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Q9JIF5

- PECR_CAVPO

UniProt

Q9JIF5 - PECR_CAVPO

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Protein

Peroxisomal trans-2-enoyl-CoA reductase

Gene

PECR

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Participates in chain elongation of fatty acids. Has no 2,4-dienoyl-CoA reductase activity.

Catalytic activityi

Acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH.1 Publication

Kineticsi

  1. KM=11 µM for decenoyl-CoA1 Publication
  2. KM=53 µM for NADPH1 Publication

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei178 – 1781Proton acceptorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi23 – 4725NADPBy similarityAdd
BLAST

GO - Molecular functioni

  1. trans-2-enoyl-CoA reductase (NADPH) activity Source: UniProtKB

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-UniPathway
  2. phytol metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

SABIO-RKQ9JIF5.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisomal trans-2-enoyl-CoA reductase (EC:1.3.1.38)
Gene namesi
Name:PECR
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
ProteomesiUP000005447: Unplaced

Subcellular locationi

Peroxisome 1 Publication

GO - Cellular componenti

  1. intracellular membrane-bounded organelle Source: UniProtKB
  2. mitochondrion Source: UniProtKB
  3. peroxisomal membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 302301Peroxisomal trans-2-enoyl-CoA reductasePRO_0000054739Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylglycineBy similarity
Modified residuei32 – 321N6-succinyllysineBy similarity
Modified residuei83 – 831N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Expressioni

Tissue specificityi

Expressed in liver.1 Publication

Interactioni

Subunit structurei

Interacts with PEX5, probably required to target it into peroxisomes.By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000010538.

Structurei

3D structure databases

ProteinModelPortaliQ9JIF5.
SMRiQ9JIF5. Positions 8-302.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi300 – 3023Microbody targeting signalBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
GeneTreeiENSGT00760000118868.
HOVERGENiHBG105268.
InParanoidiQ9JIF5.
OMAiNISSRAW.
OrthoDBiEOG7Q5HFK.
TreeFamiTF315256.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PRINTSiPR00081. GDHRDH.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JIF5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGSWTKCQSC LAPGLLQNRA AIVTGGGTGI GKAIAKELLH LGCNVVIASR
60 70 80 90 100
KFDRLRAAAE ELKATLPPSN KAEVTPIQCN IRKEEEVNNL MKSTLALYGK
110 120 130 140 150
IDFLVNNGGG QFWSSPEHIS SKGWHAVIET NLTGTFYMCK AAYNSWMKEH
160 170 180 190 200
GGAIVNIIIL LNGQPFVAHS GAARGGVYNL TKSLALGWAR SGIRINCVAP
210 220 230 240 250
GTVYSQTAMD NYGDMGKTLF ADAFQKIPAK RLGVPEEVSS LVCFLLSPAA
260 270 280 290 300
SFITGQLVNV DGGQSLYCQN HDIPDHDNWP EGVGDLSTVK KMKESFKQKA

KL
Length:302
Mass (Da):32,529
Last modified:October 1, 2000 - v1
Checksum:i9C1430D90D4C07C2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF232010 mRNA. Translation: AAF69799.1.
RefSeqiXP_003462124.1. XM_003462076.2.

Genome annotation databases

EnsembliENSCPOT00000011831; ENSCPOP00000010538; ENSCPOG00000011717.
GeneIDi100725791.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF232010 mRNA. Translation: AAF69799.1 .
RefSeqi XP_003462124.1. XM_003462076.2.

3D structure databases

ProteinModelPortali Q9JIF5.
SMRi Q9JIF5. Positions 8-302.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10141.ENSCPOP00000010538.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSCPOT00000011831 ; ENSCPOP00000010538 ; ENSCPOG00000011717 .
GeneIDi 100725791.

Organism-specific databases

CTDi 55825.

Phylogenomic databases

eggNOGi COG1028.
GeneTreei ENSGT00760000118868.
HOVERGENi HBG105268.
InParanoidi Q9JIF5.
OMAi NISSRAW.
OrthoDBi EOG7Q5HFK.
TreeFami TF315256.

Enzyme and pathway databases

UniPathwayi UPA00094 .
SABIO-RK Q9JIF5.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PRINTSi PR00081. GDHRDH.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of mammalian peroxisomal trans-2-enoyl-coenzyme A reductase cDNAs."
    Das A.K., Uhler M.D., Hajra A.K.
    J. Biol. Chem. 275:24333-24340(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 92-118, ENZYME ACTIVITY, BIOPHYSICOCHEMICAL PROPERTIES, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    Tissue: Liver.

Entry informationi

Entry nameiPECR_CAVPO
AccessioniPrimary (citable) accession number: Q9JIF5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3