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Protein

Kelch-like protein 1

Gene

Klhl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in organizing the actin cytoskeleton of the brain cells.

GO - Biological processi

  • adult walking behavior Source: MGI
  • cerebellar Purkinje cell layer development Source: MGI
  • dendrite development Source: MGI
  • locomotory behavior Source: MGI
  • protein ubiquitination Source: GOC
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch-like protein 1
Gene namesi
Name:Klhl1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2136335. Klhl1.

Subcellular locationi

GO - Cellular componenti

  • Cul3-RING ubiquitin ligase complex Source: GO_Central
  • cytoplasm Source: UniProtKB
  • cytoskeleton Source: UniProtKB-SubCell
  • dendrite Source: MGI
  • neuronal cell body Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 751751Kelch-like protein 1PRO_0000119100Add
BLAST

Proteomic databases

PaxDbiQ9JI74.
PRIDEiQ9JI74.

2D gel databases

UCD-2DPAGEQ9JI74.

PTM databases

iPTMnetiQ9JI74.
PhosphoSiteiQ9JI74.

Expressioni

Tissue specificityi

Highly expressed in brain.

Gene expression databases

BgeeiQ9JI74.
CleanExiMM_KLHL1.
GenevisibleiQ9JI74. MM.

Interactioni

Protein-protein interaction databases

BioGridi220238. 3 interactions.
STRINGi10090.ENSMUSP00000022666.

Structurei

3D structure databases

ProteinModelPortaliQ9JI74.
SMRiQ9JI74. Positions 197-388, 411-750.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini215 – 28268BTBPROSITE-ProRule annotationAdd
BLAST
Repeati463 – 50947Kelch 1Add
BLAST
Repeati510 – 55647Kelch 2Add
BLAST
Repeati558 – 60346Kelch 3Add
BLAST
Repeati604 – 65047Kelch 4Add
BLAST
Repeati652 – 70352Kelch 5Add
BLAST
Repeati704 – 75047Kelch 6Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi45 – 9046Ser-richAdd
BLAST

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118931.
HOVERGENiHBG014286.
InParanoidiQ9JI74.
KOiK10442.
OMAiDVCCHFL.
OrthoDBiEOG7ZWD17.
TreeFamiTF329218.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JI74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGSGRKDFD VKHILRLRWK LFSHPSPASS SPAGGSCLQQ DSGGGSFEHW
60 70 80 90 100
GPSQSRLLKN QEKGSVSAFW KKPSSSSSSS SSSSSSASSS PFNPLNGTLL
110 120 130 140 150
PVATRLQQGA PGQGTQQPAR TLFYVESLEE EVVTGMDFSG PEDKGLALKE
160 170 180 190 200
LQAEPASSIQ ATGEGCGHRL TSTNHSLTPQ SDLDSSSSEE FYQAVHHAEQ
210 220 230 240 250
SFRKMENYLK QQQLCDVILI VGNRKIPAHR LVLSSVSDYF AAMFTSDVCE
260 270 280 290 300
AKQEEIKMEG IDPNALWDLV QFAYTGCLEL KEDTIENLLA AACLLQLPQV
310 320 330 340 350
VEVCCHFLMK LLHPSNCLGI RAFADAQGCI ELMKVAHSYT MENIMEVIRN
360 370 380 390 400
QEFLLLPAEE LHKLLASDDV NVPDEETIFH ALMMWVKYDM QRRCSDLSML
410 420 430 440 450
LAFIRLPLLP PQILADLENH ALFKNDLECQ KLILEAMKYH LLPERRTLMQ
460 470 480 490 500
SPRTKPRKST VGTLYAVGGM DNNKGATTIE KYDLRTNLWI QAGMMNGRRL
510 520 530 540 550
QFGVAVIDDK LFVIGGRDGL KTLNTVECYN PKTKTWTVLP PMSTHRHGLG
560 570 580 590 600
VTVLEGPIYA VGGHDGWSYL NTVERWDPQS QQWTYVASMS IARSTVGVAA
610 620 630 640 650
LNGKLYSVGG RDGSSCLSSM EYYDPHTNKW SMCAPMCKRR GGVGVATCDG
660 670 680 690 700
FLYAVGGHDA PASNHCSRLL DYVERYDPKT DTWTMVAPLS MPRDAVGVCL
710 720 730 740 750
LGDRLYAVGG YDGQTYLNTM ESYDPQTNEW TQMASLNIGR AGACVVVIKQ

P
Length:751
Mass (Da):82,892
Last modified:July 27, 2011 - v2
Checksum:iD8296768D56EB894
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti139 – 1391S → P in AAF81717 (PubMed:10888605).Curated
Sequence conflicti142 – 1421E → Q in AAF81717 (PubMed:10888605).Curated
Sequence conflicti196 – 1961H → R in AAF81717 (PubMed:10888605).Curated
Sequence conflicti634 – 6341A → P in AAF81717 (PubMed:10888605).Curated
Sequence conflicti639 – 6391R → K in AAF81717 (PubMed:10888605).Curated
Sequence conflicti677 – 6771D → E in AAF81717 (PubMed:10888605).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252281 mRNA. Translation: AAF81717.1.
CT025590
, AC131920, AC131989, AC154580 Genomic DNA. Translation: CAO77960.1.
BC094584 mRNA. Translation: AAH94584.1.
CCDSiCCDS27308.1.
RefSeqiNP_444335.2. NM_053105.2.
UniGeneiMm.308735.

Genome annotation databases

EnsembliENSMUST00000022666; ENSMUSP00000022666; ENSMUSG00000022076.
GeneIDi93688.
KEGGimmu:93688.
UCSCiuc007uuq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF252281 mRNA. Translation: AAF81717.1.
CT025590
, AC131920, AC131989, AC154580 Genomic DNA. Translation: CAO77960.1.
BC094584 mRNA. Translation: AAH94584.1.
CCDSiCCDS27308.1.
RefSeqiNP_444335.2. NM_053105.2.
UniGeneiMm.308735.

3D structure databases

ProteinModelPortaliQ9JI74.
SMRiQ9JI74. Positions 197-388, 411-750.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220238. 3 interactions.
STRINGi10090.ENSMUSP00000022666.

PTM databases

iPTMnetiQ9JI74.
PhosphoSiteiQ9JI74.

2D gel databases

UCD-2DPAGEQ9JI74.

Proteomic databases

PaxDbiQ9JI74.
PRIDEiQ9JI74.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022666; ENSMUSP00000022666; ENSMUSG00000022076.
GeneIDi93688.
KEGGimmu:93688.
UCSCiuc007uuq.1. mouse.

Organism-specific databases

CTDi57626.
MGIiMGI:2136335. Klhl1.

Phylogenomic databases

eggNOGiKOG4441. Eukaryota.
ENOG410XNX8. LUCA.
GeneTreeiENSGT00760000118931.
HOVERGENiHBG014286.
InParanoidiQ9JI74.
KOiK10442.
OMAiDVCCHFL.
OrthoDBiEOG7ZWD17.
TreeFamiTF329218.

Miscellaneous databases

PROiQ9JI74.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JI74.
CleanExiMM_KLHL1.
GenevisibleiQ9JI74. MM.

Family and domain databases

Gene3Di2.130.10.80. 1 hit.
InterProiIPR011705. BACK.
IPR000210. BTB/POZ_dom.
IPR015916. Gal_Oxidase_b-propeller.
IPR006652. Kelch_1.
IPR011333. SKP1/BTB/POZ.
[Graphical view]
PfamiPF07707. BACK. 1 hit.
PF00651. BTB. 1 hit.
PF01344. Kelch_1. 6 hits.
[Graphical view]
SMARTiSM00875. BACK. 1 hit.
SM00225. BTB. 1 hit.
SM00612. Kelch. 6 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The SCA8 transcript is an antisense RNA to a brain-specific transcript encoding a novel actin-binding protein (KLHL1)."
    Koob M.D., Nemes J.P., Benzow K.A.
    Hum. Mol. Genet. 9:1543-1551(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Eye.

Entry informationi

Entry nameiKLHL1_MOUSE
AccessioniPrimary (citable) accession number: Q9JI74
Secondary accession number(s): Q505E9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: July 6, 2016
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.