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Protein
Submitted name:

High mobility group protein HMGI-C

Gene

Hmga2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. DNA-(apurinic or apyrimidinic site) lyase activity Source: GO_Central
  2. DNA binding Source: InterPro
  3. enzyme binding Source: RGD
  4. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  5. sequence-specific DNA binding transcription factor activity Source: GO_Central

GO - Biological processi

  1. adrenal gland development Source: Ensembl
  2. base-excision repair Source: GO_Central
  3. cell proliferation in forebrain Source: Ensembl
  4. fat pad development Source: Ensembl
  5. male gonad development Source: Ensembl
  6. negative regulation of astrocyte differentiation Source: Ensembl
  7. negative regulation of intracellular steroid hormone receptor signaling pathway Source: RGD
  8. negative regulation of JAK-STAT cascade Source: RGD
  9. negative regulation of transcription from RNA polymerase II promoter Source: RGD
  10. pituitary gland development Source: Ensembl
  11. positive regulation of cell proliferation Source: Ensembl
  12. positive regulation of multicellular organism growth Source: Ensembl
  13. positive regulation of sequence-specific DNA binding transcription factor activity Source: RGD
  14. regulation of cell cycle process Source: Ensembl
  15. regulation of growth hormone secretion Source: Ensembl
  16. signal transduction Source: RGD
  17. somatic stem cell maintenance Source: Ensembl
  18. spermatogenesis Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_279642. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

Names & Taxonomyi

Protein namesi
Submitted name:
High mobility group protein HMGI-CImported
Gene namesi
Name:Hmga2Imported
Synonyms:Hmgi-cImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620617. Hmga2.

Subcellular locationi

GO - Cellular componenti

  1. nuclear chromosome Source: Ensembl
  2. nucleus Source: RGD
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiQ9JI54. baseline and differential.
GenevestigatoriQ9JI54.

Family & Domainsi

Phylogenomic databases

PhylomeDBiQ9JI54.

Family and domain databases

InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR000637. HMGI/Y_DNA-bd_CS.
[Graphical view]
PfamiPF02178. AT_hook. 1 hit.
[Graphical view]
PROSITEiPS00354. HMGI_Y. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9JI54-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
MSARGEGAGQ PSTSAQGQPA TPAPQKRGRG RPRKQPQ
Length:37
Mass (Da):3,828
Last modified:October 1, 2000 - v1
Checksum:i7E23A16F3EB01AC2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei37 – 371Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261719 Genomic DNA. Translation: AAF91385.1.
UniGeneiRn.29981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF261719 Genomic DNA. Translation: AAF91385.1.
UniGeneiRn.29981.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

RGDi620617. Hmga2.

Phylogenomic databases

PhylomeDBiQ9JI54.

Enzyme and pathway databases

ReactomeiREACT_279642. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

Gene expression databases

ExpressionAtlasiQ9JI54. baseline and differential.
GenevestigatoriQ9JI54.

Family and domain databases

InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR000637. HMGI/Y_DNA-bd_CS.
[Graphical view]
PfamiPF02178. AT_hook. 1 hit.
[Graphical view]
PROSITEiPS00354. HMGI_Y. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "AP-2alpha-dependent rat non-histone chromosomal protein HMGI-C expression in salivary epithelial cells."
    Wen X., Lin H.H., Deng H.-T., Hajyan K., Ann D.K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.

Entry informationi

Entry nameiQ9JI54_RAT
AccessioniPrimary (citable) accession number: Q9JI54
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: April 29, 2015
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.