ID   BIR1G_MOUSE             Reviewed;        1402 AA.
AC   Q9JIB3;
DT   24-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   08-NOV-2023, entry version 132.
DE   RecName: Full=Baculoviral IAP repeat-containing protein 1g;
DE   AltName: Full=Neuronal apoptosis inhibitory protein 7;
GN   Name=Naip7; Synonyms=Birc1g;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10958627; DOI=10.1101/gr.10.8.1095;
RA   Endrizzi M.G., Hadinoto V., Growney J.D., Miller W., Dietrich W.F.;
RT   "Genomic sequence analysis of the mouse Naip gene array.";
RL   Genome Res. 10:1095-1102(2000).
CC   -!- FUNCTION: Prevents motor-neuron apoptosis induced by a variety of
CC       signals.
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DR   EMBL; AF242433; AAF82749.1; -; Genomic_DNA.
DR   RefSeq; NP_067520.1; NM_021545.1.
DR   AlphaFoldDB; Q9JIB3; -.
DR   SMR; Q9JIB3; -.
DR   MEROPS; I32.001; -.
DR   iPTMnet; Q9JIB3; -.
DR   PhosphoSitePlus; Q9JIB3; -.
DR   MaxQB; Q9JIB3; -.
DR   ProteomicsDB; 273491; -.
DR   DNASU; 53880; -.
DR   GeneID; 53880; -.
DR   KEGG; mmu:53880; -.
DR   UCSC; uc011zdt.1; mouse.
DR   AGR; MGI:1858256; -.
DR   CTD; 53880; -.
DR   MGI; MGI:1858256; Naip7.
DR   InParanoid; Q9JIB3; -.
DR   BioGRID-ORCS; 53880; 1 hit in 17 CRISPR screens.
DR   PRO; PR:Q9JIB3; -.
DR   Proteomes; UP000000589; Unplaced.
DR   RNAct; Q9JIB3; Protein.
DR   GO; GO:0072557; C:IPAF inflammasome complex; IBA:GO_Central.
DR   GO; GO:0043025; C:neuronal cell body; ISO:MGI.
DR   GO; GO:0043204; C:perikaryon; ISO:MGI.
DR   GO; GO:0005524; F:ATP binding; ISS:UniProtKB.
DR   GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0120283; F:protein serine/threonine kinase binding; ISO:MGI.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0042742; P:defense response to bacterium; IBA:GO_Central.
DR   GO; GO:0016045; P:detection of bacterium; IBA:GO_Central.
DR   GO; GO:0006954; P:inflammatory response; IBA:GO_Central.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR   GO; GO:0010804; P:negative regulation of tumor necrosis factor-mediated signaling pathway; ISO:MGI.
DR   GO; GO:0046330; P:positive regulation of JNK cascade; ISO:MGI.
DR   GO; GO:0070269; P:pyroptosis; IBA:GO_Central.
DR   GO; GO:0042981; P:regulation of apoptotic process; ISO:MGI.
DR   CDD; cd00022; BIR; 3.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001370; BIR_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR028789; Naip.
DR   InterPro; IPR040535; NLRC4_HD.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR46914; BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR46914:SF1; BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00653; BIR; 3.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17889; NLRC4_HD; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   SMART; SM00238; BIR; 3.
DR   SUPFAM; SSF57924; Inhibitor of apoptosis (IAP) repeat; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS01282; BIR_REPEAT_1; 2.
DR   PROSITE; PS50143; BIR_REPEAT_2; 3.
DR   PROSITE; PS50837; NACHT; 1.
PE   4: Predicted;
KW   Apoptosis; ATP-binding; Metal-binding; Nucleotide-binding;
KW   Reference proteome; Repeat; Zinc.
