDVG    50
    SGLSHLLPPA MSARFRLAMS LAQACMDLGY PLELGYQNFL YPSEPDLRDL 100
    LLFLAERLPS DASEDADQPA GDSAIFLRAI GSQIRDQLAL PWVPPLLRTP 150
    KVQRLQGSAL QQPFHSSRLV LPELNSSGEL WEFQASPLLL PAPTQVPQLQ 200
    GRAASLLEHH ASQLCQHVNR DCPGDEDRVR WASRVPSQED SRAPQQRLHK 250
    QLIEHLRQSW GPLGAPTQVR DLGEMLQTWG ARAMTGVPKG SRFTHSEKFT 300
    FHLEPQVQAA QVADVPATSQ RLEQDTRAAQ EQELESLREQ LASVNHNIEE 350
    VEADMKTLGI NLVQVETECR QSELSVAEQE QALRLKSRTV ELLPDGAANL 400
    AKLQLVVESS AQRLIHLASQ WEKHRVPLLA EYRHLRRLQD CRELESSRRL 450
    AEIQELHHSV RAAAEEARRK EEVYKQLVSE LETLPKDVSR LAYTQRILEI 500
    VGNIRKQKEE ITKILSDTKE LQKEINSLSG KLDRTFAVTD ELVFKDAKKD 550
    DAVRKAYKYL AALHENCSQL IQTIEDTGTI MREVRDLEEQ IETEMGKKTL 600
    SNLEKICEDY RALRQENAGL LGRVREA 627
    Length:627
    Mass (Da):70,844
    Last modified:October 1, 2000 - v1
    Checksum:i3710732B4CD90A2E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti117 – 1171D → N in BAC30390. (PubMed:16141072)Curated
    Sequence conflicti529 – 5291S → F in BAC30390. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF229637 mRNA. Translation: AAF66951.1.
    AK010536 mRNA. Translation: BAB27013.1.
    AK039573 mRNA. Translation: BAC30390.1.
    AL672231 Genomic DNA. Translation: CAM25951.1.
    BC011195 mRNA. Translation: AAH11195.1.
    CCDSiCCDS29966.1.
    RefSeqiNP_613069.3. NM_138603.3.
    UniGeneiMm.288192.

    Genome annotation databases

    EnsembliENSMUST00000033483; ENSMUSP00000033483; ENSMUSG00000031143.
    GeneIDi54638.
    KEGGimmu:54638.
    UCSCiuc009sln.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF229637 mRNA. Translation: AAF66951.1 .
    AK010536 mRNA. Translation: BAB27013.1 .
    AK039573 mRNA. Translation: BAC30390.1 .
    AL672231 Genomic DNA. Translation: CAM25951.1 .
    BC011195 mRNA. Translation: AAH11195.1 .
    CCDSi CCDS29966.1.
    RefSeqi NP_613069.3. NM_138603.3.
    UniGenei Mm.288192.

    3D structure databases

    ProteinModelPortali Q9JIG7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 207701. 2 interactions.
    IntActi Q9JIG7. 6 interactions.
    MINTi MINT-1865494.

    PTM databases

    PhosphoSitei Q9JIG7.

    Proteomic databases

    MaxQBi Q9JIG7.
    PaxDbi Q9JIG7.
    PRIDEi Q9JIG7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000033483 ; ENSMUSP00000033483 ; ENSMUSG00000031143 .
    GeneIDi 54638.
    KEGGi mmu:54638.
    UCSCi uc009sln.1. mouse.

    Organism-specific databases

    CTDi 28952.
    MGIi MGI:1859608. Ccdc22.

    Phylogenomic databases

    eggNOGi NOG253647.
    GeneTreei ENSGT00390000003809.
    HOGENOMi HOG000039965.
    HOVERGENi HBG053063.
    InParanoidi B1AVA1.
    OMAi ECRQSEL.
    OrthoDBi EOG7QNVKR.
    PhylomeDBi Q9JIG7.
    TreeFami TF325575.

    Miscellaneous databases

    ChiTaRSi CCDC22. mouse.
    NextBioi 311476.
    PROi Q9JIG7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JIG7.
    CleanExi MM_CCDC22.
    Genevestigatori Q9JIG7.

    Family and domain databases

    InterProi IPR008530. DUF812.
    [Graphical view ]
    PANTHERi PTHR15668. PTHR15668. 1 hit.
    Pfami PF05667. DUF812. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation."
      Means G.D., Toy D.Y., Baum P.R., Derry J.M.J.
      Genomics 65:213-223(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Spinal cord.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Salivary gland.
    5. "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif."
      Tomsig J.L., Snyder S.L., Creutz C.E.
      J. Biol. Chem. 278:10048-10054(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CPNE1 AND CPNE4.

    Entry informationi

    Entry nameiCCD22_MOUSE
    AccessioniPrimary (citable) accession number: Q9JIG7
    Secondary accession number(s): B1AVA1, Q8BYH4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3