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Q9JI54

- Q9JI54_RAT

UniProt

Q9JI54 - Q9JI54_RAT

Protein
Submitted name:

High mobility group protein HMGI-C

Gene

Hmga2

Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. 5'-deoxyribose-5-phosphate lyase activity Source: Ensembl
    2. AT DNA binding Source: Ensembl
    3. cAMP response element binding Source: Ensembl
    4. core promoter binding Source: Ensembl
    5. DNA-(apurinic or apyrimidinic site) lyase activity Source: Ensembl
    6. DNA binding, bending Source: Ensembl
    7. DNA-dependent protein kinase activity Source: Ensembl
    8. enzyme binding Source: RGD
    9. protein binding transcription factor activity Source: Ensembl
    10. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
    11. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl

    GO - Biological processi

    1. adrenal gland development Source: Ensembl
    2. base-excision repair Source: Ensembl
    3. cell proliferation in forebrain Source: Ensembl
    4. chondrocyte differentiation Source: Ensembl
    5. chondrocyte proliferation Source: Ensembl
    6. chromosome breakage Source: Ensembl
    7. DNA damage response, detection of DNA damage Source: Ensembl
    8. endodermal cell differentiation Source: Ensembl
    9. epithelial to mesenchymal transition Source: Ensembl
    10. fat cell differentiation Source: Ensembl
    11. fat pad development Source: Ensembl
    12. histone H2A-S139 phosphorylation Source: Ensembl
    13. male gonad development Source: Ensembl
    14. mesodermal cell differentiation Source: Ensembl
    15. mesodermal-endodermal cell signaling Source: Ensembl
    16. mitotic G2 DNA damage checkpoint Source: Ensembl
    17. negative regulation by host of viral transcription Source: Ensembl
    18. negative regulation of apoptotic process Source: Ensembl
    19. negative regulation of astrocyte differentiation Source: Ensembl
    20. negative regulation of DNA binding Source: Ensembl
    21. negative regulation of double-strand break repair via nonhomologous end joining Source: Ensembl
    22. negative regulation of intracellular steroid hormone receptor signaling pathway Source: RGD
    23. negative regulation of JAK-STAT cascade Source: RGD
    24. negative regulation of single stranded viral RNA replication via double stranded DNA intermediate Source: Ensembl
    25. negative regulation of transcription from RNA polymerase II promoter Source: RGD
    26. oncogene-induced cell senescence Source: Ensembl
    27. pituitary gland development Source: Ensembl
    28. positive regulation of apoptotic process Source: Ensembl
    29. positive regulation of cell cycle arrest Source: Ensembl
    30. positive regulation of cellular response to X-ray Source: Ensembl
    31. positive regulation of cellular senescence Source: Ensembl
    32. positive regulation of multicellular organism growth Source: Ensembl
    33. positive regulation of response to DNA damage stimulus Source: Ensembl
    34. positive regulation of sequence-specific DNA binding transcription factor activity Source: RGD
    35. positive regulation of stem cell proliferation Source: Ensembl
    36. positive regulation of transcription regulatory region DNA binding Source: Ensembl
    37. regulation of cellular response to drug Source: Ensembl
    38. regulation of growth hormone secretion Source: Ensembl
    39. regulation of stem cell maintenance Source: Ensembl
    40. response to virus Source: Ensembl
    41. senescence-associated heterochromatin focus assembly Source: Ensembl
    42. signal transduction Source: RGD
    43. somatic stem cell maintenance Source: Ensembl
    44. spermatogenesis Source: Ensembl

    Enzyme and pathway databases

    ReactomeiREACT_198399. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    High mobility group protein HMGI-CImported
    Gene namesi
    Name:Hmga2Imported
    Synonyms:Hmgi-cImported
    OrganismiRattus norvegicus (Rat)Imported
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

    Organism-specific databases

    RGDi620617. Hmga2.

    Subcellular locationi

    GO - Cellular componenti

    1. nuclear chromosome Source: Ensembl
    2. nucleus Source: RGD
    3. protein-DNA complex Source: Ensembl
    4. senescence-associated heterochromatin focus Source: Ensembl
    5. SMAD protein complex Source: Ensembl

    Expressioni

    Gene expression databases

    GenevestigatoriQ9JI54.

    Family & Domainsi

    Phylogenomic databases

    PhylomeDBiQ9JI54.

    Family and domain databases

    InterProiIPR017956. AT_hook_DNA-bd_motif.
    IPR000637. HMGI/Y_DNA-bd_CS.
    [Graphical view]
    PfamiPF02178. AT_hook. 1 hit.
    [Graphical view]
    PROSITEiPS00354. HMGI_Y. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q9JI54-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSARGEGAGQ PSTSAQGQPA TPAPQKRGRG RPRKQPQ                 37
    Length:37
    Mass (Da):3,828
    Last modified:October 1, 2000 - v1
    Checksum:i7E23A16F3EB01AC2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei37 – 371Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF261719 Genomic DNA. Translation: AAF91385.1.
    UniGeneiRn.29981.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF261719 Genomic DNA. Translation: AAF91385.1 .
    UniGenei Rn.29981.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 620617. Hmga2.

    Phylogenomic databases

    PhylomeDBi Q9JI54.

    Enzyme and pathway databases

    Reactomei REACT_198399. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

    Gene expression databases

    Genevestigatori Q9JI54.

    Family and domain databases

    InterProi IPR017956. AT_hook_DNA-bd_motif.
    IPR000637. HMGI/Y_DNA-bd_CS.
    [Graphical view ]
    Pfami PF02178. AT_hook. 1 hit.
    [Graphical view ]
    PROSITEi PS00354. HMGI_Y. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "AP-2alpha-dependent rat non-histone chromosomal protein HMGI-C expression in salivary epithelial cells."
      Wen X., Lin H.H., Deng H.-T., Hajyan K., Ann D.K.
      Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: Sprague-DawleyImported.

    Entry informationi

    Entry nameiQ9JI54_RAT
    AccessioniPrimary (citable) accession number: Q9JI54
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2000
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)