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Protein

Calcium/calmodulin-dependent protein kinase II inhibitor 1

Gene

Camk2n1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potent and specific inhibitor of CaM-kinase II (CAMK2).1 Publication

GO - Molecular functioni

  • calcium-dependent protein kinase inhibitor activity Source: HGNC
  • protein kinase binding Source: HGNC

GO - Biological processi

  • negative regulation of cyclin-dependent protein kinase activity Source: Ensembl
  • synaptic transmission Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase II inhibitor 1
Alternative name(s):
calcium/calmodulin-dependent protein kinase II inhibitor alpha
Short name:
CaM-KIINalpha
Short name:
CaMKIINalpha
Gene namesi
Name:Camk2n1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi708430. Camk2n1.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • dendrite Source: HGNC
  • neuronal cell body Source: HGNC
  • postsynaptic density Source: UniProtKB-SubCell
  • postsynaptic membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi43 – 431R → P: Reduces at least 100-fold the inhibitory potency; when associated with 59-K--A-61. 1 Publication
Mutagenesisi58 – 581I → S: Slightly phosphorylated. 1 Publication
Mutagenesisi59 – 613EDD → KLA: Reduces at least 100-fold the inhibitory potency; when associated with P-43. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7878Calcium/calmodulin-dependent protein kinase II inhibitor 1PRO_0000338395Add
BLAST

Proteomic databases

PaxDbiQ9JI15.
PRIDEiQ9JI15.

Expressioni

Tissue specificityi

Brain specific. Highly expressed in frontal cortex, hippocampus and inferior colliculus.1 Publication

Gene expression databases

GenevisibleiQ9JI15. RN.

Interactioni

Subunit structurei

Interacts with CAMK2B; the presence of Ca2+/calmodulin increases the interaction but is not essential. Interacts with CAMK2A; this interaction requires CAMK2A activation by Ca2+ (By similarity).By similarity

GO - Molecular functioni

  • protein kinase binding Source: HGNC

Protein-protein interaction databases

BioGridi251978. 1 interaction.
DIPiDIP-58987N.
STRINGi10116.ENSRNOP00000021864.

Structurei

Secondary structure

1
78
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi47 – 504Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KL8X-ray3.37B/D/F/H/J42-58[»]
ProteinModelPortaliQ9JI15.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9JI15.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 6828CAMK2 inhibitory domainAdd
BLAST

Sequence similaritiesi

Belongs to the CAMK2N family.Curated

Phylogenomic databases

eggNOGiENOG410J0PZ. Eukaryota.
ENOG410YP01. LUCA.
GeneTreeiENSGT00390000004940.
HOGENOMiHOG000060311.
HOVERGENiHBG104926.
InParanoidiQ9JI15.
OMAiDEGHLSF.
OrthoDBiEOG7TF7CN.
PhylomeDBiQ9JI15.
TreeFamiTF333175.

Family and domain databases

InterProiIPR026779. Camk2n.
[Graphical view]
PfamiPF15170. CaM-KIIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9JI15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEVLPYGDE KLSPYGDGGD VGQIFSCRLQ DTNNFFGAGQ SKRPPKLGQI
60 70
GRSKRVVIED DRIDDVLKTM TDKAPPGV
Length:78
Mass (Da):8,513
Last modified:October 1, 2000 - v1
Checksum:iA89A9E5DA11B8E61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271156 mRNA. Translation: AAF75281.1.
RefSeqiNP_775459.1. NM_173337.1.
UniGeneiRn.12600.

Genome annotation databases

EnsembliENSRNOT00000021864; ENSRNOP00000021864; ENSRNOG00000016322.
GeneIDi287005.
KEGGirno:287005.
UCSCiRGD:708430. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271156 mRNA. Translation: AAF75281.1.
RefSeqiNP_775459.1. NM_173337.1.
UniGeneiRn.12600.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3KL8X-ray3.37B/D/F/H/J42-58[»]
ProteinModelPortaliQ9JI15.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251978. 1 interaction.
DIPiDIP-58987N.
STRINGi10116.ENSRNOP00000021864.

Proteomic databases

PaxDbiQ9JI15.
PRIDEiQ9JI15.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000021864; ENSRNOP00000021864; ENSRNOG00000016322.
GeneIDi287005.
KEGGirno:287005.
UCSCiRGD:708430. rat.

Organism-specific databases

CTDi55450.
RGDi708430. Camk2n1.

Phylogenomic databases

eggNOGiENOG410J0PZ. Eukaryota.
ENOG410YP01. LUCA.
GeneTreeiENSGT00390000004940.
HOGENOMiHOG000060311.
HOVERGENiHBG104926.
InParanoidiQ9JI15.
OMAiDEGHLSF.
OrthoDBiEOG7TF7CN.
PhylomeDBiQ9JI15.
TreeFamiTF333175.

Miscellaneous databases

EvolutionaryTraceiQ9JI15.
NextBioi625314.
PROiQ9JI15.

Gene expression databases

GenevisibleiQ9JI15. RN.

Family and domain databases

InterProiIPR026779. Camk2n.
[Graphical view]
PfamiPF15170. CaM-KIIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Calcium/calmodulin-dependent protein kinase II inhibitor protein: localization of isoforms in rat brain."
    Chang B.H., Mukherji S., Soderling T.R.
    Neuroscience 102:767-777(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, INTERACTION WITH CAMK2B, TISSUE SPECIFICITY, MUTAGENESIS OF ARG-43; ILE-58 AND 59-LYS--ALA-61.

Entry informationi

Entry nameiCK2N1_RAT
AccessioniPrimary (citable) accession number: Q9JI15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.