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Q9JI59

- JAM2_MOUSE

UniProt

Q9JI59 - JAM2_MOUSE

Protein

Junctional adhesion molecule B

Gene

Jam2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    May play a role in the processes of lymphocyte homing to secondary lymphoid organs.By similarity

    GO - Molecular functioni

    1. protein heterodimerization activity Source: MGI

    GO - Biological processi

    1. negative regulation of cell adhesion Source: MGI

    Enzyme and pathway databases

    ReactomeiREACT_216309. Integrin cell surface interactions.
    REACT_225233. Cell surface interactions at the vascular wall.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Junctional adhesion molecule B
    Short name:
    JAM-B
    Alternative name(s):
    Junctional adhesion molecule 2
    Short name:
    JAM-2
    Vascular endothelial junction-associated molecule
    Short name:
    VE-JAM
    CD_antigen: CD322
    Gene namesi
    Name:Jam2
    Synonyms:Vejam
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 16

    Organism-specific databases

    MGIiMGI:1933820. Jam2.

    Subcellular locationi

    Cell junctiontight junction 1 Publication. Cell membrane 1 Publication; Single-pass type I membrane protein 1 Publication
    Note: Localized at tight junctions of both epithelial and endothelial cells.

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell
    3. tight junction Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane, Tight junction

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 28281 PublicationAdd
    BLAST
    Chaini29 – 298270Junctional adhesion molecule BPRO_0000015070Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi51 ↔ 110PROSITE-ProRule annotation
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi156 ↔ 214PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9JI59.
    PRIDEiQ9JI59.

    PTM databases

    PhosphoSiteiQ9JI59.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9JI59.
    BgeeiQ9JI59.
    CleanExiMM_JAM2.
    GenevestigatoriQ9JI59.

    Interactioni

    Subunit structurei

    Interacts with JAM3.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000109833.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9JI59.
    SMRiQ9JI59. Positions 36-239.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 236208ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini258 – 29841CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei237 – 25721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 12897Ig-like V-typeAdd
    BLAST
    Domaini135 – 238104Ig-like C2-typeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily.Curated

    Keywords - Domaini

    Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG132289.
    GeneTreeiENSGT00730000110678.
    HOGENOMiHOG000247041.
    HOVERGENiHBG000518.
    InParanoidiA6X955.
    KOiK06735.
    OMAiSVGHRRC.
    OrthoDBiEOG7MH0Z1.
    PhylomeDBiQ9JI59.
    TreeFamiTF331459.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07679. I-set. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JI59-1 [UniParc]FASTAAdd to Basket

    « Hide

    MARSPQGLLM LLLLHYLIVA LDYHKANGFS ASKDHRQEVT VIEFQEAILA    50
    CKTPKKTTSS RLEWKKVGQG VSLVYYQQAL QGDFKDRAEM IDFNIRIKNV 100
    TRSDAGEYRC EVSAPTEQGQ NLQEDKVMLE VLVAPAVPAC EVPTSVMTGS 150
    VVELRCQDKE GNPAPEYIWF KDGTSLLGNP KGGTHNNSSY TMNTKSGILQ 200
    FNMISKMDSG EYYCEARNSV GHRRCPGKRM QVDVLNISGI IATVVVVAFV 250
    ISVCGLGTCY AQRKGYFSKE TSFQKGSPAS KVTTMSENDF KHTKSFII 298
    Length:298
    Mass (Da):33,047
    Last modified:October 1, 2000 - v1
    Checksum:i1124E0F07E6CF751
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti133 – 1331V → M in BAC26102. (PubMed:16141072)Curated
    Sequence conflicti174 – 1741T → H in BAC37139. (PubMed:16141072)Curated
    Sequence conflicti183 – 1831G → R in BAC37139. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF255911 mRNA. Translation: AAF81224.1.
    AJ291757 mRNA. Translation: CAC20699.1.
    AK010616 mRNA. Translation: BAB27064.1.
    AK013914 mRNA. Translation: BAB29053.1.
    AK028757 mRNA. Translation: BAC26102.1.
    AK078128 mRNA. Translation: BAC37139.1.
    CT027693, AC164162 Genomic DNA. Translation: CAO78081.1.
    BC028778 mRNA. Translation: AAH28778.1.
    CCDSiCCDS37381.1.
    RefSeqiNP_076333.3. NM_023844.5.
    UniGeneiMm.41758.

    Genome annotation databases

    EnsembliENSMUST00000114195; ENSMUSP00000109833; ENSMUSG00000053062.
    GeneIDi67374.
    KEGGimmu:67374.
    UCSCiuc007ztg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF255911 mRNA. Translation: AAF81224.1 .
    AJ291757 mRNA. Translation: CAC20699.1 .
    AK010616 mRNA. Translation: BAB27064.1 .
    AK013914 mRNA. Translation: BAB29053.1 .
    AK028757 mRNA. Translation: BAC26102.1 .
    AK078128 mRNA. Translation: BAC37139.1 .
    CT027693 , AC164162 Genomic DNA. Translation: CAO78081.1 .
    BC028778 mRNA. Translation: AAH28778.1 .
    CCDSi CCDS37381.1.
    RefSeqi NP_076333.3. NM_023844.5.
    UniGenei Mm.41758.

    3D structure databases

    ProteinModelPortali Q9JI59.
    SMRi Q9JI59. Positions 36-239.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000109833.

    PTM databases

    PhosphoSitei Q9JI59.

    Proteomic databases

    PaxDbi Q9JI59.
    PRIDEi Q9JI59.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000114195 ; ENSMUSP00000109833 ; ENSMUSG00000053062 .
    GeneIDi 67374.
    KEGGi mmu:67374.
    UCSCi uc007ztg.2. mouse.

    Organism-specific databases

    CTDi 58494.
    MGIi MGI:1933820. Jam2.

    Phylogenomic databases

    eggNOGi NOG132289.
    GeneTreei ENSGT00730000110678.
    HOGENOMi HOG000247041.
    HOVERGENi HBG000518.
    InParanoidi A6X955.
    KOi K06735.
    OMAi SVGHRRC.
    OrthoDBi EOG7MH0Z1.
    PhylomeDBi Q9JI59.
    TreeFami TF331459.

    Enzyme and pathway databases

    Reactomei REACT_216309. Integrin cell surface interactions.
    REACT_225233. Cell surface interactions at the vascular wall.

    Miscellaneous databases

    NextBioi 324388.
    PROi Q9JI59.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JI59.
    Bgeei Q9JI59.
    CleanExi MM_JAM2.
    Genevestigatori Q9JI59.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07679. I-set. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells."
      Palmeri D., van Zante A., Huang C.-C., Hemmerich S., Rosen S.D.
      J. Biol. Chem. 275:19139-19145(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 29-33.
      Strain: C57BL/6J.
    2. "Cloning of JAM-2 and JAM-3: an emerging junctional adhesion molecular family?"
      Aurrand-Lions M.A., Duncan L., Du Pasquier L., Imhof B.A.
      Curr. Top. Microbiol. Immunol. 251:91-98(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Head, Medulla oblongata and Skin.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Mammary gland.
    6. "Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response."
      Muller W.A.
      Trends Immunol. 24:327-334(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW, NOMENCLATURE.

    Entry informationi

    Entry nameiJAM2_MOUSE
    AccessioniPrimary (citable) accession number: Q9JI59
    Secondary accession number(s): A6X955, Q8C5K9, Q8CE95
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 29, 2005
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3