Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9JI67

- B3GT5_MOUSE

UniProt

Q9JI67 - B3GT5_MOUSE

Protein

Beta-1,3-galactosyltransferase 5

Gene

B3galt5

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. Can use glycolipid LC3Cer as an efficient acceptor. Also catalyzes the transfer of Gal to the terminal GalNAc unit of the globoside GB4, thereby synthesizing the glycolipid GB5, also known as the stage-specific embryonic antigen-3 (SSEA-3).

    Pathwayi

    GO - Molecular functioni

    1. galactosyltransferase activity Source: InterPro

    GO - Biological processi

    1. protein glycosylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT31. Glycosyltransferase Family 31.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-1,3-galactosyltransferase 5 (EC:2.4.1.-)
    Short name:
    Beta-1,3-GalTase 5
    Short name:
    Beta3Gal-T5
    Short name:
    Beta3GalT5
    Short name:
    b3Gal-T5
    Alternative name(s):
    Beta-3-Gx-T5
    Stage-specific embryonic antigen 3 synthase
    Short name:
    SSEA-3 synthase
    UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 5
    UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 5
    Gene namesi
    Name:B3galt5
    Synonyms:B3gt5
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:2136878. B3galt5.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: Ensembl
    2. Golgi membrane Source: UniProtKB-SubCell
    3. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 308308Beta-1,3-galactosyltransferase 5PRO_0000219165Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi128 – 1281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi229 – 2291N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    MaxQBiQ9JI67.
    PaxDbiQ9JI67.
    PRIDEiQ9JI67.

    Expressioni

    Tissue specificityi

    Expressed in brain and kidney.

    Gene expression databases

    BgeeiQ9JI67.
    GenevestigatoriQ9JI67.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000109431.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JI67.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 77CytoplasmicSequence Analysis
    Topological domaini26 – 308283LumenalSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei8 – 2518Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 31 family.Curated

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293774.
    GeneTreeiENSGT00740000114871.
    HOGENOMiHOG000059604.
    HOVERGENiHBG094868.
    InParanoidiQ9JI67.
    KOiK03877.
    OMAiRFCPQAA.
    OrthoDBiEOG7M3J0F.
    PhylomeDBiQ9JI67.
    TreeFamiTF318639.

    Family and domain databases

    InterProiIPR002659. Glyco_trans_31.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PANTHERiPTHR11214. PTHR11214. 1 hit.
    PfamiPF01762. Galactosyl_T. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9JI67-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAHMKTRLVY ASILMMGALC LYFSMDSFRE LPFVFKKSHG KFLQIPDIDC    50
    KQKPPFLVLL VTSSHKQLAA RMAIRKTWGR ETSVQGQQVR TFFLLGTSDS 100
    TEEMDATTLE SEQHRDIIQK DFKDAYFNLT LKTMMGMEWV YHFCPQTAYV 150
    MKTDSDMFVN VGYLTELLLK KNKTTRFFTG YIKPHDFPIR QKFNKWFVSK 200
    FEYPWDRYPP FCSGTGYVFS SDVAIQVYNV SESVPFIKLE DVFVGLCLAK 250
    LKIRPEELHT KQTFFPGGLR FSVCRFQKIV ACHFMKPQDL LTYWQALENS 300
    KEQDCPAV 308
    Length:308
    Mass (Da):35,964
    Last modified:October 1, 2000 - v1
    Checksum:i789073A5178825B1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF254738 Genomic DNA. Translation: AAF86241.1.
    BC057887 mRNA. Translation: AAH57887.1.
    CCDSiCCDS28356.1.
    RefSeqiNP_001116465.1. NM_001122993.1.
    NP_149161.1. NM_033149.3.
    XP_006523179.1. XM_006523116.1.
    XP_006523180.1. XM_006523117.1.
    UniGeneiMm.154783.

    Genome annotation databases

    EnsembliENSMUST00000099497; ENSMUSP00000097096; ENSMUSG00000074892.
    ENSMUST00000113800; ENSMUSP00000109431; ENSMUSG00000074892.
    GeneIDi93961.
    KEGGimmu:93961.
    UCSCiuc008acv.2. mouse.

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - GTase

    b3GalT5

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF254738 Genomic DNA. Translation: AAF86241.1 .
    BC057887 mRNA. Translation: AAH57887.1 .
    CCDSi CCDS28356.1.
    RefSeqi NP_001116465.1. NM_001122993.1.
    NP_149161.1. NM_033149.3.
    XP_006523179.1. XM_006523116.1.
    XP_006523180.1. XM_006523117.1.
    UniGenei Mm.154783.

    3D structure databases

    ProteinModelPortali Q9JI67.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000109431.

    Protein family/group databases

    CAZyi GT31. Glycosyltransferase Family 31.

    Proteomic databases

    MaxQBi Q9JI67.
    PaxDbi Q9JI67.
    PRIDEi Q9JI67.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000099497 ; ENSMUSP00000097096 ; ENSMUSG00000074892 .
    ENSMUST00000113800 ; ENSMUSP00000109431 ; ENSMUSG00000074892 .
    GeneIDi 93961.
    KEGGi mmu:93961.
    UCSCi uc008acv.2. mouse.

    Organism-specific databases

    CTDi 10317.
    MGIi MGI:2136878. B3galt5.

    Phylogenomic databases

    eggNOGi NOG293774.
    GeneTreei ENSGT00740000114871.
    HOGENOMi HOG000059604.
    HOVERGENi HBG094868.
    InParanoidi Q9JI67.
    KOi K03877.
    OMAi RFCPQAA.
    OrthoDBi EOG7M3J0F.
    PhylomeDBi Q9JI67.
    TreeFami TF318639.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .

    Miscellaneous databases

    NextBioi 351957.
    PROi Q9JI67.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9JI67.
    Genevestigatori Q9JI67.

    Family and domain databases

    InterProi IPR002659. Glyco_trans_31.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    PANTHERi PTHR11214. PTHR11214. 1 hit.
    Pfami PF01762. Galactosyl_T. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The beta1,3-galactosyltransferase beta3GalT-V is a stage-specific embryonic antigen-3 (SSEA-3) synthase."
      Zhou D., Henion T.R., Jungalwala F.B., Berger E.G., Hennet T.
      J. Biol. Chem. 275:22631-22634(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129/SvJ.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon.

    Entry informationi

    Entry nameiB3GT5_MOUSE
    AccessioniPrimary (citable) accession number: Q9JI67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3