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Q9JIA1

- LGI1_MOUSE

UniProt

Q9JIA1 - LGI1_MOUSE

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Protein
Leucine-rich glioma-inactivated protein 1
Gene
Lgi1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway By similarity.

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. axon guidance Source: Ensembl
  2. positive regulation of cell growth Source: Ensembl
  3. positive regulation of synaptic transmission Source: UniProtKB
  4. protein homooligomerization Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich glioma-inactivated protein 1
Gene namesi
Name:Lgi1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1861691. Lgi1.

Subcellular locationi

Secreted. Cell junctionsynapse By similarity
Note: Isoform 1 and isoform 2 are detected in the cytosolic and microsomal fractions respectively.2 Publications

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. extracellular space Source: UniProtKB
  3. synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434 Reviewed prediction
Add
BLAST
Chaini35 – 557523Leucine-rich glioma-inactivated protein 1
PRO_0000017706Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi192 – 1921N-linked (GlcNAc...) Reviewed prediction
Glycosylationi277 – 2771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi422 – 4221N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Glycosylated By similarity.

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9JIA1.
PaxDbiQ9JIA1.
PRIDEiQ9JIA1.

PTM databases

PhosphoSiteiQ9JIA1.

Expressioni

Tissue specificityi

Brain.1 Publication

Gene expression databases

ArrayExpressiQ9JIA1.
BgeeiQ9JIA1.
CleanExiMM_LGI1.
GenevestigatoriQ9JIA1.

Interactioni

Subunit structurei

Oligomer By similarity. Interacts with KCNA1 within a complex containing KCNA1, KCNA4 and KCNAB1 By similarity. Part of a complex containing ADAM22, DLG4/PSD95 and CACNG2 (stargazin) By similarity. Can bind to ADAM11 and ADAM23.1 Publication

Protein-protein interaction databases

IntActiQ9JIA1. 4 interactions.
MINTiMINT-4100357.
STRINGi10090.ENSMUSP00000084507.

Structurei

3D structure databases

ProteinModelPortaliQ9JIA1.
SMRiQ9JIA1. Positions 42-221.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 7238LRRNT
Add
BLAST
Repeati92 – 11322LRR 1
Add
BLAST
Repeati116 – 13722LRR 2
Add
BLAST
Repeati140 – 16122LRR 3
Add
BLAST
Domaini173 – 22351LRRCT
Add
BLAST
Repeati224 – 26744EAR 1
Add
BLAST
Repeati270 – 31344EAR 2
Add
BLAST
Repeati316 – 36449EAR 3
Add
BLAST
Repeati365 – 41551EAR 4
Add
BLAST
Repeati418 – 46245EAR 5
Add
BLAST
Repeati463 – 50644EAR 6
Add
BLAST
Repeati509 – 55244EAR 7
Add
BLAST

Sequence similaritiesi

Contains 7 EAR repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiNOG304734.
GeneTreeiENSGT00390000016191.
HOGENOMiHOG000286015.
HOVERGENiHBG036744.
InParanoidiQ9JIA1.
OMAiRGNAFNC.
OrthoDBiEOG78SQHH.
PhylomeDBiQ9JIA1.
TreeFamiTF333155.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR009039. EAR.
IPR005492. EPTP.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF03736. EPTP. 7 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS50912. EAR. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9JIA1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MESESSRRMG NACIPLKRIA YFLCLFSVVL LTEGKKPAKP KCPAVCTCSK    50
DNALCENARS IPRTVPPDVI SLSFVRSGFT EISEGSFLFT PSLQLLLFTS 100
NSFDVISDDA FIGLPHLEYL FIENNNIKSI SRHTFRGLKS LIHLSLANNN 150
LQTLPKDIFK GLDSLTNVDL RGNAFNCDCK LKWLVEWLGH TNATVEDIYC 200
EGPPEYKKRK INSLSPKDFD CIITEFAKSQ DLPYQSLSID TFSYLNDEYV 250
VIAQPFTGKC IFLEWDHVEK TFRNYDNITG TSTVVCKPIV IDTQLYVIVA 300
QLFGGSHIYK RDGFANKFIK IQDIEVLKIR KPNDIETFKI EDNWYFVVAD 350
SSKAGFTTIY KWNGNGFYSH QSLHAWYRDT DVEYLEIARP PLALRTPHLI 400
LSSSSQRPVI YQWSKATQLF TNQTDIPNME DVYAVKHFSV KGDVYICLTR 450
FIGDSKVMKW GGSSFQDIQR MPSRGSMVFQ PLQINNYQYA ILGSDYSFTQ 500
VYNWDAEKAK FVKFQELNVQ APRSFTHVSI NKRNFLFASS FKGNTQIYKH 550
VIVDLSA 557
Length:557
Mass (Da):63,644
Last modified:October 1, 2000 - v1
Checksum:i2692D53F13DEC431
GO
Isoform 2 (identifier: Q9JIA1-2)

