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Protein

ATP-binding cassette sub-family B member 10, mitochondrial

Gene

Abcb10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May mediate critical mitochondrial transport functions related to heme biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi492 – 499ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-binding cassette sub-family B member 10, mitochondrial
Alternative name(s):
ABC-mitochondrial erythroid protein
Short name:
ABC-me protein
ATP-binding cassette transporter 10
Short name:
ABC transporter 10 protein
Gene namesi
Name:Abcb10
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1860508. Abcb10.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini83 – 137Mitochondrial intermembraneSequence analysisAdd BLAST55
Transmembranei138 – 158HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini159 – 180Mitochondrial matrixSequence analysisAdd BLAST22
Transmembranei181 – 201HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini202 – 266Mitochondrial intermembraneSequence analysisAdd BLAST65
Transmembranei267 – 287HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini288 – 360Mitochondrial matrixSequence analysisAdd BLAST73
Transmembranei361 – 381HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini382 – 395Mitochondrial intermembraneSequence analysisAdd BLAST14
Transmembranei396 – 416HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini417 – 715Mitochondrial matrixSequence analysisAdd BLAST299

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • integral component of mitochondrial membrane Source: MGI
  • mitochondrial inner membrane Source: MGI
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 82Mitochondrion1 PublicationAdd BLAST82
ChainiPRO_000000025683 – 715ATP-binding cassette sub-family B member 10, mitochondrialAdd BLAST633

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei230N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9JI39.
MaxQBiQ9JI39.
PaxDbiQ9JI39.
PeptideAtlasiQ9JI39.
PRIDEiQ9JI39.

PTM databases

iPTMnetiQ9JI39.
PhosphoSitePlusiQ9JI39.

Expressioni

Tissue specificityi

Expressed at particularly high levels in fetal liver, and erythroid tissues of embryos and adults. Found also in adult bone marrow, liver and kidney, and at lower levels in heart, brain and spleen.

Developmental stagei

Abundant in the liver but not in non-hematopoietic tissues of E13 embryos.

Inductioni

By transcription factor GATA-1 during erythroid differentiation and in vitro, by DMSO during terminal erythroid maturation.

Gene expression databases

BgeeiENSMUSG00000031974.
GenevisibleiQ9JI39. MM.

Interactioni

Subunit structurei

Homodimer or homooligomer.1 Publication

GO - Molecular functioni

  • protein homodimerization activity Source: MGI

Protein-protein interaction databases

BioGridi207837. 1 interactor.
IntActiQ9JI39. 5 interactors.
STRINGi10090.ENSMUSP00000075011.

Structurei

3D structure databases

ProteinModelPortaliQ9JI39.
SMRiQ9JI39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini136 – 422ABC transmembrane type-1PROSITE-ProRule annotationAdd BLAST287
Domaini457 – 696ABC transporterPROSITE-ProRule annotationAdd BLAST240

