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Protein

Protein phosphatase 1 regulatory subunit 3F

Gene

Ppp1r3f

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Glycogen-targeting subunit for protein phosphatase 1 (PP1).1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Protein family/group databases

CAZyiCBM21. Carbohydrate-Binding Module Family 21.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 3F
Short name:
R3F
Gene namesi
Name:Ppp1r3f
Synonyms:DXImx48e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1859617. Ppp1r3f.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 772CytoplasmicSequence analysisAdd BLAST772
Transmembranei773 – 793HelicalSequence analysisAdd BLAST21
Topological domaini794 – 799ExtracellularSequence analysis6

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi39F → A: Abrogates PP1-binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002574971 – 799Protein phosphatase 1 regulatory subunit 3FAdd BLAST799

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineBy similarity1
Modified residuei545PhosphoserineCombined sources1
Modified residuei587PhosphoserineCombined sources1
Modified residuei592PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JIG4.
PRIDEiQ9JIG4.

PTM databases

iPTMnetiQ9JIG4.
PhosphoSitePlusiQ9JIG4.

Expressioni

Tissue specificityi

Highly expressed in brain (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000039556.
ExpressionAtlasiQ9JIG4. baseline and differential.
GenevisibleiQ9JIG4. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045402.

Structurei

3D structure databases

ProteinModelPortaliQ9JIG4.
SMRiQ9JIG4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 283CBM21PROSITE-ProRule annotationAdd BLAST157

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 39PP1-binding motif4

Sequence similaritiesi

Contains 1 CBM21 (carbohydrate binding type-21) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3986. Eukaryota.
ENOG4111FT1. LUCA.
GeneTreeiENSGT00390000013859.
InParanoidiQ9JIG4.
KOiK17453.
OMAiHPARYVP.
OrthoDBiEOG091G055Q.
PhylomeDBiQ9JIG4.
TreeFamiTF352142.

Family and domain databases

InterProiIPR005036. CBM21_dom.
[Graphical view]
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JIG4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARTAPVEPP LRHPAPPSPA AGEPRASAEA AVAPRRVLFA DEALGLPLAQ
60 70 80 90 100
LRRYRPWGGP GAGKMAAATG QDGGGGGADE EDDGEDGDEG EEEEEAFPDP
110 120 130 140 150
SPPCPVPAGG GFYLVPTFSL PPALGRLERL GRVMVELEAL LPPPGAVPGG
160 170 180 190 200
SGVWVPGGRP PVVRGLVRVL NRSFEKAVHV RASHDGWATF CDHPARYVPR
210 220 230 240 250
SPPGAGVGGT GAGDPLLDPG LGLGPGQMSA SSPDDGGCTD RFAFQLPFAE
260 270 280 290 300
GASDGARLDF VVRYETPEGT FWANNHGRNY TVLLRIAPAP TPTDAEGLPQ
310 320 330 340 350
QQQLQQLEPQ PECQGPVEAE ARQLKSCMKP VRRRPFEEEP RMRSADDNTL
360 370 380 390 400
AEHPDVRESL GPLLAPTPLR PWPQMTLQVP EVMLTSNPQE EGDIPRSNPP
410 420 430 440 450
VAFTEVRQAP AIRILPATCG LGGPPRDQAS GPDASDRAAG SFLEPTQQQV
460 470 480 490 500
EAAWESGGGR KAPMVGALTD EPARGLEIVS GLDELLGEDT IDQELEQLYL
510 520 530 540 550
SHLSRLRAVA AAGGGEGTSP THALGILTDR DLILKWPGPE RALNSALAEE
560 570 580 590 600
ITLHYARLGC GVELIKDTED PDDEGEGEDG LSITPSSPEG GSPKESPPEI
610 620 630 640 650
LSGARSVIAT MGDVWVPWAE RSSSRCDSPV VLGTQGQFTE NPEKGMGKDT
660 670 680 690 700
KSLHLNRVIV GMSKSPGEAG TESQMEELPT ERESSWVPSS EKELPLPVQQ
710 720 730 740 750
EQSPALLGPT GTEVCLSSVA KPHVNSQEEE GGSLNLESPK RSPMPAAPAE
760 770 780 790
CACGLAPQLW GPLTQTLGVL AGLVMVPVAL NSGVSLLVLV LCLSLAWFS
Length:799
Mass (Da):84,120
Last modified:April 14, 2009 - v3
Checksum:iDF6572A80FECB7BC
GO
Isoform 2 (identifier: Q9JIG4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     377-377: L → LQ

