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Protein

Double-stranded RNA-specific editase B2

Gene

Adarb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi438ZincPROSITE-ProRule annotation1
Active sitei440Proton donorPROSITE-ProRule annotation1
Metal bindingi496ZincPROSITE-ProRule annotation1
Metal bindingi561ZincPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Double-stranded RNA-specific editase B2 (EC:3.5.-.-)
Alternative name(s):
RNA-dependent adenosine deaminase 3
RNA-editing deaminase 2
RNA-editing enzyme 2
dsRNA adenosine deaminase B2
Gene namesi
Name:Adarb2
Synonyms:Adar3, Red2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2151118. Adarb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001717831 – 745Double-stranded RNA-specific editase B2Add BLAST745

Proteomic databases

EPDiQ9JI20.
PaxDbiQ9JI20.
PRIDEiQ9JI20.

PTM databases

iPTMnetiQ9JI20.
PhosphoSitePlusiQ9JI20.

Expressioni

Tissue specificityi

Brain specific.

Gene expression databases

BgeeiENSMUSG00000052551.
CleanExiMM_ADARB2.
ExpressionAtlasiQ9JI20. baseline and differential.
GenevisibleiQ9JI20. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064775.

Structurei

3D structure databases

ProteinModelPortaliQ9JI20.
SMRiQ9JI20.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini125 – 191DRBM 1PROSITE-ProRule annotationAdd BLAST67
Domaini283 – 347DRBM 2PROSITE-ProRule annotationAdd BLAST65
Domaini414 – 741A to I editasePROSITE-ProRule annotationAdd BLAST328

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni23 – 35R-domain (ssRNA-binding)By similarityAdd BLAST13

Sequence similaritiesi

Contains 1 A to I editase domain.PROSITE-ProRule annotation
Contains 2 DRBM (double-stranded RNA-binding) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2777. Eukaryota.
ENOG410XT0Z. LUCA.
GeneTreeiENSGT00550000074412.
HOGENOMiHOG000290164.
HOVERGENiHBG003836.
InParanoidiQ9JI20.
KOiK13194.
OMAiCKLQLIW.
OrthoDBiEOG091G0MZP.
PhylomeDBiQ9JI20.
TreeFamiTF315806.

Family and domain databases

Gene3Di3.30.160.20. 2 hits.
InterProiIPR002466. A_deamin.
IPR014720. dsRBD_dom.
[Graphical view]
PfamiPF02137. A_deamin. 1 hit.
PF00035. dsrm. 2 hits.
[Graphical view]
SMARTiSM00552. ADEAMc. 1 hit.
SM00358. DSRM. 2 hits.
[Graphical view]
PROSITEiPS50141. A_DEAMIN_EDITASE. 1 hit.
PS50137. DS_RBD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JI20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVLGSGRG SGGLSSQLKC KSKRRRRRRS KRKDKVSILS TFLAPFKYLS
60 70 80 90 100
PGTTNTEDED NLSTSSAEVK ENRNVSNLGT RPLPPGDWAR GSTPSVKRKR
110 120 130 140 150
PLEEGNGGHF CKLQLIWKKL SWSVTPKNAL VQLHELKPGL QYRMVSQTGP
160 170 180 190 200
VHAPVFAVAV EVNGLTFEGT GPTKKKAKMR AAEMALKSFV QFPNAFQAHL
210 220 230 240 250
AMGSSTSPCT DFTSDQADFP DTLFKEFEPS SKNEDFPGCH PVDTEFLSSA
260 270 280 290 300
YRRGRLLYHT LDLMGQALPD RSRLAPGALG ERNPVVVLNE LRSGLRYVCL
310 320 330 340 350
SETAEKPRVK SFVMAVCVDG RTFEGSGRSK KLAKGQAAQA ALQALFDIRL
360 370 380 390 400
PGHIPSRSKS NLLPQDFADS VSQLVTQKFR ELTVGLTSVY ARHKTLAGIV
410 420 430 440 450
MTKGLDTKQA QVIVLSSGTK CISGEHISDQ GLVVNDCHAE IVARRAFLHF
460 470 480 490 500
LYSQLELHLS KHQEDPERSI FIRLKEGGYR LRENILFHLY VSTSPCGDAR
510 520 530 540 550
VNSPYEITTD LNSSKHIVRK FRGHLRTKIE SGEGTVPVRG PSAVQTWDGI
560 570 580 590 600
LLGEQLITMS CTDKIASWNV LGLQGALLCH FIEPVYLHSI IVGSLHHTGH
610 620 630 640 650
LARVMSHRME GIGQLPASYR QNRPLLSGVS HAEARQPGKS PHFSANWVVG
660 670 680 690 700
SADLEIINAT TGKRSCGGSS RLCKHVFSAW WARLHGRLST RIPSHGDTPS
710 720 730 740
MYCEAKQGAH TYQSVKQQLF KAFQKAGLGT WVRKPPEQDQ FLLSL
Length:745
Mass (Da):82,187
Last modified:July 19, 2003 - v2
Checksum:iA336473C760902F7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25R → G in AAF76894 (Ref. 1) Curated1
Sequence conflicti65S → N in AAF78580 (PubMed:10854777).Curated1
Sequence conflicti310K → R in AAF76894 (Ref. 1) Curated1
Sequence conflicti410A → G in AAF78580 (PubMed:10854777).Curated1
Sequence conflicti731W → R in AAF76894 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF270495 mRNA. Translation: AAF76894.1.
AK033916 mRNA. Translation: BAC28513.1.
AK139079 mRNA. Translation: BAE23882.1.
AK139273 mRNA. Translation: BAE23939.1.
BC052426 mRNA. Translation: AAH52426.1.
AF232942 mRNA. Translation: AAF78580.1.
CCDSiCCDS26231.1.
RefSeqiNP_443209.2. NM_052977.5.
UniGeneiMm.425794.

Genome annotation databases

EnsembliENSMUST00000064473; ENSMUSP00000064775; ENSMUSG00000052551.
ENSMUST00000135574; ENSMUSP00000115148; ENSMUSG00000052551.
GeneIDi94191.
KEGGimmu:94191.
UCSCiuc007pkf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF270495 mRNA. Translation: AAF76894.1.
AK033916 mRNA. Translation: BAC28513.1.
AK139079 mRNA. Translation: BAE23882.1.
AK139273 mRNA. Translation: BAE23939.1.
BC052426 mRNA. Translation: AAH52426.1.
AF232942 mRNA. Translation: AAF78580.1.
CCDSiCCDS26231.1.
RefSeqiNP_443209.2. NM_052977.5.
UniGeneiMm.425794.

3D structure databases

ProteinModelPortaliQ9JI20.
SMRiQ9JI20.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064775.

PTM databases

iPTMnetiQ9JI20.
PhosphoSitePlusiQ9JI20.

Proteomic databases

EPDiQ9JI20.
PaxDbiQ9JI20.
PRIDEiQ9JI20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064473; ENSMUSP00000064775; ENSMUSG00000052551.
ENSMUST00000135574; ENSMUSP00000115148; ENSMUSG00000052551.
GeneIDi94191.
KEGGimmu:94191.
UCSCiuc007pkf.2. mouse.

Organism-specific databases

CTDi105.
MGIiMGI:2151118. Adarb2.

Phylogenomic databases

eggNOGiKOG2777. Eukaryota.
ENOG410XT0Z. LUCA.
GeneTreeiENSGT00550000074412.
HOGENOMiHOG000290164.
HOVERGENiHBG003836.
InParanoidiQ9JI20.
KOiK13194.
OMAiCKLQLIW.
OrthoDBiEOG091G0MZP.
PhylomeDBiQ9JI20.
TreeFamiTF315806.

Miscellaneous databases

PROiQ9JI20.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052551.
CleanExiMM_ADARB2.
ExpressionAtlasiQ9JI20. baseline and differential.
GenevisibleiQ9JI20. MM.

Family and domain databases

Gene3Di3.30.160.20. 2 hits.
InterProiIPR002466. A_deamin.
IPR014720. dsRBD_dom.
[Graphical view]
PfamiPF02137. A_deamin. 1 hit.
PF00035. dsrm. 2 hits.
[Graphical view]
SMARTiSM00552. ADEAMc. 1 hit.
SM00358. DSRM. 2 hits.
[Graphical view]
PROSITEiPS50141. A_DEAMIN_EDITASE. 1 hit.
PS50137. DS_RBD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRED2_MOUSE
AccessioniPrimary (citable) accession number: Q9JI20
Secondary accession number(s): Q3UTP1, Q8CC51, Q9JIE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 19, 2003
Last modified: November 2, 2016
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.