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Protein

Coiled-coil domain-containing protein 22

Gene

Ccdc22

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in regulation of NF-kappa-B signaling. Promotes ubiquitination of I-kappa-B-kinase subunit IKBKB and its subsequent proteasomal degradation leading to NF-kappa-B activation; the function may involve association with COMMD8 and a CUL1-dependent E3 ubiquitin ligase complex. May down-regulate NF-kappa-B activity via assocation with COMMD1 and involving a CUL2-dependent E3 ubiquitin ligase complex. Regulates the cellular localization of COMM domain-containing proteins, such as COMMD1 and COMMD10. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes.

GO - Molecular functioni

  1. cullin family protein binding Source: MGI

GO - Biological processi

  1. cellular copper ion homeostasis Source: MGI
  2. cytoplasmic sequestering of NF-kappaB Source: MGI
  3. Golgi to plasma membrane transport Source: MGI
  4. negative regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  5. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  6. positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: MGI
  7. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Coiled-coil domain-containing protein 22
Gene namesi
Name:Ccdc22
Synonyms:DXImx40e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1859608. Ccdc22.

Subcellular locationi

Endosome Curated

GO - Cellular componenti

  1. endosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 627627Coiled-coil domain-containing protein 22PRO_0000076200Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei410 – 4101PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JIG7.
PaxDbiQ9JIG7.
PRIDEiQ9JIG7.

PTM databases

PhosphoSiteiQ9JIG7.

Expressioni

Gene expression databases

BgeeiQ9JIG7.
CleanExiMM_CCDC22.
GenevestigatoriQ9JIG7.

Interactioni

Subunit structurei

Interacts with CPNE1 and CPNE4 (PubMed:12522145). Interacts with COMMD1, COMMD2 COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8, COMMD9, COMMD10. Interacts with CUL1, CUL2, CUL3, SKP1, BTRC. Interacts with CCDC93 and C16orf62 homolog; proposed to be a component of the CCC (COMMD/CCDC22/CCDC93) complex which contains at least COMMD1 (and possibly other COMM domain-containing proteins), CCDC22, CCDC93 and C16orf62 homolog; in the complex interacts directly with CCDC93 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi207701. 2 interactions.
IntActiQ9JIG7. 6 interactions.
MINTiMINT-1865494.

Structurei

3D structure databases

ProteinModelPortaliQ9JIG7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 447447Sufficicient and required for interaction with CCDC93By similarityAdd
BLAST
Regioni1 – 321321Sufficient for interaction with COMMD1By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili448 – 53588Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the CCDC22 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG253647.
GeneTreeiENSGT00390000003809.
HOGENOMiHOG000039965.
HOVERGENiHBG053063.
InParanoidiQ9JIG7.
OMAiECRQSEL.
OrthoDBiEOG7QNVKR.
PhylomeDBiQ9JIG7.
TreeFamiTF325575.

