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Protein

Protein phosphatase 1 regulatory subunit 3F

Gene

Ppp1r3f

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Glycogen-targeting subunit for protein phosphatase 1 (PP1).1 Publication

GO - Molecular functioni

GO - Biological processi

Protein family/group databases

CAZyiCBM21 Carbohydrate-Binding Module Family 21

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 3F
Short name:
R3F
Gene namesi
Name:Ppp1r3f
Synonyms:DXImx48e
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:1859617 Ppp1r3f

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 772CytoplasmicSequence analysisAdd BLAST772
Transmembranei773 – 793HelicalSequence analysisAdd BLAST21
Topological domaini794 – 799ExtracellularSequence analysis6

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi39F → A: Abrogates PP1-binding. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002574971 – 799Protein phosphatase 1 regulatory subunit 3FAdd BLAST799

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei18PhosphoserineBy similarity1
Modified residuei545PhosphoserineCombined sources1
Modified residuei587PhosphoserineCombined sources1
Modified residuei592PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9JIG4
PRIDEiQ9JIG4

PTM databases

iPTMnetiQ9JIG4
PhosphoSitePlusiQ9JIG4

Expressioni

Tissue specificityi

Highly expressed in brain (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000039556
ExpressionAtlasiQ9JIG4 baseline and differential
GenevisibleiQ9JIG4 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi207708, 1 interactor
IntActiQ9JIG4, 1 interactor
STRINGi10090.ENSMUSP00000045402

Structurei

3D structure databases

ProteinModelPortaliQ9JIG4
SMRiQ9JIG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 283CBM21PROSITE-ProRule annotationAdd BLAST157

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi36 – 39PP1-binding motif4

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3986 Eukaryota
ENOG4111FT1 LUCA
GeneTreeiENSGT00390000013859
InParanoidiQ9JIG4
KOiK17453
OMAiFCDHPAR
OrthoDBiEOG091G055Q
PhylomeDBiQ9JIG4
TreeFamiTF352142

Family and domain databases

Gene3Di2.60.40.2440, 2 hits
InterProiView protein in InterPro
IPR005036 CBM21_dom
IPR038175 CBM21_dom_sf
PfamiView protein in Pfam
PF03370 CBM_21, 1 hit
PROSITEiView protein in PROSITE
PS51159 CBM21, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JIG4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARTAPVEPP LRHPAPPSPA AGEPRASAEA AVAPRRVLFA DEALGLPLAQ
60 70 80 90 100
LRRYRPWGGP GAGKMAAATG QDGGGGGADE EDDGEDGDEG EEEEEAFPDP
110 120 130 140 150
SPPCPVPAGG GFYLVPTFSL PPALGRLERL GRVMVELEAL LPPPGAVPGG
160 170 180 190 200
SGVWVPGGRP PVVRGLVRVL NRSFEKAVHV RASHDGWATF CDHPARYVPR
210 220 230 240 250
SPPGAGVGGT GAGDPLLDPG LGLGPGQMSA SSPDDGGCTD RFAFQLPFAE
260 270 280 290 300
GASDGARLDF VVRYETPEGT FWANNHGRNY TVLLRIAPAP TPTDAEGLPQ
310 320 330 340 350
QQQLQQLEPQ PECQGPVEAE ARQLKSCMKP VRRRPFEEEP RMRSADDNTL
360 370 380 390 400
AEHPDVRESL GPLLAPTPLR PWPQMTLQVP EVMLTSNPQE EGDIPRSNPP
410 420 430 440 450
VAFTEVRQAP AIRILPATCG LGGPPRDQAS GPDASDRAAG SFLEPTQQQV
460 470 480 490 500
EAAWESGGGR KAPMVGALTD EPARGLEIVS GLDELLGEDT IDQELEQLYL
510 520 530 540 550
SHLSRLRAVA AAGGGEGTSP THALGILTDR DLILKWPGPE RALNSALAEE
560 570 580 590 600
ITLHYARLGC GVELIKDTED PDDEGEGEDG LSITPSSPEG GSPKESPPEI
610 620 630 640 650
LSGARSVIAT MGDVWVPWAE RSSSRCDSPV VLGTQGQFTE NPEKGMGKDT
660 670 680 690 700
KSLHLNRVIV GMSKSPGEAG TESQMEELPT ERESSWVPSS EKELPLPVQQ
710 720 730 740 750
EQSPALLGPT GTEVCLSSVA KPHVNSQEEE GGSLNLESPK RSPMPAAPAE
760 770 780 790
CACGLAPQLW GPLTQTLGVL AGLVMVPVAL NSGVSLLVLV LCLSLAWFS
Length:799
Mass (Da):84,120
Last modified:April 14, 2009 - v3
Checksum:iDF6572A80FECB7BC
GO
Isoform 2 (identifier: Q9JIG4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     377-377: L → LQ

Note: No experimental confirmation available.
Show »
Length:800
Mass (Da):84,249
Checksum:i377CBDE41376272D
GO

Sequence cautioni

The sequence AAF66954 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAH59275 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAM14759 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti266T → N in AAH59275 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_021363377L → LQ in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL731793 Genomic DNA Translation: CAM14759.1 Different initiation.
AL731793 Genomic DNA Translation: CAM14760.1
BC059275 mRNA Translation: AAH59275.1 Different initiation.
AF229644 mRNA Translation: AAF66954.2 Different initiation.
AK147873 mRNA Translation: BAE28194.1
CCDSiCCDS29964.2 [Q9JIG4-1]
CCDS72328.1 [Q9JIG4-2]
RefSeqiNP_613071.3, NM_138605.3 [Q9JIG4-1]
UniGeneiMm.148163

Genome annotation databases

EnsembliENSMUST00000115742; ENSMUSP00000111407; ENSMUSG00000039556 [Q9JIG4-1]
ENSMUST00000150787; ENSMUSP00000122903; ENSMUSG00000039556 [Q9JIG4-2]
GeneIDi54646
KEGGimmu:54646
UCSCiuc009slj.2 mouse [Q9JIG4-1]
uc057aqo.1 mouse [Q9JIG4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPPR3F_MOUSE
AccessioniPrimary (citable) accession number: Q9JIG4
Secondary accession number(s): B1AW09
, B1AW10, Q3UGL4, Q6PCL6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: April 14, 2009
Last modified: March 28, 2018
This is version 104 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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