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Q9JIE6

- TSLP_MOUSE

UniProt

Q9JIE6 - TSLP_MOUSE

Protein

Thymic stromal lymphopoietin

Gene

Tslp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells By similarity.By similarity

    GO - Molecular functioni

    1. cytokine activity Source: MGI

    Keywords - Molecular functioni

    Cytokine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymic stromal lymphopoietin
    Alternative name(s):
    Thymic stroma-derived lymphopoietin
    Gene namesi
    Name:Tslp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:1855696. Tslp.

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular space Source: UniProtKB-KW

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Sequence AnalysisAdd
    BLAST
    Chaini20 – 140121Thymic stromal lymphopoietinPRO_0000300874Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi21 – 211N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi26 – 261N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi123 – 1231N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ9JIE6.

    PTM databases

    PhosphoSiteiQ9JIE6.

    Expressioni

    Gene expression databases

    BgeeiQ9JIE6.
    CleanExiMM_TSLP.
    GenevestigatoriQ9JIE6.

    Interactioni

    Subunit structurei

    Interacts with a receptor composed of CRLF2 and IL7R.

    Protein-protein interaction databases

    DIPiDIP-60842N.
    STRINGi10090.ENSMUSP00000025237.

    Structurei

    Secondary structure

    1
    140
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi22 – 243
    Helixi27 – 3610
    Helixi38 – 469
    Helixi60 – 7213
    Helixi81 – 833
    Helixi85 – 9713
    Helixi118 – 13720

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4NN5X-ray1.90A20-140[»]
    4NN6X-ray2.54A20-140[»]
    4NN7X-ray3.78A20-140[»]
    ProteinModelPortaliQ9JIE6.
    SMRiQ9JIE6. Positions 20-140.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG42670.
    GeneTreeiENSGT00390000012541.
    HOGENOMiHOG000154693.
    HOVERGENiHBG094875.
    InParanoidiQ9JIE6.
    KOiK05436.
    OMAiDFTNCDF.
    OrthoDBiEOG7R56W9.
    PhylomeDBiQ9JIE6.
    TreeFamiTF338216.

    Family and domain databases

    InterProiIPR029189. TSLP.
    [Graphical view]
    PfamiPF15216. TSLP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JIE6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVLLRSLFIL QVLVRMGLTY NFSNCNFTSI TKIYCNIIFH DLTGDLKGAK    50
    FEQIEDCESK PACLLKIEYY TLNPIPGCPS LPDKTFARRT REALNDHCPG 100
    YPETERNDGT QEMAQEVQNI CLNQTSQILR LWYSFMQSPE 140
    Length:140
    Mass (Da):16,152
    Last modified:October 1, 2000 - v1
    Checksum:i5B6D3196E73BAA8B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF232937 mRNA. Translation: AAF81677.1.
    BC130230 mRNA. Translation: AAI30231.1.
    CCDSiCCDS29121.1.
    RefSeqiNP_067342.1. NM_021367.2.
    UniGeneiMm.143716.

    Genome annotation databases

    EnsembliENSMUST00000025237; ENSMUSP00000025237; ENSMUSG00000024379.
    GeneIDi53603.
    KEGGimmu:53603.
    UCSCiuc008ejl.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF232937 mRNA. Translation: AAF81677.1 .
    BC130230 mRNA. Translation: AAI30231.1 .
    CCDSi CCDS29121.1.
    RefSeqi NP_067342.1. NM_021367.2.
    UniGenei Mm.143716.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4NN5 X-ray 1.90 A 20-140 [» ]
    4NN6 X-ray 2.54 A 20-140 [» ]
    4NN7 X-ray 3.78 A 20-140 [» ]
    ProteinModelPortali Q9JIE6.
    SMRi Q9JIE6. Positions 20-140.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60842N.
    STRINGi 10090.ENSMUSP00000025237.

    PTM databases

    PhosphoSitei Q9JIE6.

    Proteomic databases

    PRIDEi Q9JIE6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025237 ; ENSMUSP00000025237 ; ENSMUSG00000024379 .
    GeneIDi 53603.
    KEGGi mmu:53603.
    UCSCi uc008ejl.2. mouse.

    Organism-specific databases

    CTDi 85480.
    MGIi MGI:1855696. Tslp.

    Phylogenomic databases

    eggNOGi NOG42670.
    GeneTreei ENSGT00390000012541.
    HOGENOMi HOG000154693.
    HOVERGENi HBG094875.
    InParanoidi Q9JIE6.
    KOi K05436.
    OMAi DFTNCDF.
    OrthoDBi EOG7R56W9.
    PhylomeDBi Q9JIE6.
    TreeFami TF338216.

    Miscellaneous databases

    NextBioi 310289.
    PROi Q9JIE6.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JIE6.
    CleanExi MM_TSLP.
    Genevestigatori Q9JIE6.

    Family and domain databases

    InterProi IPR029189. TSLP.
    [Graphical view ]
    Pfami PF15216. TSLP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, FUNCTION.
      Strain: BALB/c.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiTSLP_MOUSE
    AccessioniPrimary (citable) accession number: Q9JIE6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references

    External Data

    Dasty 3