ID TSLP_MOUSE Reviewed; 140 AA. AC Q9JIE6; DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot. DT 01-OCT-2000, sequence version 1. DT 27-MAR-2024, entry version 115. DE RecName: Full=Thymic stromal lymphopoietin; DE AltName: Full=Thymic stroma-derived lymphopoietin; DE Flags: Precursor; GN Name=Tslp; OS Mus musculus (Mouse). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; OC Murinae; Mus; Mus. OX NCBI_TaxID=10090; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND FUNCTION. RC STRAIN=BALB/cJ; RX PubMed=10974033; DOI=10.1084/jem.192.5.671; RA Sims J.E., Williams D.E., Morrissey P.J., Garka K., Foxworthe D., Price V., RA Friend S.L., Farr A., Bedell M.A., Jenkins N.A., Copeland N.G., RA Grabstein K., Paxton R.J.; RT "Molecular cloning and biological characterization of a novel murine RT lymphoid growth factor."; RL J. Exp. Med. 192:671-680(2000). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [3] RP X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 20-140 IN COMPLEX WITH IL7R AND RP CRLF2, SUBUNIT, AND DISULFIDE BONDS. RX PubMed=24632570; DOI=10.1038/nsmb.2794; RA Verstraete K., van Schie L., Vyncke L., Bloch Y., Tavernier J., Pauwels E., RA Peelman F., Savvides S.N.; RT "Structural basis of the proinflammatory signaling complex mediated by RT TSLP."; RL Nat. Struct. Mol. Biol. 21:375-382(2014). CC -!- FUNCTION: Cytokine that induces the release of T-cell-attracting CC chemokines from monocytes and, in particular, enhances the maturation CC of CD11c(+) dendritic cells. Can induce allergic inflammation by CC directly activating mast cells (By similarity). {ECO:0000250, CC ECO:0000269|PubMed:10974033}. CC -!- SUBUNIT: Interacts with a receptor composed of CRLF2 and IL7R. Binding CC of TSLP to CRLF2/TSLPR is a mechanistic prerequisite for recruitment of CC IL7R to the high-affinity ternary complex. CC {ECO:0000269|PubMed:24632570}. CC -!- INTERACTION: CC Q9JIE6; Q8CII9: Crlf2; NbExp=9; IntAct=EBI-16096402, EBI-15887886; CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10974033}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF232937; AAF81677.1; -; mRNA. DR EMBL; BC130230; AAI30231.1; -; mRNA. DR CCDS; CCDS29121.1; -. DR RefSeq; NP_067342.1; NM_021367.2. DR PDB; 4NN5; X-ray; 1.90 A; A=20-140. DR PDB; 4NN6; X-ray; 2.54 A; A=20-140. DR PDB; 4NN7; X-ray; 3.78 A; A=20-140. DR PDBsum; 4NN5; -. DR PDBsum; 4NN6; -. DR PDBsum; 4NN7; -. DR AlphaFoldDB; Q9JIE6; -. DR SMR; Q9JIE6; -. DR DIP; DIP-60842N; -. DR IntAct; Q9JIE6; 2. DR STRING; 10090.ENSMUSP00000025237; -. DR GlyCosmos; Q9JIE6; 3 sites, No reported glycans. DR GlyGen; Q9JIE6; 3 sites. DR PhosphoSitePlus; Q9JIE6; -. DR PaxDb; 10090-ENSMUSP00000025237; -. DR Antibodypedia; 25309; 886 antibodies from 42 providers. DR DNASU; 53603; -. DR Ensembl; ENSMUST00000025237.5; ENSMUSP00000025237.4; ENSMUSG00000024379.5. DR GeneID; 53603; -. DR KEGG; mmu:53603; -. DR UCSC; uc008ejl.2; mouse. DR AGR; MGI:1855696; -. DR CTD; 85480; -. DR MGI; MGI:1855696; Tslp. DR VEuPathDB; HostDB:ENSMUSG00000024379; -. DR eggNOG; ENOG502TEM0; Eukaryota. DR GeneTree; ENSGT00390000012541; -. DR HOGENOM; CLU_143224_0_0_1; -. DR InParanoid; Q9JIE6; -. DR OMA; CLEQVSY; -. DR OrthoDB; 4835294at2759; -. DR PhylomeDB; Q9JIE6; -. DR TreeFam; TF338216; -. DR Reactome; R-MMU-1266695; Interleukin-7 signaling. DR BioGRID-ORCS; 53603; 1 hit in 75 CRISPR screens. DR PRO; PR:Q9JIE6; -. DR Proteomes; UP000000589; Chromosome 18. DR RNAct; Q9JIE6; Protein. DR Bgee; ENSMUSG00000024379; Expressed in ureter smooth muscle and 77 other cell types or tissues. DR GO; GO:0005576; C:extracellular region; ISO:MGI. DR GO; GO:0005615; C:extracellular space; IDA:UniProt. DR GO; GO:0005125; F:cytokine activity; IDA:MGI. DR GO; GO:0005139; F:interleukin-7 receptor binding; ISO:MGI. DR GO; GO:0061844; P:antimicrobial humoral immune response mediated by antimicrobial peptide; ISO:MGI. DR GO; GO:0050832; P:defense response to fungus; ISO:MGI. DR GO; GO:0050829; P:defense response to Gram-negative bacterium; ISO:MGI. DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:MGI. DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI. DR GO; GO:0071654; P:positive regulation of chemokine (C-C motif) ligand 1 production; ISO:MGI. DR GO; GO:0032722; P:positive regulation of chemokine production; ISO:MGI. DR GO; GO:0001961; P:positive regulation of cytokine-mediated signaling pathway; ISO:MGI. DR GO; GO:0071657; P:positive regulation of granulocyte colony-stimulating factor production; ISO:MGI. DR GO; GO:0050729; P:positive regulation of inflammatory response; ISO:MGI. DR GO; GO:0032733; P:positive regulation of interleukin-10 production; ISO:MGI. DR GO; GO:0032736; P:positive regulation of interleukin-13 production; ISO:MGI. DR GO; GO:0032754; P:positive regulation of interleukin-5 production; ISO:MGI. DR GO; GO:0032755; P:positive regulation of interleukin-6 production; ISO:MGI. DR GO; GO:0033005; P:positive regulation of mast cell activation; ISO:MGI. DR GO; GO:1904894; P:positive regulation of receptor signaling pathway via STAT; ISO:MGI. DR GO; GO:0042531; P:positive regulation of tyrosine phosphorylation of STAT protein; ISO:MGI. DR Gene3D; 1.20.1250.90; Thymic stromal lymphopoietin; 1. DR InterPro; IPR029189; TSLP. DR InterPro; IPR038329; TSLP_sf. DR PANTHER; PTHR38003; THYMIC STROMAL LYMPHOPOIETIN; 1. DR PANTHER; PTHR38003:SF1; THYMIC STROMAL LYMPHOPOIETIN; 1. DR Pfam; PF15216; TSLP; 1. DR Genevisible; Q9JIE6; MM. PE 1: Evidence at protein level; KW 3D-structure; Cytokine; Disulfide bond; Glycoprotein; Reference proteome; KW Secreted; Signal. FT SIGNAL 1..19 FT /evidence="ECO:0000255" FT CHAIN 20..140 FT /note="Thymic stromal lymphopoietin" FT /id="PRO_0000300874" FT SITE 37 FT /note="Inserts into a conserved IL7R hydrophobic pocket, FT important for IL7R-binding" FT /evidence="ECO:0000269|PubMed:24632570" FT CARBOHYD 21 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 26 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT CARBOHYD 123 FT /note="N-linked (GlcNAc...) asparagine" FT /evidence="ECO:0000255" FT DISULFID 25..98 FT /evidence="ECO:0000269|PubMed:24632570" FT DISULFID 57..63 FT /evidence="ECO:0000269|PubMed:24632570" FT DISULFID 78..121 FT /evidence="ECO:0000269|PubMed:24632570" FT HELIX 22..24 FT /evidence="ECO:0007829|PDB:4NN5" FT HELIX 27..36 FT /evidence="ECO:0007829|PDB:4NN5" FT HELIX 38..46 FT /evidence="ECO:0007829|PDB:4NN5" FT HELIX 60..72 FT /evidence="ECO:0007829|PDB:4NN5" FT HELIX 81..83 FT /evidence="ECO:0007829|PDB:4NN5" FT HELIX 85..97 FT /evidence="ECO:0007829|PDB:4NN5" FT HELIX 118..137 FT /evidence="ECO:0007829|PDB:4NN5" SQ SEQUENCE 140 AA; 16152 MW; 5B6D3196E73BAA8B CRC64; MVLLRSLFIL QVLVRMGLTY NFSNCNFTSI TKIYCNIIFH DLTGDLKGAK FEQIEDCESK PACLLKIEYY TLNPIPGCPS LPDKTFARRT REALNDHCPG YPETERNDGT QEMAQEVQNI CLNQTSQILR LWYSFMQSPE //