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Q9JI83 (PLAC1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 77. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Placenta-specific protein 1
Alternative name(s):
EPCS26
Gene names
Name:Plac1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length173 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in placental development. Ref.2

Subcellular location

Secreted Probable.

Tissue specificity

Expressed in placenta. Ref.2

Developmental stage

Strongly expressed at 7 dpc and gradually declines with the progression of embryogenesis. Expression detected from 7.5 to 14.5 dpc in ectoplacental cone, trophoblast giant cells, and labyrinthine trophoblasts. Ref.2

Sequence similarities

Belongs to the PLAC1 family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processplacenta development

Inferred from expression pattern Ref.2. Source: UniProtKB

spongiotrophoblast layer developmental growth

Inferred from mutant phenotype PubMed 22729990. Source: MGI

   Cellular_componentextracellular region

Inferred from direct assay PubMed 11747200. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 173150Placenta-specific protein 1
PRO_0000251145

Experimental info

Sequence conflict691H → R in AAH51666. Ref.4
Sequence conflict1571E → G in AAH51666. Ref.4
Sequence conflict1591P → R in BAE26717. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9JI83 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 674AEF2B68181162

FASTA17319,626
        10         20         30         40         50         60 
MNLRKFLGGT VLVAFMLFSY SEQNQVNVLC STDWFMVTVH PFLLNNDVYV HFYEVHLGLG 

        70         80         90        100        110        120 
CPPNHVHPHF YQFHYRVTEC GIRIKAVSPD VVIYSSEIHY ASKGSSTKYV IPVSCAAPRR 

       130        140        150        160        170 
SPWLTKPYSA KAPSNNMGAT PKNDTSYHVF TLPEPSEQPN CSCPPYVYNQ KSM 

« Hide

References

« Hide 'large scale' references
[1]"cDNA subtraction cloning reveals novel genes whose temporal and spatial expression indicates association with trophoblast invasion."
Hemberger M., Himmelbauer H., Ruschmann J., Zeitz C., Fundele R.
Dev. Biol. 222:158-169(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"PLAC1, an Xq26 gene with placenta-specific expression."
Cocchia M., Huber R., Pantano S., Chen E.Y., Ma P., Forabosco A., Ko M.S.H., Schlessinger D.
Genomics 68:305-312(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Placenta.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF250838 mRNA. Translation: AAF81275.1.
AF234653 mRNA. Translation: AAG22595.1.
AK005501 mRNA. Translation: BAB24083.1.
AK145876 mRNA. Translation: BAE26717.1.
BC051666 mRNA. Translation: AAH51666.1.
CCDSCCDS30128.1.
RefSeqNP_062411.1. NM_019538.4.
XP_006541587.1. XM_006541524.1.
XP_006541588.1. XM_006541525.1.
UniGeneMm.274842.

3D structure databases

ProteinModelPortalQ9JI83.
SMRQ9JI83. Positions 24-122.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ9JI83.

Proteomic databases

PRIDEQ9JI83.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000074861; ENSMUSP00000074404; ENSMUSG00000061082.
ENSMUST00000114843; ENSMUSP00000110492; ENSMUSG00000061082.
ENSMUST00000174390; ENSMUSP00000133862; ENSMUSG00000061082.
GeneID56096.
KEGGmmu:56096.
UCSCuc009tet.1. mouse.

Organism-specific databases

CTD10761.
MGIMGI:1926287. Plac1.

Phylogenomic databases

eggNOGNOG44687.
GeneTreeENSGT00530000064049.
HOGENOMHOG000049283.
HOVERGENHBG080610.
InParanoidQ9JI83.
OMAFHELHLG.
OrthoDBEOG73JKWP.
PhylomeDBQ9JI83.
TreeFamTF338479.

Gene expression databases

BgeeQ9JI83.
CleanExMM_PLAC1.
GenevestigatorQ9JI83.

Family and domain databases

InterProIPR001507. ZP_dom.
[Graphical view]
PfamPF00100. Zona_pellucida. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio311924.
PROQ9JI83.
SOURCESearch...

Entry information

Entry namePLAC1_MOUSE
AccessionPrimary (citable) accession number: Q9JI83
Secondary accession number(s): Q3UKT4, Q80WW3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot