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Q9JI18

- LRP1B_MOUSE

UniProt

Q9JI18 - LRP1B_MOUSE

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Protein

Low-density lipoprotein receptor-related protein 1B

Gene
Lrp1b, Lrpdit
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. low-density lipoprotein particle receptor binding Source: MGI
  3. low-density lipoprotein receptor activity Source: MGI
  4. protein binding Source: IntAct

GO - Biological processi

  1. receptor-mediated endocytosis Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Endocytosis

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Low-density lipoprotein receptor-related protein 1B
Short name:
LRP-1B
Alternative name(s):
Low-density lipoprotein receptor-related protein-deleted in tumor
Short name:
LRP-DIT
Gene namesi
Name:Lrp1b
Synonyms:Lrpdit
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:2151136. Lrp1b.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 44444424Extracellular Reviewed predictionAdd
BLAST
Transmembranei4445 – 446723Helical; Reviewed predictionAdd
BLAST
Topological domaini4468 – 4599132Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. membrane Source: MGI
  3. receptor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 45994579Low-density lipoprotein receptor-related protein 1BPRO_0000017320Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi32 ↔ 45 By similarity
Disulfide bondi39 ↔ 58 By similarity
Disulfide bondi52 ↔ 69 By similarity
Disulfide bondi77 ↔ 90 By similarity
Disulfide bondi84 ↔ 103 By similarity
Disulfide bondi97 ↔ 113 By similarity
Glycosylationi134 – 1341N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi159 ↔ 169 By similarity
Disulfide bondi165 ↔ 178 By similarity
Disulfide bondi180 ↔ 193 By similarity
Glycosylationi190 – 1901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi220 – 2201N-linked (GlcNAc...) Reviewed prediction
Glycosylationi313 – 3131N-linked (GlcNAc...) Reviewed prediction
Glycosylationi360 – 3601N-linked (GlcNAc...) Reviewed prediction
Glycosylationi443 – 4431N-linked (GlcNAc...) Reviewed prediction
Glycosylationi725 – 7251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi758 – 7581N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi798 ↔ 809 By similarity
Disulfide bondi805 ↔ 818 By similarity
Disulfide bondi820 ↔ 833 By similarity
Glycosylationi829 – 8291N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi845 ↔ 857 By similarity
Disulfide bondi852 ↔ 870 By similarity
Disulfide bondi864 ↔ 881 By similarity
Glycosylationi883 – 8831N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi886 ↔ 898 By similarity
Disulfide bondi893 ↔ 911 By similarity
Disulfide bondi905 ↔ 922 By similarity
Glycosylationi919 – 9191N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi927 ↔ 939 By similarity
Disulfide bondi934 ↔ 952 By similarity
Disulfide bondi946 ↔ 962 By similarity
Disulfide bondi967 ↔ 980 By similarity
Disulfide bondi975 ↔ 993 By similarity
Disulfide bondi987 ↔ 1002 By similarity
Disulfide bondi1006 ↔ 1018 By similarity
Disulfide bondi1013 ↔ 1031 By similarity
Disulfide bondi1025 ↔ 1042 By similarity
Glycosylationi1041 – 10411N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1053 ↔ 1066 By similarity
Disulfide bondi1060 ↔ 1079 By similarity
Disulfide bondi1073 ↔ 1088 By similarity
Glycosylationi1089 – 10891N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1095 ↔ 1109 By similarity
Disulfide bondi1103 ↔ 1122 By similarity
Disulfide bondi1116 ↔ 1131 By similarity
Disulfide bondi1136 ↔ 1150 By similarity
Disulfide bondi1143 ↔ 1163 By similarity
Glycosylationi1145 – 11451N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1157 ↔ 1173 By similarity
Disulfide bondi1176 ↔ 1187 By similarity
Disulfide bondi1183 ↔ 1197 By similarity
Disulfide bondi1199 ↔ 1212 By similarity
Glycosylationi1209 – 12091N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1298 – 12981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1502 – 15021N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1531 ↔ 1544 By similarity
Disulfide bondi1540 ↔ 1554 By similarity
Glycosylationi1549 – 15491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1556 ↔ 1569 By similarity
Glycosylationi1636 – 16361N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1754 – 17541N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1816 – 18161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi1838 ↔ 1849 By similarity
Disulfide bondi1845 ↔ 1859 By similarity
Disulfide bondi1861 ↔ 1874 By similarity
Glycosylationi1921 – 19211N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1983 – 19831N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2105 – 21051N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2147 ↔ 2158 By similarity
Disulfide bondi2154 ↔ 2168 By similarity
Disulfide bondi2170 ↔ 2182 By similarity
Glycosylationi2458 – 24581N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2488 – 24881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi2507 – 25071N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2510 ↔ 2523 By similarity
