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Protein

Delta-like protein 4

Gene

Dll4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the Notch signaling pathway as Notch ligand (PubMed:11134954). Activates NOTCH1 and NOTCH4. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting (By similarity). Essential for retinal progenitor proliferation. Required for suppressing rod fates in late retinal progenitors as well as for proper generation of other retinal cell types (PubMed:22323600). During spinal cord neurogenesis, inhibits V2a interneuron fate (By similarity).By similarity2 Publications

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • Notch binding Source: MGI

GO - Biological processi

  • angiogenesis Source: MGI
  • blood vessel lumenization Source: BHF-UCL
  • blood vessel remodeling Source: BHF-UCL
  • cardiac atrium morphogenesis Source: BHF-UCL
  • cardiac ventricle morphogenesis Source: BHF-UCL
  • cellular response to fibroblast growth factor stimulus Source: UniProtKB
  • cellular response to vascular endothelial growth factor stimulus Source: UniProtKB
  • dorsal aorta morphogenesis Source: BHF-UCL
  • negative regulation of blood vessel endothelial cell migration Source: MGI
  • negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis Source: MGI
  • negative regulation of cell migration involved in sprouting angiogenesis Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of endothelial cell migration Source: UniProtKB
  • negative regulation of gene expression Source: MGI
  • negative regulation of Notch signaling pathway Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • Notch signaling involved in heart development Source: BHF-UCL
  • Notch signaling pathway Source: MGI
  • patterning of blood vessels Source: BHF-UCL
  • pericardium morphogenesis Source: BHF-UCL
  • positive regulation of gene expression Source: MGI
  • positive regulation of neural precursor cell proliferation Source: UniProtKB
  • positive regulation of Notch signaling pathway Source: UniProtKB
  • regulation of neural retina development Source: UniProtKB
  • regulation of neurogenesis Source: MGI
  • T cell differentiation Source: UniProtKB
  • ventral spinal cord interneuron fate commitment Source: UniProtKB
  • ventricular trabecula myocardium morphogenesis Source: BHF-UCL
  • visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Angiogenesis, Differentiation, Neurogenesis, Notch signaling pathway, Sensory transduction, Vision

Enzyme and pathway databases

ReactomeiR-MMU-1980148. Signaling by NOTCH3.
R-MMU-1980150. Signaling by NOTCH4.
R-MMU-2979096. NOTCH2 Activation and Transmission of Signal to the Nucleus.

Names & Taxonomyi

Protein namesi
Recommended name:
Delta-like protein 4
Alternative name(s):
Drosophila Delta homolog 4
Short name:
Delta4
Gene namesi
Name:Dll4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1859388. Dll4.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 532506ExtracellularSequence analysisAdd
BLAST
Transmembranei533 – 55321HelicalSequence analysisAdd
BLAST
Topological domaini554 – 686133CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: MGI
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Conditional knockdowns in retinal progenitors have thinner retinas with occasional regions abnormally organized into rosette-like structures in the outer nuclear layer and an optic nerve with a reduced diameter.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 686660Delta-like protein 4PRO_0000007513Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 55By similarity
Disulfide bondi62 ↔ 75By similarity
Glycosylationi79 – 791N-linked (GlcNAc...)By similarity
Glycosylationi109 – 1091N-linked (GlcNAc...)By similarity
Glycosylationi162 – 1621N-linked (GlcNAc...)By similarity
Disulfide bondi176 ↔ 185PROSITE-ProRule annotationBy similarity
Disulfide bondi189 ↔ 201PROSITE-ProRule annotationBy similarity
Disulfide bondi209 ↔ 218PROSITE-ProRule annotationBy similarity
Disulfide bondi223 ↔ 234PROSITE-ProRule annotationBy similarity
Disulfide bondi227 ↔ 240PROSITE-ProRule annotationBy similarity
Disulfide bondi242 ↔ 251PROSITE-ProRule annotationBy similarity
Disulfide bondi254 ↔ 265By similarity
Disulfide bondi260 ↔ 271By similarity
Disulfide bondi273 ↔ 282PROSITE-ProRule annotationBy similarity
Disulfide bondi289 ↔ 301By similarity
Disulfide bondi295 ↔ 311By similarity
Glycosylationi297 – 2971N-linked (GlcNAc...)Sequence analysis
Disulfide bondi313 ↔ 322By similarity
Disulfide bondi329 ↔ 340By similarity
Disulfide bondi334 ↔ 349By similarity
Disulfide bondi351 ↔ 360By similarity
Disulfide bondi367 ↔ 378By similarity
Disulfide bondi372 ↔ 389By similarity
Disulfide bondi391 ↔ 400By similarity
Glycosylationi394 – 3941N-linked (GlcNAc...)Sequence analysis
Disulfide bondi407 ↔ 418By similarity
Disulfide bondi412 ↔ 427By similarity
Disulfide bondi429 ↔ 438By similarity
Disulfide bondi445 ↔ 456By similarity
Disulfide bondi450 ↔ 465By similarity
Disulfide bondi467 ↔ 476By similarity
Disulfide bondi485 ↔ 496By similarity
Disulfide bondi490 ↔ 507By similarity
Disulfide bondi509 ↔ 518By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JI71.
PRIDEiQ9JI71.

