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Q9JIB4

- TF2H2_MOUSE

UniProt

Q9JIB4 - TF2H2_MOUSE

Protein

General transcription factor IIH subunit 2

Gene

Gtf2h2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri292 – 30918C4-typeAdd
    BLAST

    GO - Molecular functioni

    1. zinc ion binding Source: InterPro

    GO - Biological processi

    1. ATP catabolic process Source: GOC
    2. nucleotide-excision repair Source: InterPro
    3. protein phosphorylation Source: GOC
    4. regulation of transcription, DNA-templated Source: UniProtKB-KW
    5. transcription from RNA polymerase II promoter Source: UniProtKB

    Keywords - Biological processi

    DNA damage, DNA repair, Transcription, Transcription regulation

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_203462. Formation of the Early Elongation Complex.
    REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
    REACT_224562. Dual incision reaction in TC-NER.
    REACT_226490. RNA Polymerase II Transcription Elongation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General transcription factor IIH subunit 2
    Alternative name(s):
    Basic transcription factor 2 44 kDa subunit
    Short name:
    BTF2 p44
    General transcription factor IIH polypeptide 2
    TFIIH basal transcription factor complex p44 subunit
    Gene namesi
    Name:Gtf2h2
    Synonyms:Btf2p44
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 13

    Organism-specific databases

    MGIiMGI:1345669. Gtf2h2.

    Subcellular locationi

    GO - Cellular componenti

    1. core TFIIH complex Source: InterPro
    2. holo TFIIH complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 396396General transcription factor IIH subunit 2PRO_0000119249Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei95 – 951PhosphotyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9JIB4.
    PaxDbiQ9JIB4.
    PRIDEiQ9JIB4.

    PTM databases

    PhosphoSiteiQ9JIB4.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9JIB4.
    BgeeiQ9JIB4.
    CleanExiMM_GTF2H2.
    GenevestigatoriQ9JIB4.

    Interactioni

    Subunit structurei

    One of the 6 subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor. Interacts with XPB, XPD, GTF2H1 and GTF2H3 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi204782. 3 interactions.
    IntActiQ9JIB4. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JIB4.
    SMRiQ9JIB4. Positions 329-387.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini60 – 236177VWFAPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi242 – 2454Poly-Ser

    Sequence similaritiesi

    Belongs to the GTF2H2 family.Curated
    Contains 1 VWFA domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri292 – 30918C4-typeAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5151.
    GeneTreeiENSGT00490000043395.
    HOGENOMiHOG000159415.
    HOVERGENiHBG059468.
    KOiK03142.
    OrthoDBiEOG7WQ7SP.
    PhylomeDBiQ9JIB4.
    TreeFamiTF314037.

    Family and domain databases

    Gene3Di3.40.50.410. 1 hit.
    InterProiIPR007198. Ssl1-like.
    IPR004595. TFIIH_C1-like_dom.
    IPR012170. TFIIH_SSL1/p44.
    IPR002035. VWF_A.
    IPR007087. Znf_C2H2.
    [Graphical view]
    PANTHERiPTHR12695. PTHR12695. 1 hit.
    PfamiPF07975. C1_4. 1 hit.
    PF04056. Ssl1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF015919. TFIIH_SSL1. 1 hit.
    SMARTiSM01047. C1_4. 1 hit.
    SM00327. VWA. 1 hit.
    [Graphical view]
    SUPFAMiSSF53300. SSF53300. 1 hit.
    TIGRFAMsiTIGR00622. ssl1. 1 hit.
    PROSITEiPS50234. VWFA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9JIB4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDEEPERTKR WEGGYERTWE ILKEDETGSL KATIEDILFK AKRKRVFEHH    50
    GQVRLGMMRH LYVVVDGSRT MEDQDLKPNR LTCTLKLLEY FVEEYFDQNP 100
    ISQIGIIVTK SKRAEKLTEL SGNPRKHITS LKKAVDMTCH GEPSLYNSLS 150
    MAMQTLKHMP GHTSREVLII FSSLTTCDPS NIYDLIKTLK TAKIRVSVIG 200
    LSAEVRVCTV LARETGGTYH VILDETHYKE LLAHHVSPPP ASSSSECSLI 250
    RMGFPQHTIA SLSDQDAKPS FSMAHLDNNS TEPGLTLGGY FCPQCRAKYC 300
    ELPVECKICG LTLVSAPHLA RSYHHLFPLD AFQEISLEEY KGERFCYGCQ 350
    GELKDQHVYV CTVCQNVFCV DCDVFVHDSL HCCPGCIHKI PTPSGI 396
    Length:396
    Mass (Da):44,687
    Last modified:October 1, 2000 - v1
    Checksum:i1BC57AFD464AA83F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF242432 Genomic DNA. Translation: AAF82753.1.
    CCDSiCCDS26730.1.
    RefSeqiNP_071294.3. NM_022011.4.
    UniGeneiMm.272533.

