SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9JID2

- GNA11_RAT

UniProt

Q9JID2 - GNA11_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Guanine nucleotide-binding protein subunit alpha-11
Gene
Gna11
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Magnesium By similarity
Metal bindingi186 – 1861Magnesium By similarity
Binding sitei331 – 3311GTP; via amide nitrogen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 538GTP By similarity
Nucleotide bindingi180 – 1867GTP By similarity
Nucleotide bindingi205 – 2095GTP By similarity
Nucleotide bindingi274 – 2774GTP By similarity

GO - Molecular functioni

  1. G-protein beta/gamma-subunit complex binding Source: RefGenome
  2. G-protein coupled receptor binding Source: RefGenome
  3. GTP binding Source: RGD
  4. GTPase activity Source: RefGenome
  5. guanyl nucleotide binding Source: RGD
  6. metal ion binding Source: UniProtKB-KW
  7. protein complex binding Source: RGD
  8. signal transducer activity Source: RefGenome
  9. type 2A serotonin receptor binding Source: RGD

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: RGD
  2. action potential Source: RefGenome
  3. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RefGenome
  4. phospholipase C-activating dopamine receptor signaling pathway Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein subunit alpha-11
Short name:
G alpha-11
Short name:
G-protein subunit alpha-11
Gene namesi
Name:Gna11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi619749. Gna11.

Subcellular locationi

Cell membrane; Lipid-anchor By similarity. Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: RGD
  2. extrinsic component of cytoplasmic side of plasma membrane Source: RefGenome
  3. heterotrimeric G-protein complex Source: RefGenome
  4. membrane Source: RGD
  5. plasma membrane Source: RGD
  6. protein complex Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Guanine nucleotide-binding protein subunit alpha-11
PRO_0000203748Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Lipidationi9 – 91S-palmitoyl cysteine By similarity
Lipidationi10 – 101S-palmitoyl cysteine By similarity

Keywords - PTMi

Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ9JID2.
PRIDEiQ9JID2.

PTM databases

PhosphoSiteiQ9JID2.

Expressioni

Gene expression databases

GenevestigatoriQ9JID2.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RGS22 By similarity.

Protein-protein interaction databases

BioGridi249562. 1 interaction.
MINTiMINT-4569256.

Structurei

3D structure databases

ProteinModelPortaliQ9JID2.
SMRiQ9JID2. Positions 36-358.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiNOG322962.
HOGENOMiHOG000038729.
HOVERGENiHBG063184.
InParanoidiQ9JID2.
KOiK04635.
PhylomeDBiQ9JID2.

Family and domain databases

Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR000654. Gprotein_alpha_Q.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 1 hit.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00442. GPROTEINAQ.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9JID2-1 [UniParc]FASTAAdd to Basket

« Hide

MTLESMIACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES    50
GKSTFIKQMR IIHGAGYSEE DKRGFTKLVY QNIFTAMQAV VRAMDTLKIR 100
YKYEQNKANA LLIREVDVEK VTTFEHQYVN AIKTLWSDPG VQECYDRRRE 150
FQLSDSAKYY LTDVDRIATV GYLPTQQDVL RVRVPTTGII EYPFDLENII 200
FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV ESDNENRMEE 250
SKALFRTIIT YPWFQHSSVI LFLNKKDLLE DKILHSHLVD YFPEFDGPQR 300
DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ 350
LNLKEYNLV 359
Length:359
Mass (Da):42,026
Last modified:October 1, 2000 - v1
Checksum:iB4CD057E9FC7092A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF239674 mRNA. Translation: AAF81690.1.
RefSeqiNP_112295.1. NM_031033.1.
UniGeneiRn.21925.

Genome annotation databases

GeneIDi81662.
KEGGirno:81662.
UCSCiRGD:619749. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF239674 mRNA. Translation: AAF81690.1 .
RefSeqi NP_112295.1. NM_031033.1.
UniGenei Rn.21925.

3D structure databases

ProteinModelPortali Q9JID2.
SMRi Q9JID2. Positions 36-358.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 249562. 1 interaction.
MINTi MINT-4569256.

PTM databases

PhosphoSitei Q9JID2.

Proteomic databases

PaxDbi Q9JID2.
PRIDEi Q9JID2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 81662.
KEGGi rno:81662.
UCSCi RGD:619749. rat.

Organism-specific databases

CTDi 2767.
RGDi 619749. Gna11.

Phylogenomic databases

eggNOGi NOG322962.
HOGENOMi HOG000038729.
HOVERGENi HBG063184.
InParanoidi Q9JID2.
KOi K04635.
PhylomeDBi Q9JID2.

Miscellaneous databases

NextBioi 615236.
PROi Q9JID2.

Gene expression databases

Genevestigatori Q9JID2.

Family and domain databases

Gene3Di 1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProi IPR000654. Gprotein_alpha_Q.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view ]
PANTHERi PTHR10218. PTHR10218. 1 hit.
Pfami PF00503. G-alpha. 1 hit.
[Graphical view ]
PRINTSi PR00318. GPROTEINA.
PR00442. GPROTEINAQ.
SMARTi SM00275. G_alpha. 1 hit.
[Graphical view ]
SUPFAMi SSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Rattus norvegicus guanine nucleotide binding protein alpha 11 subunit (G11)."
    Strotmann R.
    Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiGNA11_RAT
AccessioniPrimary (citable) accession number: Q9JID2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi