Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9JIB4

- TF2H2_MOUSE

UniProt

Q9JIB4 - TF2H2_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

General transcription factor IIH subunit 2

Gene

Gtf2h2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri292 – 30918C4-typeAdd
BLAST

GO - Molecular functioni

  1. zinc ion binding Source: InterPro

GO - Biological processi

  1. ATP catabolic process Source: GOC
  2. nucleotide-excision repair Source: InterPro
  3. protein phosphorylation Source: GOC
  4. regulation of transcription, DNA-templated Source: UniProtKB-KW
  5. transcription from RNA polymerase II promoter Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_203462. Formation of the Early Elongation Complex.
REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_224562. Dual incision reaction in TC-NER.
REACT_226490. RNA Polymerase II Transcription Elongation.
REACT_230204. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_232235. RNA Polymerase I Promoter Escape.
REACT_232708. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_235780. RNA Polymerase I Transcription Initiation.
REACT_240507. Dual incision reaction in GG-NER.
REACT_244380. RNA Polymerase II Transcription Initiation.
REACT_252106. Formation of incision complex in GG-NER.
REACT_255009. RNA Polymerase II Pre-transcription Events.
REACT_255334. RNA Polymerase II Promoter Escape.
REACT_257165. RNA Polymerase I Transcription Termination.
REACT_257596. RNA Pol II CTD phosphorylation and interaction with CE.
REACT_258231. mRNA Capping.
REACT_259097. RNA Polymerase I Chain Elongation.

Names & Taxonomyi

Protein namesi
Recommended name:
General transcription factor IIH subunit 2
Alternative name(s):
Basic transcription factor 2 44 kDa subunit
Short name:
BTF2 p44
General transcription factor IIH polypeptide 2
TFIIH basal transcription factor complex p44 subunit
Gene namesi
Name:Gtf2h2
Synonyms:Btf2p44
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 13

Organism-specific databases

MGIiMGI:1345669. Gtf2h2.

Subcellular locationi

GO - Cellular componenti

  1. core TFIIH complex Source: InterPro
  2. holo TFIIH complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 396396General transcription factor IIH subunit 2PRO_0000119249Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei95 – 951PhosphotyrosineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9JIB4.
PaxDbiQ9JIB4.
PRIDEiQ9JIB4.

PTM databases

PhosphoSiteiQ9JIB4.

Expressioni

Gene expression databases

BgeeiQ9JIB4.
CleanExiMM_GTF2H2.
ExpressionAtlasiQ9JIB4. baseline and differential.
GenevestigatoriQ9JIB4.

Interactioni

Subunit structurei

One of the 6 subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor. Interacts with XPB, XPD, GTF2H1 and GTF2H3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi204782. 3 interactions.
IntActiQ9JIB4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9JIB4.
SMRiQ9JIB4. Positions 329-387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini60 – 236177VWFAPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi242 – 2454Poly-Ser

Sequence similaritiesi

Belongs to the GTF2H2 family.Curated
Contains 1 VWFA domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri292 – 30918C4-typeAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5151.
GeneTreeiENSGT00490000043395.
HOGENOMiHOG000159415.
HOVERGENiHBG059468.
InParanoidiQ9JIB4.
KOiK03142.
OrthoDBiEOG7WQ7SP.
PhylomeDBiQ9JIB4.
TreeFamiTF314037.

Family and domain databases

Gene3Di3.40.50.410. 1 hit.
InterProiIPR007198. Ssl1-like.
IPR004595. TFIIH_C1-like_dom.
IPR012170. TFIIH_SSL1/p44.
IPR002035. VWF_A.
IPR007087. Znf_C2H2.
[Graphical view]
PANTHERiPTHR12695:SF2. PTHR12695:SF2. 1 hit.
PfamiPF07975. C1_4. 1 hit.
PF04056. Ssl1. 1 hit.
[Graphical view]
PIRSFiPIRSF015919. TFIIH_SSL1. 1 hit.
SMARTiSM01047. C1_4. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
TIGRFAMsiTIGR00622. ssl1. 1 hit.
PROSITEiPS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JIB4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDEEPERTKR WEGGYERTWE ILKEDETGSL KATIEDILFK AKRKRVFEHH
60 70 80 90 100
GQVRLGMMRH LYVVVDGSRT MEDQDLKPNR LTCTLKLLEY FVEEYFDQNP
110 120 130 140 150
ISQIGIIVTK SKRAEKLTEL SGNPRKHITS LKKAVDMTCH GEPSLYNSLS
160 170 180 190 200
MAMQTLKHMP GHTSREVLII FSSLTTCDPS NIYDLIKTLK TAKIRVSVIG
210 220 230 240 250
LSAEVRVCTV LARETGGTYH VILDETHYKE LLAHHVSPPP ASSSSECSLI
260 270 280 290 300
RMGFPQHTIA SLSDQDAKPS FSMAHLDNNS TEPGLTLGGY FCPQCRAKYC
310 320 330 340 350
ELPVECKICG LTLVSAPHLA RSYHHLFPLD AFQEISLEEY KGERFCYGCQ
360 370 380 390
GELKDQHVYV CTVCQNVFCV DCDVFVHDSL HCCPGCIHKI PTPSGI
Length:396
Mass (Da):44,687
Last modified:October 1, 2000 - v1
Checksum:i1BC57AFD464AA83F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242432 Genomic DNA. Translation: AAF82753.1.
CCDSiCCDS26730.1.
RefSeqiNP_071294.3. NM_022011.4.
UniGeneiMm.272533.