Disulfide bondi2518 ↔ 2536 By similarity
Disulfide bondi2530 ↔ 2547 By similarity
Glycosylationi2549 – 25491N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2552 ↔ 2564 By similarity
Disulfide bondi2559 ↔ 2577 By similarity
Disulfide bondi2571 ↔ 2586 By similarity
Disulfide bondi2591 ↔ 2603 By similarity
Disulfide bondi2598 ↔ 2616 By similarity
Disulfide bondi2610 ↔ 2625 By similarity
Glycosylationi2626 – 26261N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2630 ↔ 2652 By similarity
Disulfide bondi2646 ↔ 2665 By similarity
Glycosylationi2647 – 26471N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2659 ↔ 2674 By similarity
Disulfide bondi2682 ↔ 2694 By similarity
Disulfide bondi2689 ↔ 2707 By similarity
Disulfide bondi2701 ↔ 2716 By similarity
Disulfide bondi2720 ↔ 2732 By similarity
Disulfide bondi2727 ↔ 2745 By similarity
Disulfide bondi2739 ↔ 2756 By similarity
Disulfide bondi2761 ↔ 2774 By similarity
Disulfide bondi2768 ↔ 2787 By similarity
Disulfide bondi2781 ↔ 2799 By similarity
Glycosylationi2802 – 28021N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2805 ↔ 2817 By similarity
Disulfide bondi2812 ↔ 2830 By similarity
Disulfide bondi2824 ↔ 2840 By similarity
Disulfide bondi2845 ↔ 2857 By similarity
Disulfide bondi2852 ↔ 2871 By similarity
Disulfide bondi2865 ↔ 2884 By similarity
Disulfide bondi2891 ↔ 2903 By similarity
Glycosylationi2892 – 28921N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi2898 ↔ 2916 By similarity
Disulfide bondi2910 ↔ 2925 By similarity
Disulfide bondi2930 ↔ 2942 By similarity
Disulfide bondi2938 ↔ 2951 By similarity
Disulfide bondi2953 ↔ 2966 By similarity
Disulfide bondi2972 ↔ 2982 By similarity
Disulfide bondi2978 ↔ 2991 By similarity
Disulfide bondi2993 ↔ 3007 By similarity
Glycosylationi3034 – 30341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3066 – 30661N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3076 – 30761N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3164 – 31641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3310 – 33101N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3316 – 33161N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3317 ↔ 3329 By similarity
Disulfide bondi3324 ↔ 3342 By similarity
Disulfide bondi3336 ↔ 3352 By similarity
Disulfide bondi3357 ↔ 3369 By similarity
Disulfide bondi3364 ↔ 3382 By similarity
Disulfide bondi3376 ↔ 3391 By similarity
Disulfide bondi3396 ↔ 3409 By similarity
Disulfide bondi3403 ↔ 3422 By similarity
Disulfide bondi3416 ↔ 3431 By similarity
Disulfide bondi3436 ↔ 3449 By similarity
Disulfide bondi3443 ↔ 3462 By similarity
Disulfide bondi3456 ↔ 3471 By similarity
Disulfide bondi3476 ↔ 3488 By similarity
Disulfide bondi3483 ↔ 3501 By similarity
Disulfide bondi3495 ↔ 3510 By similarity
Disulfide bondi3515 ↔ 3527 By similarity
Disulfide bondi3522 ↔ 3540 By similarity
Disulfide bondi3534 ↔ 3549 By similarity
Disulfide bondi3553 ↔ 3565 By similarity
Disulfide bondi3560 ↔ 3578 By similarity
Disulfide bondi3572 ↔ 3587 By similarity
Disulfide bondi3594 ↔ 3606 By similarity
Disulfide bondi3601 ↔ 3619 By similarity
Disulfide bondi3613 ↔ 3628 By similarity
Disulfide bondi3632 ↔ 3645 By similarity
Disulfide bondi3639 ↔ 3658 By similarity
Disulfide bondi3652 ↔ 3667 By similarity
Disulfide bondi3674 ↔ 3686 By similarity
Disulfide bondi3681 ↔ 3699 By similarity
Glycosylationi3682 – 36821N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi3693 ↔ 3710 By similarity
Disulfide bondi3715 ↔ 3729 By similarity
Disulfide bondi3723 ↔ 3742 By similarity
Disulfide bondi3736 ↔ 3751 By similarity
Disulfide bondi3762 ↔ 3774 By similarity
Disulfide bondi3769 ↔ 3787 By similarity
Disulfide bondi3781 ↔ 3796 By similarity
Disulfide bondi3805 ↔ 3818 By similarity
Disulfide bondi3812 ↔ 3827 By similarity
Disulfide bondi3829 ↔ 3842 By similarity
Disulfide bondi3848 ↔ 3858 By similarity
Disulfide bondi3854 ↔ 3867 By similarity
Glycosylationi3877 – 38771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3894 – 38941N-linked (GlcNAc...) Reviewed prediction
Glycosylationi3906 – 39061N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4017 – 40171N-linked (GlcNAc...) Reviewed prediction
Glycosylationi4204 – 42041N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4217 ↔ 4227 By similarity
Disulfide bondi4221 ↔ 4237 By similarity
Disulfide bondi4239 ↔ 4248 By similarity
Disulfide bondi4253 ↔ 4263 By similarity
Disulfide bondi4257 ↔ 4273 By similarity
Disulfide bondi4275 ↔ 4284 By similarity
Disulfide bondi4289 ↔ 4299 By similarity
Disulfide bondi4293 ↔ 4309 By similarity
Disulfide bondi4311 ↔ 4320 By similarity
Disulfide bondi4325 ↔ 4335 By similarity
Disulfide bondi4329 ↔ 4345 By similarity
Disulfide bondi4347 ↔ 4356 By similarity
Glycosylationi4381 – 43811N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi4394 ↔ 4404 By similarity
Disulfide bondi4398 ↔ 4415 By similarity
Disulfide bondi4417 ↔ 4426 By similarity
Glycosylationi4420 – 44201N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9JI18.
PRIDEiQ9JI18.

