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Q9JI59

- JAM2_MOUSE

UniProt

Q9JI59 - JAM2_MOUSE

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Protein

Junctional adhesion molecule B

Gene

Jam2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May play a role in the processes of lymphocyte homing to secondary lymphoid organs.By similarity

GO - Molecular functioni

  1. protein heterodimerization activity Source: MGI

GO - Biological processi

  1. negative regulation of cell adhesion Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_216309. Integrin cell surface interactions.
REACT_225233. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Junctional adhesion molecule B
Short name:
JAM-B
Alternative name(s):
Junctional adhesion molecule 2
Short name:
JAM-2
Vascular endothelial junction-associated molecule
Short name:
VE-JAM
CD_antigen: CD322
Gene namesi
Name:Jam2
Synonyms:Vejam
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 16

Organism-specific databases

MGIiMGI:1933820. Jam2.

Subcellular locationi

Cell junctiontight junction 1 Publication. Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Note: Localized at tight junctions of both epithelial and endothelial cells.

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
  3. tight junction Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 28281 PublicationAdd
BLAST
Chaini29 – 298270Junctional adhesion molecule BPRO_0000015070Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi51 ↔ 110PROSITE-ProRule annotation
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi156 ↔ 214PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9JI59.
PaxDbiQ9JI59.
PRIDEiQ9JI59.

PTM databases

PhosphoSiteiQ9JI59.

Expressioni

Gene expression databases

BgeeiQ9JI59.
CleanExiMM_JAM2.
ExpressionAtlasiQ9JI59. baseline and differential.
GenevestigatoriQ9JI59.

Interactioni

Subunit structurei

Interacts with JAM3.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000109833.

Structurei

3D structure databases

ProteinModelPortaliQ9JI59.
SMRiQ9JI59. Positions 36-239.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 236208ExtracellularSequence AnalysisAdd
BLAST
Topological domaini258 – 29841CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei237 – 25721HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 12897Ig-like V-typeAdd
BLAST
Domaini135 – 238104Ig-like C2-typeAdd
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG132289.
GeneTreeiENSGT00730000110678.
HOGENOMiHOG000247041.
HOVERGENiHBG000518.
InParanoidiQ9JI59.
KOiK06735.
OMAiSVGHRRC.
OrthoDBiEOG7MH0Z1.
PhylomeDBiQ9JI59.
TreeFamiTF331459.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07679. I-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JI59-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MARSPQGLLM LLLLHYLIVA LDYHKANGFS ASKDHRQEVT VIEFQEAILA
60 70 80 90 100
CKTPKKTTSS RLEWKKVGQG VSLVYYQQAL QGDFKDRAEM IDFNIRIKNV
110 120 130 140 150
TRSDAGEYRC EVSAPTEQGQ NLQEDKVMLE VLVAPAVPAC EVPTSVMTGS
160 170 180 190 200
VVELRCQDKE GNPAPEYIWF KDGTSLLGNP KGGTHNNSSY TMNTKSGILQ
210 220 230 240 250
FNMISKMDSG EYYCEARNSV GHRRCPGKRM QVDVLNISGI IATVVVVAFV
260 270 280 290
ISVCGLGTCY AQRKGYFSKE TSFQKGSPAS KVTTMSENDF KHTKSFII
Length:298
Mass (Da):33,047
Last modified:October 1, 2000 - v1
Checksum:i1124E0F07E6CF751
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti133 – 1331V → M in BAC26102. (PubMed:16141072)Curated
Sequence conflicti174 – 1741T → H in BAC37139. (PubMed:16141072)Curated
Sequence conflicti183 – 1831G → R in BAC37139. (PubMed:16141072)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF255911 mRNA. Translation: AAF81224.1.
AJ291757 mRNA. Translation: CAC20699.1.
AK010616 mRNA. Translation: BAB27064.1.
AK013914 mRNA. Translation: BAB29053.1.
AK028757 mRNA. Translation: BAC26102.1.
AK078128 mRNA. Translation: BAC37139.1.
CT027693, AC164162 Genomic DNA. Translation: CAO78081.1.
BC028778 mRNA. Translation: AAH28778.1.
CCDSiCCDS37381.1.
RefSeqiNP_076333.3. NM_023844.5.
UniGeneiMm.41758.

Genome annotation databases

EnsembliENSMUST00000114195; ENSMUSP00000109833; ENSMUSG00000053062.
GeneIDi67374.
KEGGimmu:67374.
UCSCiuc007ztg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF255911 mRNA. Translation: AAF81224.1 .
AJ291757 mRNA. Translation: CAC20699.1 .
AK010616 mRNA. Translation: BAB27064.1 .
AK013914 mRNA. Translation: BAB29053.1 .
AK028757 mRNA. Translation: BAC26102.1 .
AK078128 mRNA. Translation: BAC37139.1 .
CT027693 , AC164162 Genomic DNA. Translation: CAO78081.1 .
BC028778 mRNA. Translation: AAH28778.1 .
CCDSi CCDS37381.1.
RefSeqi NP_076333.3. NM_023844.5.
UniGenei Mm.41758.

3D structure databases

ProteinModelPortali Q9JI59.
SMRi Q9JI59. Positions 36-239.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000109833.

PTM databases

PhosphoSitei Q9JI59.

Proteomic databases

MaxQBi Q9JI59.
PaxDbi Q9JI59.
PRIDEi Q9JI59.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000114195 ; ENSMUSP00000109833 ; ENSMUSG00000053062 .
GeneIDi 67374.
KEGGi mmu:67374.
UCSCi uc007ztg.2. mouse.

Organism-specific databases

CTDi 58494.
MGIi MGI:1933820. Jam2.

Phylogenomic databases

eggNOGi NOG132289.
GeneTreei ENSGT00730000110678.
HOGENOMi HOG000247041.
HOVERGENi HBG000518.
InParanoidi Q9JI59.
KOi K06735.
OMAi SVGHRRC.
OrthoDBi EOG7MH0Z1.
PhylomeDBi Q9JI59.
TreeFami TF331459.

Enzyme and pathway databases

Reactomei REACT_216309. Integrin cell surface interactions.
REACT_225233. Cell surface interactions at the vascular wall.

Miscellaneous databases

NextBioi 324388.
PROi Q9JI59.
SOURCEi Search...

Gene expression databases

Bgeei Q9JI59.
CleanExi MM_JAM2.
ExpressionAtlasi Q9JI59. baseline and differential.
Genevestigatori Q9JI59.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07679. I-set. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells."
    Palmeri D., van Zante A., Huang C.-C., Hemmerich S., Rosen S.D.
    J. Biol. Chem. 275:19139-19145(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 29-33.
    Strain: C57BL/6J.
  2. "Cloning of JAM-2 and JAM-3: an emerging junctional adhesion molecular family?"
    Aurrand-Lions M.A., Duncan L., Du Pasquier L., Imhof B.A.
    Curr. Top. Microbiol. Immunol. 251:91-98(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Head, Medulla oblongata and Skin.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Mammary gland.
  6. "Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response."
    Muller W.A.
    Trends Immunol. 24:327-334(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW, NOMENCLATURE.

Entry informationi

Entry nameiJAM2_MOUSE
AccessioniPrimary (citable) accession number: Q9JI59
Secondary accession number(s): A6X955, Q8C5K9, Q8CE95
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3