Sequence similaritiesi

Contains 1 ABC transmembrane type-1 domain.PROSITE-ProRule annotation
Contains 1 ABC transporter domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0058. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00550000074497.
HOVERGENiHBG008358.
InParanoidiQ9JI39.
KOiK05657.
OMAiWAGDEAW.
OrthoDBiEOG091G0HVA.
PhylomeDBiQ9JI39.
TreeFamiTF105198.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030260. ABCB10.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24221:SF121. PTHR24221:SF121. 2 hits.
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JI39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRAPSARALL LIPRRGPAVR AWAPAVSSRI WLASEWTPLV RAWTSLIHKP
60 70 80 90 100
GSGLRFPAPL SGLPGGVGQW ATSSGARRCW VLAGPRAAHP LFARLQGAAA
110 120 130 140 150
TGVRDLGNDS QRRPAATGRS EVWKLLGLVR PERGRLSAAV GFLAVSSVIT
160 170 180 190 200
MSAPFFLGRI IDVIYTNPSE GYGDSLTRLC AVLTCVFLCG AAANGIRVYL
210 220 230 240 250
MQSSGQSIVN RLRTSLFSSI LRQEVAFFDK TRTGELINRL SSDTALLGRS
260 270 280 290 300
VTENLSDGLR AGAQASVGVG MMFFVSPSLA TFVLSVVPPI SVLAVIYGRY
310 320 330 340 350
LRKLSKATQD SLAEATQLAE ERIGNIRTIR AFGKEMTEVE KYTGRVDQLL
360 370 380 390 400
QLAQKEALAR AGFFGAAGLS GNLIVLSVLY KGGLLMGSAH MTVGELSSFL
410 420 430 440 450
MYAFWVGLSI GGLSSFYSEL MKGLGAGGRL WELLERQPRL PFNEGMVLDE
460 470 480 490 500
KTFQGALEFR NVHFTYPARP EVSVFQDFSL SIPSGSVTAL VGPSGSGKST
510 520 530 540 550
VVSLLLRLYD PNSGTVSLDG HDIRQLNPVW LRSKIGTVSQ EPVLFSCSVA
560 570 580 590 600
ENIAYGADNL SSVTAQQVER AAEVANAAEF IRSFPQGFDT VVGEKGILLS
610 620 630 640 650
GGQKQRIAIA RALLKNPKIL LLDEATSALD AENEHLVQEA LDRLMEGRTV
660 670 680 690 700
LIIAHRLSTI KNANFVAVLD HGKICEHGTH EELLLKPNGL YRKLMNKQSF
710
LSYNGAEQFL EPARA
Length:715
Mass (Da):77,188
Last modified:October 1, 2000 - v1
Checksum:iC07BE44A478B89A2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF266284 mRNA. Translation: AAF76889.1.
AK081782 mRNA. Translation: BAC38331.1.
BC046818 mRNA. Translation: AAH46818.1.
BC053020 mRNA. Translation: AAH53020.1.
BC054793 mRNA. Translation: AAH54793.1.
CCDSiCCDS22766.1.
RefSeqiNP_062425.1. NM_019552.2.
UniGeneiMm.274243.

Genome annotation databases

EnsembliENSMUST00000075578; ENSMUSP00000075011; ENSMUSG00000031974.
GeneIDi56199.
KEGGimmu:56199.
UCSCiuc009nwv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF266284 mRNA. Translation: AAF76889.1.
AK081782 mRNA. Translation: BAC38331.1.
BC046818 mRNA. Translation: AAH46818.1.
BC053020 mRNA. Translation: AAH53020.1.
BC054793 mRNA. Translation: AAH54793.1.
CCDSiCCDS22766.1.
RefSeqiNP_062425.1. NM_019552.2.
UniGeneiMm.274243.

3D structure databases

ProteinModelPortaliQ9JI39.
SMRiQ9JI39.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi207837. 1 interactor.
IntActiQ9JI39. 5 interactors.
STRINGi10090.ENSMUSP00000075011.

PTM databases

iPTMnetiQ9JI39.
PhosphoSitePlusiQ9JI39.

Proteomic databases

EPDiQ9JI39.
MaxQBiQ9JI39.
PaxDbiQ9JI39.
PeptideAtlasiQ9JI39.
PRIDEiQ9JI39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075578; ENSMUSP00000075011; ENSMUSG00000031974.
GeneIDi56199.
KEGGimmu:56199.
UCSCiuc009nwv.1. mouse.

Organism-specific databases

CTDi23456.
MGIiMGI:1860508. Abcb10.

Phylogenomic databases

eggNOGiKOG0058. Eukaryota.
COG1132. LUCA.
GeneTreeiENSGT00550000074497.
HOVERGENiHBG008358.
InParanoidiQ9JI39.
KOiK05657.
OMAiWAGDEAW.
OrthoDBiEOG091G0HVA.
PhylomeDBiQ9JI39.
TreeFamiTF105198.

Miscellaneous databases

ChiTaRSiAbcb10. mouse.
PROiQ9JI39.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031974.
GenevisibleiQ9JI39. MM.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR030260. ABCB10.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR24221:SF121. PTHR24221:SF121. 2 hits.
PfamiPF00664. ABC_membrane. 1 hit.
PF00005. ABC_tran. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 1 hit.
PROSITEiPS50929. ABC_TM1F. 1 hit.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiABCBA_MOUSE
AccessioniPrimary (citable) accession number: Q9JI39
Secondary accession number(s): Q542P7, Q9D0C7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 2, 2002
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.