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Q9JI19

- FIBP_MOUSE

UniProt

Q9JI19 - FIBP_MOUSE

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Protein

Acidic fibroblast growth factor intracellular-binding protein

Gene
Fibp
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

May be involved in mitogenic function of FGF1 By similarity.

Names & Taxonomyi

Protein namesi
Recommended name:
Acidic fibroblast growth factor intracellular-binding protein
Short name:
aFGF intracellular-binding protein
Alternative name(s):
FGF-1 intracellular-binding protein
Gene namesi
Name:Fibp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:1926233. Fibp.

Subcellular locationi

Nucleus By similarity. Endomembrane system; Peripheral membrane protein By similarity
Note: Also associated with cytoplasmic membranes, particularly of mitochondria By similarity.

GO - Cellular componenti

  1. endomembrane system Source: UniProtKB-SubCell
  2. membrane Source: UniProtKB-KW
  3. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 357356Acidic fibroblast growth factor intracellular-binding proteinPRO_0000087238Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylthreonine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9JI19.
PaxDbiQ9JI19.
PRIDEiQ9JI19.

PTM databases

PhosphoSiteiQ9JI19.

Expressioni

Gene expression databases

ArrayExpressiQ9JI19.
BgeeiQ9JI19.
GenevestigatoriQ9JI19.

Interactioni

Subunit structurei

Binds to internalized FGF1; this interaction is increased in the presence of CSNKB, suggesting a possible cooperative interaction between CSNKB and FIBP in binding to FGF1 By similarity.

Protein-protein interaction databases

IntActiQ9JI19. 2 interactions.
MINTiMINT-1760583.

Family & Domainsi

Phylogenomic databases

eggNOGiNOG70779.
HOVERGENiHBG005728.
InParanoidiQ9JI19.

Family and domain databases

InterProiIPR008614. FIBP.
[Graphical view]
PANTHERiPTHR13223. PTHR13223. 1 hit.
PfamiPF05427. FIBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JI19-1 [UniParc]FASTAAdd to Basket

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MTSELDIFVG NTTLIDEDVY RLWLDGYSVN DAVALRVRSG ILEQTGATTG    50
VLQSDTMDHY RTFHMLERLL HAPPKLLHQL IFQIPPSRQT LLIERYYTFD 100
EAFVREVLGK KLSKGTKKDL DDISTKTGIT LKSCRRQFDN FKRVFKVVEE 150
MRGSLVDNIQ QHFLLSDRLA RDYAAIVFFA NNRFETGKKK LQYLSFGDFA 200
FCAELMIQNW TLGAVDSQVD DMDVDLDKEF LQDLKELKVL VADKDLLDLH 250
KSLVCTALRG KLGVFSEMET NFKNLSRGLV NVAAKLTHNK DVRDLFVDLV 300
EKFVEPCRSD HWPLSDVRLF LSQYSASVHS LDGFRHQALW DRYMGTLRGC 350
LLRLYHD 357
Length:357
Mass (Da):41,204
Last modified:October 1, 2000 - v1
Checksum:i51A6D28F5879D94B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF270700 mRNA. Translation: AAF76201.1.
AK012629 mRNA. Translation: BAB28367.1.
AK028029 mRNA. Translation: BAC25708.1.
RefSeqiNP_067413.1. NM_021438.4.
UniGeneiMm.329656.

Genome annotation databases

GeneIDi58249.
KEGGimmu:58249.
UCSCiuc008gdg.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF270700 mRNA. Translation: AAF76201.1 .
AK012629 mRNA. Translation: BAB28367.1 .
AK028029 mRNA. Translation: BAC25708.1 .
RefSeqi NP_067413.1. NM_021438.4.
UniGenei Mm.329656.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9JI19. 2 interactions.
MINTi MINT-1760583.

PTM databases

PhosphoSitei Q9JI19.

Proteomic databases

MaxQBi Q9JI19.
PaxDbi Q9JI19.
PRIDEi Q9JI19.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 58249.
KEGGi mmu:58249.
UCSCi uc008gdg.2. mouse.

Organism-specific databases

CTDi 9158.
MGIi MGI:1926233. Fibp.

Phylogenomic databases

eggNOGi NOG70779.
HOVERGENi HBG005728.
InParanoidi Q9JI19.

Miscellaneous databases

ChiTaRSi FIBP. mouse.
NextBioi 314313.
PROi Q9JI19.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9JI19.
Bgeei Q9JI19.
Genevestigatori Q9JI19.

Family and domain databases

InterProi IPR008614. FIBP.
[Graphical view ]
PANTHERi PTHR13223. PTHR13223. 1 hit.
Pfami PF05427. FIBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Organization, chromosomal localization and promoter analysis of the gene encoding human acidic fibroblast growth factor intracellular binding protein."
    Kolpakova E., Frengen E., Stokke T., Olsnes S.
    Biochem. J. 352:629-635(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Embryo.

Entry informationi

Entry nameiFIBP_MOUSE
AccessioniPrimary (citable) accession number: Q9JI19
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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