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Protein

Thymic stromal lymphopoietin

Gene

Tslp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Cytokine that induces the release of T-cell-attracting chemokines from monocytes and, in particular, enhances the maturation of CD11c+ dendritic cells. Can induce allergic inflammation by directly activating mast cells (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei37Inserts into a conserved IL7R hydrophobic pocket, important for IL7R-binding1 Publication1

GO - Molecular functioni

  • cytokine activity Source: MGI

Keywordsi

Molecular functionCytokine

Names & Taxonomyi

Protein namesi
Recommended name:
Thymic stromal lymphopoietin
Alternative name(s):
Thymic stroma-derived lymphopoietin
Gene namesi
Name:Tslp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1855696. Tslp.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000030087420 – 140Thymic stromal lymphopoietinAdd BLAST121

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi25 ↔ 981 Publication
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi57 ↔ 631 Publication
Disulfide bondi78 ↔ 1211 Publication
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JIE6.
PRIDEiQ9JIE6.

PTM databases

PhosphoSitePlusiQ9JIE6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024379.
CleanExiMM_TSLP.
GenevisibleiQ9JIE6. MM.

Interactioni

Subunit structurei

Interacts with a receptor composed of CRLF2 and IL7R. Binding of TSLP to CRLF2/TSLPR is a mechanistic prerequisite for recruitment of IL7R to the high-affinity ternary complex.1 Publication

GO - Molecular functioni

  • cytokine activity Source: MGI

Protein-protein interaction databases

DIPiDIP-60842N.
STRINGi10090.ENSMUSP00000025237.

Structurei

Secondary structure

1140
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi22 – 24Combined sources3
Helixi27 – 36Combined sources10
Helixi38 – 46Combined sources9
Helixi60 – 72Combined sources13
Helixi81 – 83Combined sources3
Helixi85 – 97Combined sources13
Helixi118 – 137Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4NN5X-ray1.90A20-140[»]
4NN6X-ray2.54A20-140[»]
4NN7X-ray3.78A20-140[»]
ProteinModelPortaliQ9JIE6.
SMRiQ9JIE6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J13Z. Eukaryota.
ENOG4111BHG. LUCA.
GeneTreeiENSGT00390000012541.
HOGENOMiHOG000154693.
HOVERGENiHBG094875.
InParanoidiQ9JIE6.
KOiK05436.
OMAiCLEQVSQ.
OrthoDBiEOG091G12VL.
PhylomeDBiQ9JIE6.
TreeFamiTF338216.

Family and domain databases

InterProiView protein in InterPro
IPR029189. TSLP.
PfamiView protein in Pfam
PF15216. TSLP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JIE6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLRSLFIL QVLVRMGLTY NFSNCNFTSI TKIYCNIIFH DLTGDLKGAK
60 70 80 90 100
FEQIEDCESK PACLLKIEYY TLNPIPGCPS LPDKTFARRT REALNDHCPG
110 120 130 140
YPETERNDGT QEMAQEVQNI CLNQTSQILR LWYSFMQSPE
Length:140
Mass (Da):16,152
Last modified:October 1, 2000 - v1
Checksum:i5B6D3196E73BAA8B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF232937 mRNA. Translation: AAF81677.1.
BC130230 mRNA. Translation: AAI30231.1.
CCDSiCCDS29121.1.
RefSeqiNP_067342.1. NM_021367.2.
UniGeneiMm.143716.

Genome annotation databases

EnsembliENSMUST00000025237; ENSMUSP00000025237; ENSMUSG00000024379.
GeneIDi53603.
KEGGimmu:53603.
UCSCiuc008ejl.2. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTSLP_MOUSE
AccessioniPrimary (citable) accession number: Q9JIE6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: October 1, 2000
Last modified: June 7, 2017
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references