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Protein

DNA methyltransferase 1-associated protein 1

Gene

Dmap1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in transcription repression and activation. Its interaction with HDAC2 may provide a mechanism for histone deacetylation in heterochromatin following replication of DNA at late firing origins. Can also repress transcription independently of histone deacetylase activity. May specifically potentiate DAXX-mediated repression of glucocorticoid receptor-dependent transcription. Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Participates in the nuclear localization of URI1 and increases its transcriptional corepressor activity (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Repressor

Keywords - Biological processi

Growth regulation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA methyltransferase 1-associated protein 1
Short name:
DNMAP1
Short name:
DNMT1-associated protein 1
Alternative name(s):
MAT1-mediated transcriptional repressor
Gene namesi
Name:Dmap1
Synonyms:Mmtr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913483. Dmap1.

Subcellular locationi

  • Nucleus
  • Cytoplasm By similarity

  • Note: Targeted to replication foci throughout S phase by DNMT1.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • NuA4 histone acetyltransferase complex Source: UniProtKB
  • nucleus Source: UniProtKB
  • replication fork Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 468468DNA methyltransferase 1-associated protein 1PRO_0000079936Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei446 – 4461PhosphothreonineCombined sources
Modified residuei449 – 4491PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9JI44.
MaxQBiQ9JI44.
PaxDbiQ9JI44.
PeptideAtlasiQ9JI44.
PRIDEiQ9JI44.

PTM databases

iPTMnetiQ9JI44.
PhosphoSiteiQ9JI44.

Expressioni

Gene expression databases

BgeeiENSMUSG00000009640.
CleanExiMM_DMAP1.
GenevisibleiQ9JI44. MM.

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. DMAP1 also forms a complex with DNMT1 and HDAC2. Throughout S phase it interacts directly with the N-terminus of DNMT1, which serves to recruit DMAP1 to replication foci. DMAP1 interacts with ING1, a component of the mSIN3A transcription repressor complex, although this interaction is not required for recruitment of ING1 to heterochromatin. Interacts directly with the transcriptional corepressor TSG101. Interacts with URI1 (By similarity). Interacts with the pro-apoptotic protein DAXX.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211314. 10 interactions.
IntActiQ9JI44. 20 interactions.
MINTiMINT-1172683.
STRINGi10090.ENSMUSP00000099748.

Structurei

3D structure databases

ProteinModelPortaliQ9JI44.
SMRiQ9JI44. Positions 133-207.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 19951SANTAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili225 – 27551Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi406 – 4116Poly-Ala
Compositional biasi455 – 4617Poly-Ser

Sequence similaritiesi

Contains 1 SANT domain.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2656. Eukaryota.
ENOG410XSA4. LUCA.
GeneTreeiENSGT00390000016466.
HOGENOMiHOG000007018.
HOVERGENiHBG051364.
InParanoidiQ9JI44.
KOiK11324.
OMAiTDYPFAK.
OrthoDBiEOG091G0B27.
PhylomeDBiQ9JI44.
TreeFamiTF354261.

Family and domain databases

InterProiIPR032563. DAMP1_SANT_like.
IPR008468. DMAP1.
IPR027109. Swc4/Dmap1.
[Graphical view]
PANTHERiPTHR12855. PTHR12855. 1 hit.
PfamiPF05499. DMAP1. 1 hit.
PF16282. SANT_DAMP1_like. 1 hit.
[Graphical view]
ProDomiPD492828. DMAP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9JI44-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATGADVRDI LELGGPEGDA ASGTISKKDI INPDKKKSKK SSETLTFKRP
60 70 80 90 100
EGMHREVYAL LYSDKKDAPP LLPSDTGQGY RTVKAKLGSK KVRPWKWMPF
110 120 130 140 150
TNPARKDGAM FFHWRRAAEE GKDYPFARFN KTVQVPVYSE QEYQLYLHDD
160 170 180 190 200
AWTKAETDHL FDLSRRFDLR FVVIHDRYDH QQFKKRSVED LKERYYHICA
210 220 230 240 250
KLANVRAVPG TDLKIPVFDA GHERRRKEQL ERLYNRTPEQ VAEEEYLLQE
260 270 280 290 300
LRKIEARKKE REKRSQDLQK LITAADTTAE QRRTERKAPK KKLPQKKEAE
310 320 330 340 350
KPAVPETAGI KFPDFKSAGV TLRSQRMKLP SSVGQKKIKA LEQMLLELGV
360 370 380 390 400
ELSPTPTEEL VHMFNELRSD LVLLYELKQA CANCEYELQM LRHRHEALAR
410 420 430 440 450
AGVLGAPAAA AVGPTPASAE PTVSESGLGL DPTKDTIIDV VGAPLTPNSR
460
KRRESASSSS SVKKAKKP
Length:468
Mass (Da):53,130
Last modified:October 1, 2000 - v1
Checksum:iCDDADF2165801C9B
GO
Isoform 2 (identifier: Q9JI44-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     242-323: AEEEYLLQEL...DFKSAGVTLR → ITSSTPPSTA...RGGVPPTGAA
     324-468: Missing.

