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Q9JI83

- PLAC1_MOUSE

UniProt

Q9JI83 - PLAC1_MOUSE

Protein

Placenta-specific protein 1

Gene

Plac1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    May play a role in placental development.1 Publication

    GO - Biological processi

    1. placenta development Source: UniProtKB
    2. spongiotrophoblast layer developmental growth Source: MGI

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Placenta-specific protein 1
    Alternative name(s):
    EPCS26
    Gene namesi
    Name:Plac1Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome X

    Organism-specific databases

    MGIiMGI:1926287. Plac1.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: MGI

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 173150Placenta-specific protein 1Sequence AnalysisPRO_0000251145Add
    BLAST

    Proteomic databases

    PRIDEiQ9JI83.

    PTM databases

    PhosphoSiteiQ9JI83.

    Expressioni

    Tissue specificityi

    Expressed in placenta.1 Publication

    Developmental stagei

    Strongly expressed at 7 dpc and gradually declines with the progression of embryogenesis. Expression detected from 7.5 to 14.5 dpc in ectoplacental cone, trophoblast giant cells, and labyrinthine trophoblasts.1 Publication

    Gene expression databases

    BgeeiQ9JI83.
    CleanExiMM_PLAC1.
    GenevestigatoriQ9JI83.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JI83.
    SMRiQ9JI83. Positions 24-122.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PLAC1 family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG44687.
    GeneTreeiENSGT00530000064049.
    HOGENOMiHOG000049283.
    HOVERGENiHBG080610.
    InParanoidiQ9JI83.
    OMAiFHELHLG.
    OrthoDBiEOG73JKWP.
    PhylomeDBiQ9JI83.
    TreeFamiTF338479.

    Family and domain databases

    InterProiIPR001507. ZP_dom.
    [Graphical view]
    PfamiPF00100. Zona_pellucida. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JI83-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLRKFLGGT VLVAFMLFSY SEQNQVNVLC STDWFMVTVH PFLLNNDVYV    50
    HFYEVHLGLG CPPNHVHPHF YQFHYRVTEC GIRIKAVSPD VVIYSSEIHY 100
    ASKGSSTKYV IPVSCAAPRR SPWLTKPYSA KAPSNNMGAT PKNDTSYHVF 150
    TLPEPSEQPN CSCPPYVYNQ KSM 173
    Length:173
    Mass (Da):19,626
    Last modified:October 1, 2000 - v1
    Checksum:i674AEF2B68181162
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti69 – 691H → R in AAH51666. (PubMed:15489334)Curated
    Sequence conflicti157 – 1571E → G in AAH51666. (PubMed:15489334)Curated
    Sequence conflicti159 – 1591P → R in BAE26717. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF250838 mRNA. Translation: AAF81275.1.
    AF234653 mRNA. Translation: AAG22595.1.
    AK005501 mRNA. Translation: BAB24083.1.
    AK145876 mRNA. Translation: BAE26717.1.
    BC051666 mRNA. Translation: AAH51666.1.
    CCDSiCCDS30128.1.
    RefSeqiNP_062411.1. NM_019538.4.
    XP_006541587.1. XM_006541524.1.
    XP_006541588.1. XM_006541525.1.
    UniGeneiMm.274842.

    Genome annotation databases

    EnsembliENSMUST00000074861; ENSMUSP00000074404; ENSMUSG00000061082.
    ENSMUST00000114843; ENSMUSP00000110492; ENSMUSG00000061082.
    ENSMUST00000174390; ENSMUSP00000133862; ENSMUSG00000061082.
    GeneIDi56096.
    KEGGimmu:56096.
    UCSCiuc009tet.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF250838 mRNA. Translation: AAF81275.1 .
    AF234653 mRNA. Translation: AAG22595.1 .
    AK005501 mRNA. Translation: BAB24083.1 .
    AK145876 mRNA. Translation: BAE26717.1 .
    BC051666 mRNA. Translation: AAH51666.1 .
    CCDSi CCDS30128.1.
    RefSeqi NP_062411.1. NM_019538.4.
    XP_006541587.1. XM_006541524.1.
    XP_006541588.1. XM_006541525.1.
    UniGenei Mm.274842.

    3D structure databases

    ProteinModelPortali Q9JI83.
    SMRi Q9JI83. Positions 24-122.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q9JI83.

    Proteomic databases

    PRIDEi Q9JI83.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000074861 ; ENSMUSP00000074404 ; ENSMUSG00000061082 .
    ENSMUST00000114843 ; ENSMUSP00000110492 ; ENSMUSG00000061082 .
    ENSMUST00000174390 ; ENSMUSP00000133862 ; ENSMUSG00000061082 .
    GeneIDi 56096.
    KEGGi mmu:56096.
    UCSCi uc009tet.1. mouse.

    Organism-specific databases

    CTDi 10761.
    MGIi MGI:1926287. Plac1.

    Phylogenomic databases

    eggNOGi NOG44687.
    GeneTreei ENSGT00530000064049.
    HOGENOMi HOG000049283.
    HOVERGENi HBG080610.
    InParanoidi Q9JI83.
    OMAi FHELHLG.
    OrthoDBi EOG73JKWP.
    PhylomeDBi Q9JI83.
    TreeFami TF338479.

    Miscellaneous databases

    NextBioi 311924.
    PROi Q9JI83.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JI83.
    CleanExi MM_PLAC1.
    Genevestigatori Q9JI83.

    Family and domain databases

    InterProi IPR001507. ZP_dom.
    [Graphical view ]
    Pfami PF00100. Zona_pellucida. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "cDNA subtraction cloning reveals novel genes whose temporal and spatial expression indicates association with trophoblast invasion."
      Hemberger M., Himmelbauer H., Ruschmann J., Zeitz C., Fundele R.
      Dev. Biol. 222:158-169(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported.
      Tissue: PlacentaImported.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported.
      Tissue: EmbryoImported.

    Entry informationi

    Entry nameiPLAC1_MOUSE
    AccessioniPrimary (citable) accession number: Q9JI83
    Secondary accession number(s): Q3UKT4, Q80WW3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3