SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9JIE6

- TSLP_MOUSE

UniProt

Q9JIE6 - TSLP_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Thymic stromal lymphopoietin
Gene
Tslp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells By similarity.1 Publication

GO - Molecular functioni

  1. cytokine activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Thymic stromal lymphopoietin
Alternative name(s):
Thymic stroma-derived lymphopoietin
Gene namesi
Name:Tslp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1855696. Tslp.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 Reviewed prediction
Add
BLAST
Chaini20 – 140121Thymic stromal lymphopoietin
PRO_0000300874Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi26 – 261N-linked (GlcNAc...) Reviewed prediction
Glycosylationi123 – 1231N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9JIE6.

PTM databases

PhosphoSiteiQ9JIE6.

Expressioni

Gene expression databases

BgeeiQ9JIE6.
CleanExiMM_TSLP.
GenevestigatoriQ9JIE6.

Interactioni

Subunit structurei

Interacts with a receptor composed of CRLF2 and IL7R.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000025237.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi22 – 243
Helixi27 – 3610
Helixi38 – 469
Helixi60 – 7213
Helixi81 – 833
Helixi85 – 9713
Helixi118 – 13720

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NN5X-ray1.90A20-140[»]
4NN6X-ray2.54A20-140[»]
4NN7X-ray3.78A20-140[»]
ProteinModelPortaliQ9JIE6.
SMRiQ9JIE6. Positions 20-140.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42670.
GeneTreeiENSGT00390000012541.
HOGENOMiHOG000154693.
HOVERGENiHBG094875.
InParanoidiQ9JIE6.
KOiK05436.
OMAiDFTNCDF.
OrthoDBiEOG7R56W9.
PhylomeDBiQ9JIE6.
TreeFamiTF338216.

Family and domain databases

InterProiIPR029189. TSLP.
[Graphical view]
PfamiPF15216. TSLP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JIE6-1 [UniParc]FASTAAdd to Basket

« Hide

MVLLRSLFIL QVLVRMGLTY NFSNCNFTSI TKIYCNIIFH DLTGDLKGAK    50
FEQIEDCESK PACLLKIEYY TLNPIPGCPS LPDKTFARRT REALNDHCPG 100
YPETERNDGT QEMAQEVQNI CLNQTSQILR LWYSFMQSPE 140
Length:140
Mass (Da):16,152
Last modified:October 1, 2000 - v1
Checksum:i5B6D3196E73BAA8B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF232937 mRNA. Translation: AAF81677.1.
BC130230 mRNA. Translation: AAI30231.1.
CCDSiCCDS29121.1.
RefSeqiNP_067342.1. NM_021367.2.
UniGeneiMm.143716.

Genome annotation databases

EnsembliENSMUST00000025237; ENSMUSP00000025237; ENSMUSG00000024379.
GeneIDi53603.
KEGGimmu:53603.
UCSCiuc008ejl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF232937 mRNA. Translation: AAF81677.1 .
BC130230 mRNA. Translation: AAI30231.1 .
CCDSi CCDS29121.1.
RefSeqi NP_067342.1. NM_021367.2.
UniGenei Mm.143716.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4NN5 X-ray 1.90 A 20-140 [» ]
4NN6 X-ray 2.54 A 20-140 [» ]
4NN7 X-ray 3.78 A 20-140 [» ]
ProteinModelPortali Q9JIE6.
SMRi Q9JIE6. Positions 20-140.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000025237.

PTM databases

PhosphoSitei Q9JIE6.

Proteomic databases

PRIDEi Q9JIE6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025237 ; ENSMUSP00000025237 ; ENSMUSG00000024379 .
GeneIDi 53603.
KEGGi mmu:53603.
UCSCi uc008ejl.2. mouse.

Organism-specific databases

CTDi 85480.
MGIi MGI:1855696. Tslp.

Phylogenomic databases

eggNOGi NOG42670.
GeneTreei ENSGT00390000012541.
HOGENOMi HOG000154693.
HOVERGENi HBG094875.
InParanoidi Q9JIE6.
KOi K05436.
OMAi DFTNCDF.
OrthoDBi EOG7R56W9.
PhylomeDBi Q9JIE6.
TreeFami TF338216.

Miscellaneous databases

NextBioi 310289.
PROi Q9JIE6.
SOURCEi Search...

Gene expression databases

Bgeei Q9JIE6.
CleanExi MM_TSLP.
Genevestigatori Q9JIE6.

Family and domain databases

InterProi IPR029189. TSLP.
[Graphical view ]
Pfami PF15216. TSLP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, FUNCTION.
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTSLP_MOUSE
AccessioniPrimary (citable) accession number: Q9JIE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3