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Q9JIA1

- LGI1_MOUSE

UniProt

Q9JIA1 - LGI1_MOUSE

Protein

Leucine-rich glioma-inactivated protein 1

Gene

Lgi1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway By similarity.By similarity

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. axon guidance Source: Ensembl
    2. positive regulation of cell growth Source: Ensembl
    3. positive regulation of synaptic transmission Source: UniProtKB
    4. protein homooligomerization Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Leucine-rich glioma-inactivated protein 1
    Gene namesi
    Name:Lgi1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1861691. Lgi1.

    Subcellular locationi

    Secreted 2 Publications. Cell junctionsynapse By similarity
    Note: Isoform 1 and isoform 2 are detected in the cytosolic and microsomal fractions respectively.

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. extracellular space Source: UniProtKB
    3. synapse Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Secreted, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 557523Leucine-rich glioma-inactivated protein 1PRO_0000017706Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi192 – 1921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi277 – 2771N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi422 – 4221N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Glycosylated.By similarity

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9JIA1.
    PaxDbiQ9JIA1.
    PRIDEiQ9JIA1.

    PTM databases

    PhosphoSiteiQ9JIA1.

    Expressioni

    Tissue specificityi

    Brain.1 Publication

    Gene expression databases

    ArrayExpressiQ9JIA1.
    BgeeiQ9JIA1.
    CleanExiMM_LGI1.
    GenevestigatoriQ9JIA1.

    Interactioni

    Subunit structurei

    Oligomer By similarity. Interacts with KCNA1 within a complex containing KCNA1, KCNA4 and KCNAB1 By similarity. Part of a complex containing ADAM22, DLG4/PSD95 and CACNG2 (stargazin) By similarity. Can bind to ADAM11 and ADAM23.By similarity1 Publication

    Protein-protein interaction databases

    IntActiQ9JIA1. 4 interactions.
    MINTiMINT-4100357.
    STRINGi10090.ENSMUSP00000084507.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JIA1.
    SMRiQ9JIA1. Positions 42-221.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 7238LRRNTAdd
    BLAST
    Repeati92 – 11322LRR 1Add
    BLAST
    Repeati116 – 13722LRR 2Add
    BLAST
    Repeati140 – 16122LRR 3Add
    BLAST
    Domaini173 – 22351LRRCTAdd
    BLAST
    Repeati224 – 26744EAR 1Add
    BLAST
    Repeati270 – 31344EAR 2Add
    BLAST
    Repeati316 – 36449EAR 3Add
    BLAST
    Repeati365 – 41551EAR 4Add
    BLAST
    Repeati418 – 46245EAR 5Add
    BLAST
    Repeati463 – 50644EAR 6Add
    BLAST
    Repeati509 – 55244EAR 7Add
    BLAST

    Sequence similaritiesi

    Contains 7 EAR repeats.PROSITE-ProRule annotation
    Contains 3 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 LRRNT domain.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG304734.
    GeneTreeiENSGT00390000016191.
    HOGENOMiHOG000286015.
    HOVERGENiHBG036744.
    InParanoidiQ9JIA1.
    OMAiRGNAFNC.
    OrthoDBiEOG78SQHH.
    PhylomeDBiQ9JIA1.
    TreeFamiTF333155.

    Family and domain databases

    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR009039. EAR.
    IPR005492. EPTP.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view]
    PfamiPF03736. EPTP. 7 hits.
    PF13855. LRR_8. 1 hit.
    [Graphical view]
    SMARTiSM00369. LRR_TYP. 2 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    PROSITEiPS50912. EAR. 7 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9JIA1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MESESSRRMG NACIPLKRIA YFLCLFSVVL LTEGKKPAKP KCPAVCTCSK    50
    DNALCENARS IPRTVPPDVI SLSFVRSGFT EISEGSFLFT PSLQLLLFTS 100
    NSFDVISDDA FIGLPHLEYL FIENNNIKSI SRHTFRGLKS LIHLSLANNN 150
    LQTLPKDIFK GLDSLTNVDL RGNAFNCDCK LKWLVEWLGH TNATVEDIYC 200
    EGPPEYKKRK INSLSPKDFD CIITEFAKSQ DLPYQSLSID TFSYLNDEYV 250
    VIAQPFTGKC IFLEWDHVEK TFRNYDNITG TSTVVCKPIV IDTQLYVIVA 300
    QLFGGSHIYK RDGFANKFIK IQDIEVLKIR KPNDIETFKI EDNWYFVVAD 350
    SSKAGFTTIY KWNGNGFYSH QSLHAWYRDT DVEYLEIARP PLALRTPHLI 400
    LSSSSQRPVI YQWSKATQLF TNQTDIPNME DVYAVKHFSV KGDVYICLTR 450
    FIGDSKVMKW GGSSFQDIQR MPSRGSMVFQ PLQINNYQYA ILGSDYSFTQ 500
    VYNWDAEKAK FVKFQELNVQ APRSFTHVSI NKRNFLFASS FKGNTQIYKH 550
    VIVDLSA 557
    Length:557
    Mass (Da):63,644
    Last modified:October 1, 2000 - v1
    Checksum:i2692D53F13DEC431
    GO
    Isoform 2 (identifier: Q9JIA1-2)

