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Protein

Double-stranded RNA-specific editase B2

Gene

Adarb2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi438 – 4381ZincPROSITE-ProRule annotation
Active sitei440 – 4401Proton donorPROSITE-ProRule annotation
Metal bindingi496 – 4961ZincPROSITE-ProRule annotation
Metal bindingi561 – 5611ZincPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Double-stranded RNA-specific editase B2 (EC:3.5.-.-)
Alternative name(s):
RNA-dependent adenosine deaminase 3
RNA-editing deaminase 2
RNA-editing enzyme 2
dsRNA adenosine deaminase B2
Gene namesi
Name:Adarb2
Synonyms:Adar3, Red2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2151118. Adarb2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 745745Double-stranded RNA-specific editase B2PRO_0000171783Add
BLAST

Proteomic databases

EPDiQ9JI20.
MaxQBiQ9JI20.
PaxDbiQ9JI20.
PRIDEiQ9JI20.

PTM databases

PhosphoSiteiQ9JI20.

Expressioni

Tissue specificityi

Brain specific.

Gene expression databases

BgeeiQ9JI20.
CleanExiMM_ADARB2.
ExpressionAtlasiQ9JI20. baseline and differential.
GenevisibleiQ9JI20. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064775.

Structurei

3D structure databases

ProteinModelPortaliQ9JI20.
SMRiQ9JI20. Positions 124-194, 282-350, 354-744.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini125 – 19167DRBM 1PROSITE-ProRule annotationAdd
BLAST
Domaini283 – 34765DRBM 2PROSITE-ProRule annotationAdd
BLAST
Domaini414 – 741328A to I editasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni23 – 3513R-domain (ssRNA-binding)By similarityAdd
BLAST

Sequence similaritiesi

Contains 1 A to I editase domain.PROSITE-ProRule annotation
Contains 2 DRBM (double-stranded RNA-binding) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2777. Eukaryota.
ENOG410XT0Z. LUCA.
GeneTreeiENSGT00550000074412.
HOGENOMiHOG000290164.
HOVERGENiHBG003836.
InParanoidiQ9JI20.
KOiK13194.
OMAiCKLQLIW.
OrthoDBiEOG7VHSX4.
PhylomeDBiQ9JI20.
TreeFamiTF315806.

Family and domain databases

Gene3Di3.30.160.20. 2 hits.
InterProiIPR002466. A_deamin.
IPR014720. dsRBD_dom.
[Graphical view]
PfamiPF02137. A_deamin. 1 hit.
PF00035. dsrm. 2 hits.
[Graphical view]
SMARTiSM00552. ADEAMc. 1 hit.
SM00358. DSRM. 2 hits.
[Graphical view]
PROSITEiPS50141. A_DEAMIN_EDITASE. 1 hit.
PS50137. DS_RBD. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JI20-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVLGSGRG SGGLSSQLKC KSKRRRRRRS KRKDKVSILS TFLAPFKYLS
60 70 80 90 100
PGTTNTEDED NLSTSSAEVK ENRNVSNLGT RPLPPGDWAR GSTPSVKRKR
110 120 130 140 150
PLEEGNGGHF CKLQLIWKKL SWSVTPKNAL VQLHELKPGL QYRMVSQTGP
160 170 180 190 200
VHAPVFAVAV EVNGLTFEGT GPTKKKAKMR AAEMALKSFV QFPNAFQAHL
210 220 230 240 250
AMGSSTSPCT DFTSDQADFP DTLFKEFEPS SKNEDFPGCH PVDTEFLSSA
260 270 280 290 300
YRRGRLLYHT LDLMGQALPD RSRLAPGALG ERNPVVVLNE LRSGLRYVCL
310 320 330 340 350
SETAEKPRVK SFVMAVCVDG RTFEGSGRSK KLAKGQAAQA ALQALFDIRL
360 370 380 390 400
PGHIPSRSKS NLLPQDFADS VSQLVTQKFR ELTVGLTSVY ARHKTLAGIV
410 420 430 440 450
MTKGLDTKQA QVIVLSSGTK CISGEHISDQ GLVVNDCHAE IVARRAFLHF
460 470 480 490 500
LYSQLELHLS KHQEDPERSI FIRLKEGGYR LRENILFHLY VSTSPCGDAR
510 520 530 540 550
VNSPYEITTD LNSSKHIVRK FRGHLRTKIE SGEGTVPVRG PSAVQTWDGI
560 570 580 590 600
LLGEQLITMS CTDKIASWNV LGLQGALLCH FIEPVYLHSI IVGSLHHTGH
610 620 630 640 650
LARVMSHRME GIGQLPASYR QNRPLLSGVS HAEARQPGKS PHFSANWVVG
660 670 680 690 700
SADLEIINAT TGKRSCGGSS RLCKHVFSAW WARLHGRLST RIPSHGDTPS
710 720 730 740
MYCEAKQGAH TYQSVKQQLF KAFQKAGLGT WVRKPPEQDQ FLLSL
Length:745
Mass (Da):82,187
Last modified:July 19, 2003 - v2
Checksum:iA336473C760902F7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251R → G in AAF76894 (Ref. 1) Curated
Sequence conflicti65 – 651S → N in AAF78580 (PubMed:10854777).Curated
Sequence conflicti310 – 3101K → R in AAF76894 (Ref. 1) Curated
Sequence conflicti410 – 4101A → G in AAF78580 (PubMed:10854777).Curated
Sequence conflicti731 – 7311W → R in AAF76894 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF270495 mRNA. Translation: AAF76894.1.
AK033916 mRNA. Translation: BAC28513.1.
AK139079 mRNA. Translation: BAE23882.1.
AK139273 mRNA. Translation: BAE23939.1.
BC052426 mRNA. Translation: AAH52426.1.
AF232942 mRNA. Translation: AAF78580.1.
CCDSiCCDS26231.1.
RefSeqiNP_443209.2. NM_052977.5.
UniGeneiMm.425794.

