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Protein

Syntenin-1

Gene

Sdcbp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.By similarity

GO - Molecular functioni

  • cell adhesion molecule binding Source: RGD
  • ephrin receptor binding Source: RGD
  • glycoprotein binding Source: RGD
  • growth factor binding Source: RGD
  • interleukin-5 receptor binding Source: UniProtKB
  • neurexin family protein binding Source: UniProtKB
  • protein C-terminus binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD
  • syndecan binding Source: RGD

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-3928664. Ephrin signaling.
R-RNO-447043. Neurofascin interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Syntenin-1
Alternative name(s):
Syndecan-binding protein 1
Gene namesi
Name:Sdcbp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi621497. Sdcbp.

Subcellular locationi

  • Cell junctionfocal adhesion By similarity
  • Cell junctionadherens junction By similarity
  • Cell membrane By similarity; Peripheral membrane protein By similarity
  • Endoplasmic reticulum membrane By similarity; Peripheral membrane protein By similarity
  • Nucleus By similarity
  • Melanosome By similarity
  • Cytoplasmcytosol By similarity
  • Cytoplasmcytoskeleton By similarity
  • Secretedexosome By similarity
  • Membrane raft By similarity

  • Note: Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoskeleton, Endoplasmic reticulum, Membrane, Nucleus, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 300299Syntenin-1PRO_0000184003Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity
Modified residuei6 – 61PhosphoserineCombined sources
Modified residuei48 – 481PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylated on tyrosine residues.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ9JI92.
PRIDEiQ9JI92.

PTM databases

iPTMnetiQ9JI92.

Expressioni

Gene expression databases

GenevisibleiQ9JI92. RN.

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with neurofascin and SDCBP2 (PubMed:11152476). Interacts with PTPRJ (PubMed:11434923). Interacts with SDC1, SDC2, SDC3, SDC4, NRXN2, EPHA7, EPHB1, NF2 isoform 1, TGFA and IL5RA (By similarity). Interacts with PDCD6IP. Forms a complex with PDCD6IP and SDC2. Interacts (via C-terminus) with TGFBR1 (By similarity).By similarity2 Publications

GO - Molecular functioni

  • cell adhesion molecule binding Source: RGD
  • ephrin receptor binding Source: RGD
  • glycoprotein binding Source: RGD
  • growth factor binding Source: RGD
  • interleukin-5 receptor binding Source: UniProtKB
  • neurexin family protein binding Source: UniProtKB
  • protein C-terminus binding Source: RGD
  • protein heterodimerization activity Source: RGD
  • protein homodimerization activity Source: RGD
  • syndecan binding Source: RGD

Protein-protein interaction databases

BioGridi249867. 8 interactions.
IntActiQ9JI92. 10 interactions.
MINTiMINT-1776939.
STRINGi10116.ENSRNOP00000013563.

Structurei

3D structure databases

ProteinModelPortaliQ9JI92.
SMRiQ9JI92. Positions 115-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini116 – 19580PDZ 1PROSITE-ProRule annotationAdd
BLAST
Domaini200 – 27475PDZ 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 104103Interaction with PDCD6IPBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi3 – 75LYPX(n)L motif 1By similarity
Motifi47 – 515LYPX(n)L motif 2By similarity
Motifi51 – 555LYPX(n)L motif 3By similarity

Sequence similaritiesi

Contains 2 PDZ (DHR) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IEB7. Eukaryota.
ENOG410YNPQ. LUCA.
GeneTreeiENSGT00390000014465.
HOGENOMiHOG000231604.
HOVERGENiHBG053211.
InParanoidiQ9JI92.
KOiK17254.
OMAiHICEING.
OrthoDBiEOG75MVWZ.
PhylomeDBiQ9JI92.
TreeFamiTF327131.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR001478. PDZ.
IPR030528. SDCBP.
[Graphical view]
PANTHERiPTHR12345:SF10. PTHR12345:SF10. 1 hit.
PfamiPF00595. PDZ. 2 hits.
[Graphical view]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JI92-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLYPSLEDL KVDKVIQAQT ASSANPASQA FFLNVVDSAA FPPGGNLYPK
60 70 80 90 100
LYPELSQYMG LSLSEAEICE NMPVVSGAPT QGQLVARPSS VNYMVAPVTG
110 120 130 140 150
NDAGIRRAEI KQGIREVILC KDQDGKIGLR LKSVDNGIFV QLVQANSPAS
160 170 180 190 200
LVGLRFGDQV LQINGENCAG WSSDKAHKVL KQAFGEKITM TIRDRPFERT
210 220 230 240 250
VTMHKDSSGH VGFIFKSGKI TSIVKDSSAA RNGLLTDHHI CEINGQNVIG
260 270 280 290 300
LKDAQIADIL STAGTVVTIT IMPAFIFEHI IKRMAPSIMK SLMDHTIPEV
Length:300
Mass (Da):32,423
Last modified:October 1, 2000 - v1
Checksum:iF52D8918DE17F710
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF248548 mRNA. Translation: AAF86960.1.
AJ292243 mRNA. Translation: CAC21602.1.
BC064651 mRNA. Translation: AAH64651.1.
RefSeqiNP_114192.1. NM_031986.1.
UniGeneiRn.4309.

