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Protein
Submitted name:

Integrin beta 2 alpha subunit

Gene

Itgam

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IntegrinUniRule annotationSAAS annotationImported, ReceptorUniRule annotationSAAS annotation

Keywords - Biological processi

Cell adhesionUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin beta 2 alpha subunitImported
Gene namesi
Name:ItgamImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2926. Itgam.

Subcellular locationi

  • Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1105 – 112723HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616UniRule annotationAdd
BLAST
Chaini17 – 11511135UniRule annotationPRO_5001426296Add
BLAST

Proteomic databases

PaxDbiQ9JI30.
PRIDEiQ9JI30.

PTM databases

PhosphoSiteiQ9JI30.

Expressioni

Gene expression databases

GenevisibleiQ9JI30. RN.

Interactioni

GO - Molecular functioni

  • protein heterodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026748.

Structurei

3D structure databases

ProteinModelPortaliQ9JI30.
SMRiQ9JI30. Positions 144-335.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini150 – 328179VWFAInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation
Contains FG-GAP repeats.SAAS annotation
Contains VWFA domain.SAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IPBA. Eukaryota.
ENOG410ZFBE. LUCA.
HOGENOMiHOG000113114.
HOVERGENiHBG100530.
KOiK06461.
PhylomeDBiQ9JI30.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JI30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLKVLLATV LTLCHGFNLD TENPMTFQEN ASGFGQSVIQ LGETRVVVAA
60 70 80 90 100
PQEVKAVNQT GALYQCDYST NRCDPIPLQV PPEAVNMSLG LSLAATTVPP
110 120 130 140 150
QLLACGPTVH QNCKENTYVN GLCYLFGSNL LRKPQQFPEA LRGCPQQESN
160 170 180 190 200
IAFLIDGSGS INTIDFQKMK EFVSTVMDQF QKSKTLFSLM QYSDEFRTHF
210 220 230 240 250
TFNDFKRNPD PKSHVRPIRQ LNGRTKTASG IRKVVRELFQ KINGARDNAA
260 270 280 290 300
KILVVITDGE KFGDPLNYED VIPEAEEAGI IRYVIGVGNA FHKPQSRREL
310 320 330 340 350
DTIASKPAGD HVFQVDNFEA LNTIRNQLQE KIFAIEGTQT GSTSSFEHEM
360 370 380 390 400
SQEGFSAAIT SNGPLLGSVG SFDWAGGAFL YPSKDKASFI NTTRIDSDMN
410 420 430 440 450
DAYLGYASAV ISRNRVQSLV LGAPRYQHIG LVVMFKQNFG AWEPHTDIKG
460 470 480 490 500
SQIGSYFGAS LCSVDMDADG NTNLILIGAP HHYEKTRGGQ VSVCPLPRGR
510 520 530 540 550
ARWQCEAILH GDQGHPWGRF GAALTVLGDV NGDKLTDVAI GAPGEQENQG
560 570 580 590 600
AVYIFHGASV ASISTPHSQR IAGARFSPGL QYFGQSLSGG KDLTMDGLMD
610 620 630 640 650
LAVGAQGRLL LIRAQPVLRL EATMEFSPKN LARSVFACQE EVVKNKDAGE
660 670 680 690 700
VRVCLQVRKN TKDRLREGDI QSTVTYDLAL DPGRSVVRAF FDETKNGILR
710 720 730 740 750
RIRVFGLTQK CETLKLILPD CVDNSVSPII LRLNYTLVGE PLRSSRDLRP
760 770 780 790 800
VLAMEAQRIF TAMFPFEKNC GNDTICQDDL SITVSSTRVN TLVVGDSRDF
810 820 830 840 850
DVSVTLRNDG EDSYGTKVTC YYPSGLSYRK VSASQNQFSK KPWRVIAEPS
860 870 880 890 900
SSEGQGVLKS TIWDINHPIF PANSEVTFNV TFDVDSDASL GNKLLLKVVV
910 920 930 940 950
TSENNVSRTD KTESQLELPV KYAIYMVVTS GESSIKYLNF TASEMTSKVI
960 970 980 990 1000
QHQYQFNNLG QRSFPVSVVF WIPVQINKVT IWDPPQVTFS QNLSSVCRTE
1010 1020 1030 1040 1050
QKSPSHSKFQ DELERTPVLN CSVAVCKRIQ CDIPSFNSKE IFNVTLQGNL
1060 1070 1080 1090 1100
LFDWYIETSH DHLLLVSTAE ILFNDSAFAL LPGQETFVKA QTETKVEPYT
1110 1120 1130 1140 1150
VHNPVPLIVG SSVGGLVLLA LITAGLYKLG FFKRQYKDMM NEAGGQDGPP

Q
Length:1,151
Mass (Da):126,944
Last modified:October 1, 2000 - v1
Checksum:i8F785695D4074CA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268593 mRNA. Translation: AAF81280.1.
RefSeqiNP_036843.1. NM_012711.1.
UniGeneiRn.54465.

Genome annotation databases

GeneIDi25021.
KEGGirno:25021.
UCSCiRGD:2926. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268593 mRNA. Translation: AAF81280.1.
RefSeqiNP_036843.1. NM_012711.1.
UniGeneiRn.54465.

3D structure databases

ProteinModelPortaliQ9JI30.
SMRiQ9JI30. Positions 144-335.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026748.

PTM databases

PhosphoSiteiQ9JI30.

Proteomic databases

PaxDbiQ9JI30.
PRIDEiQ9JI30.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25021.
KEGGirno:25021.
UCSCiRGD:2926. rat.

Organism-specific databases

CTDi3684.
RGDi2926. Itgam.

Phylogenomic databases

eggNOGiENOG410IPBA. Eukaryota.
ENOG410ZFBE. LUCA.
HOGENOMiHOG000113114.
HOVERGENiHBG100530.
KOiK06461.
PhylomeDBiQ9JI30.

Miscellaneous databases

NextBioi605115.

Gene expression databases

GenevisibleiQ9JI30. RN.

Family and domain databases

InterProiIPR013517. FG-GAP.
IPR013519. Int_alpha_beta-p.
IPR000413. Integrin_alpha.
IPR013649. Integrin_alpha-2.
IPR018184. Integrin_alpha_C_CS.
IPR032695. Integrin_dom.
IPR002035. VWF_A.
[Graphical view]
PfamiPF01839. FG-GAP. 1 hit.
PF00357. Integrin_alpha. 1 hit.
PF08441. Integrin_alpha2. 1 hit.
PF00092. VWA. 1 hit.
[Graphical view]
PRINTSiPR01185. INTEGRINA.
SMARTiSM00191. Int_alpha. 5 hits.
SM00327. VWA. 1 hit.
[Graphical view]
SUPFAMiSSF53300. SSF53300. 1 hit.
SSF69179. SSF69179. 3 hits.
PROSITEiPS51470. FG_GAP. 7 hits.
PS00242. INTEGRIN_ALPHA. 1 hit.
PS50234. VWFA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning of the rat CR3 alphaM (CD11b) subunit, expression and binding assay of recombinant isolated CD11b VA (A-domain) and ICAM-1 Ig modules."
    Zerria K., Bebbiche N., Barbouche M.R., Dellagi K., Fathallah D.M.
    Arch. Inst. Pasteur Tunis 79:11-17(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ9JI30_RAT
AccessioniPrimary (citable) accession number: Q9JI30
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.