Note: No experimental confirmation available.
Show »
Length:800
Mass (Da):84,249
Checksum:i377CBDE41376272D
GO

Sequence cautioni

The sequence AAF66954 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH59275 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM14759 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti266T → N in AAH59275 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021363377L → LQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731793 Genomic DNA. Translation: CAM14759.1. Different initiation.
AL731793 Genomic DNA. Translation: CAM14760.1.
BC059275 mRNA. Translation: AAH59275.1. Different initiation.
AF229644 mRNA. Translation: AAF66954.2. Different initiation.
AK147873 mRNA. Translation: BAE28194.1.
CCDSiCCDS29964.2. [Q9JIG4-1]
CCDS72328.1. [Q9JIG4-2]
RefSeqiNP_613071.3. NM_138605.3. [Q9JIG4-1]
UniGeneiMm.148163.

Genome annotation databases

EnsembliENSMUST00000115742; ENSMUSP00000111407; ENSMUSG00000039556. [Q9JIG4-1]
ENSMUST00000150787; ENSMUSP00000122903; ENSMUSG00000039556. [Q9JIG4-2]
GeneIDi54646.
KEGGimmu:54646.
UCSCiuc009slj.2. mouse. [Q9JIG4-1]
uc057aqo.1. mouse. [Q9JIG4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731793 Genomic DNA. Translation: CAM14759.1. Different initiation.
AL731793 Genomic DNA. Translation: CAM14760.1.
BC059275 mRNA. Translation: AAH59275.1. Different initiation.
AF229644 mRNA. Translation: AAF66954.2. Different initiation.
AK147873 mRNA. Translation: BAE28194.1.
CCDSiCCDS29964.2. [Q9JIG4-1]
CCDS72328.1. [Q9JIG4-2]
RefSeqiNP_613071.3. NM_138605.3. [Q9JIG4-1]
UniGeneiMm.148163.

3D structure databases

ProteinModelPortaliQ9JIG4.
SMRiQ9JIG4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000045402.

Protein family/group databases

CAZyiCBM21. Carbohydrate-Binding Module Family 21.

PTM databases

iPTMnetiQ9JIG4.
PhosphoSitePlusiQ9JIG4.

Proteomic databases

PaxDbiQ9JIG4.
PRIDEiQ9JIG4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000115742; ENSMUSP00000111407; ENSMUSG00000039556. [Q9JIG4-1]
ENSMUST00000150787; ENSMUSP00000122903; ENSMUSG00000039556. [Q9JIG4-2]
GeneIDi54646.
KEGGimmu:54646.
UCSCiuc009slj.2. mouse. [Q9JIG4-1]
uc057aqo.1. mouse. [Q9JIG4-2]

Organism-specific databases

CTDi89801.
MGIiMGI:1859617. Ppp1r3f.

Phylogenomic databases

eggNOGiKOG3986. Eukaryota.
ENOG4111FT1. LUCA.
GeneTreeiENSGT00390000013859.
InParanoidiQ9JIG4.
KOiK17453.
OMAiHPARYVP.
OrthoDBiEOG091G055Q.
PhylomeDBiQ9JIG4.
TreeFamiTF352142.

Miscellaneous databases

PROiQ9JIG4.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039556.
ExpressionAtlasiQ9JIG4. baseline and differential.
GenevisibleiQ9JIG4. MM.

Family and domain databases

InterProiIPR005036. CBM21_dom.
[Graphical view]
PfamiPF03370. CBM_21. 1 hit.
[Graphical view]
PROSITEiPS51159. CBM21. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPPR3F_MOUSE
AccessioniPrimary (citable) accession number: Q9JIG4
Secondary accession number(s): B1AW09
, B1AW10, Q3UGL4, Q6PCL6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 14, 2009
Last modified: November 2, 2016
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.