    Sequence is not available
    Length:
    Mass (Da):

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF246818 mRNA. Translation: AAF87077.1.
    AK045443 mRNA. Translation: BAC32370.1.
    BC066090 mRNA. Translation: AAH66090.1.
    CCDSiCCDS29786.1. [Q9JIA1-1]
    RefSeqiNP_064674.1. NM_020278.2. [Q9JIA1-1]
    UniGeneiMm.298251.

    Genome annotation databases

    EnsembliENSMUST00000087252; ENSMUSP00000084507; ENSMUSG00000067242. [Q9JIA1-1]
    GeneIDi56839.
    KEGGimmu:56839.
    UCSCiuc008hji.1. mouse. [Q9JIA1-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF246818 mRNA. Translation: AAF87077.1 .
    AK045443 mRNA. Translation: BAC32370.1 .
    BC066090 mRNA. Translation: AAH66090.1 .
    CCDSi CCDS29786.1. [Q9JIA1-1 ]
    RefSeqi NP_064674.1. NM_020278.2. [Q9JIA1-1 ]
    UniGenei Mm.298251.

    3D structure databases

    ProteinModelPortali Q9JIA1.
    SMRi Q9JIA1. Positions 42-221.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9JIA1. 4 interactions.
    MINTi MINT-4100357.
    STRINGi 10090.ENSMUSP00000084507.

    PTM databases

    PhosphoSitei Q9JIA1.

    Proteomic databases

    MaxQBi Q9JIA1.
    PaxDbi Q9JIA1.
    PRIDEi Q9JIA1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000087252 ; ENSMUSP00000084507 ; ENSMUSG00000067242 . [Q9JIA1-1 ]
    GeneIDi 56839.
    KEGGi mmu:56839.
    UCSCi uc008hji.1. mouse. [Q9JIA1-1 ]

    Organism-specific databases

    CTDi 9211.
    MGIi MGI:1861691. Lgi1.

    Phylogenomic databases

    eggNOGi NOG304734.
    GeneTreei ENSGT00390000016191.
    HOGENOMi HOG000286015.
    HOVERGENi HBG036744.
    InParanoidi Q9JIA1.
    OMAi RGNAFNC.
    OrthoDBi EOG78SQHH.
    PhylomeDBi Q9JIA1.
    TreeFami TF333155.

    Miscellaneous databases

    NextBioi 313387.
    PROi Q9JIA1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JIA1.
    Bgeei Q9JIA1.
    CleanExi MM_LGI1.
    Genevestigatori Q9JIA1.

    Family and domain databases

    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR009039. EAR.
    IPR005492. EPTP.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    [Graphical view ]
    Pfami PF03736. EPTP. 7 hits.
    PF13855. LRR_8. 1 hit.
    [Graphical view ]
    SMARTi SM00369. LRR_TYP. 2 hits.
    SM00082. LRRCT. 1 hit.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    PROSITEi PS50912. EAR. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of the promoter, genomic structure, and mouse ortholog of LGI1."
      Somerville R.P.T., Chernova O., Liu S., Shoshan Y., Cowell J.K.
      Mamm. Genome 11:622-627(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
      Tissue: Brain.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: C57BL/6.
      Tissue: Brain.
    4. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 161-171 AND 442-450, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    5. "ADPEAF mutations reduce levels of secreted LGI1, a putative tumor suppressor protein linked to epilepsy."
      Senechal K.R., Thaller C., Noebels J.L.
      Hum. Mol. Genet. 14:1613-1620(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    6. "The LGI1/epitempin gene encodes two protein isoforms differentially expressed in human brain."
      Furlan S., Roncaroli F., Forner F., Vitiello L., Calabria E., Piquer-Sirerol S., Valle G., Perez-Tur J., Michelucci R., Nobile C.
      J. Neurochem. 98:985-991(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY, ALTERNATIVE SPLICING, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    7. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
      Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
      Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    8. "LGI1 and LGI4 bind to ADAM22, ADAM23 and ADAM11."
      Sagane K., Ishihama Y., Sugimoto H.
      Int. J. Biol. Sci. 4:387-396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ADAM11; ADAM22 AND ADAM23.

    Entry informationi

    Entry nameiLGI1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JIA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 3, 2003
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 111 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3