PTM databases

iPTMnetiQ9JI71.

Expressioni

Tissue specificityi

Expressed in vascular endothelium. Expressed in retina at least during embryogenesis.1 Publication

Developmental stagei

At 14.5, expressed within the retina outer neuroblastic layer.1 Publication

Gene expression databases

BgeeiQ9JI71.
CleanExiMM_DLL4.
GenevisibleiQ9JI71. MM.

Interactioni

Subunit structurei

Interacts with NOTCH4. Interacts (via N-terminal DSL and MNNL domains) with NOTCH1 (via EGF-like domains).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei111 – 1111Interaction with Notch1By similarity
Sitei217 – 2171Interaction with Notch1By similarity

GO - Molecular functioni

  • Notch binding Source: MGI

Protein-protein interaction databases

BioGridi207669. 3 interactions.
STRINGi10090.ENSMUSP00000099575.

Structurei

3D structure databases

ProteinModelPortaliQ9JI71.
SMRiQ9JI71. Positions 28-529.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini174 – 21845DSLPROSITE-ProRule annotationAdd
BLAST
Domaini219 – 25234EGF-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini253 – 28331EGF-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini285 – 32339EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini325 – 36137EGF-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini364 – 40138EGF-like 5PROSITE-ProRule annotationAdd
BLAST
Domaini403 – 43937EGF-like 6PROSITE-ProRule annotationAdd
BLAST
Domaini441 – 47737EGF-like 7PROSITE-ProRule annotationAdd
BLAST
Domaini481 – 51939EGF-like 8PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni186 – 1883Interaction with Notch1By similarity
Regioni192 – 1965Interaction with Notch1By similarity

Sequence similaritiesi

Contains 1 DSL domain.PROSITE-ProRule annotation
Contains 8 EGF-like domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
GeneTreeiENSGT00810000125346.
HOGENOMiHOG000267024.
HOVERGENiHBG007139.
InParanoidiQ9JI71.
KOiK06051.
OMAiNYYGDSC.
OrthoDBiEOG7GQXZ5.
TreeFamiTF351835.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR009030. Growth_fac_rcpt_.
IPR011651. Notch_ligand_N.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 4 hits.
PF12661. hEGF. 2 hits.
PF07657. MNNL. 1 hit.
[Graphical view]
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 9 hits.
SM00179. EGF_CA. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 8 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JI71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTPASRSACR WALLLLAVLW PQQRAAGSGI FQLRLQEFVN QRGMLANGQS
60 70 80 90 100
CEPGCRTFFR ICLKHFQATF SEGPCTFGNV STPVLGTNSF VVRDKNSGSG
110 120 130 140 150
RNPLQLPFNF TWPGTFSLNI QAWHTPGDDL RPETSPGNSL ISQIIIQGSL
160 170 180 190 200
AVGKIWRTDE QNDTLTRLSY SYRVICSDNY YGESCSRLCK KRDDHFGHYE
210 220 230 240 250
CQPDGSLSCL PGWTGKYCDQ PICLSGCHEQ NGYCSKPDEC ICRPGWQGRL
260 270 280 290 300
CNECIPHNGC RHGTCSIPWQ CACDEGWGGL FCDQDLNYCT HHSPCKNGST
310 320 330 340 350
CSNSGPKGYT CTCLPGYTGE HCELGLSKCA SNPCRNGGSC KDQENSYHCL
360 370 380 390 400
CPPGYYGQHC EHSTLTCADS PCFNGGSCRE RNQGSSYACE CPPNFTGSNC
410 420 430 440 450
EKKVDRCTSN PCANGGQCQN RGPSRTCRCR PGFTGTHCEL HISDCARSPC
460 470 480 490 500
AHGGTCHDLE NGPVCTCPAG FSGRRCEVRI THDACASGPC FNGATCYTGL
510 520 530 540 550
SPNNFVCNCP YGFVGSRCEF PVGLPPSFPW VAVSLGVGLV VLLVLLVMVV
560 570 580 590 600
VAVRQLRLRR PDDESREAMN NLSDFQKDNL IPAAQLKNTN QKKELEVDCG
610 620 630 640 650
LDKSNCGKLQ NHTLDYNLAP GLLGRGGMPG KYPHSDKSLG EKVPLRLHSE
660 670 680
KPECRISAIC SPRDSMYQSV CLISEERNEC VIATEV
Length:686
Mass (Da):74,991
Last modified:July 27, 2011 - v2
Checksum:iE7DD4FC15C4AFFBA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti419 – 4191Q → L in AAF76428 (PubMed:10837024).Curated
Sequence conflicti419 – 4191Q → L in AAF78785 (Ref. 3) Curated
Sequence conflicti527 – 5282SF → CS in AAF78785 (Ref. 3) Curated
Sequence conflicti627 – 6271G → S in AAF76428 (PubMed:10837024).Curated
Sequence conflicti627 – 6271G → S in AAF78785 (Ref. 3) Curated
Sequence conflicti639 – 64911LGEKVPLRLHS → IGQGATSVTH in AAF78785 (Ref. 3) CuratedAdd
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF253469 mRNA. Translation: AAF76428.1.
AF273454 mRNA. Translation: AAF78785.1.
AB043893 mRNA. Translation: BAB18580.1.
AK004739 mRNA. Translation: BAB23520.1.
AL929318 Genomic DNA. Translation: CAM25342.1.
BC042497 mRNA. Translation: AAH42497.1.
BC049130 mRNA. Translation: AAH49130.1.
CCDSiCCDS16600.1.
PIRiJC7569.
RefSeqiNP_062327.2. NM_019454.3.
UniGeneiMm.143719.