    Genome annotation databases

    EnsembliENSMUST00000066984; ENSMUSP00000065228; ENSMUSG00000021639.
    GeneIDi23894.
    KEGGimmu:23894.
    UCSCiuc007rqu.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF242432 Genomic DNA. Translation: AAF82753.1 .
    CCDSi CCDS26730.1.
    RefSeqi NP_071294.3. NM_022011.4.
    UniGenei Mm.272533.

    3D structure databases

    ProteinModelPortali Q9JIB4.
    SMRi Q9JIB4. Positions 329-387.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 204782. 3 interactions.
    IntActi Q9JIB4. 1 interaction.

    PTM databases

    PhosphoSitei Q9JIB4.

    Proteomic databases

    MaxQBi Q9JIB4.
    PaxDbi Q9JIB4.
    PRIDEi Q9JIB4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000066984 ; ENSMUSP00000065228 ; ENSMUSG00000021639 .
    GeneIDi 23894.
    KEGGi mmu:23894.
    UCSCi uc007rqu.2. mouse.

    Organism-specific databases

    CTDi 2966.
    MGIi MGI:1345669. Gtf2h2.

    Phylogenomic databases

    eggNOGi COG5151.
    GeneTreei ENSGT00490000043395.
    HOGENOMi HOG000159415.
    HOVERGENi HBG059468.
    KOi K03142.
    OrthoDBi EOG7WQ7SP.
    PhylomeDBi Q9JIB4.
    TreeFami TF314037.

    Enzyme and pathway databases

    Reactomei REACT_203462. Formation of the Early Elongation Complex.
    REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
    REACT_224562. Dual incision reaction in TC-NER.
    REACT_226490. RNA Polymerase II Transcription Elongation.

    Miscellaneous databases

    ChiTaRSi GTF2H2. mouse.
    NextBioi 303657.
    PROi Q9JIB4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JIB4.
    Bgeei Q9JIB4.
    CleanExi MM_GTF2H2.
    Genevestigatori Q9JIB4.

    Family and domain databases

    Gene3Di 3.40.50.410. 1 hit.
    InterProi IPR007198. Ssl1-like.
    IPR004595. TFIIH_C1-like_dom.
    IPR012170. TFIIH_SSL1/p44.
    IPR002035. VWF_A.
    IPR007087. Znf_C2H2.
    [Graphical view ]
    PANTHERi PTHR12695. PTHR12695. 1 hit.
    Pfami PF07975. C1_4. 1 hit.
    PF04056. Ssl1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF015919. TFIIH_SSL1. 1 hit.
    SMARTi SM01047. C1_4. 1 hit.
    SM00327. VWA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53300. SSF53300. 1 hit.
    TIGRFAMsi TIGR00622. ssl1. 1 hit.
    PROSITEi PS50234. VWFA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Lubec G., Sunyer B., Chen W.-Q.
      Submitted (JAN-2009) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 188-195, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: OF1.
      Tissue: Hippocampus.

    Entry informationi

    Entry nameiTF2H2_MOUSE
    AccessioniPrimary (citable) accession number: Q9JIB4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 110 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3