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Q9JIE6

- TSLP_MOUSE

UniProt

Q9JIE6 - TSLP_MOUSE

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Protein

Thymic stromal lymphopoietin

Gene

Tslp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity).By similarity

GO - Molecular functioni

  1. cytokine activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Thymic stromal lymphopoietin
Alternative name(s):
Thymic stroma-derived lymphopoietin
Gene namesi
Name:Tslp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:1855696. Tslp.

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular space Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence AnalysisAdd
BLAST
Chaini20 – 140121Thymic stromal lymphopoietinPRO_0000300874Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ9JIE6.

PTM databases

PhosphoSiteiQ9JIE6.

Expressioni

Gene expression databases

BgeeiQ9JIE6.
CleanExiMM_TSLP.
GenevestigatoriQ9JIE6.

Interactioni

Subunit structurei

Interacts with a receptor composed of CRLF2 and IL7R.

Protein-protein interaction databases

DIPiDIP-60842N.
STRINGi10090.ENSMUSP00000025237.

Structurei

Secondary structure

1
140
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi22 – 243Combined sources
Helixi27 – 3610Combined sources
Helixi38 – 469Combined sources
Helixi60 – 7213Combined sources
Helixi81 – 833Combined sources
Helixi85 – 9713Combined sources
Helixi118 – 13720Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4NN5X-ray1.90A20-140[»]
4NN6X-ray2.54A20-140[»]
4NN7X-ray3.78A20-140[»]
ProteinModelPortaliQ9JIE6.
SMRiQ9JIE6. Positions 20-140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG42670.
GeneTreeiENSGT00390000012541.
HOGENOMiHOG000154693.
HOVERGENiHBG094875.
InParanoidiQ9JIE6.
KOiK05436.
OMAiDFTNCDF.
OrthoDBiEOG7R56W9.
PhylomeDBiQ9JIE6.
TreeFamiTF338216.

Family and domain databases

InterProiIPR029189. TSLP.
[Graphical view]
PfamiPF15216. TSLP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JIE6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLLRSLFIL QVLVRMGLTY NFSNCNFTSI TKIYCNIIFH DLTGDLKGAK
60 70 80 90 100
FEQIEDCESK PACLLKIEYY TLNPIPGCPS LPDKTFARRT REALNDHCPG
110 120 130 140
YPETERNDGT QEMAQEVQNI CLNQTSQILR LWYSFMQSPE
Length:140
Mass (Da):16,152
Last modified:October 1, 2000 - v1
Checksum:i5B6D3196E73BAA8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF232937 mRNA. Translation: AAF81677.1.
BC130230 mRNA. Translation: AAI30231.1.
CCDSiCCDS29121.1.
RefSeqiNP_067342.1. NM_021367.2.
UniGeneiMm.143716.

Genome annotation databases

EnsembliENSMUST00000025237; ENSMUSP00000025237; ENSMUSG00000024379.
GeneIDi53603.
KEGGimmu:53603.
UCSCiuc008ejl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF232937 mRNA. Translation: AAF81677.1 .
BC130230 mRNA. Translation: AAI30231.1 .
CCDSi CCDS29121.1.
RefSeqi NP_067342.1. NM_021367.2.
UniGenei Mm.143716.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4NN5 X-ray 1.90 A 20-140 [» ]
4NN6 X-ray 2.54 A 20-140 [» ]
4NN7 X-ray 3.78 A 20-140 [» ]
ProteinModelPortali Q9JIE6.
SMRi Q9JIE6. Positions 20-140.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

DIPi DIP-60842N.
STRINGi 10090.ENSMUSP00000025237.

PTM databases

PhosphoSitei Q9JIE6.

Proteomic databases

PRIDEi Q9JIE6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025237 ; ENSMUSP00000025237 ; ENSMUSG00000024379 .
GeneIDi 53603.
KEGGi mmu:53603.
UCSCi uc008ejl.2. mouse.

Organism-specific databases

CTDi 85480.
MGIi MGI:1855696. Tslp.

Phylogenomic databases

eggNOGi NOG42670.
GeneTreei ENSGT00390000012541.
HOGENOMi HOG000154693.
HOVERGENi HBG094875.
InParanoidi Q9JIE6.
KOi K05436.
OMAi DFTNCDF.
OrthoDBi EOG7R56W9.
PhylomeDBi Q9JIE6.
TreeFami TF338216.

Miscellaneous databases

NextBioi 310289.
PROi Q9JIE6.
SOURCEi Search...

Gene expression databases

Bgeei Q9JIE6.
CleanExi MM_TSLP.
Genevestigatori Q9JIE6.

Family and domain databases

InterProi IPR029189. TSLP.
[Graphical view ]
Pfami PF15216. TSLP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, FUNCTION.
    Strain: BALB/c.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiTSLP_MOUSE
AccessioniPrimary (citable) accession number: Q9JIE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

External Data

Dasty 3