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Q9JI67 (B3GT5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 101. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Beta-1,3-galactosyltransferase 5

Short name=Beta-1,3-GalTase 5
Short name=Beta3Gal-T5
Short name=Beta3GalT5
Short name=b3Gal-T5
EC=2.4.1.-
Alternative name(s):
Beta-3-Gx-T5
Stage-specific embryonic antigen 3 synthase
Short name=SSEA-3 synthase
UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5
Gene names
Name:B3galt5
Synonyms:B3gt5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length308 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor. Also catalyzes the transfer of Gal to the terminal GalNAc unit of the globoside GB4, thereby synthesizing the glycolipid GB5, also known as the stage-specific embryonic antigen-3 (SSEA-3).

Pathway

Protein modification; protein glycosylation.

Subcellular location

Golgi apparatus membrane; Single-pass type II membrane protein Potential.

Tissue specificity

Expressed in brain and kidney.

Sequence similarities

Belongs to the glycosyltransferase 31 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 308308Beta-1,3-galactosyltransferase 5
PRO_0000219165

Regions

Topological domain1 – 77Cytoplasmic Potential
Transmembrane8 – 2518Helical; Signal-anchor for type II membrane protein; Potential
Topological domain26 – 308283Lumenal Potential

Amino acid modifications

Glycosylation1281N-linked (GlcNAc...) Potential
Glycosylation1721N-linked (GlcNAc...) Potential
Glycosylation2291N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q9JI67 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 789073A5178825B1

FASTA30835,964
        10         20         30         40         50         60 
MAHMKTRLVY ASILMMGALC LYFSMDSFRE LPFVFKKSHG KFLQIPDIDC KQKPPFLVLL 

        70         80         90        100        110        120 
VTSSHKQLAA RMAIRKTWGR ETSVQGQQVR TFFLLGTSDS TEEMDATTLE SEQHRDIIQK 

       130        140        150        160        170        180 
DFKDAYFNLT LKTMMGMEWV YHFCPQTAYV MKTDSDMFVN VGYLTELLLK KNKTTRFFTG 

       190        200        210        220        230        240 
YIKPHDFPIR QKFNKWFVSK FEYPWDRYPP FCSGTGYVFS SDVAIQVYNV SESVPFIKLE 

       250        260        270        280        290        300 
DVFVGLCLAK LKIRPEELHT KQTFFPGGLR FSVCRFQKIV ACHFMKPQDL LTYWQALENS 


KEQDCPAV 

« Hide

References

« Hide 'large scale' references
[1]"The beta1,3-galactosyltransferase beta3GalT-V is a stage-specific embryonic antigen-3 (SSEA-3) synthase."
Zhou D., Henion T.R., Jungalwala F.B., Berger E.G., Hennet T.
J. Biol. Chem. 275:22631-22634(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 129/SvJ.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF254738 Genomic DNA. Translation: AAF86241.1.
BC057887 mRNA. Translation: AAH57887.1.
CCDSCCDS28356.1.
RefSeqNP_001116465.1. NM_001122993.1.
NP_149161.1. NM_033149.3.
XP_006523179.1. XM_006523116.1.
XP_006523180.1. XM_006523117.1.
UniGeneMm.154783.

3D structure databases

ProteinModelPortalQ9JI67.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000109431.

Protein family/group databases

CAZyGT31. Glycosyltransferase Family 31.

Proteomic databases

MaxQBQ9JI67.
PaxDbQ9JI67.
PRIDEQ9JI67.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000099497; ENSMUSP00000097096; ENSMUSG00000074892.
ENSMUST00000113800; ENSMUSP00000109431; ENSMUSG00000074892.
GeneID93961.
KEGGmmu:93961.
UCSCuc008acv.2. mouse.

Organism-specific databases

CTD10317.
MGIMGI:2136878. B3galt5.

Phylogenomic databases

eggNOGNOG293774.
GeneTreeENSGT00740000114871.
HOGENOMHOG000059604.
HOVERGENHBG094868.
InParanoidQ9JI67.
KOK03877.
OMARFCPQAA.
OrthoDBEOG7M3J0F.
PhylomeDBQ9JI67.
TreeFamTF318639.

Enzyme and pathway databases

UniPathwayUPA00378.

Gene expression databases

BgeeQ9JI67.
GenevestigatorQ9JI67.

Family and domain databases

InterProIPR002659. Glyco_trans_31.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERPTHR11214. PTHR11214. 1 hit.
PfamPF01762. Galactosyl_T. 1 hit.
[Graphical view]
SUPFAMSSF53448. SSF53448. 1 hit.
ProtoNetSearch...

Other

NextBio351957.
PROQ9JI67.
SOURCESearch...

Entry information

Entry nameB3GT5_MOUSE
AccessionPrimary (citable) accession number: Q9JI67
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: October 1, 2000
Last modified: July 9, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot