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Q9JI19

- FIBP_MOUSE

UniProt

Q9JI19 - FIBP_MOUSE

Protein

Acidic fibroblast growth factor intracellular-binding protein

Gene

Fibp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    May be involved in mitogenic function of FGF1.By similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acidic fibroblast growth factor intracellular-binding protein
    Short name:
    aFGF intracellular-binding protein
    Alternative name(s):
    FGF-1 intracellular-binding protein
    Gene namesi
    Name:Fibp
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1926233. Fibp.

    Subcellular locationi

    Nucleus By similarity. Endomembrane system By similarity; Peripheral membrane protein By similarity
    Note: Also associated with cytoplasmic membranes, particularly of mitochondria.By similarity

    GO - Cellular componenti

    1. endomembrane system Source: UniProtKB-SubCell
    2. membrane Source: UniProtKB-KW
    3. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 357356Acidic fibroblast growth factor intracellular-binding proteinPRO_0000087238Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylthreonineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9JI19.
    PaxDbiQ9JI19.
    PRIDEiQ9JI19.

    PTM databases

    PhosphoSiteiQ9JI19.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9JI19.
    BgeeiQ9JI19.
    GenevestigatoriQ9JI19.

    Interactioni

    Subunit structurei

    Binds to internalized FGF1; this interaction is increased in the presence of CSNKB, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.By similarity

    Protein-protein interaction databases

    IntActiQ9JI19. 2 interactions.
    MINTiMINT-1760583.

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG70779.
    HOVERGENiHBG005728.
    InParanoidiQ9JI19.

    Family and domain databases

    InterProiIPR008614. FIBP.
    [Graphical view]
    PANTHERiPTHR13223. PTHR13223. 1 hit.
    PfamiPF05427. FIBP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9JI19-1 [UniParc]FASTAAdd to Basket

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    MTSELDIFVG NTTLIDEDVY RLWLDGYSVN DAVALRVRSG ILEQTGATTG    50
    VLQSDTMDHY RTFHMLERLL HAPPKLLHQL IFQIPPSRQT LLIERYYTFD 100
    EAFVREVLGK KLSKGTKKDL DDISTKTGIT LKSCRRQFDN FKRVFKVVEE 150
    MRGSLVDNIQ QHFLLSDRLA RDYAAIVFFA NNRFETGKKK LQYLSFGDFA 200
    FCAELMIQNW TLGAVDSQVD DMDVDLDKEF LQDLKELKVL VADKDLLDLH 250
    KSLVCTALRG KLGVFSEMET NFKNLSRGLV NVAAKLTHNK DVRDLFVDLV 300
    EKFVEPCRSD HWPLSDVRLF LSQYSASVHS LDGFRHQALW DRYMGTLRGC 350
    LLRLYHD 357
    Length:357
    Mass (Da):41,204
    Last modified:October 1, 2000 - v1
    Checksum:i51A6D28F5879D94B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF270700 mRNA. Translation: AAF76201.1.
    AK012629 mRNA. Translation: BAB28367.1.
    AK028029 mRNA. Translation: BAC25708.1.
    RefSeqiNP_067413.1. NM_021438.4.
    UniGeneiMm.329656.

    Genome annotation databases

    GeneIDi58249.
    KEGGimmu:58249.
    UCSCiuc008gdg.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF270700 mRNA. Translation: AAF76201.1 .
    AK012629 mRNA. Translation: BAB28367.1 .
    AK028029 mRNA. Translation: BAC25708.1 .
    RefSeqi NP_067413.1. NM_021438.4.
    UniGenei Mm.329656.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9JI19. 2 interactions.
    MINTi MINT-1760583.

    PTM databases

    PhosphoSitei Q9JI19.

    Proteomic databases

    MaxQBi Q9JI19.
    PaxDbi Q9JI19.
    PRIDEi Q9JI19.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 58249.
    KEGGi mmu:58249.
    UCSCi uc008gdg.2. mouse.

    Organism-specific databases

    CTDi 9158.
    MGIi MGI:1926233. Fibp.

    Phylogenomic databases

    eggNOGi NOG70779.
    HOVERGENi HBG005728.
    InParanoidi Q9JI19.

    Miscellaneous databases

    ChiTaRSi FIBP. mouse.
    NextBioi 314313.
    PROi Q9JI19.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9JI19.
    Bgeei Q9JI19.
    Genevestigatori Q9JI19.

    Family and domain databases

    InterProi IPR008614. FIBP.
    [Graphical view ]
    PANTHERi PTHR13223. PTHR13223. 1 hit.
    Pfami PF05427. FIBP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein."
      Kolpakova E., Frengen E., Stokke T., Olsnes S.
      Biochem. J. 352:629-635(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo.

    Entry informationi

    Entry nameiFIBP_MOUSE
    AccessioniPrimary (citable) accession number: Q9JI19
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3