PTM databases

PhosphoSiteiQ9JI18.

Expressioni

Gene expression databases

GenevestigatoriQ9JI18.

Interactioni

Subunit structurei

Binds LRPAP1, PLAU, PLAT and SERPINE1; binding is followed by internalization and degradation of the ligands By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
Mapk8ip1Q9WVI9-13EBI-8294317,EBI-288461
Pick1Q80VC84EBI-8294317,EBI-8521477
Ranbp9P695662EBI-8294317,EBI-772305

Protein-protein interaction databases

IntActiQ9JI18. 7 interactions.
MINTiMINT-4998267.
STRINGi10090.ENSMUSP00000054275.

Structurei

3D structure databases

ProteinModelPortaliQ9JI18.
SMRiQ9JI18. Positions 32-111, 129-833, 845-4430.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 7040LDL-receptor class A 1Add
BLAST
Domaini76 – 11439LDL-receptor class A 2Add
BLAST
Domaini116 – 15439EGF-like 1Add
BLAST
Domaini155 – 19440EGF-like 2; calcium-binding Reviewed predictionAdd
BLAST
Repeati295 – 33743LDL-receptor class B 1Add
BLAST
Repeati338 – 38144LDL-receptor class B 2Add
BLAST
Repeati382 – 42544LDL-receptor class B 3Add
BLAST
Domaini471 – 51747EGF-like 3Add
BLAST
Repeati568 – 61043LDL-receptor class B 4Add
BLAST
Repeati611 – 65646LDL-receptor class B 5Add
BLAST
Repeati657 – 70650LDL-receptor class B 6Add
BLAST
Repeati707 – 75044LDL-receptor class B 7Add
BLAST
Domaini794 – 83441EGF-like 4Add
BLAST
Domaini844 – 88239LDL-receptor class A 3Add
BLAST
Domaini885 – 92339LDL-receptor class A 4Add
BLAST
Domaini926 – 96338LDL-receptor class A 5Add
BLAST
Domaini966 – 100338LDL-receptor class A 6Add
BLAST
Domaini1005 – 104339LDL-receptor class A 7Add
BLAST
Domaini1052 – 108938LDL-receptor class A 8Add
BLAST
Domaini1094 – 113239LDL-receptor class A 9Add
BLAST
Domaini1135 – 117440LDL-receptor class A 10Add
BLAST
Domaini1174 – 121340EGF-like 5Add
BLAST
Domaini1214 – 125340EGF-like 6Add
BLAST
Repeati1300 – 134647LDL-receptor class B 8Add
BLAST
Repeati1347 – 138943LDL-receptor class B 9Add
BLAST
Repeati1390 – 143647LDL-receptor class B 10Add
BLAST
Repeati1437 – 148044LDL-receptor class B 11Add
BLAST
Repeati1481 – 152242LDL-receptor class B 12Add
BLAST
Domaini1527 – 157044EGF-like 7Add
BLAST
Repeati1618 – 166043LDL-receptor class B 13Add
BLAST
Repeati1661 – 170444LDL-receptor class B 14Add
BLAST
Repeati1705 – 174440LDL-receptor class B 15Add
BLAST
Repeati1745 – 178743LDL-receptor class B 16Add
BLAST
Domaini1834 – 187542EGF-like 8Add
BLAST
Repeati1922 – 196443LDL-receptor class B 17Add
BLAST
Repeati1965 – 200743LDL-receptor class B 28Add
BLAST
Repeati2008 – 205144LDL-receptor class B 19Add
BLAST
Repeati2052 – 209544LDL-receptor class B 20Add
BLAST
Domaini2143 – 218341EGF-like 9Add
BLAST
