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Q9JIA1

- LGI1_MOUSE

UniProt

Q9JIA1 - LGI1_MOUSE

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Protein

Leucine-rich glioma-inactivated protein 1

Gene

Lgi1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity).By similarity

GO - Biological processi

  1. axon guidance Source: Ensembl
  2. positive regulation of cell growth Source: Ensembl
  3. positive regulation of synaptic transmission Source: UniProtKB
  4. protein homooligomerization Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich glioma-inactivated protein 1
Gene namesi
Name:Lgi1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:1861691. Lgi1.

Subcellular locationi

Secreted 2 Publications. Cell junctionsynapse By similarity
Note: Isoform 1 and isoform 2 are detected in the cytosolic and microsomal fractions respectively.

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. extracellular space Source: UniProtKB
  3. synapse Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 557523Leucine-rich glioma-inactivated protein 1PRO_0000017706Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
Glycosylationi277 – 2771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi422 – 4221N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9JIA1.
PaxDbiQ9JIA1.
PRIDEiQ9JIA1.

PTM databases

PhosphoSiteiQ9JIA1.

Expressioni

Tissue specificityi

Brain.1 Publication

Gene expression databases

BgeeiQ9JIA1.
CleanExiMM_LGI1.
ExpressionAtlasiQ9JIA1. baseline and differential.
GenevestigatoriQ9JIA1.

Interactioni

Subunit structurei

Oligomer (By similarity). Interacts with KCNA1 within a complex containing KCNA1, KCNA4 and KCNAB1 (By similarity). Part of a complex containing ADAM22, DLG4/PSD95 and CACNG2 (stargazin) (By similarity). Can bind to ADAM11 and ADAM23.By similarity1 Publication

Protein-protein interaction databases

IntActiQ9JIA1. 4 interactions.
MINTiMINT-4100357.
STRINGi10090.ENSMUSP00000084507.

Structurei

3D structure databases

ProteinModelPortaliQ9JIA1.
SMRiQ9JIA1. Positions 42-221.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 7238LRRNTAdd
BLAST
Repeati92 – 11322LRR 1Add
BLAST
Repeati116 – 13722LRR 2Add
BLAST
Repeati140 – 16122LRR 3Add
BLAST
Domaini173 – 22351LRRCTAdd
BLAST
Repeati224 – 26744EAR 1Add
BLAST
Repeati270 – 31344EAR 2Add
BLAST
Repeati316 – 36449EAR 3Add
BLAST
Repeati365 – 41551EAR 4Add
BLAST
Repeati418 – 46245EAR 5Add
BLAST
Repeati463 – 50644EAR 6Add
BLAST
Repeati509 – 55244EAR 7Add
BLAST

Sequence similaritiesi

Contains 7 EAR repeats.PROSITE-ProRule annotation
Contains 3 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiNOG304734.
GeneTreeiENSGT00390000016191.
HOGENOMiHOG000286015.
HOVERGENiHBG036744.
InParanoidiQ9JIA1.
OMAiRGNAFNC.
OrthoDBiEOG78SQHH.
PhylomeDBiQ9JIA1.
TreeFamiTF333155.

Family and domain databases

InterProiIPR000483. Cys-rich_flank_reg_C.
IPR009039. EAR.
IPR005492. EPTP.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamiPF03736. EPTP. 7 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEiPS50912. EAR. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9JIA1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESESSRRMG NACIPLKRIA YFLCLFSVVL LTEGKKPAKP KCPAVCTCSK
60 70 80 90 100
DNALCENARS IPRTVPPDVI SLSFVRSGFT EISEGSFLFT PSLQLLLFTS
110 120 130 140 150
NSFDVISDDA FIGLPHLEYL FIENNNIKSI SRHTFRGLKS LIHLSLANNN
160 170 180 190 200
LQTLPKDIFK GLDSLTNVDL RGNAFNCDCK LKWLVEWLGH TNATVEDIYC
210 220 230 240 250
EGPPEYKKRK INSLSPKDFD CIITEFAKSQ DLPYQSLSID TFSYLNDEYV
260 270 280 290 300
VIAQPFTGKC IFLEWDHVEK TFRNYDNITG TSTVVCKPIV IDTQLYVIVA
310 320 330 340 350
QLFGGSHIYK RDGFANKFIK IQDIEVLKIR KPNDIETFKI EDNWYFVVAD
360 370 380 390 400
SSKAGFTTIY KWNGNGFYSH QSLHAWYRDT DVEYLEIARP PLALRTPHLI
410 420 430 440 450
LSSSSQRPVI YQWSKATQLF TNQTDIPNME DVYAVKHFSV KGDVYICLTR
460 470 480 490 500
FIGDSKVMKW GGSSFQDIQR MPSRGSMVFQ PLQINNYQYA ILGSDYSFTQ
510 520 530 540 550
VYNWDAEKAK FVKFQELNVQ APRSFTHVSI NKRNFLFASS FKGNTQIYKH

VIVDLSA
Length:557
Mass (Da):63,644
Last modified:October 1, 2000 - v1
Checksum:i2692D53F13DEC431
GO
Isoform 2 (identifier: Q9JIA1-2)

Sequence is not available
Length:
Mass (Da):

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF246818 mRNA. Translation: AAF87077.1.
AK045443 mRNA. Translation: BAC32370.1.
BC066090 mRNA. Translation: AAH66090.1.
CCDSiCCDS29786.1. [Q9JIA1-1]
RefSeqiNP_064674.1. NM_020278.2. [Q9JIA1-1]
UniGeneiMm.298251.

Genome annotation databases

EnsembliENSMUST00000087252; ENSMUSP00000084507; ENSMUSG00000067242. [Q9JIA1-1]
GeneIDi56839.
KEGGimmu:56839.
UCSCiuc008hji.1. mouse. [Q9JIA1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF246818 mRNA. Translation: AAF87077.1 .
AK045443 mRNA. Translation: BAC32370.1 .
BC066090 mRNA. Translation: AAH66090.1 .
CCDSi CCDS29786.1. [Q9JIA1-1 ]
RefSeqi NP_064674.1. NM_020278.2. [Q9JIA1-1 ]
UniGenei Mm.298251.

3D structure databases

ProteinModelPortali Q9JIA1.
SMRi Q9JIA1. Positions 42-221.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9JIA1. 4 interactions.
MINTi MINT-4100357.
STRINGi 10090.ENSMUSP00000084507.

PTM databases

PhosphoSitei Q9JIA1.

Proteomic databases

MaxQBi Q9JIA1.
PaxDbi Q9JIA1.
PRIDEi Q9JIA1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000087252 ; ENSMUSP00000084507 ; ENSMUSG00000067242 . [Q9JIA1-1 ]
GeneIDi 56839.
KEGGi mmu:56839.
UCSCi uc008hji.1. mouse. [Q9JIA1-1 ]

Organism-specific databases

CTDi 9211.
MGIi MGI:1861691. Lgi1.

Phylogenomic databases

eggNOGi NOG304734.
GeneTreei ENSGT00390000016191.
HOGENOMi HOG000286015.
HOVERGENi HBG036744.
InParanoidi Q9JIA1.
OMAi RGNAFNC.
OrthoDBi EOG78SQHH.
PhylomeDBi Q9JIA1.
TreeFami TF333155.

Miscellaneous databases

NextBioi 313387.
PROi Q9JIA1.
SOURCEi Search...

Gene expression databases

Bgeei Q9JIA1.
CleanExi MM_LGI1.
ExpressionAtlasi Q9JIA1. baseline and differential.
Genevestigatori Q9JIA1.

Family and domain databases

InterProi IPR000483. Cys-rich_flank_reg_C.
IPR009039. EAR.
IPR005492. EPTP.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view ]
Pfami PF03736. EPTP. 7 hits.
PF13855. LRR_8. 1 hit.
[Graphical view ]
SMARTi SM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view ]
PROSITEi PS50912. EAR. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of the promoter, genomic structure, and mouse ortholog of LGI1."
    Somerville R.P.T., Chernova O., Liu S., Shoshan Y., Cowell J.K.
    Mamm. Genome 11:622-627(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6.
    Tissue: Brain.
  4. Lubec G., Kang S.U.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 161-171 AND 442-450, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: C57BL/6.
    Tissue: Brain.
  5. "ADPEAF mutations reduce levels of secreted LGI1, a putative tumor suppressor protein linked to epilepsy."
    Senechal K.R., Thaller C., Noebels J.L.
    Hum. Mol. Genet. 14:1613-1620(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. "The LGI1/epitempin gene encodes two protein isoforms differentially expressed in human brain."
    Furlan S., Roncaroli F., Forner F., Vitiello L., Calabria E., Piquer-Sirerol S., Valle G., Perez-Tur J., Michelucci R., Nobile C.
    J. Neurochem. 98:985-991(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY, ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  7. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  8. "LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11."
    Sagane K., Ishihama Y., Sugimoto H.
    Int. J. Biol. Sci. 4:387-396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ADAM11; ADAM22 AND ADAM23.

Entry informationi

Entry nameiLGI1_MOUSE
AccessioniPrimary (citable) accession number: Q9JIA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3