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Q9JIB4 (TF2H2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
General transcription factor IIH subunit 2
Alternative name(s):
Basic transcription factor 2 44 kDa subunit
Short name=BTF2 p44
General transcription factor IIH polypeptide 2
TFIIH basal transcription factor complex p44 subunit
Gene names
Name:Gtf2h2
Synonyms:Btf2p44
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length396 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter By similarity.

Subunit structure

One of the 6 subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor. Interacts with XPB, XPD, GTF2H1 and GTF2H3 By similarity.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the GTF2H2 family.

Contains 1 VWFA domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 396396General transcription factor IIH subunit 2
PRO_0000119249

Regions

Domain60 – 236177VWFA
Zinc finger292 – 30918C4-type
Compositional bias242 – 2454Poly-Ser

Amino acid modifications

Modified residue951Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JIB4 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 1BC57AFD464AA83F

FASTA39644,687
        10         20         30         40         50         60 
MDEEPERTKR WEGGYERTWE ILKEDETGSL KATIEDILFK AKRKRVFEHH GQVRLGMMRH 

        70         80         90        100        110        120 
LYVVVDGSRT MEDQDLKPNR LTCTLKLLEY FVEEYFDQNP ISQIGIIVTK SKRAEKLTEL 

       130        140        150        160        170        180 
SGNPRKHITS LKKAVDMTCH GEPSLYNSLS MAMQTLKHMP GHTSREVLII FSSLTTCDPS 

       190        200        210        220        230        240 
NIYDLIKTLK TAKIRVSVIG LSAEVRVCTV LARETGGTYH VILDETHYKE LLAHHVSPPP 

       250        260        270        280        290        300 
ASSSSECSLI RMGFPQHTIA SLSDQDAKPS FSMAHLDNNS TEPGLTLGGY FCPQCRAKYC 

       310        320        330        340        350        360 
ELPVECKICG LTLVSAPHLA RSYHHLFPLD AFQEISLEEY KGERFCYGCQ GELKDQHVYV 

       370        380        390 
CTVCQNVFCV DCDVFVHDSL HCCPGCIHKI PTPSGI 

« Hide

References

[1]"Genomic sequence analysis of the mouse Naip gene array."
Endrizzi M.G., Hadinoto V., Growney J.D., Miller W., Dietrich W.F.
Genome Res. 10:1095-1102(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Lubec G., Sunyer B., Chen W.-Q.
Submitted (JAN-2009) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 188-195, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: OF1.
Tissue: Hippocampus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF242432 Genomic DNA. Translation: AAF82753.1.
CCDSCCDS26730.1.
RefSeqNP_071294.3. NM_022011.4.
UniGeneMm.272533.

3D structure databases

ProteinModelPortalQ9JIB4.
SMRQ9JIB4. Positions 329-387.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid204782. 3 interactions.
IntActQ9JIB4. 1 interaction.

PTM databases

PhosphoSiteQ9JIB4.

Proteomic databases

MaxQBQ9JIB4.
PaxDbQ9JIB4.
PRIDEQ9JIB4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000066984; ENSMUSP00000065228; ENSMUSG00000021639.
GeneID23894.
KEGGmmu:23894.
UCSCuc007rqu.2. mouse.

Organism-specific databases

CTD2966.
MGIMGI:1345669. Gtf2h2.

Phylogenomic databases

eggNOGCOG5151.
GeneTreeENSGT00490000043395.
HOGENOMHOG000159415.
HOVERGENHBG059468.
KOK03142.
OrthoDBEOG7WQ7SP.
PhylomeDBQ9JIB4.
TreeFamTF314037.

Gene expression databases

ArrayExpressQ9JIB4.
BgeeQ9JIB4.
CleanExMM_GTF2H2.
GenevestigatorQ9JIB4.

Family and domain databases

Gene3D3.40.50.410. 1 hit.
InterProIPR007198. Ssl1-like.
IPR004595. TFIIH_C1-like_dom.
IPR012170. TFIIH_SSL1/p44.
IPR002035. VWF_A.
IPR007087. Znf_C2H2.
[Graphical view]
PANTHERPTHR12695. PTHR12695. 1 hit.
PfamPF07975. C1_4. 1 hit.
PF04056. Ssl1. 1 hit.
[Graphical view]
PIRSFPIRSF015919. TFIIH_SSL1. 1 hit.
SMARTSM01047. C1_4. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMSSF53300. SSF53300. 1 hit.
TIGRFAMsTIGR00622. ssl1. 1 hit.
PROSITEPS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSGTF2H2. mouse.
NextBio303657.
PROQ9JIB4.
SOURCESearch...

Entry information

Entry nameTF2H2_MOUSE
AccessionPrimary (citable) accession number: Q9JIB4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot