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Protein

Histamine H3 receptor

Gene

HRH3

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Histamine H3 receptor
Short name:
H3R
Short name:
HH3R
Gene namesi
Name:HRH3
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4040ExtracellularSequence analysisAdd
BLAST
Transmembranei41 – 6121Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini62 – 7110CytoplasmicSequence analysis
Transmembranei72 – 9221Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini93 – 10917ExtracellularSequence analysisAdd
BLAST
Transmembranei110 – 13021Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini131 – 15727CytoplasmicSequence analysisAdd
BLAST
Transmembranei158 – 17821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini179 – 19719ExtracellularSequence analysisAdd
BLAST
Transmembranei198 – 21821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini219 – 359141CytoplasmicSequence analysisAdd
BLAST
Transmembranei360 – 38021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini381 – 39818ExtracellularSequence analysisAdd
BLAST
Transmembranei399 – 41921Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini420 – 44526CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL5076.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Histamine H3 receptorPRO_0000069689Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi11 – 111N-linked (GlcNAc...)Sequence analysis
Modified residuei439 – 4391PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Expressioni

Tissue specificityi

Expressed widely and abundantly throughout the brain. Highly expressed in discrete neuronal populations such as pyramidal cells in cerebral cortex or cerebellar Purkinje cells.

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000020710.

Chemistry

BindingDBiQ9JI35.

Structurei

3D structure databases

ProteinModelPortaliQ9JI35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi20 – 245Poly-Ala

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000048707.
HOVERGENiHBG102132.
InParanoidiQ9JI35.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003980. Histamine_H3_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01471. HISTAMINEH3R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q9JI35-1) [UniParc]FASTAAdd to basket

Also known as: H3L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MERAPPDGLM NASGALAGEA AAAAGGARTF SAAWTAVLAA LMALLIVATV
60 70 80 90 100
LGNALVMLAF VADSSLRTQN NFFLLNLAIS DFLVGVFCIP LYVPYVLTGR
110 120 130 140 150
WTFGRGLCKL WLVVDYLLCT SSVFNIVLIS YDRFLSVTRA VSYRAQQGDT
160 170 180 190 200
RRAVRKMVLV WVLAFLLYGP AILSWEYLSG GSSIPEGHCY AEFFYNWYFL
210 220 230 240 250
ITASTLEFFT PFLSVTFFNL SIYLNIQRRT RLRLDGGARE AGPDPLPEAQ
260 270 280 290 300
SSPPQPPPGC WGCWPKGQGE SMPLHRYGVG EAGPGAEAGE AALGGGSGAA
310 320 330 340 350
ASPTSSSGSS SRGTERPRSL KRGSKPSASS ASLEKRMKMV SQSITQRFRL
360 370 380 390 400
SRDKKVAKSL AIIVSIFGLC WAPYTLLMII RAACHGHCVP DYWYETSFWL
410 420 430 440
LWANSAVNPV LYPLCHYSFR RAFTKLLCPQ KLKVQPHSSL EHCWK
Length:445
Mass (Da):48,735
Last modified:November 16, 2001 - v2
Checksum:iBAE206A3887189A0
GO
Isoform Short (identifier: Q9JI35-2) [UniParc]FASTAAdd to basket

Also known as: H3S

The sequence of this isoform differs from the canonical sequence as follows:
     276-305: Missing.

Show »
Length:415
Mass (Da):46,177
Checksum:i647D5AECF9BDC016
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei276 – 30530Missing in isoform Short. 1 PublicationVSP_001880Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267537 mRNA. Translation: AAF78947.1.
AF267538 mRNA. Translation: AAF78950.1.
RefSeqiNP_001166208.1. NM_001172737.1. [Q9JI35-1]

Genome annotation databases

GeneIDi100135541.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF267537 mRNA. Translation: AAF78947.1.
AF267538 mRNA. Translation: AAF78950.1.
RefSeqiNP_001166208.1. NM_001172737.1. [Q9JI35-1]

3D structure databases

ProteinModelPortaliQ9JI35.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000020710.

Chemistry

BindingDBiQ9JI35.
ChEMBLiCHEMBL5076.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100135541.

Organism-specific databases

CTDi11255.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000048707.
HOVERGENiHBG102132.
InParanoidiQ9JI35.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR003980. Histamine_H3_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01471. HISTAMINEH3R.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and cerebral expression of the guinea pig histamine H3 receptor: evidence for two isoforms."
    Tardivel-Lacombe J., Rouleau A., Heron A., Morisset S., Pillot C., Cochois V., Schwartz J.-C., Arrang J.-M.
    NeuroReport 11:755-759(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
    Tissue: Brain.

Entry informationi

Entry nameiHRH3_CAVPO
AccessioniPrimary (citable) accession number: Q9JI35
Secondary accession number(s): Q9JI36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: November 16, 2001
Last modified: May 11, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.