Repeati2239 – 228042LDL-receptor class B 21Add
BLAST
Repeati2281 – 232949LDL-receptor class B 22Add
BLAST
Repeati2330 – 237445LDL-receptor class B 23Add
BLAST
Repeati2375 – 241642LDL-receptor class B 24Add
BLAST
Repeati2417 – 245943LDL-receptor class B 25Add
BLAST
Domaini2464 – 250441EGF-like 10Add
BLAST
Domaini2509 – 254840LDL-receptor class A 11Add
BLAST
Domaini2551 – 258737LDL-receptor class A 12Add
BLAST
Domaini2590 – 262637LDL-receptor class A 13Add
BLAST
Domaini2629 – 267547LDL-receptor class A 14Add
BLAST
Domaini2681 – 271737LDL-receptor class A 15Add
BLAST
Domaini2719 – 275739LDL-receptor class A 16Add
BLAST
Domaini2760 – 280041LDL-receptor class A 17Add
BLAST
Domaini2804 – 284138LDL-receptor class A 18Add
BLAST
Domaini2844 – 288542LDL-receptor class A 19Add
BLAST
Domaini2890 – 292637LDL-receptor class A 20Add
BLAST
Domaini2927 – 296741EGF-like 11Add
BLAST
Domaini2968 – 300841EGF-like 12; calcium-binding Reviewed predictionAdd
BLAST
Repeati3055 – 309844LDL-receptor class B 26Add
BLAST
Repeati3099 – 314143LDL-receptor class B 27Add
BLAST
Repeati3142 – 318544LDL-receptor class B 28Add
BLAST
Repeati3186 – 322439LDL-receptor class B 29Add
BLAST
Repeati3225 – 326844LDL-receptor class B 30Add
BLAST
Domaini3273 – 331442EGF-like 13Add
BLAST
Domaini3316 – 335338LDL-receptor class A 21Add
BLAST
Domaini3356 – 339237LDL-receptor class A 22Add
BLAST
Domaini3395 – 343238LDL-receptor class A 23Add
BLAST
Domaini3435 – 347238LDL-receptor class A 24Add
BLAST
Domaini3475 – 351137LDL-receptor class A 25Add
BLAST
Domaini3514 – 355037LDL-receptor class A 26Add
BLAST
Domaini3552 – 358837LDL-receptor class A 27Add
BLAST
Domaini3593 – 362937LDL-receptor class A 28Add
BLAST
Domaini3631 – 366838LDL-receptor class A 29Add
BLAST
Domaini3673 – 371139LDL-receptor class A 30Add
BLAST
Domaini3714 – 375239LDL-receptor class A 31Add
BLAST
Domaini3761 – 379737LDL-receptor class A 32Add
BLAST
Domaini3801 – 384343EGF-like 14Add
BLAST
Domaini3844 – 388138EGF-like 15Add
BLAST
Repeati3933 – 398048LDL-receptor class B 31Add
BLAST
Repeati3981 – 403858LDL-receptor class B 32Add
BLAST
Repeati4039 – 408244LDL-receptor class B 33Add
BLAST
Repeati4083 – 412745LDL-receptor class B 34Add
BLAST
Domaini4171 – 420838EGF-like 16Add
BLAST
Domaini4213 – 424937EGF-like 17Add
BLAST
Domaini4249 – 428537EGF-like 18Add
BLAST
Domaini4285 – 432137EGF-like 19Add
BLAST
Domaini4321 – 435737EGF-like 20Add
BLAST
Domaini4357 – 439236EGF-like 21Add
BLAST
Domaini4390 – 442738EGF-like 22Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi4492 – 44954Endocytosis signal Reviewed prediction
Motifi4559 – 45624Endocytosis signal Reviewed prediction

