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Protein
Submitted name:

Integrin beta 2 alpha subunit

Gene

Itgam

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrinUniRule annotationSAAS annotationImported, ReceptorUniRule annotationSAAS annotation
Biological processCell adhesionUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Integrin beta 2 alpha subunitImported
Gene namesi
Name:ItgamImported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus

Organism-specific databases

RGDi2926 Itgam

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei1105 – 1127HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16UniRule annotationAdd BLAST16
ChainiPRO_500142629617 – 1151UniRule annotationAdd BLAST1135

Proteomic databases

PRIDEiQ9JI30

PTM databases

iPTMnetiQ9JI30
PhosphoSitePlusiQ9JI30

Expressioni

Gene expression databases

GenevisibleiQ9JI30 RN

Structurei

3D structure databases

ProteinModelPortaliQ9JI30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati18 – 75FG-GAPPROSITE-ProRule annotationAdd BLAST58
Repeati76 – 135FG-GAPPROSITE-ProRule annotationAdd BLAST60
Domaini150 – 328VWFAInterPro annotationAdd BLAST179
Repeati339 – 390FG-GAPPROSITE-ProRule annotationAdd BLAST52
Repeati391 – 442FG-GAPPROSITE-ProRule annotationAdd BLAST52
Repeati443 – 503FG-GAPPROSITE-ProRule annotationAdd BLAST61
Repeati506 – 564FG-GAPPROSITE-ProRule annotationAdd BLAST59
Repeati569 – 629FG-GAPPROSITE-ProRule annotationAdd BLAST61

Sequence similaritiesi

Belongs to the integrin alpha chain family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG410IPBA Eukaryota
ENOG410ZFBE LUCA
HOGENOMiHOG000113114
HOVERGENiHBG100530
KOiK06461
PhylomeDBiQ9JI30

Family and domain databases

Gene3Di2.130.10.130, 2 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 1 hit
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 5 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 3 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 7 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JI30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTLKVLLATV LTLCHGFNLD TENPMTFQEN ASGFGQSVIQ LGETRVVVAA
60 70 80 90 100
PQEVKAVNQT GALYQCDYST NRCDPIPLQV PPEAVNMSLG LSLAATTVPP
110 120 130 140 150
QLLACGPTVH QNCKENTYVN GLCYLFGSNL LRKPQQFPEA LRGCPQQESN
160 170 180 190 200
IAFLIDGSGS INTIDFQKMK EFVSTVMDQF QKSKTLFSLM QYSDEFRTHF
210 220 230 240 250
TFNDFKRNPD PKSHVRPIRQ LNGRTKTASG IRKVVRELFQ KINGARDNAA
260 270 280 290 300
KILVVITDGE KFGDPLNYED VIPEAEEAGI IRYVIGVGNA FHKPQSRREL
310 320 330 340 350
DTIASKPAGD HVFQVDNFEA LNTIRNQLQE KIFAIEGTQT GSTSSFEHEM
360 370 380 390 400
SQEGFSAAIT SNGPLLGSVG SFDWAGGAFL YPSKDKASFI NTTRIDSDMN
410 420 430 440 450
DAYLGYASAV ISRNRVQSLV LGAPRYQHIG LVVMFKQNFG AWEPHTDIKG
460 470 480 490 500
SQIGSYFGAS LCSVDMDADG NTNLILIGAP HHYEKTRGGQ VSVCPLPRGR
510 520 530 540 550
ARWQCEAILH GDQGHPWGRF GAALTVLGDV NGDKLTDVAI GAPGEQENQG
560 570 580 590 600
AVYIFHGASV ASISTPHSQR IAGARFSPGL QYFGQSLSGG KDLTMDGLMD
610 620 630 640 650
LAVGAQGRLL LIRAQPVLRL EATMEFSPKN LARSVFACQE EVVKNKDAGE
660 670 680 690 700
VRVCLQVRKN TKDRLREGDI QSTVTYDLAL DPGRSVVRAF FDETKNGILR
710 720 730 740 750
RIRVFGLTQK CETLKLILPD CVDNSVSPII LRLNYTLVGE PLRSSRDLRP
760 770 780 790 800
VLAMEAQRIF TAMFPFEKNC GNDTICQDDL SITVSSTRVN TLVVGDSRDF
810 820 830 840 850
DVSVTLRNDG EDSYGTKVTC YYPSGLSYRK VSASQNQFSK KPWRVIAEPS
860 870 880 890 900
SSEGQGVLKS TIWDINHPIF PANSEVTFNV TFDVDSDASL GNKLLLKVVV
910 920 930 940 950
TSENNVSRTD KTESQLELPV KYAIYMVVTS GESSIKYLNF TASEMTSKVI
960 970 980 990 1000
QHQYQFNNLG QRSFPVSVVF WIPVQINKVT IWDPPQVTFS QNLSSVCRTE
1010 1020 1030 1040 1050
QKSPSHSKFQ DELERTPVLN CSVAVCKRIQ CDIPSFNSKE IFNVTLQGNL
1060 1070 1080 1090 1100
LFDWYIETSH DHLLLVSTAE ILFNDSAFAL LPGQETFVKA QTETKVEPYT
1110 1120 1130 1140 1150
VHNPVPLIVG SSVGGLVLLA LITAGLYKLG FFKRQYKDMM NEAGGQDGPP

Q
Length:1,151
Mass (Da):126,944
Last modified:October 1, 2000 - v1
Checksum:i8F785695D4074CA5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF268593 mRNA Translation: AAF81280.1
RefSeqiNP_036843.1, NM_012711.1
UniGeneiRn.54465

Genome annotation databases

GeneIDi25021
KEGGirno:25021
UCSCiRGD:2926 rat

Similar proteinsi

Entry informationi

Entry nameiQ9JI30_RAT
AccessioniPrimary (citable) accession number: Q9JI30
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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