FT   CHAIN           1..1402
FT                   /note="Baculoviral IAP repeat-containing protein 1g"
FT                   /id="PRO_0000122346"
FT   REPEAT          60..127
FT                   /note="BIR 1"
FT   REPEAT          159..227
FT                   /note="BIR 2"
FT   REPEAT          278..345
FT                   /note="BIR 3"
FT   DOMAIN          464..759
FT                   /note="NACHT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00136"
FT   BINDING         315
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         318
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         335
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         342
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00029"
FT   BINDING         476
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   1402 AA;  159664 MW;  C1DFFBA359893E0D CRC64;
     MAEHGESSED RISEIDYEFL AELSARFGMN LVQLAKSQEE EDHKERMKMK KGFNSQMRSE
     AKRLKTFESY DTFRSWTPQE MAAAGFYHTG VKLGVQCFCC SLILFGNSLR KLPIERHKKL
     RPECEFLQGK DVGNIGKYDI RVKSPEKMLR GGKARYHEEE ARLESFEDWP FYAHGTSPRV
     LSAAGFVFTG KRDTVQCFSC GGSLGNWEEG DDPWKEHAKW FPKCEFLQSK KSSEEIAQYI
     QGYEGFVHVT GEHFVKSWVR RELPMVSAYC NDSVFANEEL RMDMFKDWPQ ESPVGVEALV
     RAGFFYTGKK DIVRCFSCGG CLEKWAEGDD PMEDHIKFFP ECVFLQTLKS SAEVIPTLQS
     QYALPEATET TRESNHGDAA AVHSTVVDLG RSEAQWFQEA RSLSEQLRDT YTKTSFCHMN
     LPEVCSSLGT DHLLSCDVSI ISKHISQPVQ GALTIPEVFS NLSSVMCVEG EAGSGKTTFL
     KRIAFLWASG CCPLLYRFQL VFYLSLSSIT PDQGLDNIIC TQLLGAGGCI SEVCLSSSIQ
     QLQHQVLFLL DDYSGLASLP QALHTLITKN YLFRTCLLIA VHTNRVRDIR PYLGTSLEIQ
     EFPFYNTVFV LRKFFSHDII CVEKLIIYFS ENKDLQGVYK TPLFVAAVCN DWNQNASAQD
     DFQDVTLFHS YMQYLSLKYK ATAESLQATV SSCGQLALTG LFSSCFEFNS DDLAEAGVDE
     DVKLTTFLMS KFTAQRLRPV YRFLGPLFQE FLAAVRLTEL LSSDRQEDQD LGLYYLRQID
     SPLKAINSFN IFLYYVSSHS SSKAAPTVVS HLLQLVDEKE SLENMSENED YMKLHPQTFL
     WFQFVRGLWL VSPESFSSFV SEHLLRLALI FAYESNTVAE CSPFILQFLR GRTLALRVLN
     LEYFWDHPES LLLLRSLKVS INGNKMSSYV DYSFKTYFEN LQPPAINEEY TSAFEHVSEW
     RRNFAQDEEI IKNYENIWPR ALPDISEGYW NLSPKPCKIP KLEVQVNNMG PADQALLQVL
     MEVFSASQSI EFHLFNSSGF LESIRPALEL SKASVTKCSM SRLELSRAEQ ELLLTLPALQ
     SLEVSETNQL PDQLFHNLHK FLGLKELCVR LDGKPDVLSV LPEEFLNLHH MEKLSIRTST
     ESDLSKLVKF IQNFPNLHVF HLKCDFLSNC ESLMTALASC KKLREIEFSG QCFEAMTFVN
     ILPNFVSLKI LSLKGQQFAD KETSEKFAQA LGSLRNLEEL LVPTGDGIHQ VAKLIVRQCL
     QLPCLRVLAF HDILDDESVI EIGAATSGSF QKLENLDISM NHKITEEGYR NFFQALDNLP
     NLQMLNICRN IPGRIQVQAT TVKALCHCVS RLPSLTRLGM LSWLLDEEDM KVINDVKERH
     PQSKRLTIFW KWIVPFSPVV LE
//