Sequence similaritiesi

Belongs to the LDLR family.
Contains 22 EGF-like domains.

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG235850.
HOVERGENiHBG006292.
InParanoidiQ9JI18.

Family and domain databases

Gene3Di2.120.10.30. 8 hits.
4.10.400.10. 31 hits.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF00008. EGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00057. Ldl_recept_a. 30 hits.
PF00058. Ldl_recept_b. 11 hits.
[Graphical view]
PRINTSiPR00261. LDLRECEPTOR.
SMARTiSM00181. EGF. 16 hits.
SM00179. EGF_CA. 4 hits.
SM00192. LDLa. 32 hits.
SM00135. LY. 36 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 6 hits.
SSF57424. SSF57424. 32 hits.
PROSITEiPS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 5 hits.
PS01186. EGF_2. 9 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 3 hits.
PS01209. LDLRA_1. 27 hits.
PS50068. LDLRA_2. 32 hits.
PS51120. LDLRB. 36 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9JI18-1 [UniParc]FASTAAdd to Basket

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MSQLLLAILT LSGLLPNAEV LIVGANQDQH LCDPGEFLCH DHVTCVSQSW     50
LCDGDPDCPD QSDESLDTCP EEVEIKCPLN HIACHGSSAC VHLSKLCNGV 100
VDCPDGFDEG GHCQELLPSC QQLNCQFKCA MVRNATRCYC EDGFEVAEDG 150
RSCKDQDECS IYGICSQTCK NTYGSYACSC VEGYIMQSDN RSCKVKHEPT 200
DKAPMLLISS LETIELFYIN GSKMTTLSSA NRNEIHTLDF IYSEEMICWI 250
ESRESSNQLK CGQITKAGRL TDQRIINSLQ SFQNVEQMAF DWLTRNIYFV 300
DHVSDRIFVC NFNGSVCVTL IESELHNPKA IAADPIAGKL FFTDYGNVPK 350
IERCDLDGMN RTRIVYSKAE QPSALALDLV NRLVYWVDLY LDYVGVVDYQ 400
GKNRHTIVQG RQVKHLYGIT VFEDYLYATS SDNFNIIRIN RFNGTDIHSI 450
IKMESARGIR TYQKRTQPTV RSHACEVDAY GMPGGCSHIC LLSSSYKTRT 500
CRCRTGFNMG SDGRSCKRPK NELFLFYGKG RPGIVRGMDL NTKIADECMI 550
PIENLVNPRA LDFHAEANYI YFADTTSFLI GRQKIDGTER ETILKDDLDN 600
VEGIAVDWIG NNLYWTNDGH RKTINVARLE KASQSRKTLL EGGMSHPRAI 650
VVDPVNGWMY WTDWKEDKID DSVGRIEKAW MDGVNRQVFV TSKMLWPNGL 700
TLDFHTSTLY WCDAYYDHIE KVFLNGTHRK VVYSGKELNH PFGLSHHGNY 750
VFWTDYMNGS IFQLDLMTNE VTLLRHERAP LFGLQIYDPR KQQGDNMCRI 800
NNGGCGTLCL AIPAGRVCAC ADNQLLDENG TTCTFNPEEI RFHICKPGEF 850
RCKNKHCIQA RWKCDGDDDC LDGSDEDSVT CFNHSCPDDQ FKCQNNRCIP 900
KRWLCDGAND CGSNEDESNQ TCTARTCQAD QFSCGNGRCI PTAWLCDRED 950
DCGDQTDEVA SCEFPTCEPL TQFICKSGRC ISNKWHCDTD DDCGDRSDEV 1000
GCVHSCLDDQ FRCSSGRCIP GHWACDGDND CGDFSDETHI NCTKEEARSP 1050
AGCIGNEFQC RPDGNCIPDL WRCDGEKDCE DGSDEKGCNG TIRLCDHKTK 1100
FSCRSTGRCI NNAWVCDGDV DCEDQSDEED CDSFLCGPPK YPCANDTSVC 1150