Genome annotation databases

EnsembliENSMUST00000064473; ENSMUSP00000064775; ENSMUSG00000052551.
ENSMUST00000135574; ENSMUSP00000115148; ENSMUSG00000052551.
GeneIDi94191.
KEGGimmu:94191.
UCSCiuc007pkf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF270495 mRNA. Translation: AAF76894.1.
AK033916 mRNA. Translation: BAC28513.1.
AK139079 mRNA. Translation: BAE23882.1.
AK139273 mRNA. Translation: BAE23939.1.
BC052426 mRNA. Translation: AAH52426.1.
AF232942 mRNA. Translation: AAF78580.1.
CCDSiCCDS26231.1.
RefSeqiNP_443209.2. NM_052977.5.
UniGeneiMm.425794.

3D structure databases

ProteinModelPortaliQ9JI20.
SMRiQ9JI20. Positions 124-194, 282-350, 354-744.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000064775.

PTM databases

PhosphoSiteiQ9JI20.

Proteomic databases

EPDiQ9JI20.
MaxQBiQ9JI20.
PaxDbiQ9JI20.
PRIDEiQ9JI20.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000064473; ENSMUSP00000064775; ENSMUSG00000052551.
ENSMUST00000135574; ENSMUSP00000115148; ENSMUSG00000052551.
GeneIDi94191.
KEGGimmu:94191.
UCSCiuc007pkf.2. mouse.

Organism-specific databases

CTDi105.
MGIiMGI:2151118. Adarb2.

Phylogenomic databases

eggNOGiKOG2777. Eukaryota.
ENOG410XT0Z. LUCA.
GeneTreeiENSGT00550000074412.
HOGENOMiHOG000290164.
HOVERGENiHBG003836.
InParanoidiQ9JI20.
KOiK13194.
OMAiCKLQLIW.
OrthoDBiEOG7VHSX4.
PhylomeDBiQ9JI20.
TreeFamiTF315806.

Miscellaneous databases

NextBioi352163.
PROiQ9JI20.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JI20.
CleanExiMM_ADARB2.
ExpressionAtlasiQ9JI20. baseline and differential.
GenevisibleiQ9JI20. MM.

Family and domain databases

Gene3Di3.30.160.20. 2 hits.
InterProiIPR002466. A_deamin.
IPR014720. dsRBD_dom.
[Graphical view]
PfamiPF02137. A_deamin. 1 hit.
PF00035. dsrm. 2 hits.
[Graphical view]
SMARTiSM00552. ADEAMc. 1 hit.
SM00358. DSRM. 2 hits.
[Graphical view]
PROSITEiPS50141. A_DEAMIN_EDITASE. 1 hit.
PS50137. DS_RBD. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Editing activity of mouse RED2 (ADAR3) in vitro."
    Chen M.-H., Kabir K., Yang J.-H.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cerebellum and Diencephalon.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Brain.
  4. "Comparative analysis of the RED1 and RED2 A-to-I RNA editing genes from mammals, pufferfish and zebrafish."
    Slavov D., Clark M., Gardiner K.
    Gene 250:41-51(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 11-741.
    Tissue: Brain.

Entry informationi

Entry nameiRED2_MOUSE
AccessioniPrimary (citable) accession number: Q9JI20
Secondary accession number(s): Q3UTP1, Q8CC51, Q9JIE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: July 19, 2003
Last modified: May 11, 2016
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.