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Q9JID2 (GNA11_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 100. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanine nucleotide-binding protein subunit alpha-11

Short name=G alpha-11
Short name=G-protein subunit alpha-11
Gene names
Name:Gna11
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length359 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems.

Subunit structure

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with RGS22 By similarity.

Subcellular location

Cell membrane; Lipid-anchor By similarity. Cytoplasm By similarity.

Sequence similarities

Belongs to the G-alpha family. G(q) subfamily.

Ontologies

Keywords
   Cellular componentCell membrane
Cytoplasm
Membrane
   LigandGTP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionTransducer
   PTMLipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from direct assay PubMed 19016481. Source: RGD

action potential

Inferred from Biological aspect of Ancestor. Source: RefGenome

adenylate cyclase-modulating G-protein coupled receptor signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

phospholipase C-activating dopamine receptor signaling pathway

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular_componentcytosol

Inferred from direct assay PubMed 14534355PubMed 15175423. Source: RGD

extrinsic component of cytoplasmic side of plasma membrane

Inferred from Biological aspect of Ancestor. Source: RefGenome

heterotrimeric G-protein complex

Inferred from Biological aspect of Ancestor. Source: RefGenome

membrane

Inferred from direct assay PubMed 10212487PubMed 19016481. Source: RGD

plasma membrane

Inferred from direct assay PubMed 14534355PubMed 15175423. Source: RGD

protein complex

Inferred from direct assay PubMed 10212487. Source: RGD

   Molecular_functionG-protein beta/gamma-subunit complex binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

G-protein coupled receptor binding

Inferred from Biological aspect of Ancestor. Source: RefGenome

GTP binding

Inferred from direct assay PubMed 19016481. Source: RGD

GTPase activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

guanyl nucleotide binding

Traceable author statement PubMed 12684223. Source: RGD

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

protein complex binding

Inferred from physical interaction PubMed 10212487PubMed 20548297. Source: RGD

signal transducer activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

type 2A serotonin receptor binding

Inferred from mutant phenotype PubMed 19016481. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 359359Guanine nucleotide-binding protein subunit alpha-11
PRO_0000203748

Regions

Nucleotide binding46 – 538GTP By similarity
Nucleotide binding180 – 1867GTP By similarity
Nucleotide binding205 – 2095GTP By similarity
Nucleotide binding274 – 2774GTP By similarity

Sites

Metal binding531Magnesium By similarity
Metal binding1861Magnesium By similarity
Binding site3311GTP; via amide nitrogen By similarity

Amino acid modifications

Lipidation91S-palmitoyl cysteine By similarity
Lipidation101S-palmitoyl cysteine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JID2 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: B4CD057E9FC7092A

FASTA35942,026
        10         20         30         40         50         60 
MTLESMIACC LSDEVKESKR INAEIEKQLR RDKRDARREL KLLLLGTGES GKSTFIKQMR 

        70         80         90        100        110        120 
IIHGAGYSEE DKRGFTKLVY QNIFTAMQAV VRAMDTLKIR YKYEQNKANA LLIREVDVEK 

       130        140        150        160        170        180 
VTTFEHQYVN AIKTLWSDPG VQECYDRRRE FQLSDSAKYY LTDVDRIATV GYLPTQQDVL 

       190        200        210        220        230        240 
RVRVPTTGII EYPFDLENII FRMVDVGGQR SERRKWIHCF ENVTSIMFLV ALSEYDQVLV 

       250        260        270        280        290        300 
ESDNENRMEE SKALFRTIIT YPWFQHSSVI LFLNKKDLLE DKILHSHLVD YFPEFDGPQR 

       310        320        330        340        350 
DAQAAREFIL KMFVDLNPDS DKIIYSHFTC ATDTENIRFV FAAVKDTILQ LNLKEYNLV 

« Hide

References

[1]"Rattus norvegicus guanine nucleotide binding protein alpha 11 subunit (G11)."
Strotmann R.
Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF239674 mRNA. Translation: AAF81690.1.
RefSeqNP_112295.1. NM_031033.1.
UniGeneRn.21925.

3D structure databases

ProteinModelPortalQ9JID2.
SMRQ9JID2. Positions 36-358.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid249562. 1 interaction.
MINTMINT-4569256.

PTM databases

PhosphoSiteQ9JID2.

Proteomic databases

PaxDbQ9JID2.
PRIDEQ9JID2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID81662.
KEGGrno:81662.
UCSCRGD:619749. rat.

Organism-specific databases

CTD2767.
RGD619749. Gna11.

Phylogenomic databases

eggNOGNOG322962.
HOGENOMHOG000038729.
HOVERGENHBG063184.
InParanoidQ9JID2.
KOK04635.
PhylomeDBQ9JID2.

Gene expression databases

GenevestigatorQ9JID2.

Family and domain databases

Gene3D1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProIPR000654. Gprotein_alpha_Q.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERPTHR10218. PTHR10218. 1 hit.
PfamPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSPR00318. GPROTEINA.
PR00442. GPROTEINAQ.
SMARTSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNetSearch...

Other

NextBio615236.
PROQ9JID2.

Entry information

Entry nameGNA11_RAT
AccessionPrimary (citable) accession number: Q9JID2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families