LQPEKLCNGR KDCPDGSDEG DLCDECSLNN GGCSNHCSVV PGRGIVCSCP 1200
EGHQLKKDNR TCEIVDYCAS HLRCSQVCEQ QKHMVKCSCY EGWALGTDGE 1250
SCTSVDSFEA FIIFSIRHEI RRIDLHKGDY SLLVPGLRNT IALDFHFNQS 1300
LLYWTDVVED RIYRGKLSES GGVSAIEVVV EHGLATPEGL TVDWIAGNIY 1350
WIDSNLDQIE VSKLDGSLRA TLIAGAMEHP RAIALDPRYG ILFWTDWDAN 1400
FPRIESASMS GAGRKTIYKD MKTGAWPNGL TVDHFERRIV WTDARSDAIY 1450
SAFYDGTNMI EIIRGHEYLS HPFAVSLYGS EVYWTDWRTN TLAKANKWTG 1500
QNVSVIQKTS AQPFDLQIYH PSRQPQAPNP CAANEGRGPC SHLCLINHNR 1550
SAACACPHLM KLSSDKKTCY EMKKFLLYAR RSEIRGVDID NPYVNFITAF 1600
TVPDIDDVAV IDFDASEERL YWTDIKTQTI TRAFINGTGL ETVISRDIQS 1650
IRGLAVDWVS RNLYWISSEF DETQINVARL DGSLKTSIIH GIDKPQCLAA 1700
HPVRGKLYWT DGNTINMANM DGSNSKILFQ NQKEPVGLSI DYVENKLYWI 1750
SSGNGTINRC NLDGGNLEVI ESMKEELTKA TALTIMDKKL WWADQNLAQL 1800
GTCNKRDGRN PSILRNKTSG VVHMKVYDKE AQQGSNSCQV NNGGCSQLCL 1850
PTSETTRTCM CTVGYYLQKN RMSCQGIESF LMYSVHEGIR GIPLEPRDKV 1900
DALMPISGAA FAVGIDFHAE NDTIYWTDMG LNKISRAKRD QTWKEDVVTN 1950
GLGRVEGIAV DWIAGNIYWT DHGFNLIEVA RLNGSFRYVI ISQGLDQPRS 2000
IAVHPEKGFL FWTEWGQVPC IGKARLDGSE KVMIVSVGIT WPNGISIDYE 2050
ENKLYWCDAR SDKIERIDLD TGANREVLLS GSNVDLFSVA VFGAYIYWSD 2100
RAHANGSVRR GHKNDATETV TMRTGLGVNL KEIKIFNRVR EKGTNVCAKE 2150
NGGCQQLCLY RGNSRRTCAC AHGYLAGDGV TCLRHEGYLL YSGRTILKSI 2200
HLSDETNLNS PVRPYENPNY FKNIIALAFD YNQRREGTNR IFYSDAHFGN 2250
IQLIKDNWED RQVIVENVGS VEGLAYHRAW DTLYWTSSST SSITRHTVDQ 2300
TRPGAIDREA VITMSEDDHP HVLALDECQN LMFWTNWNEQ HPSIMRATLT 2350
GKNAHVVVST DILTPNGLTI DHRAEKLYFS DGSLGKIERC EYDGSQRHVI 2400
VKSGPGTFLS LAVYDSYIFW SDWGRRAILR SNKYTGGETK ILRSDIPHQP 2450
MGIIAVANDT NSCELSPCAL LNGGCHDLCL LTPDGRVNCS CRGDRVLLAN 2500
NRCVTKNSSC NIYSEFECGN GDCVDYVLTC DGIPHCKDKS DEKLLYCENR 2550
SCRSGFKPCY NRRCVPHGKL CDGTNDCGDS SDELDCKVST CSTVEFRCAD 2600
GTCIPRSARC NQNMDCSDAS DEKGCNNTDC THFYKLGVKS TGFIRCNSTS 2650
LCVLPSWICD GSNDCGDYSD ELKCPVQNKH KCEENYFGCP SGRCILNTWV 2700
CDGQKDCEDG LDELHCDSSC SWNQFACSVK KCISKHWICD GEDDCGDSLD 2750
ESDSICGAVT CAADMFSCQG SHACVPQHWL CDGERDCPDG SDELSSAGCA 2800
PNNTCDENAF MCHNKVCIPK QFVCDHDDDC GDGSDEFLQC GYRQCGPEEF 2850
RCADGRCLVN TLWQCDGDFD CPDSSDEAPI NPRCRSAEHS CNSSFFMCKN 2900
GRCIPSDGLC DIRDDCGDGS DETNCHINEC LSKKISGCSQ DCQDLPVSYK 2950
CKCWPGFQLK DDGKTCVDID ECSSGFPCSQ QCINTYGTYK CHCAEGYETQ 3000
PDNPNGCRSL SDEEPFLILA DQHEIRKIST DGSNYTLLKQ GLNNVIALDF 3050
DYREEFIYWI DSSRPNGSRI NRMCLNGSDI KVVHNTAVPN ALAVDWIGKN 3100
LYWSDTEKRI IEVSKLNGLY PTVLVSKRLK FPRDLSLDPR AGNLYWIDCC 3150
