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Q9JI67

- B3GT5_MOUSE

UniProt

Q9JI67 - B3GT5_MOUSE

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Protein
Beta-1,3-galactosyltransferase 5
Gene
B3galt5, B3gt5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor. Also catalyzes the transfer of Gal to the terminal GalNAc unit of the globoside GB4, thereby synthesizing the glycolipid GB5, also known as the stage-specific embryonic antigen-3 (SSEA-3).

Pathwayi

GO - Molecular functioni

  1. galactosyltransferase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protein glycosylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyltransferase 5 (EC:2.4.1.-)
Short name:
Beta-1,3-GalTase 5
Short name:
Beta3Gal-T5
Short name:
Beta3GalT5
Short name:
b3Gal-T5
Alternative name(s):
Beta-3-Gx-T5
Stage-specific embryonic antigen 3 synthase
Short name:
SSEA-3 synthase
UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5
Gene namesi
Name:B3galt5
Synonyms:B3gt5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:2136878. B3galt5.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 77Cytoplasmic Reviewed prediction
Transmembranei8 – 2518Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini26 – 308283Lumenal Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi membrane Source: UniProtKB-SubCell
  2. endoplasmic reticulum Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 308308Beta-1,3-galactosyltransferase 5
PRO_0000219165Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi128 – 1281N-linked (GlcNAc...) Reviewed prediction
Glycosylationi172 – 1721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi229 – 2291N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9JI67.
PaxDbiQ9JI67.
PRIDEiQ9JI67.

Expressioni

Tissue specificityi

Expressed in brain and kidney.

Gene expression databases

BgeeiQ9JI67.
GenevestigatoriQ9JI67.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109431.

Structurei

3D structure databases

ProteinModelPortaliQ9JI67.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293774.
GeneTreeiENSGT00740000114871.
HOGENOMiHOG000059604.
HOVERGENiHBG094868.
InParanoidiQ9JI67.
KOiK03877.
OMAiRFCPQAA.
OrthoDBiEOG7M3J0F.
PhylomeDBiQ9JI67.
TreeFamiTF318639.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JI67-1 [UniParc]FASTAAdd to Basket

« Hide

MAHMKTRLVY ASILMMGALC LYFSMDSFRE LPFVFKKSHG KFLQIPDIDC    50
KQKPPFLVLL VTSSHKQLAA RMAIRKTWGR ETSVQGQQVR TFFLLGTSDS 100
TEEMDATTLE SEQHRDIIQK DFKDAYFNLT LKTMMGMEWV YHFCPQTAYV 150
MKTDSDMFVN VGYLTELLLK KNKTTRFFTG YIKPHDFPIR QKFNKWFVSK 200
FEYPWDRYPP FCSGTGYVFS SDVAIQVYNV SESVPFIKLE DVFVGLCLAK 250
LKIRPEELHT KQTFFPGGLR FSVCRFQKIV ACHFMKPQDL LTYWQALENS 300
KEQDCPAV 308
Length:308
Mass (Da):35,964
Last modified:October 1, 2000 - v1
Checksum:i789073A5178825B1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF254738 Genomic DNA. Translation: AAF86241.1.
BC057887 mRNA. Translation: AAH57887.1.
CCDSiCCDS28356.1.
RefSeqiNP_001116465.1. NM_001122993.1.
NP_149161.1. NM_033149.3.
XP_006523179.1. XM_006523116.1.
XP_006523180.1. XM_006523117.1.
UniGeneiMm.154783.

Genome annotation databases

EnsembliENSMUST00000099497; ENSMUSP00000097096; ENSMUSG00000074892.
ENSMUST00000113800; ENSMUSP00000109431; ENSMUSG00000074892.
GeneIDi93961.
KEGGimmu:93961.
UCSCiuc008acv.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

b3GalT5

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF254738 Genomic DNA. Translation: AAF86241.1 .
BC057887 mRNA. Translation: AAH57887.1 .
CCDSi CCDS28356.1.
RefSeqi NP_001116465.1. NM_001122993.1.
NP_149161.1. NM_033149.3.
XP_006523179.1. XM_006523116.1.
XP_006523180.1. XM_006523117.1.
UniGenei Mm.154783.

3D structure databases

ProteinModelPortali Q9JI67.
ModBasei Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000109431.

Protein family/group databases

CAZyi GT31. Glycosyltransferase Family 31.

Proteomic databases

MaxQBi Q9JI67.
PaxDbi Q9JI67.
PRIDEi Q9JI67.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000099497 ; ENSMUSP00000097096 ; ENSMUSG00000074892 .
ENSMUST00000113800 ; ENSMUSP00000109431 ; ENSMUSG00000074892 .
GeneIDi 93961.
KEGGi mmu:93961.
UCSCi uc008acv.2. mouse.

Organism-specific databases

CTDi 10317.
MGIi MGI:2136878. B3galt5.

Phylogenomic databases

eggNOGi NOG293774.
GeneTreei ENSGT00740000114871.
HOGENOMi HOG000059604.
HOVERGENi HBG094868.
InParanoidi Q9JI67.
KOi K03877.
OMAi RFCPQAA.
OrthoDBi EOG7M3J0F.
PhylomeDBi Q9JI67.
TreeFami TF318639.

Enzyme and pathway databases

UniPathwayi UPA00378 .

Miscellaneous databases

NextBioi 351957.
PROi Q9JI67.
SOURCEi Search...

Gene expression databases

Bgeei Q9JI67.
Genevestigatori Q9JI67.

Family and domain databases

InterProi IPR002659. Glyco_trans_31.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
PANTHERi PTHR11214. PTHR11214. 1 hit.
Pfami PF01762. Galactosyl_T. 1 hit.
[Graphical view ]
SUPFAMi SSF53448. SSF53448. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The beta1,3-galactosyltransferase beta3GalT-V is a stage-specific embryonic antigen-3 (SSEA-3) synthase."
    Zhou D., Henion T.R., Jungalwala F.B., Berger E.G., Hennet T.
    J. Biol. Chem. 275:22631-22634(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/SvJ.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon.

Entry informationi

Entry nameiB3GT5_MOUSE
AccessioniPrimary (citable) accession number: Q9JI67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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