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Q9JIE6 (TSLP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymic stromal lymphopoietin
Alternative name(s):
Thymic stroma-derived lymphopoietin
Gene names
Name:Tslp
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length140 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells By similarity. Ref.1

Subunit structure

Interacts with a receptor composed of CRLF2 and IL7R.

Subcellular location

Secreted Ref.1.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMGlycoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentextracellular space

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functioncytokine activity

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 140121Thymic stromal lymphopoietin
PRO_0000300874

Amino acid modifications

Glycosylation211N-linked (GlcNAc...) Potential
Glycosylation261N-linked (GlcNAc...) Potential
Glycosylation1231N-linked (GlcNAc...) Potential

Secondary structure

............... 140
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9JIE6 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 5B6D3196E73BAA8B

FASTA14016,152
        10         20         30         40         50         60 
MVLLRSLFIL QVLVRMGLTY NFSNCNFTSI TKIYCNIIFH DLTGDLKGAK FEQIEDCESK 

        70         80         90        100        110        120 
PACLLKIEYY TLNPIPGCPS LPDKTFARRT REALNDHCPG YPETERNDGT QEMAQEVQNI 

       130        140 
CLNQTSQILR LWYSFMQSPE 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning and biological characterization of a novel murine lymphoid growth factor."
Sims J.E., Williams D.E., Morrissey P.J., Garka K., Foxworthe D., Price V., Friend S.L., Farr A., Bedell M.A., Jenkins N.A., Copeland N.G., Grabstein K., Paxton R.J.
J. Exp. Med. 192:671-680(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, FUNCTION.
Strain: BALB/c.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF232937 mRNA. Translation: AAF81677.1.
BC130230 mRNA. Translation: AAI30231.1.
CCDSCCDS29121.1.
RefSeqNP_067342.1. NM_021367.2.
UniGeneMm.143716.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4NN5X-ray1.90A20-140[»]
4NN6X-ray2.54A20-140[»]
4NN7X-ray3.78A20-140[»]
ProteinModelPortalQ9JIE6.
SMRQ9JIE6. Positions 20-140.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000025237.

PTM databases

PhosphoSiteQ9JIE6.

Proteomic databases

PRIDEQ9JIE6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000025237; ENSMUSP00000025237; ENSMUSG00000024379.
GeneID53603.
KEGGmmu:53603.
UCSCuc008ejl.2. mouse.

Organism-specific databases

CTD85480.
MGIMGI:1855696. Tslp.

Phylogenomic databases

eggNOGNOG42670.
GeneTreeENSGT00390000012541.
HOGENOMHOG000154693.
HOVERGENHBG094875.
InParanoidQ9JIE6.
KOK05436.
OMADFTNCDF.
OrthoDBEOG7R56W9.
PhylomeDBQ9JIE6.
TreeFamTF338216.

Gene expression databases

BgeeQ9JIE6.
CleanExMM_TSLP.
GenevestigatorQ9JIE6.

Family and domain databases

InterProIPR029189. TSLP.
[Graphical view]
PfamPF15216. TSLP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio310289.
PROQ9JIE6.
SOURCESearch...

Entry information

Entry nameTSLP_MOUSE
AccessionPrimary (citable) accession number: Q9JIE6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot