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Protein

Acidic fibroblast growth factor intracellular-binding protein

Gene

Fibp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in mitogenic function of FGF1.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic fibroblast growth factor intracellular-binding protein
Short name:
aFGF intracellular-binding protein
Alternative name(s):
FGF-1 intracellular-binding protein
Gene namesi
Name:Fibp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1926233. Fibp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 357356Acidic fibroblast growth factor intracellular-binding proteinPRO_0000087238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9JI19.
PaxDbiQ9JI19.
PRIDEiQ9JI19.

PTM databases

PhosphoSiteiQ9JI19.

Expressioni

Gene expression databases

BgeeiQ9JI19.
ExpressionAtlasiQ9JI19. baseline and differential.
GenevisibleiQ9JI19. MM.

Interactioni

Subunit structurei

Binds to internalized FGF1; this interaction is increased in the presence of CSNKB, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1.By similarity

Protein-protein interaction databases

IntActiQ9JI19. 2 interactions.
MINTiMINT-1760583.
STRINGi10090.ENSMUSP00000025847.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG70779.
HOVERGENiHBG005728.
InParanoidiQ9JI19.

Family and domain databases

InterProiIPR008614. FIBP.
[Graphical view]
PANTHERiPTHR13223. PTHR13223. 1 hit.
PfamiPF05427. FIBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JI19-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSELDIFVG NTTLIDEDVY RLWLDGYSVN DAVALRVRSG ILEQTGATTG
60 70 80 90 100
VLQSDTMDHY RTFHMLERLL HAPPKLLHQL IFQIPPSRQT LLIERYYTFD
110 120 130 140 150
EAFVREVLGK KLSKGTKKDL DDISTKTGIT LKSCRRQFDN FKRVFKVVEE
160 170 180 190 200
MRGSLVDNIQ QHFLLSDRLA RDYAAIVFFA NNRFETGKKK LQYLSFGDFA
210 220 230 240 250
FCAELMIQNW TLGAVDSQVD DMDVDLDKEF LQDLKELKVL VADKDLLDLH
260 270 280 290 300
KSLVCTALRG KLGVFSEMET NFKNLSRGLV NVAAKLTHNK DVRDLFVDLV
310 320 330 340 350
EKFVEPCRSD HWPLSDVRLF LSQYSASVHS LDGFRHQALW DRYMGTLRGC

LLRLYHD
Length:357
Mass (Da):41,204
Last modified:October 1, 2000 - v1
Checksum:i51A6D28F5879D94B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF270700 mRNA. Translation: AAF76201.1.
AK012629 mRNA. Translation: BAB28367.1.
AK028029 mRNA. Translation: BAC25708.1.
RefSeqiNP_067413.1. NM_021438.4.
UniGeneiMm.329656.

Genome annotation databases

GeneIDi58249.
UCSCiuc008gdg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF270700 mRNA. Translation: AAF76201.1.
AK012629 mRNA. Translation: BAB28367.1.
AK028029 mRNA. Translation: BAC25708.1.
RefSeqiNP_067413.1. NM_021438.4.
UniGeneiMm.329656.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9JI19. 2 interactions.
MINTiMINT-1760583.
STRINGi10090.ENSMUSP00000025847.

PTM databases

PhosphoSiteiQ9JI19.

Proteomic databases

MaxQBiQ9JI19.
PaxDbiQ9JI19.
PRIDEiQ9JI19.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi58249.
UCSCiuc008gdg.2. mouse.

Organism-specific databases

CTDi9158.
MGIiMGI:1926233. Fibp.

Phylogenomic databases

eggNOGiNOG70779.
HOVERGENiHBG005728.
InParanoidiQ9JI19.

Miscellaneous databases

ChiTaRSiFibp. mouse.
NextBioi314313.
PROiQ9JI19.
SOURCEiSearch...

Gene expression databases

BgeeiQ9JI19.
ExpressionAtlasiQ9JI19. baseline and differential.
GenevisibleiQ9JI19. MM.

Family and domain databases

InterProiIPR008614. FIBP.
[Graphical view]
PANTHERiPTHR13223. PTHR13223. 1 hit.
PfamiPF05427. FIBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein."
    Kolpakova E., Frengen E., Stokke T., Olsnes S.
    Biochem. J. 352:629-635(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.

Entry informationi

Entry nameiFIBP_MOUSE
AccessioniPrimary (citable) accession number: Q9JI19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: July 22, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.