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Q9JID6 (ACSL1_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Long-chain-fatty-acid--CoA ligase 1

EC=6.2.1.3
Alternative name(s):
Long-chain acyl-CoA synthetase 1
Short name=LACS 1
Palmitoyl-CoA ligase
Gene names
Name:ACSL1
Synonyms:FACL1, LACS1
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Protein attributes

Sequence length698 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate By similarity.

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Cofactor

Magnesium By similarity.

Subcellular location

Microsome membrane; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein By similarity. Peroxisome membrane; Peripheral membrane protein By similarity. Endoplasmic reticulum membrane; Peripheral membrane protein By similarity.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 698698Long-chain-fatty-acid--CoA ligase 1
PRO_0000193103

Amino acid modifications

Modified residue11N-acetylmethionine By similarity
Modified residue91Nitrated tyrosine By similarity
Modified residue841Phosphotyrosine By similarity
Modified residue3561N6-acetyllysine By similarity
Modified residue3861N6-acetyllysine By similarity
Modified residue6201Phosphoserine By similarity
Modified residue6321N6-acetyllysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JID6 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: CF8CB413209476AD

FASTA69877,698
        10         20         30         40         50         60 
MQAHELLQYF RLPELVDIRQ YVRTLPTNTL MGFGAFAALT TFWYATRPKA LKPPCDLSMQ 

        70         80         90        100        110        120 
SVEVAGSDGA RRSTLLDSDE PLVYFYDDVR TLYDVFQRGI QVSNNGPCLG SRKPDQPYEW 

       130        140        150        160        170        180 
LSYKQVEDLS ECIGSALLQK GFQASPDQFI GIFAQNRPEW VIIEQACFAY SMVVVPLYDT 

       190        200        210        220        230        240 
LGADAITYIV NKAELSVIFA DKPEKARILL ESVENKLTPG LKIIVVMDSY GSELVEQGKK 

       250        260        270        280        290        300 
CGVEVISLKA MEGLGRANRR KPKPPEPDDL AVICFTSGTT GNPKGAMITH KNVVSDCSAF 

       310        320        330        340        350        360 
VKATEKALVL NASDIHISFL PLAHMYEQLL QCVMLCHGAK IGFFQGDIRL LMDDLKALQP 

       370        380        390        400        410        420 
TIFPVVPRLL NRMFDRIFAQ ANTTVKRWLL DFASKRKEAE LRSGIIRNNS VWDKLIFHKI 

       430        440        450        460        470        480 
QSSLGGKVRL MVTGAAPVSA TVLTFLRAAL GCQFYEGYGQ TECTAGCSLS VPGDWTAGHV 

       490        500        510        520        530        540 
GAPMPCNFIK LVDVEEMNYM AAMGEGEVCV KGPNVFKGYL KDPAKTAEAL DKDGWLHTGD 

       550        560        570        580        590        600 
IGKWLPNGTL KIIDRKKHIF KLAQGEYIAP EKIENIYVRS EPVAQVFVHG ESLQAFLIAI 

       610        620        630        640        650        660 
VVPDAESLAS WARKRGFEGS FEELCRNKDV KKAILEDMVR IGKDSGLKSF EQVRGIALHP 

       670        680        690 
ELFSVDNGLL TPTMKAKRPE LRNYFRSQID ELYSTIKV 

« Hide

References

[1]"Molecular characterization and expression of guinea-pig acyl-CoA synthetase 1."
Sevoz C., Benoit E., Buronfosse T.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF236818 mRNA. Translation: AAF91295.1.
RefSeqNP_001166379.1. NM_001172908.1.

3D structure databases

ProteinModelPortalQ9JID6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10141.ENSCPOP00000002483.

Proteomic databases

PRIDEQ9JID6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCPOT00000002769; ENSCPOP00000002484; ENSCPOG00000002734.
GeneID100135469.

Organism-specific databases

CTD2180.

Phylogenomic databases

eggNOGCOG1022.
GeneTreeENSGT00690000101725.
HOGENOMHOG000159459.
HOVERGENHBG050452.
OrthoDBEOG71CFKN.

Family and domain databases

InterProIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACSL1_CAVPO
AccessionPrimary (citable) accession number: Q9JID6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families