##gff-version 3 Q9JIF0 UniProtKB Chain 1 371 . . . ID=PRO_0000212322;Note=Protein arginine N-methyltransferase 1 Q9JIF0 UniProtKB Domain 50 371 . . . Note=SAM-dependent MTase PRMT-type;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU01015 Q9JIF0 UniProtKB Active site 162 162 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9JIF0 UniProtKB Active site 171 171 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q9JIF0 UniProtKB Binding site 63 63 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63009 Q9JIF0 UniProtKB Binding site 72 72 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63009 Q9JIF0 UniProtKB Binding site 96 96 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63009 Q9JIF0 UniProtKB Binding site 118 118 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63009 Q9JIF0 UniProtKB Binding site 147 147 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q63009 Q9JIF0 UniProtKB Modified residue 134 134 . . . Note=N6-succinyllysine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:23806337;Dbxref=PMID:23806337 Q9JIF0 UniProtKB Modified residue 228 228 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28883095;Dbxref=PMID:28883095 Q9JIF0 UniProtKB Modified residue 233 233 . . . Note=N6-acetyllysine;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28883095;Dbxref=PMID:28883095 Q9JIF0 UniProtKB Modified residue 304 304 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99873 Q9JIF0 UniProtKB Modified residue 307 307 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q99873 Q9JIF0 UniProtKB Cross-link 145 145 . . . Note=Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin);Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28883095;Dbxref=PMID:28883095 Q9JIF0 UniProtKB Alternative sequence 1 29 . . . ID=VSP_005211;Note=In isoform 3. MAAAEAANCIMENFVATLANGMSLQPPLE->M;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q9JIF0 UniProtKB Alternative sequence 13 30 . . . ID=VSP_005210;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:10848611;Dbxref=PMID:10848611 Q9JIF0 UniProtKB Mutagenesis 98 98 . . . Note=Inhibits methionine-stimulated mTORC1signaling pathway. G->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:38006878;Dbxref=PMID:38006878 Q9JIF0 UniProtKB Mutagenesis 145 145 . . . Note=Increased stability of the protein caused by impaired ubiquitination by the SCF(FBXL17) complex. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28883095;Dbxref=PMID:28883095 Q9JIF0 UniProtKB Mutagenesis 162 162 . . . Note=Inhibits methionine-stimulated mTORC1 signaling pathway. E->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:38006878;Dbxref=PMID:38006878 Q9JIF0 UniProtKB Mutagenesis 212 212 . . . Note=Increased stability of the protein. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28883095;Dbxref=PMID:28883095 Q9JIF0 UniProtKB Mutagenesis 227 227 . . . Note=Slightly reduced degradation%2C probably caused by reduced ubiquitination by the SCF(FBXL17) complex. I->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28883095;Dbxref=PMID:28883095 Q9JIF0 UniProtKB Mutagenesis 228 228 . . . Note=Mimicks residue acetylation%3B impaired interaction with FBXL17%2C leading to decreased ubiquitination by the SCF(FBXL17) complex. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28883095;Dbxref=PMID:28883095 Q9JIF0 UniProtKB Mutagenesis 228 228 . . . Note=Increased interaction with FBXL17%2C leading to increased ubiquitination by the SCF(FBXL17) complex. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28883095;Dbxref=PMID:28883095 Q9JIF0 UniProtKB Mutagenesis 232 232 . . . Note=Slightly reduced degradation%2C probably caused by reduced ubiquitination by the SCF(FBXL17) complex. I->D;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28883095;Dbxref=PMID:28883095 Q9JIF0 UniProtKB Mutagenesis 233 233 . . . Note=Mimicks residue acetylation%3B increased interaction with FBXL17%2C leading to increased ubiquitination by the SCF(FBXL17) complex. K->Q;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28883095;Dbxref=PMID:28883095 Q9JIF0 UniProtKB Mutagenesis 233 233 . . . Note=Impaired interaction with FBXL17%2C leading to decreased ubiquitination by the SCF(FBXL17) complex. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28883095;Dbxref=PMID:28883095 Q9JIF0 UniProtKB Mutagenesis 356 356 . . . Note=Increased stability of the protein. K->R;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:28883095;Dbxref=PMID:28883095