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Protein

Sphingosine-1-phosphate phosphatase 1

Gene

Sgpp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Has enzymatic activity against both sphingosine 1-phosphate (S1P) and dihydro-S1P. Regulates intracellular and extracellular S1P levels (By similarity).By similarity

GO - Molecular functioni

  • sphingosine-1-phosphate phosphatase activity Source: MGI

GO - Biological processi

  • dephosphorylation Source: GOC
  • extrinsic apoptotic signaling pathway Source: MGI
  • intrinsic apoptotic signaling pathway Source: MGI
  • sphinganine-1-phosphate metabolic process Source: MGI
  • sphingolipid metabolic process Source: MGI
  • sphingosine metabolic process Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.

Chemistry

SwissLipidsiSLP:000000381.

Names & Taxonomyi

Protein namesi
Recommended name:
Sphingosine-1-phosphate phosphatase 1 (EC:3.1.3.-)
Short name:
SPP
Short name:
SPPase1
Short name:
mSPP1
Alternative name(s):
Sphingosine-1-phosphatase 1
Gene namesi
Name:Sgpp1
Synonyms:Spp1, Spph1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2135760. Sgpp1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei121 – 14121HelicalSequence analysisAdd
BLAST
Transmembranei152 – 17221HelicalSequence analysisAdd
BLAST
Transmembranei193 – 21321HelicalSequence analysisAdd
BLAST
Transmembranei216 – 23621HelicalSequence analysisAdd
BLAST
Transmembranei246 – 26621HelicalSequence analysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence analysisAdd
BLAST
Transmembranei311 – 33121HelicalSequence analysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence analysisAdd
BLAST
Transmembranei409 – 42921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • endoplasmic reticulum Source: MGI
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 430430Sphingosine-1-phosphate phosphatase 1PRO_0000114478Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei101 – 1011PhosphoserineCombined sources
Modified residuei103 – 1031PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JI99.
MaxQBiQ9JI99.
PaxDbiQ9JI99.
PRIDEiQ9JI99.

PTM databases

iPTMnetiQ9JI99.
PhosphoSiteiQ9JI99.

Expressioni

Tissue specificityi

Highly expressed in liver and kidney.1 Publication

Gene expression databases

BgeeiQ9JI99.
CleanExiMM_SGPP1.
MM_SPP1.
ExpressionAtlasiQ9JI99. baseline and differential.
GenevisibleiQ9JI99. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021450.

Structurei

3D structure databases

ProteinModelPortaliQ9JI99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQK8. Eukaryota.
ENOG410Z1GR. LUCA.
GeneTreeiENSGT00390000017322.
HOGENOMiHOG000234228.
HOVERGENiHBG079185.
InParanoidiQ9JI99.
KOiK04716.
OMAiWIWNLDP.
OrthoDBiEOG72VH66.
PhylomeDBiQ9JI99.
TreeFamiTF323419.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JI99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLGQRLALL ASRLQEPQRV ASFQRLCGVE VPLSSPAADE DAETEVRGAP
60 70 80 90 100
GEPRRRGRQP GAEDSPAKAD CCGAPNGVRN GLAAEPGPTG PRRAGSQRRN
110 120 130 140 150
SLTGEEGELV KVSNLPLYYL FCLGTELGNE LFYILFFPFW IWNLDPFVGR
160 170 180 190 200
RLVIIWVLVM YLGQCTKDII RWPRPASPPV IKLEVFYNSE YSMPSTHAMS
210 220 230 240 250
GTAIPIAMFL LTYGRWQYPL IYGLILIPCW SSLVCLSRIY MGMHSILDVI
260 270 280 290 300
AGFLYTILIL IIFYPLVDLI DNFNQTYKYA PLIIIGLHLI LGIFSFTLDT
310 320 330 340 350
WSTSRGDTAE ILGSGAGIAC GSHAAYTLGL SLEPSLHMLP LAIPPLTVTL
360 370 380 390 400
FGKAILRIVL GMLLVLFVRD IMKKITIPLA CKLSSIPCHD IRQARQHMEV
410 420 430
ELPYRYITYG MVGFSITFLV PYVFSFIGIS
Length:430
Mass (Da):47,744
Last modified:October 1, 2000 - v1
Checksum:i503A6D8162C141C7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247177 mRNA. Translation: AAF90052.1.
AF415215 mRNA. Translation: AAL07501.1.
BC037592 mRNA. Translation: AAH37592.1.
CCDSiCCDS25986.1.
RefSeqiNP_109675.1. NM_030750.3.
UniGeneiMm.280199.

Genome annotation databases

EnsembliENSMUST00000021450; ENSMUSP00000021450; ENSMUSG00000021054.
GeneIDi81535.
KEGGimmu:81535.
UCSCiuc007nxk.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF247177 mRNA. Translation: AAF90052.1.
AF415215 mRNA. Translation: AAL07501.1.
BC037592 mRNA. Translation: AAH37592.1.
CCDSiCCDS25986.1.
RefSeqiNP_109675.1. NM_030750.3.
UniGeneiMm.280199.

3D structure databases

ProteinModelPortaliQ9JI99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000021450.

Chemistry

SwissLipidsiSLP:000000381.

PTM databases

iPTMnetiQ9JI99.
PhosphoSiteiQ9JI99.

Proteomic databases

EPDiQ9JI99.
MaxQBiQ9JI99.
PaxDbiQ9JI99.
PRIDEiQ9JI99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000021450; ENSMUSP00000021450; ENSMUSG00000021054.
GeneIDi81535.
KEGGimmu:81535.
UCSCiuc007nxk.2. mouse.

Organism-specific databases

CTDi81537.
MGIiMGI:2135760. Sgpp1.

Phylogenomic databases

eggNOGiENOG410IQK8. Eukaryota.
ENOG410Z1GR. LUCA.
GeneTreeiENSGT00390000017322.
HOGENOMiHOG000234228.
HOVERGENiHBG079185.
InParanoidiQ9JI99.
KOiK04716.
OMAiWIWNLDP.
OrthoDBiEOG72VH66.
PhylomeDBiQ9JI99.
TreeFamiTF323419.

Enzyme and pathway databases

ReactomeiR-MMU-1660661. Sphingolipid de novo biosynthesis.

Miscellaneous databases

ChiTaRSiSgpp1. mouse.
PROiQ9JI99.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JI99.
CleanExiMM_SGPP1.
MM_SPP1.
ExpressionAtlasiQ9JI99. baseline and differential.
GenevisibleiQ9JI99. MM.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1-phosphate and induces cell death."
    Mandala S.M., Thornton R., Galve-Roperh I., Poulton S., Peterson C., Olivera A., Bergstrom J., Kurtz M.B., Spiegel S.
    Proc. Natl. Acad. Sci. U.S.A. 97:7859-7864(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. Thompson D., Pyne S.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N-3.
    Tissue: Mammary cancer.
  4. "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations."
    Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F., Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D., Gerrits B., Panse C., Schlapbach R., Mansuy I.M.
    Mol. Cell. Proteomics 6:283-293(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain cortex.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
    Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J.
    Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.
  7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-101, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiSGPP1_MOUSE
AccessioniPrimary (citable) accession number: Q9JI99
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2003
Last sequence update: October 1, 2000
Last modified: June 8, 2016
This is version 113 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.