Family and domain databases

InterProiIPR008530. DUF812.
[Graphical view]
PANTHERiPTHR15668. PTHR15668. 1 hit.
PfamiPF05667. DUF812. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JIG7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEADRILIH SLRQAGTAVP PEVQTLRAFT TELVVEAVVR CLRVINPDVG
60 70 80 90 100
SGLSHLLPPA MSARFRLAMS LAQACMDLGY PLELGYQNFL YPSEPDLRDL
110 120 130 140 150
LLFLAERLPS DASEDADQPA GDSAIFLRAI GSQIRDQLAL PWVPPLLRTP
160 170 180 190 200
KVQRLQGSAL QQPFHSSRLV LPELNSSGEL WEFQASPLLL PAPTQVPQLQ
210 220 230 240 250
GRAASLLEHH ASQLCQHVNR DCPGDEDRVR WASRVPSQED SRAPQQRLHK
260 270 280 290 300
QLIEHLRQSW GPLGAPTQVR DLGEMLQTWG ARAMTGVPKG SRFTHSEKFT
310 320 330 340 350
FHLEPQVQAA QVADVPATSQ RLEQDTRAAQ EQELESLREQ LASVNHNIEE
360 370 380 390 400
VEADMKTLGI NLVQVETECR QSELSVAEQE QALRLKSRTV ELLPDGAANL
410 420 430 440 450
AKLQLVVESS AQRLIHLASQ WEKHRVPLLA EYRHLRRLQD CRELESSRRL
460 470 480 490 500
AEIQELHHSV RAAAEEARRK EEVYKQLVSE LETLPKDVSR LAYTQRILEI
510 520 530 540 550
VGNIRKQKEE ITKILSDTKE LQKEINSLSG KLDRTFAVTD ELVFKDAKKD
560 570 580 590 600
DAVRKAYKYL AALHENCSQL IQTIEDTGTI MREVRDLEEQ IETEMGKKTL
610 620
SNLEKICEDY RALRQENAGL LGRVREA
Length:627
Mass (Da):70,844
Last modified:September 30, 2000 - v1
Checksum:i3710732B4CD90A2E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti117 – 1171D → N in BAC30390 (PubMed:16141072).Curated
Sequence conflicti529 – 5291S → F in BAC30390 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229637 mRNA. Translation: AAF66951.1.
AK010536 mRNA. Translation: BAB27013.1.
AK039573 mRNA. Translation: BAC30390.1.
AL672231 Genomic DNA. Translation: CAM25951.1.
BC011195 mRNA. Translation: AAH11195.1.
CCDSiCCDS29966.1.
RefSeqiNP_613069.3. NM_138603.3.
UniGeneiMm.288192.

Genome annotation databases

EnsembliENSMUST00000033483; ENSMUSP00000033483; ENSMUSG00000031143.
GeneIDi54638.
KEGGimmu:54638.
UCSCiuc009sln.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229637 mRNA. Translation: AAF66951.1.
AK010536 mRNA. Translation: BAB27013.1.
AK039573 mRNA. Translation: BAC30390.1.
AL672231 Genomic DNA. Translation: CAM25951.1.
BC011195 mRNA. Translation: AAH11195.1.
CCDSiCCDS29966.1.
RefSeqiNP_613069.3. NM_138603.3.
UniGeneiMm.288192.

3D structure databases

ProteinModelPortaliQ9JIG7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207701. 2 interactions.
IntActiQ9JIG7. 6 interactions.
MINTiMINT-1865494.

PTM databases

PhosphoSiteiQ9JIG7.

Proteomic databases

MaxQBiQ9JIG7.
PaxDbiQ9JIG7.
PRIDEiQ9JIG7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033483; ENSMUSP00000033483; ENSMUSG00000031143.
GeneIDi54638.
KEGGimmu:54638.
UCSCiuc009sln.1. mouse.

Organism-specific databases

CTDi28952.
MGIiMGI:1859608. Ccdc22.

Phylogenomic databases

eggNOGiNOG253647.
GeneTreeiENSGT00390000003809.
HOGENOMiHOG000039965.
HOVERGENiHBG053063.
InParanoidiQ9JIG7.
OMAiECRQSEL.
OrthoDBiEOG7QNVKR.
PhylomeDBiQ9JIG7.
TreeFamiTF325575.

Miscellaneous databases

ChiTaRSiCcdc22. mouse.
NextBioi311476.
PROiQ9JIG7.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JIG7.
CleanExiMM_CCDC22.
GenevestigatoriQ9JIG7.

Family and domain databases

InterProiIPR008530. DUF812.
[Graphical view]
PANTHERiPTHR15668. PTHR15668. 1 hit.
PfamiPF05667. DUF812. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A transcript map of a 2-Mb BAC contig in the proximal portion of the mouse X chromosome and regional mapping of the scurfy mutation."
    Means G.D., Toy D.Y., Baum P.R., Derry J.M.J.
    Genomics 65:213-223(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Spinal cord.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Salivary gland.
  5. "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif."
    Tomsig J.L., Snyder S.L., Creutz C.E.
    J. Biol. Chem. 278:10048-10054(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CPNE1 AND CPNE4.

Entry informationi

Entry nameiCCD22_MOUSE
AccessioniPrimary (citable) accession number: Q9JIG7
Secondary accession number(s): B1AVA1, Q8BYH4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2005
Last sequence update: September 30, 2000
Last modified: March 31, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.