Note: May be due to intron retention. No experimental confirmation available.
Show »
Length:323
Mass (Da):36,704
Checksum:iAE92851DE5154712
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei242 – 32382AEEEY…GVTLR → ITSSTPPSTAQLSLPPGPFT SSPFLWSLFLPSLQESPYLW SLIDNLVSRQLPSHLLPHSP HTHGSISCFAGGRGGVPPTG AA in isoform 2. 1 PublicationVSP_003850Add
BLAST
Alternative sequencei324 – 468145Missing in isoform 2. 1 PublicationVSP_003851Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF265229 mRNA. Translation: AAF87080.1.
AF438610 mRNA. Translation: AAL31640.1.
AK005270 mRNA. No translation available.
AK012055 mRNA. Translation: BAB27996.3.
BC002321 mRNA. Translation: AAH02321.1.
BC045160 mRNA. Translation: AAH45160.1.
CCDSiCCDS18536.1. [Q9JI44-1]
RefSeqiNP_075667.1. NM_023178.2. [Q9JI44-1]
XP_006503329.1. XM_006503266.2. [Q9JI44-1]
XP_006503330.1. XM_006503267.2. [Q9JI44-1]
XP_006503331.1. XM_006503268.2. [Q9JI44-1]
UniGeneiMm.29142.

Genome annotation databases

EnsembliENSMUST00000102687; ENSMUSP00000099748; ENSMUSG00000009640. [Q9JI44-1]
GeneIDi66233.
KEGGimmu:66233.
UCSCiuc008uiw.1. mouse. [Q9JI44-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF265229 mRNA. Translation: AAF87080.1.
AF438610 mRNA. Translation: AAL31640.1.
AK005270 mRNA. No translation available.
AK012055 mRNA. Translation: BAB27996.3.
BC002321 mRNA. Translation: AAH02321.1.
BC045160 mRNA. Translation: AAH45160.1.
CCDSiCCDS18536.1. [Q9JI44-1]
RefSeqiNP_075667.1. NM_023178.2. [Q9JI44-1]
XP_006503329.1. XM_006503266.2. [Q9JI44-1]
XP_006503330.1. XM_006503267.2. [Q9JI44-1]
XP_006503331.1. XM_006503268.2. [Q9JI44-1]
UniGeneiMm.29142.

3D structure databases

ProteinModelPortaliQ9JI44.
SMRiQ9JI44. Positions 133-207.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211314. 10 interactions.
IntActiQ9JI44. 20 interactions.
MINTiMINT-1172683.
STRINGi10090.ENSMUSP00000099748.

PTM databases

iPTMnetiQ9JI44.
PhosphoSiteiQ9JI44.

Proteomic databases

EPDiQ9JI44.
MaxQBiQ9JI44.
PaxDbiQ9JI44.
PeptideAtlasiQ9JI44.
PRIDEiQ9JI44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102687; ENSMUSP00000099748; ENSMUSG00000009640. [Q9JI44-1]
GeneIDi66233.
KEGGimmu:66233.
UCSCiuc008uiw.1. mouse. [Q9JI44-1]

Organism-specific databases

CTDi55929.
MGIiMGI:1913483. Dmap1.

Phylogenomic databases

eggNOGiKOG2656. Eukaryota.
ENOG410XSA4. LUCA.
GeneTreeiENSGT00390000016466.
HOGENOMiHOG000007018.
HOVERGENiHBG051364.
InParanoidiQ9JI44.
KOiK11324.
OMAiTDYPFAK.
OrthoDBiEOG091G0B27.
PhylomeDBiQ9JI44.
TreeFamiTF354261.

Miscellaneous databases

PROiQ9JI44.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000009640.
CleanExiMM_DMAP1.
GenevisibleiQ9JI44. MM.

Family and domain databases

InterProiIPR032563. DAMP1_SANT_like.
IPR008468. DMAP1.
IPR027109. Swc4/Dmap1.
[Graphical view]
PANTHERiPTHR12855. PTHR12855. 1 hit.
PfamiPF05499. DMAP1. 1 hit.
PF16282. SANT_DAMP1_like. 1 hit.
[Graphical view]
ProDomiPD492828. DMAP1. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiDMAP1_MOUSE
AccessioniPrimary (citable) accession number: Q9JI44
Secondary accession number(s): Q99LM0, Q9CSS9, Q9DB33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 143 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.