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Protein

Interleukin-24

Gene

Il24

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Has antiproliferative properties on melanoma cells and may contribute to terminal cell differentiation.By similarity

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • cellular response to interleukin-4 Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • immune response Source: GO_Central
  • inflammatory response Source: GO_Central
  • negative regulation of cell migration Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • positive regulation of cell proliferation Source: RGD
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: RGD
  • serine phosphorylation of STAT3 protein Source: RGD
  • wound healing Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-RNO-8854691. Interleukin-19, 20, 22, 24.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-24
Short name:
IL-24
Alternative name(s):
Cytokine-like protein Mob-5
Gene namesi
Name:Il24
Synonyms:Mob5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 13

Organism-specific databases

RGDi621484. Il24.

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000001538829 – 183Interleukin-24Add BLAST155

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi76N-linked (GlcNAc...)Sequence analysis1
Cross-linki99Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity

Post-translational modificationi

Ubiquitination at Lys-99 promotes proteasomal degradation.By similarity

Keywords - PTMi

Glycoprotein, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9JI24.
PRIDEiQ9JI24.

Expressioni

Gene expression databases

BgeeiENSRNOG00000004470.
GenevisibleiQ9JI24. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006106.

Structurei

3D structure databases

ProteinModelPortaliQ9JI24.
SMRiQ9JI24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-10 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZYS. Eukaryota.
ENOG41119SI. LUCA.
GeneTreeiENSGT00410000025637.
HOGENOMiHOG000113033.
HOVERGENiHBG098494.
InParanoidiQ9JI24.
KOiK05444.
OMAiWEAFWAV.
OrthoDBiEOG091G0Q0Q.
PhylomeDBiQ9JI24.
TreeFamiTF333253.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
IPR020444. IL-24.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PRINTSiPR01937. INTRLEUKIN24.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JI24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQTSLRQQIL PGLSLILLVL NQVPELQGQE FRFGPCQVTG VVLPELWEAF
60 70 80 90 100
WTVKNTVKTQ DELTSVRLLK PQVLQNVSDA ESCYLAHSLL KFYLNTVFKN
110 120 130 140 150
YHSKIVKFKV LKSFSTLANN FLVIMSKLQP SKDNAMLPIS DSARRRFLLY
160 170 180
HRTFKQLDIE VALAKAFGEV DILLAWMQNF YQL
Length:183
Mass (Da):21,096
Last modified:October 1, 2000 - v1
Checksum:iAF7A11466C491AC4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269251 mRNA. Translation: AAF75553.1.
RefSeqiNP_579845.1. NM_133311.1.
UniGeneiRn.48710.

Genome annotation databases

EnsembliENSRNOT00000006106; ENSRNOP00000006106; ENSRNOG00000004470.
GeneIDi170819.
KEGGirno:170819.
UCSCiRGD:621484. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF269251 mRNA. Translation: AAF75553.1.
RefSeqiNP_579845.1. NM_133311.1.
UniGeneiRn.48710.

3D structure databases

ProteinModelPortaliQ9JI24.
SMRiQ9JI24.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006106.

Proteomic databases

PaxDbiQ9JI24.
PRIDEiQ9JI24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006106; ENSRNOP00000006106; ENSRNOG00000004470.
GeneIDi170819.
KEGGirno:170819.
UCSCiRGD:621484. rat.

Organism-specific databases

CTDi11009.
RGDi621484. Il24.

Phylogenomic databases

eggNOGiENOG410IZYS. Eukaryota.
ENOG41119SI. LUCA.
GeneTreeiENSGT00410000025637.
HOGENOMiHOG000113033.
HOVERGENiHBG098494.
InParanoidiQ9JI24.
KOiK05444.
OMAiWEAFWAV.
OrthoDBiEOG091G0Q0Q.
PhylomeDBiQ9JI24.
TreeFamiTF333253.

Enzyme and pathway databases

ReactomeiR-RNO-8854691. Interleukin-19, 20, 22, 24.

Miscellaneous databases

PROiQ9JI24.

Gene expression databases

BgeeiENSRNOG00000004470.
GenevisibleiQ9JI24. RN.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR020443. IL-10/19/20/22/24/26_fam.
IPR020423. IL-10_CS.
IPR020444. IL-24.
[Graphical view]
PANTHERiPTHR11585. PTHR11585. 1 hit.
PRINTSiPR01937. INTRLEUKIN24.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00520. INTERLEUKIN_10. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL24_RAT
AccessioniPrimary (citable) accession number: Q9JI24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 16, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.