Genome annotation databases

EnsembliENSMUST00000102517; ENSMUSP00000099575; ENSMUSG00000027314.
GeneIDi54485.
KEGGimmu:54485.
UCSCiuc008ltr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF253469 mRNA. Translation: AAF76428.1.
AF273454 mRNA. Translation: AAF78785.1.
AB043893 mRNA. Translation: BAB18580.1.
AK004739 mRNA. Translation: BAB23520.1.
AL929318 Genomic DNA. Translation: CAM25342.1.
BC042497 mRNA. Translation: AAH42497.1.
BC049130 mRNA. Translation: AAH49130.1.
CCDSiCCDS16600.1.
PIRiJC7569.
RefSeqiNP_062327.2. NM_019454.3.
UniGeneiMm.143719.

3D structure databases

ProteinModelPortaliQ9JI71.
SMRiQ9JI71. Positions 28-529.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207669. 3 interactions.
STRINGi10090.ENSMUSP00000099575.

PTM databases

iPTMnetiQ9JI71.

Proteomic databases

PaxDbiQ9JI71.
PRIDEiQ9JI71.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102517; ENSMUSP00000099575; ENSMUSG00000027314.
GeneIDi54485.
KEGGimmu:54485.
UCSCiuc008ltr.2. mouse.

Organism-specific databases

CTDi54567.
MGIiMGI:1859388. Dll4.

Phylogenomic databases

eggNOGiKOG1217. Eukaryota.
ENOG410XP6K. LUCA.
GeneTreeiENSGT00810000125346.
HOGENOMiHOG000267024.
HOVERGENiHBG007139.
InParanoidiQ9JI71.
KOiK06051.
OMAiNYYGDSC.
OrthoDBiEOG7GQXZ5.
TreeFamiTF351835.

Enzyme and pathway databases

ReactomeiR-MMU-1980148. Signaling by NOTCH3.
R-MMU-1980150. Signaling by NOTCH4.
R-MMU-2979096. NOTCH2 Activation and Transmission of Signal to the Nucleus.

Miscellaneous databases

NextBioi311348.
PROiQ9JI71.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JI71.
CleanExiMM_DLL4.
GenevisibleiQ9JI71. MM.

Family and domain databases

InterProiIPR001774. DSL.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR009030. Growth_fac_rcpt_.
IPR011651. Notch_ligand_N.
[Graphical view]
PfamiPF01414. DSL. 1 hit.
PF00008. EGF. 4 hits.
PF12661. hEGF. 2 hits.
PF07657. MNNL. 1 hit.
[Graphical view]
SMARTiSM00051. DSL. 1 hit.
SM00181. EGF. 9 hits.
SM00179. EGF_CA. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 1 hit.
PS51051. DSL. 1 hit.
PS00022. EGF_1. 8 hits.
PS01186. EGF_2. 7 hits.
PS50026. EGF_3. 8 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Dll4, a novel Notch ligand expressed in arterial endothelium."
    Shutter J.R., Scully S., Fan W., Richards W.G., Kitajewski J., Deblandre G.A., Kintner C.R., Stark K.L.
    Genes Dev. 14:1313-1318(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Adipose tissue.
  2. "Molecular cloning of Delta-4, a new mouse and human Notch ligand."
    Yoneya T., Tahara T., Nagao K., Yamada Y., Yamamoto T., Miyatani S., Nishikawa M.
    J. Biochem. 129:27-34(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
  3. "A novel Notch ligand expressed in embryonic and tumour vasculation."
    Mailhos C., Lewis J., Ish-Horowicz D.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: 129/Ola.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and Czech II.
    Tissue: Brain and Mammary tumor.
  7. "Forkhead box N4 (Foxn4) activates Dll4-Notch signaling to suppress photoreceptor cell fates of early retinal progenitors."
    Luo H., Jin K., Xie Z., Qiu F., Li S., Zou M., Cai L., Hozumi K., Shima D.T., Xiang M.
    Proc. Natl. Acad. Sci. U.S.A. 109:E553-E562(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN RETINAL DEVELOPMENT, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiDLL4_MOUSE
AccessioniPrimary (citable) accession number: Q9JI71
Secondary accession number(s): Q9DBU9, Q9JHZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: July 27, 2011
Last modified: May 11, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.