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Q9JID2

- GNA11_RAT

UniProt

Q9JID2 - GNA11_RAT

Protein

Guanine nucleotide-binding protein subunit alpha-11

Gene

Gna11

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi53 – 531MagnesiumBy similarity
    Metal bindingi186 – 1861MagnesiumBy similarity
    Binding sitei331 – 3311GTP; via amide nitrogenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi46 – 538GTPBy similarity
    Nucleotide bindingi180 – 1867GTPBy similarity
    Nucleotide bindingi205 – 2095GTPBy similarity
    Nucleotide bindingi274 – 2774GTPBy similarity

    GO - Molecular functioni

    1. G-protein beta/gamma-subunit complex binding Source: RefGenome
    2. GTPase activity Source: RefGenome
    3. GTP binding Source: RGD
    4. guanyl nucleotide binding Source: RGD
    5. metal ion binding Source: UniProtKB-KW
    6. protein complex binding Source: RGD
    7. signal transducer activity Source: RefGenome
    8. type 2A serotonin receptor binding Source: RGD

    GO - Biological processi

    1. action potential Source: RefGenome
    2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RefGenome
    3. G-protein coupled receptor signaling pathway Source: RGD
    4. phospholipase C-activating dopamine receptor signaling pathway Source: RefGenome

    Keywords - Molecular functioni

    Transducer

    Keywords - Ligandi

    GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanine nucleotide-binding protein subunit alpha-11
    Short name:
    G alpha-11
    Short name:
    G-protein subunit alpha-11
    Gene namesi
    Name:Gna11
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi619749. Gna11.

    Subcellular locationi

    Cell membrane By similarity; Lipid-anchor By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: RGD
    2. heterotrimeric G-protein complex Source: RefGenome
    3. membrane Source: RGD
    4. plasma membrane Source: RGD
    5. protein complex Source: RGD

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 359359Guanine nucleotide-binding protein subunit alpha-11PRO_0000203748Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi9 – 91S-palmitoyl cysteineBy similarity
    Lipidationi10 – 101S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Lipoprotein, Palmitate

    Proteomic databases

    PaxDbiQ9JID2.
    PRIDEiQ9JID2.

    PTM databases

    PhosphoSiteiQ9JID2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9JID2.

    Interactioni

    Subunit structurei

    G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RGS22. Interacts with NTSR1 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi249562. 1 interaction.
    MINTiMINT-4569256.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JID2.
    SMRiQ9JID2. Positions 36-358.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-alpha family. G(q) subfamily.Curated

    Phylogenomic databases

    eggNOGiNOG322962.
    HOGENOMiHOG000038729.
    HOVERGENiHBG063184.
    InParanoidiQ9JID2.
    KOiK04635.
    PhylomeDBiQ9JID2.

    Family and domain databases

    Gene3Di1.10.400.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProiIPR000654. Gprotein_alpha_Q.
    IPR001019. Gprotein_alpha_su.
    IPR011025. GproteinA_insert.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PANTHERiPTHR10218. PTHR10218. 1 hit.
    PfamiPF00503. G-alpha. 1 hit.
    [Graphical view]
    PRINTSiPR00318. GPROTEINA.
    PR00442. GPROTEINAQ.
    SMARTiSM00275. G_alpha. 1 hit.
    [Graphical view]
    SUPFAMiSSF47895. SSF47895. 1 hit.
    SSF52540. SSF52540. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q9JID2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTLESMIACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES    50
    GKSTFIKQMR IIHGAGYSEE DKRGFTKLVY QNIFTAMQAV VRAMDTLKIR 100
    YKYEQNKANA LLIREVDVEK VTTFEHQYVN AIKTLWSDPG VQECYDRRRE 150
    FQLSDSAKYY LTDVDRIATV GYLPTQQDVL RVRVPTTGII EYPFDLENII 200
    FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV ESDNENRMEE 250
    SKALFRTIIT YPWFQHSSVI LFLNKKDLLE DKILHSHLVD YFPEFDGPQR 300
    DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ 350
    LNLKEYNLV 359
    Length:359
    Mass (Da):42,026
    Last modified:October 1, 2000 - v1
    Checksum:iB4CD057E9FC7092A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF239674 mRNA. Translation: AAF81690.1.
    RefSeqiNP_112295.1. NM_031033.1.
    UniGeneiRn.21925.

    Genome annotation databases

    GeneIDi81662.
    KEGGirno:81662.
    UCSCiRGD:619749. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF239674 mRNA. Translation: AAF81690.1 .
    RefSeqi NP_112295.1. NM_031033.1.
    UniGenei Rn.21925.

    3D structure databases

    ProteinModelPortali Q9JID2.
    SMRi Q9JID2. Positions 36-358.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 249562. 1 interaction.
    MINTi MINT-4569256.

    PTM databases

    PhosphoSitei Q9JID2.

    Proteomic databases

    PaxDbi Q9JID2.
    PRIDEi Q9JID2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 81662.
    KEGGi rno:81662.
    UCSCi RGD:619749. rat.

    Organism-specific databases

    CTDi 2767.
    RGDi 619749. Gna11.

    Phylogenomic databases

    eggNOGi NOG322962.
    HOGENOMi HOG000038729.
    HOVERGENi HBG063184.
    InParanoidi Q9JID2.
    KOi K04635.
    PhylomeDBi Q9JID2.

    Miscellaneous databases

    NextBioi 615236.
    PROi Q9JID2.

    Gene expression databases

    Genevestigatori Q9JID2.

    Family and domain databases

    Gene3Di 1.10.400.10. 1 hit.
    3.40.50.300. 2 hits.
    InterProi IPR000654. Gprotein_alpha_Q.
    IPR001019. Gprotein_alpha_su.
    IPR011025. GproteinA_insert.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    PANTHERi PTHR10218. PTHR10218. 1 hit.
    Pfami PF00503. G-alpha. 1 hit.
    [Graphical view ]
    PRINTSi PR00318. GPROTEINA.
    PR00442. GPROTEINAQ.
    SMARTi SM00275. G_alpha. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47895. SSF47895. 1 hit.
    SSF52540. SSF52540. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Rattus norvegicus guanine nucleotide binding protein alpha 11 subunit (G11)."
      Strotmann R.
      Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiGNA11_RAT
    AccessioniPrimary (citable) accession number: Q9JID2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 24, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3