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Protein

Calcium/calmodulin-dependent protein kinase II inhibitor 1

Gene

Camk2n1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potent and specific inhibitor of CaM-kinase II (CAMK2).1 Publication

GO - Molecular functioni

  • calcium-dependent protein kinase inhibitor activity Source: HGNC
  • protein kinase binding Source: HGNC

GO - Biological processi

Keywordsi

Molecular functionProtein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase II inhibitor 1
Alternative name(s):
calcium/calmodulin-dependent protein kinase II inhibitor alpha
Short name:
CaM-KIINalpha
Short name:
CaMKIINalpha
Gene namesi
Name:Camk2n1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi708430 Camk2n1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi43R → P: Reduces at least 100-fold the inhibitory potency; when associated with 59-K--A-61. 1 Publication1
Mutagenesisi58I → S: Slightly phosphorylated. 1 Publication1
Mutagenesisi59 – 61EDD → KLA: Reduces at least 100-fold the inhibitory potency; when associated with P-43. 1 Publication3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003383951 – 78Calcium/calmodulin-dependent protein kinase II inhibitor 1Add BLAST78

Proteomic databases

PaxDbiQ9JI15

Expressioni

Tissue specificityi

Brain specific. Highly expressed in frontal cortex, hippocampus and inferior colliculus.1 Publication

Gene expression databases

BgeeiENSRNOG00000016322
GenevisibleiQ9JI15 RN

Interactioni

Subunit structurei

Interacts with CAMK2B; the presence of Ca2+/calmodulin increases the interaction but is not essential. Interacts with CAMK2A; this interaction requires CAMK2A activation by Ca2+ (By similarity).By similarity

GO - Molecular functioni

  • protein kinase binding Source: HGNC

Protein-protein interaction databases

BioGridi251978, 1 interactor
DIPiDIP-58987N
IntActiQ9JI15, 1 interactor

Structurei

Secondary structure

178
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi47 – 50Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3KL8X-ray3.37B/D/F/H/J42-58[»]
ProteinModelPortaliQ9JI15
SMRiQ9JI15
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9JI15

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 68CAMK2 inhibitory domainAdd BLAST28

Sequence similaritiesi

Belongs to the CAMK2N family.Curated

Phylogenomic databases

eggNOGiENOG410J0PZ Eukaryota
ENOG410YP01 LUCA
GeneTreeiENSGT00390000004940
HOGENOMiHOG000060311
HOVERGENiHBG104926
InParanoidiQ9JI15
OMAiKLGHYGD
OrthoDBiEOG091G15S0
PhylomeDBiQ9JI15
TreeFamiTF333175

Family and domain databases

InterProiView protein in InterPro
IPR026779 Camk2n
PANTHERiPTHR31007 PTHR31007, 1 hit
PfamiView protein in Pfam
PF15170 CaM-KIIN, 1 hit

Sequencei

Sequence statusi: Complete.

Q9JI15-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEVLPYGDE KLSPYGDGGD VGQIFSCRLQ DTNNFFGAGQ SKRPPKLGQI
60 70
GRSKRVVIED DRIDDVLKTM TDKAPPGV
Length:78
Mass (Da):8,513
Last modified:October 1, 2000 - v1
Checksum:iA89A9E5DA11B8E61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF271156 mRNA Translation: AAF75281.1
RefSeqiNP_775459.1, NM_173337.1
UniGeneiRn.12600

Genome annotation databases

EnsembliENSRNOT00000021864; ENSRNOP00000021864; ENSRNOG00000016322
GeneIDi287005
KEGGirno:287005
UCSCiRGD:708430 rat

Similar proteinsi

Entry informationi

Entry nameiCK2N1_RAT
AccessioniPrimary (citable) accession number: Q9JI15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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