EYPHIGRVGM DGTNQSVVIE TKISRPMALT IDYVNHRLYW ADENHIEFSN 3200
MDGSHRHKVP NQDIPGVIAL TLFEDYIYWT DGKTKSLSRV HKTSGADRLS 3250
LINSWHAITD IQVYHSYRQP DVSKHLCTVN NGGCSHLCLL GPGKTHTCAC 3300
PTNFYLAADN RTCLSNCTAS QFRCKTDKCI PFWWKCDTVD DCGDGSDEPD 3350
DCPEFKCQPG RFQCGTGLCA LPAFICDGEN DCGDNSDELN CDTHVCLAGQ 3400
FKCTKNKKCI PVNLRCNGQD DCGDEEDEKD CPENSCSPDY FQCKTTKHCI 3450
SKLWVCDEDP DCADASDEAN CDKKTCGPHE FQCKNNNCIP DHWRCDNQND 3500
CSDNSDEDNC KPQTCTLKDF LCSNGDCVSS RFWCDGEFDC ADGSDEKNCE 3550
TSCSKDQFQC SNGQCLSAKW KCDGHEDCKY GEDEKNCEPA FPVCSSSEYM 3600
CASGGCLSAS LKCNGEPDCV DGSDEMDCVI ECKEDQFQCK NKAYCIPIRW 3650
LCDGIYDCVD GSDEETCGRG GSICRDDEFL CNNSLCKLHF WVCDGEDDCG 3700
DNSDEAPDMC VKFLCPPTRP YRCRNDRICL QLEKICNGIN DCGDNSDEEH 3750
CSGKLSLKSK PCKKDEFTCS NRNCIPMELQ CDSLDDCGDG SDEQGCLKTP 3800
IEHTCENNGN PCGDDAYCNQ IKTSVFCRCK PGFQRNMKGR ECADLNECLL 3850
FGICSHHCLN TRGSYKCVCD QNFQEKNNSC IAKGSEDQAL YIANDTDILG 3900
FVYPFNYSGG HQQISHVEHN SRITGMDVHY QRNVIVWSTQ FNPGGIFYKM 3950
IDAREKRQAN SGLICPEFKR PRDIAVDWVA GNVYWTDHSR MHWFSYYTTH 4000
WTSLRYSINV GQLNGPNCTR LLTNMAGEPY AIAVNPKRGM MYWTVIGDHS 4050
HIEEAAMDGT LRRVLVQKNL QRPTGLTVDH FGERIYWADF ELSIIGSVLY 4100
DGSSPVVSVS SKQGLLHPHR IDVFEDYIYG AGPKNGIFRV QKFGHGSVEV 4150
LALGVDKTKS ILVSHRYKQL NLPNPCLDLS CDFLCLLNPS GATCICPEGK 4200
YMMNGTCHDD SLLDDSCKLT CENGGRCILN EKGDLRCHCW PSYSGGRCEV 4250
NHCSNYCQNG GTCIPSTLGR PTCICALGFT GPNCGKAVCE DSCHNGGSCV 4300
VTAGNQPYCH CQADYTGDRC QYYVCHHYCV NSESCTIGND GSVECVCPTR 4350
YEGPKCEIDK CVRCHGGHCI INKDNEDIFC NCTNGKIASS CQLCDGYCYN 4400
GGTCQLDPET SIPVCVCSTN WSGTQCERPA PKSSKSEHIS TRSIAIIVPL 4450
VLLVTLVTTL VIGLVVCKRK RRTKTIRRQP IINGGINVEI GNPSYNMYEV 4500
DHDHSDGGLL EPSFMIDPVK SRYIGGGSSA FKLPHTAPPI YLNSDLKGPL 4550
TFGPTNYSNP VYAKLYMDGQ NCRNSLASVD ERKELLPKKI EIGIRETVA 4599
Length:4,599
Mass (Da):513,634
Last modified:October 1, 2000 - v1
Checksum:i11462A3354FFB200
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti4521 – 455333Missing in BAC29188. 1 PublicationAdd
BLAST
Sequence conflicti4552 – 45521F → S in BAC28594. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF270884 mRNA. Translation: AAF81758.1.
AK035795 mRNA. Translation: BAC29188.1.
AK034122 mRNA. Translation: BAC28594.1.
UniGeneiMm.441398.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF270884 mRNA. Translation: AAF81758.1 .
AK035795 mRNA. Translation: BAC29188.1 .
AK034122 mRNA. Translation: BAC28594.1 .
UniGenei Mm.441398.

