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Protein

Beta-1,3-galactosyltransferase 5

Gene

B3galt5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor. Also catalyzes the transfer of Gal to the terminal GalNAc unit of the globoside GB4, thereby synthesizing the glycolipid GB5, also known as the stage-specific embryonic antigen-3 (SSEA-3).

Pathwayi: protein glycosylation

This protein is involved in the pathway protein glycosylation, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein glycosylation and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00378.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-1,3-galactosyltransferase 5 (EC:2.4.1.-)
Short name:
Beta-1,3-GalTase 5
Short name:
Beta3Gal-T5
Short name:
Beta3GalT5
Short name:
b3Gal-T5
Alternative name(s):
Beta-3-Gx-T5
Stage-specific embryonic antigen 3 synthase
Short name:
SSEA-3 synthase
UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5
Gene namesi
Name:B3galt5
Synonyms:B3gt5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:2136878. B3galt5.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 25Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST18
Topological domaini26 – 308LumenalSequence analysisAdd BLAST283

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002191651 – 308Beta-1,3-galactosyltransferase 5Add BLAST308

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi128N-linked (GlcNAc...)Sequence analysis1
Glycosylationi172N-linked (GlcNAc...)Sequence analysis1
Glycosylationi229N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ9JI67.
PaxDbiQ9JI67.
PRIDEiQ9JI67.

PTM databases

PhosphoSitePlusiQ9JI67.

Expressioni

Tissue specificityi

Expressed in brain and kidney.

Gene expression databases

BgeeiENSMUSG00000074892.
GenevisibleiQ9JI67. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097096.

Structurei

3D structure databases

ProteinModelPortaliQ9JI67.
SMRiQ9JI67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 31 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2287. Eukaryota.
ENOG410ZZ1B. LUCA.
GeneTreeiENSGT00760000118879.
HOGENOMiHOG000059604.
HOVERGENiHBG094868.
InParanoidiQ9JI67.
KOiK03877.
OMAiKLPDTDC.
OrthoDBiEOG091G0AXM.
PhylomeDBiQ9JI67.
TreeFamiTF318639.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9JI67-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAHMKTRLVY ASILMMGALC LYFSMDSFRE LPFVFKKSHG KFLQIPDIDC
60 70 80 90 100
KQKPPFLVLL VTSSHKQLAA RMAIRKTWGR ETSVQGQQVR TFFLLGTSDS
110 120 130 140 150
TEEMDATTLE SEQHRDIIQK DFKDAYFNLT LKTMMGMEWV YHFCPQTAYV
160 170 180 190 200
MKTDSDMFVN VGYLTELLLK KNKTTRFFTG YIKPHDFPIR QKFNKWFVSK
210 220 230 240 250
FEYPWDRYPP FCSGTGYVFS SDVAIQVYNV SESVPFIKLE DVFVGLCLAK
260 270 280 290 300
LKIRPEELHT KQTFFPGGLR FSVCRFQKIV ACHFMKPQDL LTYWQALENS

KEQDCPAV
Length:308
Mass (Da):35,964
Last modified:October 1, 2000 - v1
Checksum:i789073A5178825B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254738 Genomic DNA. Translation: AAF86241.1.
BC057887 mRNA. Translation: AAH57887.1.
CCDSiCCDS28356.1.
RefSeqiNP_001116465.1. NM_001122993.1.
NP_149161.1. NM_033149.3.
XP_006523179.1. XM_006523116.3.
XP_006523180.1. XM_006523117.1.
XP_017172660.1. XM_017317171.1.
UniGeneiMm.154783.

Genome annotation databases

EnsembliENSMUST00000099497; ENSMUSP00000097096; ENSMUSG00000074892.
ENSMUST00000113800; ENSMUSP00000109431; ENSMUSG00000074892.
GeneIDi93961.
KEGGimmu:93961.
UCSCiuc008acv.2. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - GTase

b3GalT5

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF254738 Genomic DNA. Translation: AAF86241.1.
BC057887 mRNA. Translation: AAH57887.1.
CCDSiCCDS28356.1.
RefSeqiNP_001116465.1. NM_001122993.1.
NP_149161.1. NM_033149.3.
XP_006523179.1. XM_006523116.3.
XP_006523180.1. XM_006523117.1.
XP_017172660.1. XM_017317171.1.
UniGeneiMm.154783.

3D structure databases

ProteinModelPortaliQ9JI67.
SMRiQ9JI67.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000097096.

Protein family/group databases

CAZyiGT31. Glycosyltransferase Family 31.

PTM databases

PhosphoSitePlusiQ9JI67.

Proteomic databases

MaxQBiQ9JI67.
PaxDbiQ9JI67.
PRIDEiQ9JI67.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099497; ENSMUSP00000097096; ENSMUSG00000074892.
ENSMUST00000113800; ENSMUSP00000109431; ENSMUSG00000074892.
GeneIDi93961.
KEGGimmu:93961.
UCSCiuc008acv.2. mouse.

Organism-specific databases

CTDi10317.
MGIiMGI:2136878. B3galt5.

Phylogenomic databases

eggNOGiKOG2287. Eukaryota.
ENOG410ZZ1B. LUCA.
GeneTreeiENSGT00760000118879.
HOGENOMiHOG000059604.
HOVERGENiHBG094868.
InParanoidiQ9JI67.
KOiK03877.
OMAiKLPDTDC.
OrthoDBiEOG091G0AXM.
PhylomeDBiQ9JI67.
TreeFamiTF318639.

Enzyme and pathway databases

UniPathwayiUPA00378.

Miscellaneous databases

PROiQ9JI67.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074892.
GenevisibleiQ9JI67. MM.

Family and domain databases

InterProiIPR002659. Glyco_trans_31.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR11214. PTHR11214. 1 hit.
PfamiPF01762. Galactosyl_T. 1 hit.
[Graphical view]
SUPFAMiSSF53448. SSF53448. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB3GT5_MOUSE
AccessioniPrimary (citable) accession number: Q9JI67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.