Genome annotation databases

EnsembliENSRNOT00000013563; ENSRNOP00000013563; ENSRNOG00000009683.
GeneIDi83841.
KEGGirno:83841.
UCSCiRGD:621497. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF248548 mRNA. Translation: AAF86960.1.
AJ292243 mRNA. Translation: CAC21602.1.
BC064651 mRNA. Translation: AAH64651.1.
RefSeqiNP_114192.1. NM_031986.1.
UniGeneiRn.4309.

3D structure databases

ProteinModelPortaliQ9JI92.
SMRiQ9JI92. Positions 115-275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi249867. 8 interactions.
IntActiQ9JI92. 10 interactions.
MINTiMINT-1776939.
STRINGi10116.ENSRNOP00000013563.

PTM databases

iPTMnetiQ9JI92.

Proteomic databases

PaxDbiQ9JI92.
PRIDEiQ9JI92.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000013563; ENSRNOP00000013563; ENSRNOG00000009683.
GeneIDi83841.
KEGGirno:83841.
UCSCiRGD:621497. rat.

Organism-specific databases

CTDi6386.
RGDi621497. Sdcbp.

Phylogenomic databases

eggNOGiENOG410IEB7. Eukaryota.
ENOG410YNPQ. LUCA.
GeneTreeiENSGT00390000014465.
HOGENOMiHOG000231604.
HOVERGENiHBG053211.
InParanoidiQ9JI92.
KOiK17254.
OMAiHICEING.
OrthoDBiEOG75MVWZ.
PhylomeDBiQ9JI92.
TreeFamiTF327131.

Enzyme and pathway databases

ReactomeiR-RNO-3928664. Ephrin signaling.
R-RNO-447043. Neurofascin interactions.

Miscellaneous databases

NextBioi616501.
PROiQ9JI92.

Gene expression databases

GenevisibleiQ9JI92. RN.

Family and domain databases

Gene3Di2.30.42.10. 2 hits.
InterProiIPR001478. PDZ.
IPR030528. SDCBP.
[Graphical view]
PANTHERiPTHR12345:SF10. PTHR12345:SF10. 1 hit.
PfamiPF00595. PDZ. 2 hits.
[Graphical view]
SMARTiSM00228. PDZ. 2 hits.
[Graphical view]
SUPFAMiSSF50156. SSF50156. 2 hits.
PROSITEiPS50106. PDZ. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The neural cell recognition molecule neurofascin interacts with syntenin-1 but not with syntenin-2, both of which reveal self-associating activity."
    Koroll M., Rathjen F.G., Volkmer H.
    J. Biol. Chem. 276:10646-10654(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH SDCBP2 AND NEUROFASCIN.
    Strain: Sprague-Dawley.
    Tissue: Brain.
  2. "Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilaments."
    Zimmermann P., Tomatis D., Rosas M., Grootjans J.J., Leenaerts I., Degeest G., Reekmans G., Coomans C., David G.
    Mol. Biol. Cell 12:339-350(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  4. "Rat protein tyrosine phosphatase eta physically interacts with the PDZ domains of syntenin."
    Iuliano R., Trapasso F., Sama I., Le Pera I., Martelli M.L., Lembo F., Santoro M., Viglietto G., Chiariotti L., Fusco A.
    FEBS Lett. 500:41-44(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTPRJ.
  5. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSDCB1_RAT
AccessioniPrimary (citable) accession number: Q9JI92
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.