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Q9JI54

- Q9JI54_RAT

UniProt

Q9JI54 - Q9JI54_RAT

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Protein
Submitted name: High mobility group protein HMGI-C
Gene
Hmga2, Hmgi-c
Organism
Rattus norvegicus (Rat)
Status
Unreviewed - Annotation score: 5 out of 5 - Protein predictedi

Functioni

GO - Molecular functioni

  1. 5'-deoxyribose-5-phosphate lyase activity Source: Ensembl
  2. AT DNA binding Source: Ensembl
  3. DNA binding, bending Source: Ensembl
  4. DNA-(apurinic or apyrimidinic site) lyase activity Source: Ensembl
  5. DNA-dependent protein kinase activity Source: Ensembl
  6. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription Source: Ensembl
  7. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  8. cAMP response element binding Source: Ensembl
  9. core promoter binding Source: Ensembl
  10. enzyme binding Source: RGD
  11. protein binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. DNA damage response, detection of DNA damage Source: Ensembl
  2. adrenal gland development Source: Ensembl
  3. base-excision repair Source: Ensembl
  4. cell proliferation in forebrain Source: Ensembl
  5. chondrocyte differentiation Source: Ensembl
  6. chondrocyte proliferation Source: Ensembl
  7. chromosome breakage Source: Ensembl
  8. endodermal cell differentiation Source: Ensembl
  9. epithelial to mesenchymal transition Source: Ensembl
  10. fat cell differentiation Source: Ensembl
  11. fat pad development Source: Ensembl
  12. histone H2A-S139 phosphorylation Source: Ensembl
  13. male gonad development Source: Ensembl
  14. mesodermal cell differentiation Source: Ensembl
  15. mesodermal-endodermal cell signaling Source: Ensembl
  16. mitotic G2 DNA damage checkpoint Source: Ensembl
  17. negative regulation by host of viral transcription Source: Ensembl
  18. negative regulation of DNA binding Source: Ensembl
  19. negative regulation of JAK-STAT cascade Source: RGD
  20. negative regulation of apoptotic process Source: Ensembl
  21. negative regulation of astrocyte differentiation Source: Ensembl
  22. negative regulation of double-strand break repair via nonhomologous end joining Source: Ensembl
  23. negative regulation of intracellular steroid hormone receptor signaling pathway Source: RGD
  24. negative regulation of single stranded viral RNA replication via double stranded DNA intermediate Source: Ensembl
  25. negative regulation of transcription from RNA polymerase II promoter Source: RGD
  26. oncogene-induced cell senescence Source: Ensembl
  27. pituitary gland development Source: Ensembl
  28. positive regulation of apoptotic process Source: Ensembl
  29. positive regulation of cell cycle arrest Source: Ensembl
  30. positive regulation of cellular response to X-ray Source: Ensembl
  31. positive regulation of cellular senescence Source: Ensembl
  32. positive regulation of multicellular organism growth Source: Ensembl
  33. positive regulation of response to DNA damage stimulus Source: Ensembl
  34. positive regulation of sequence-specific DNA binding transcription factor activity Source: RGD
  35. positive regulation of stem cell proliferation Source: Ensembl
  36. positive regulation of transcription regulatory region DNA binding Source: Ensembl
  37. regulation of cellular response to drug Source: Ensembl
  38. regulation of growth hormone secretion Source: Ensembl
  39. regulation of stem cell maintenance Source: Ensembl
  40. response to virus Source: Ensembl
  41. senescence-associated heterochromatin focus assembly Source: Ensembl
  42. signal transduction Source: RGD
  43. somatic stem cell maintenance Source: Ensembl
  44. spermatogenesis Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_198399. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

Names & Taxonomyi

Protein namesi
Submitted name:
High mobility group protein HMGI-CImported
Gene namesi
Name:Hmga2Imported
Synonyms:Hmgi-cImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi620617. Hmga2.

Subcellular locationi

GO - Cellular componenti

  1. SMAD protein complex Source: Ensembl
  2. nuclear chromosome Source: Ensembl
  3. nucleus Source: RGD
  4. protein-DNA complex Source: Ensembl
  5. senescence-associated heterochromatin focus Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ9JI54.

Family & Domainsi

Phylogenomic databases

PhylomeDBiQ9JI54.

Family and domain databases

InterProiIPR017956. AT_hook_DNA-bd_motif.
IPR000637. HMGI/Y_DNA-bd_CS.
[Graphical view]
PfamiPF02178. AT_hook. 1 hit.
[Graphical view]
PROSITEiPS00354. HMGI_Y. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q9JI54-1 [UniParc]FASTAAdd to Basket

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MSARGEGAGQ PSTSAQGQPA TPAPQKRGRG RPRKQPQ                 37
Length:37
Mass (Da):3,828
Last modified:October 1, 2000 - v1
Checksum:i7E23A16F3EB01AC2
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei37 – 371Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF261719 Genomic DNA. Translation: AAF91385.1.
UniGeneiRn.29981.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF261719 Genomic DNA. Translation: AAF91385.1 .
UniGenei Rn.29981.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

RGDi 620617. Hmga2.

Phylogenomic databases

PhylomeDBi Q9JI54.

Enzyme and pathway databases

Reactomei REACT_198399. Formation of Senescence-Associated Heterochromatin Foci (SAHF).

Gene expression databases

Genevestigatori Q9JI54.

Family and domain databases

InterProi IPR017956. AT_hook_DNA-bd_motif.
IPR000637. HMGI/Y_DNA-bd_CS.
[Graphical view ]
Pfami PF02178. AT_hook. 1 hit.
[Graphical view ]
PROSITEi PS00354. HMGI_Y. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "AP-2alpha-dependent rat non-histone chromosomal protein HMGI-C expression in salivary epithelial cells."
    Wen X., Lin H.H., Deng H.-T., Hajyan K., Ann D.K.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: Sprague-DawleyImported.

Entry informationi

Entry nameiQ9JI54_RAT
AccessioniPrimary (citable) accession number: Q9JI54
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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