Genome annotation databases

EnsembliENSMUST00000066984; ENSMUSP00000065228; ENSMUSG00000021639.
GeneIDi23894.
KEGGimmu:23894.
UCSCiuc007rqu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF242432 Genomic DNA. Translation: AAF82753.1 .
CCDSi CCDS26730.1.
RefSeqi NP_071294.3. NM_022011.4.
UniGenei Mm.272533.

3D structure databases

ProteinModelPortali Q9JIB4.
SMRi Q9JIB4. Positions 329-387.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 204782. 3 interactions.
IntActi Q9JIB4. 1 interaction.

PTM databases

PhosphoSitei Q9JIB4.

Proteomic databases

MaxQBi Q9JIB4.
PaxDbi Q9JIB4.
PRIDEi Q9JIB4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000066984 ; ENSMUSP00000065228 ; ENSMUSG00000021639 .
GeneIDi 23894.
KEGGi mmu:23894.
UCSCi uc007rqu.2. mouse.

Organism-specific databases

CTDi 2966.
MGIi MGI:1345669. Gtf2h2.

Phylogenomic databases

eggNOGi COG5151.
GeneTreei ENSGT00490000043395.
HOGENOMi HOG000159415.
HOVERGENi HBG059468.
InParanoidi Q9JIB4.
KOi K03142.
OrthoDBi EOG7WQ7SP.
PhylomeDBi Q9JIB4.
TreeFami TF314037.

Enzyme and pathway databases

Reactomei REACT_203462. Formation of the Early Elongation Complex.
REACT_223654. Formation of transcription-coupled NER (TC-NER) repair complex.
REACT_224562. Dual incision reaction in TC-NER.
REACT_226490. RNA Polymerase II Transcription Elongation.
REACT_230204. RNA Polymerase II Transcription Initiation And Promoter Clearance.
REACT_232235. RNA Polymerase I Promoter Escape.
REACT_232708. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_235780. RNA Polymerase I Transcription Initiation.
REACT_240507. Dual incision reaction in GG-NER.
REACT_244380. RNA Polymerase II Transcription Initiation.
REACT_252106. Formation of incision complex in GG-NER.
REACT_255009. RNA Polymerase II Pre-transcription Events.
REACT_255334. RNA Polymerase II Promoter Escape.
REACT_257165. RNA Polymerase I Transcription Termination.
REACT_257596. RNA Pol II CTD phosphorylation and interaction with CE.
REACT_258231. mRNA Capping.
REACT_259097. RNA Polymerase I Chain Elongation.

Miscellaneous databases

ChiTaRSi Gtf2h2. mouse.
NextBioi 303657.
PROi Q9JIB4.
SOURCEi Search...

Gene expression databases

Bgeei Q9JIB4.
CleanExi MM_GTF2H2.
ExpressionAtlasi Q9JIB4. baseline and differential.
Genevestigatori Q9JIB4.

Family and domain databases

Gene3Di 3.40.50.410. 1 hit.
InterProi IPR007198. Ssl1-like.
IPR004595. TFIIH_C1-like_dom.
IPR012170. TFIIH_SSL1/p44.
IPR002035. VWF_A.
IPR007087. Znf_C2H2.
[Graphical view ]
PANTHERi PTHR12695:SF2. PTHR12695:SF2. 1 hit.
Pfami PF07975. C1_4. 1 hit.
PF04056. Ssl1. 1 hit.
[Graphical view ]
PIRSFi PIRSF015919. TFIIH_SSL1. 1 hit.
SMARTi SM01047. C1_4. 1 hit.
SM00327. VWA. 1 hit.
[Graphical view ]
SUPFAMi SSF53300. SSF53300. 1 hit.
TIGRFAMsi TIGR00622. ssl1. 1 hit.
PROSITEi PS50234. VWFA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Lubec G., Sunyer B., Chen W.-Q.
    Submitted (JAN-2009) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 188-195, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: OF1.
    Tissue: Hippocampus.

Entry informationi

Entry nameiTF2H2_MOUSE
AccessioniPrimary (citable) accession number: Q9JIB4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3