3D structure databases

ProteinModelPortali Q9JI18.
SMRi Q9JI18. Positions 32-111, 129-833, 845-4430.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9JI18. 7 interactions.
MINTi MINT-4998267.
STRINGi 10090.ENSMUSP00000054275.

PTM databases

PhosphoSitei Q9JI18.

Proteomic databases

PaxDbi Q9JI18.
PRIDEi Q9JI18.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:2151136. Lrp1b.

Phylogenomic databases

eggNOGi NOG235850.
HOVERGENi HBG006292.
InParanoidi Q9JI18.

Miscellaneous databases

ChiTaRSi LRP1B. mouse.
PROi Q9JI18.
SOURCEi Search...

Gene expression databases

Genevestigatori Q9JI18.

Family and domain databases

Gene3Di 2.120.10.30. 8 hits.
4.10.400.10. 31 hits.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR026823. cEGF.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR009030. Growth_fac_rcpt_N_dom.
IPR023415. LDLR_class-A_CS.
IPR000033. LDLR_classB_rpt.
IPR002172. LDrepeatLR_classA_rpt.
[Graphical view ]
Pfami PF12662. cEGF. 1 hit.
PF00008. EGF. 1 hit.
PF07645. EGF_CA. 2 hits.
PF00057. Ldl_recept_a. 30 hits.
PF00058. Ldl_recept_b. 11 hits.
[Graphical view ]
PRINTSi PR00261. LDLRECEPTOR.
SMARTi SM00181. EGF. 16 hits.
SM00179. EGF_CA. 4 hits.
SM00192. LDLa. 32 hits.
SM00135. LY. 36 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 6 hits.
SSF57424. SSF57424. 32 hits.
PROSITEi PS00010. ASX_HYDROXYL. 4 hits.
PS00022. EGF_1. 5 hits.
PS01186. EGF_2. 9 hits.
PS50026. EGF_3. 9 hits.
PS01187. EGF_CA. 3 hits.
PS01209. LDLRA_1. 27 hits.
PS50068. LDLRA_2. 32 hits.
PS51120. LDLRB. 36 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The structure of the mouse homologue of the human candidate tumor suppressor gene LRP1B/LRP-DIT."
    Yaklichkin S., Lisitsyn N.
    Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3770-4599.
    Strain: C57BL/6J.
    Tissue: Cerebellum.

Entry informationi

Entry nameiLRP1B_MOUSE
AccessioniPrimary (citable) accession number: Q9JI18
Secondary accession number(s): Q8BZD3, Q8BZM7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi