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Protein

Thymic stromal lymphopoietin

Gene

Tslp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei37Inserts into a conserved IL7R hydrophobic pocket, important for IL7R-binding1 Publication1

GO - Molecular functioni

  • cytokine activity Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Thymic stromal lymphopoietin
Alternative name(s):
Thymic stroma-derived lymphopoietin
Gene namesi
Name:Tslp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1855696. Tslp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000030087420 – 140Thymic stromal lymphopoietinAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi25 ↔ 981 Publication
Glycosylationi26N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi57 ↔ 631 Publication
Disulfide bondi78 ↔ 1211 Publication
Glycosylationi123N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JIE6.
PRIDEiQ9JIE6.

PTM databases

PhosphoSitePlusiQ9JIE6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024379.
CleanExiMM_TSLP.
GenevisibleiQ9JIE6. MM.

Interactioni

Subunit structurei

Interacts with a receptor composed of CRLF2 and IL7R. Binding of TSLP to CRLF2/TSLPR is a mechanistic prerequisite for recruitment of IL7R to the high-affinity ternary complex.1 Publication

GO - Molecular functioni

  • cytokine activity Source: MGI

Protein-protein interaction databases

DIPiDIP-60842N.
STRINGi10090.ENSMUSP00000025237.

Structurei

Secondary structure

1140
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi22 – 24Combined sources3
Helixi27 – 36Combined sources10
Helixi38 – 46Combined sources9
Helixi60 – 72Combined sources13
Helixi81 – 83Combined sources3
Helixi85 – 97Combined sources13
Helixi118 – 137Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NN5X-ray1.90A20-140[»]
4NN6X-ray2.54A20-140[»]
4NN7X-ray3.78A20-140[»]
ProteinModelPortaliQ9JIE6.
SMRiQ9JIE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J13Z. Eukaryota.
ENOG4111BHG. LUCA.
GeneTreeiENSGT00390000012541.
HOGENOMiHOG000154693.
HOVERGENiHBG094875.
InParanoidiQ9JIE6.
KOiK05436.
OMAiTYDFTNC.
OrthoDBiEOG091G12VL.
PhylomeDBiQ9JIE6.
TreeFamiTF338216.

Family and domain databases

InterProiIPR029189. TSLP.
[Graphical view]
PfamiPF15216. TSLP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JIE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLRSLFIL QVLVRMGLTY NFSNCNFTSI TKIYCNIIFH DLTGDLKGAK
60 70 80 90 100
FEQIEDCESK PACLLKIEYY TLNPIPGCPS LPDKTFARRT REALNDHCPG
110 120 130 140
YPETERNDGT QEMAQEVQNI CLNQTSQILR LWYSFMQSPE
Length:140
Mass (Da):16,152
Last modified:October 1, 2000 - v1
Checksum:i5B6D3196E73BAA8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF232937 mRNA. Translation: AAF81677.1.
BC130230 mRNA. Translation: AAI30231.1.
CCDSiCCDS29121.1.
RefSeqiNP_067342.1. NM_021367.2.
UniGeneiMm.143716.

Genome annotation databases

EnsembliENSMUST00000025237; ENSMUSP00000025237; ENSMUSG00000024379.
GeneIDi53603.
KEGGimmu:53603.
UCSCiuc008ejl.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF232937 mRNA. Translation: AAF81677.1.
BC130230 mRNA. Translation: AAI30231.1.
CCDSiCCDS29121.1.
RefSeqiNP_067342.1. NM_021367.2.
UniGeneiMm.143716.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NN5X-ray1.90A20-140[»]
4NN6X-ray2.54A20-140[»]
4NN7X-ray3.78A20-140[»]
ProteinModelPortaliQ9JIE6.
SMRiQ9JIE6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60842N.
STRINGi10090.ENSMUSP00000025237.

PTM databases

PhosphoSitePlusiQ9JIE6.

Proteomic databases

PaxDbiQ9JIE6.
PRIDEiQ9JIE6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000025237; ENSMUSP00000025237; ENSMUSG00000024379.
GeneIDi53603.
KEGGimmu:53603.
UCSCiuc008ejl.2. mouse.

Organism-specific databases

CTDi85480.
MGIiMGI:1855696. Tslp.

Phylogenomic databases

eggNOGiENOG410J13Z. Eukaryota.
ENOG4111BHG. LUCA.
GeneTreeiENSGT00390000012541.
HOGENOMiHOG000154693.
HOVERGENiHBG094875.
InParanoidiQ9JIE6.
KOiK05436.
OMAiTYDFTNC.
OrthoDBiEOG091G12VL.
PhylomeDBiQ9JIE6.
TreeFamiTF338216.

Miscellaneous databases

PROiQ9JIE6.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024379.
CleanExiMM_TSLP.
GenevisibleiQ9JIE6. MM.

Family and domain databases

InterProiIPR029189. TSLP.
[Graphical view]
PfamiPF15216. TSLP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTSLP_MOUSE
AccessioniPrimary (citable) accession number: Q9JIE6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.