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Reviewed, UniProtKB/Swiss-Prot Q9JI33 (NET4_MOUSE)

Last modified October 13, 2009. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Netrin-4
Alternative name(s):
    Beta-netrin
Gene names
Name: Ntn4
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMus

Protein attributes

Sequence length628 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

May play an important role in neural, kidney and vascular development. Promotes neurite elongation from olfactory bulb explants. Ref.2

Subunit structure

May form a homodimer.

Subcellular location

Secretedextracellular spaceextracellular matrixbasement membrane. Note: Major component.

Tissue specificity

Expressed in kidney, liver, heart, ovary, testis, retina, brain, olfactory bulb, and widely expressed in embryo. Ref.2 Ref.1

Sequence similarities

Contains 3 laminin EGF-like domains.

Contains 1 laminin N-terminal domain.

Contains 1 NTR domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 Potential
Chain20 – 628609Netrin-4
PRO_0000042117

Regions

Domain30 – 261232Laminin N-terminal
Domain262 – 33170Laminin EGF-like 1
Domain332 – 39463Laminin EGF-like 2
Domain395 – 44854Laminin EGF-like 3
Domain506 – 627122NTR

Amino acid modifications

Glycosylation561N-linked (GlcNAc...) Potential
Glycosylation1631N-linked (GlcNAc...) Potential
Glycosylation3531N-linked (GlcNAc...) Potential
Glycosylation4831N-linked (GlcNAc...) Potential
Disulfide bond262 ↔ 271 By similarity
Disulfide bond264 ↔ 293 By similarity
Disulfide bond295 ↔ 304 By similarity
Disulfide bond307 ↔ 329 By similarity
Disulfide bond332 ↔ 341 By similarity
Disulfide bond334 ↔ 359 By similarity
Disulfide bond362 ↔ 371 By similarity
Disulfide bond374 ↔ 392 By similarity
Disulfide bond395 ↔ 413 By similarity
Disulfide bond397 ↔ 420 By similarity
Disulfide bond422 ↔ 431 By similarity
Disulfide bond434 ↔ 446 By similarity
Disulfide bond506 ↔ 576 By similarity
Disulfide bond520 ↔ 627 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9JI33-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 474F747475F236C7

FASTA62869,897
        10         20         30         40         50         60 
MGSCARLLLL WGCSAVAAGL NGVAGANSRC EKACNPRMGN LALGRKLRAD TMCGQNATEL 

        70         80         90        100        110        120 
FCFYSENADL TCRQPKCDKC NAAHSHLAHP PSAMADSSFR FPRTWWQSAE DVHREKIQLD 

       130        140        150        160        170        180 
LEAEFYFTHL IMVFKSPRPA AMVLDRSQDF GKTWKPYKYF ATNCSATFGL EDDVVKKGAI 

       190        200        210        220        230        240 
CTSRYSNPFP CTGGEVIFRA LSPPYDIENP YSAKVQEQLK ITNLRVRLLK RQSCPCQIND 

       250        260        270        280        290        300 
LNAKPHHFMH YAVYDFIVKG SCFCNGHADQ CLPVEGFRPI KAPGAFHVVH GRCMCKHNTA 

       310        320        330        340        350        360 
GSHCQHCAPL YNDRPWEAAD GRTGAPNECR TCKCNGHADT CHFDVNVWEA SGNRSGGVCN 

       370        380        390        400        410        420 
NCQHNTEGQH CQRCKPGFYR DLRRPFSAPD ACKACSCHPV GSAILPFSSV TFCDPSNGDC 

       430        440        450        460        470        480 
PCKPGVAGPH CDRCMVGYWG FGDYGCRPCD CAGSCDPLTG DCISSNADVD WYHEVPTFHS 

       490        500        510        520        530        540 
MHNKSEPSWE WEDEQGFSAL RHSGKCECKE QVLGNPKAFC GMKYSYVLKI KILSAHDKGS 

       550        560        570        580        590        600 
HAEVNVKIKK VLKSTKLKIL RGKRTLYPES WTNRGCTCPI LNPGLEYLVA GHEDVRTGKL 

       610        620 
IVNMKSFVQH WKPALGRRVM HILKRDCV 

« Hide

References

[1]"Identification and expression of mouse netrin-4."
Yin Y., Sanes J.R., Miner J.H.
Mech. Dev. 96:115-119(2000) [PubMed: 10940631] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: ICR.
[2]"A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin. Identification, expression, and functional characterization."
Koch M., Murrell J.R., Hunter D.D., Olson P.F., Jin W., Keene D.R., Brunken W.J., Burgeson R.E.
J. Cell Biol. 151:221-234(2000) [PubMed: 11038171] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Strain: BALB/c.
+Additional computationally mapped references.

Cross-references

Sequence databases

AF268066 mRNA. Translation: AAF91404.1.
AF281278 mRNA. Translation: AAG30823.1.
IPIIPI00119840.
UniGeneMm.448571

3D structure databases

HSSPHSSP built from PDB template 1NPE based on UniProtKB P02468.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9JI33.

Proteomic databases

PRIDEQ9JI33.

Genome annotation databases

EnsemblENSMUST00000020204; ENSMUSP00000020204; ENSMUSG00000020019; Mus musculus. [Genome view]
UCSCuc007gux.1. mouse.

Organism-specific databases

MGIMGI:1888978. Ntn4.

Phylogenomic databases

HOGENOMQ9JI33.
HOVERGENQ9JI33.

Gene expression databases

ArrayExpressQ9JI33.
BgeeQ9JI33.
CleanExMM_NTN4.
GenevestigatorQ9JI33.
GermOnlineENSMUSG00000020019. Mus musculus.

Family and domain databases

InterProIPR013032. EGF-like_reg_CS.
IPR002049. EGF_laminin.
IPR008211. Laminin_N.
IPR001134. Netrin_domain.
IPR018933. Netrin_module_non-TIMP.
[Graphical view]
PfamPF00053. Laminin_EGF. 3 hits.
PF00055. Laminin_N. 1 hit.
PF01759. NTR. 1 hit.
[Graphical view]
PRINTSPR00011. EGFLAMININ.
SMARTSM00643. C345C. 1 hit.
SM00180. EGF_Lam. 3 hits.
SM00136. LamNT. 1 hit.
[Graphical view]
PROSITEPS00022. EGF_1. 2 hits.
PS01248. EGF_LAM_1. 2 hits.
PS50027. EGF_LAM_2. 3 hits.
PS51117. LAMININ_NTER. 1 hit.
PS50189. NTR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio313932.
SOURCESearch...

Entry information

Entry nameNET4_MOUSE
AccessionPrimary (citable) accession number: Q9JI33
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 1, 2000
Last modified: October 13, 2009
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents