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Q9JIA1 (LGI1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 107. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine-rich glioma-inactivated protein 1
Gene names
Name:Lgi1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length557 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway By similarity.

Subunit structure

Oligomer By similarity. Interacts with KCNA1 within a complex containing KCNA1, KCNA4 and KCNAB1 By similarity. Part of a complex containing ADAM22, DLG4/PSD95 and CACNG2 (stargazin) By similarity. Can bind to ADAM11 and ADAM23. Ref.8

Subcellular location

Secreted. Cell junctionsynapse By similarity. Note: Isoform 1 and isoform 2 are detected in the cytosolic and microsomal fractions respectively. Ref.5 Ref.6

Tissue specificity

Brain. Ref.6

Post-translational modification

Glycosylated By similarity.

Sequence similarities

Contains 7 EAR repeats.

Contains 3 LRR (leucine-rich) repeats.

Contains 1 LRRCT domain.

Contains 1 LRRNT domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Select]
Isoform 1 (identifier: Q9JIA1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9JIA1-2)

The sequence of this isoform is not available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 557523Leucine-rich glioma-inactivated protein 1
PRO_0000017706

Regions

Domain35 – 7238LRRNT
Repeat92 – 11322LRR 1
Repeat116 – 13722LRR 2
Repeat140 – 16122LRR 3
Domain173 – 22351LRRCT
Repeat224 – 26744EAR 1
Repeat270 – 31344EAR 2
Repeat316 – 36449EAR 3
Repeat365 – 41551EAR 4
Repeat418 – 46245EAR 5
Repeat463 – 50644EAR 6
Repeat509 – 55244EAR 7

Amino acid modifications

Glycosylation1921N-linked (GlcNAc...) Potential
Glycosylation2771N-linked (GlcNAc...) Potential
Glycosylation4221N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 2692D53F13DEC431

FASTA55763,644
        10         20         30         40         50         60 
MESESSRRMG NACIPLKRIA YFLCLFSVVL LTEGKKPAKP KCPAVCTCSK DNALCENARS 

        70         80         90        100        110        120 
IPRTVPPDVI SLSFVRSGFT EISEGSFLFT PSLQLLLFTS NSFDVISDDA FIGLPHLEYL 

       130        140        150        160        170        180 
FIENNNIKSI SRHTFRGLKS LIHLSLANNN LQTLPKDIFK GLDSLTNVDL RGNAFNCDCK 

       190        200        210        220        230        240 
LKWLVEWLGH TNATVEDIYC EGPPEYKKRK INSLSPKDFD CIITEFAKSQ DLPYQSLSID 

       250        260        270        280        290        300 
TFSYLNDEYV VIAQPFTGKC IFLEWDHVEK TFRNYDNITG TSTVVCKPIV IDTQLYVIVA 

       310        320        330        340        350        360 
QLFGGSHIYK RDGFANKFIK IQDIEVLKIR KPNDIETFKI EDNWYFVVAD SSKAGFTTIY 

       370        380        390        400        410        420 
KWNGNGFYSH QSLHAWYRDT DVEYLEIARP PLALRTPHLI LSSSSQRPVI YQWSKATQLF 

       430        440        450        460        470        480 
TNQTDIPNME DVYAVKHFSV KGDVYICLTR FIGDSKVMKW GGSSFQDIQR MPSRGSMVFQ 

       490        500        510        520        530        540 
PLQINNYQYA ILGSDYSFTQ VYNWDAEKAK FVKFQELNVQ APRSFTHVSI NKRNFLFASS 

       550 
FKGNTQIYKH VIVDLSA 

« Hide

Isoform 2 (Sequence not available).

References

« Hide 'large scale' references
[1]"Identification of the promoter, genomic structure, and mouse ortholog of LGI1."
Somerville R.P.T., Chernova O., Liu S., Shoshan Y., Cowell J.K.
Mamm. Genome 11:622-627(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6J.
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Strain: C57BL/6.
Tissue: Brain.
[4]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 161-171 AND 442-450, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
[5]"ADPEAF mutations reduce levels of secreted LGI1, a putative tumor suppressor protein linked to epilepsy."
Senechal K.R., Thaller C., Noebels J.L.
Hum. Mol. Genet. 14:1613-1620(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[6]"The LGI1/epitempin gene encodes two protein isoforms differentially expressed in human brain."
Furlan S., Roncaroli F., Forner F., Vitiello L., Calabria E., Piquer-Sirerol S., Valle G., Perez-Tur J., Michelucci R., Nobile C.
J. Neurochem. 98:985-991(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[7]"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
[8]"LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11."
Sagane K., Ishihama Y., Sugimoto H.
Int. J. Biol. Sci. 4:387-396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH ADAM11; ADAM22 AND ADAM23.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF246818 mRNA. Translation: AAF87077.1.
AK045443 mRNA. Translation: BAC32370.1.
BC066090 mRNA. Translation: AAH66090.1.
RefSeqNP_064674.1. NM_020278.2.
UniGeneMm.298251.

3D structure databases

ProteinModelPortalQ9JIA1.
SMRQ9JIA1. Positions 42-221.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ9JIA1. 4 interactions.
MINTMINT-4100357.
STRING10090.ENSMUSP00000084507.

PTM databases

PhosphoSiteQ9JIA1.

Proteomic databases

PaxDbQ9JIA1.
PRIDEQ9JIA1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000087252; ENSMUSP00000084507; ENSMUSG00000067242. [Q9JIA1-1]
GeneID56839.
KEGGmmu:56839.
UCSCuc008hji.1. mouse. [Q9JIA1-1]

Organism-specific databases

CTD9211.
MGIMGI:1861691. Lgi1.

Phylogenomic databases

eggNOGNOG304734.
GeneTreeENSGT00390000016191.
HOGENOMHOG000286015.
HOVERGENHBG036744.
InParanoidQ9JIA1.
OMAYKRDGFA.
OrthoDBEOG78SQHH.
PhylomeDBQ9JIA1.
TreeFamTF333155.

Gene expression databases

ArrayExpressQ9JIA1.
BgeeQ9JIA1.
CleanExMM_LGI1.
GenevestigatorQ9JIA1.

Family and domain databases

InterProIPR000483. Cys-rich_flank_reg_C.
IPR009039. EAR.
IPR005492. EPTP.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
[Graphical view]
PfamPF03736. EPTP. 7 hits.
[Graphical view]
SMARTSM00369. LRR_TYP. 2 hits.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
[Graphical view]
PROSITEPS50912. EAR. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio313387.
PROQ9JIA1.
SOURCESearch...

Entry information

Entry nameLGI1_MOUSE
AccessionPrimary (citable) accession number: Q9JIA1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: October 1, 2000
Last modified: April 16, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot