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Protein

Junctional adhesion molecule B

Gene

Jam2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May play a role in the processes of lymphocyte homing to secondary lymphoid organs.By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI

GO - Biological processi

  • negative regulation of cell adhesion Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-202733. Cell surface interactions at the vascular wall.
R-MMU-216083. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Junctional adhesion molecule B
Short name:
JAM-B
Alternative name(s):
Junctional adhesion molecule 2
Short name:
JAM-2
Vascular endothelial junction-associated molecule
Short name:
VE-JAM
CD_antigen: CD322
Gene namesi
Name:Jam2
Synonyms:Vejam
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 16

Organism-specific databases

MGIiMGI:1933820. Jam2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 236ExtracellularSequence analysisAdd BLAST208
Transmembranei237 – 257HelicalSequence analysisAdd BLAST21
Topological domaini258 – 298CytoplasmicSequence analysisAdd BLAST41

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 281 PublicationAdd BLAST28
ChainiPRO_000001507029 – 298Junctional adhesion molecule BAdd BLAST270

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi51 ↔ 110PROSITE-ProRule annotation
Glycosylationi99N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi156 ↔ 214PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ9JI59.
PaxDbiQ9JI59.
PeptideAtlasiQ9JI59.
PRIDEiQ9JI59.

PTM databases

iPTMnetiQ9JI59.
PhosphoSitePlusiQ9JI59.
SwissPalmiQ9JI59.

Expressioni

Gene expression databases

BgeeiENSMUSG00000053062.
CleanExiMM_JAM2.
ExpressionAtlasiQ9JI59. baseline and differential.
GenevisibleiQ9JI59. MM.

Interactioni

Subunit structurei

Interacts with JAM3.By similarity

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI

Protein-protein interaction databases

DIPiDIP-61078N.
STRINGi10090.ENSMUSP00000109833.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5GMJX-ray2.99C/D280-298[»]
ProteinModelPortaliQ9JI59.
SMRiQ9JI59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 128Ig-like V-typeAdd BLAST97
Domaini135 – 238Ig-like C2-typeAdd BLAST104

Sequence similaritiesi

Belongs to the immunoglobulin superfamily.Curated

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDXS. Eukaryota.
ENOG41100KX. LUCA.
GeneTreeiENSGT00730000110678.
HOGENOMiHOG000247041.
HOVERGENiHBG000518.
InParanoidiQ9JI59.
KOiK06735.
OMAiSCEVPNS.
OrthoDBiEOG091G05PI.
PhylomeDBiQ9JI59.
TreeFamiTF331459.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
PfamiView protein in Pfam
PF07686. V-set. 1 hit.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SM00406. IGv. 1 hit.
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JI59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARSPQGLLM LLLLHYLIVA LDYHKANGFS ASKDHRQEVT VIEFQEAILA
60 70 80 90 100
CKTPKKTTSS RLEWKKVGQG VSLVYYQQAL QGDFKDRAEM IDFNIRIKNV
110 120 130 140 150
TRSDAGEYRC EVSAPTEQGQ NLQEDKVMLE VLVAPAVPAC EVPTSVMTGS
160 170 180 190 200
VVELRCQDKE GNPAPEYIWF KDGTSLLGNP KGGTHNNSSY TMNTKSGILQ
210 220 230 240 250
FNMISKMDSG EYYCEARNSV GHRRCPGKRM QVDVLNISGI IATVVVVAFV
260 270 280 290
ISVCGLGTCY AQRKGYFSKE TSFQKGSPAS KVTTMSENDF KHTKSFII
Length:298
Mass (Da):33,047
Last modified:October 1, 2000 - v1
Checksum:i1124E0F07E6CF751
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti133V → M in BAC26102 (PubMed:16141072).Curated1
Sequence conflicti174T → H in BAC37139 (PubMed:16141072).Curated1
Sequence conflicti183G → R in BAC37139 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF255911 mRNA. Translation: AAF81224.1.
AJ291757 mRNA. Translation: CAC20699.1.
AK010616 mRNA. Translation: BAB27064.1.
AK013914 mRNA. Translation: BAB29053.1.
AK028757 mRNA. Translation: BAC26102.1.
AK078128 mRNA. Translation: BAC37139.1.
CT027693, AC164162 Genomic DNA. Translation: CAO78081.1.
BC028778 mRNA. Translation: AAH28778.1.
CCDSiCCDS37381.1.
RefSeqiNP_076333.3. NM_023844.5.
UniGeneiMm.41758.

Genome annotation databases

EnsembliENSMUST00000114195; ENSMUSP00000109833; ENSMUSG00000053062.
GeneIDi67374.
KEGGimmu:67374.
UCSCiuc007ztg.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiJAM2_MOUSE
AccessioniPrimary (citable) accession number: Q9JI59
Secondary accession number(s): A6X955, Q8C5K9, Q8CE95
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 29, 2005
Last sequence update: October 1, 2000
Last modified: August 30, 2017
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families