Sequence is not available
Length:
Mass (Da):

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF246818 mRNA. Translation: AAF87077.1.
AK045443 mRNA. Translation: BAC32370.1.
BC066090 mRNA. Translation: AAH66090.1.
CCDSiCCDS29786.1. [Q9JIA1-1]
RefSeqiNP_064674.1. NM_020278.2. [Q9JIA1-1]
UniGeneiMm.298251.

Genome annotation databases

EnsembliENSMUST00000087252; ENSMUSP00000084507; ENSMUSG00000067242. [Q9JIA1-1]
GeneIDi56839.
KEGGimmu:56839.
UCSCiuc008hji.1. mouse. [Q9JIA1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF246818 mRNA. Translation: AAF87077.1 .
AK045443 mRNA. Translation: BAC32370.1 .
BC066090 mRNA. Translation: AAH66090.1 .
CCDSi CCDS29786.1. [Q9JIA1-1 ]
RefSeqi NP_064674.1. NM_020278.2. [Q9JIA1-1 ]
UniGenei Mm.298251.

3D structure databases

ProteinModelPortali Q9JIA1.
SMRi Q9JIA1. Positions 42-221.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9JIA1. 4 interactions.
MINTi MINT-4100357.
STRINGi 10090.ENSMUSP00000084507.

PTM databases

PhosphoSitei Q9JIA1.

Proteomic databases

MaxQBi Q9JIA1.
PaxDbi Q9JIA1.
PRIDEi Q9JIA1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000087252 ; ENSMUSP00000084507 ; ENSMUSG00000067242 . [Q9JIA1-1 ]
GeneIDi 56839.
KEGGi mmu:56839.
UCSCi uc008hji.1. mouse. [Q9JIA1-1 ]

Organism-specific databases

CTDi 9211.
MGIi MGI:1861691. Lgi1.

Phylogenomic databases

eggNOGi NOG304734.
GeneTreei ENSGT00390000016191.
HOGENOMi HOG000286015.
HOVERGENi HBG036744.
InParanoidi Q9JIA1.
OMAi RGNAFNC.
OrthoDBi EOG78SQHH.
PhylomeDBi Q9JIA1.
TreeFami TF333155.

Miscellaneous databases

NextBioi 313387.
PROi Q9JIA1.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JIA1.
Bgeei Q9JIA1.
CleanExi MM_LGI1.
Genevestigatori Q9JIA1.

Family and domain databases

InterProi IPR000483. Cys-rich_flank_reg_C.
IPR009039. EAR.
IPR005492. EPTP.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF03736. EPTP. 7 hits.
PF13855. LRR_8. 1 hit.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS50912. EAR. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the promoter, genomic structure, and mouse ortholog of LGI1."
    Somerville R.P.T., Chernova O., Liu S., Shoshan Y., Cowell J.K.
    Mamm. Genome 11:622-627(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 161-171 AND 442-450, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  5. "ADPEAF mutations reduce levels of secreted LGI1, a putative tumor suppressor protein linked to epilepsy."
    Senechal K.R., Thaller C., Noebels J.L.
    Hum. Mol. Genet. 14:1613-1620(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "The LGI1/epitempin gene encodes two protein isoforms differentially expressed in human brain."
    Furlan S., Roncaroli F., Forner F., Vitiello L., Calabria E., Piquer-Sirerol S., Valle G., Perez-Tur J., Michelucci R., Nobile C.
    J. Neurochem. 98:985-991(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  8. "LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11."
    Sagane K., Ishihama Y., Sugimoto H.
    Int. J. Biol. Sci. 4:387-396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ADAM11; ADAM22 AND ADAM23.

Entry informationi

Entry nameiLGI1_MOUSE
AccessioniPrimary (citable) accession number: Q9JIA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi