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Protein

Something about silencing protein 10

Gene

Utp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Developmental protein

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
Something about silencing protein 10
Alternative name(s):
Charged amino acid-rich leucine zipper 1
Short name:
Crl-1
Disrupter of silencing SAS10
UTP3 homolog
Gene namesi
Name:Utp3
Synonyms:Crl1, Crlz1, Sas10Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1919230. Utp3.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: MGI
  • nucleus Source: MGI
  • small-subunit processome Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Something about silencing protein 10PRO_0000114327Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei37 – 371PhosphoserineBy similarity
Modified residuei140 – 1401N6-acetyllysineCombined sources
Modified residuei146 – 1461PhosphoserineBy similarity
Modified residuei375 – 3751Citrulline1 Publication

Post-translational modificationi

Citrullinated by PADI4.1 Publication

Keywords - PTMi

Acetylation, Citrullination, Phosphoprotein

Proteomic databases

EPDiQ9JI13.
MaxQBiQ9JI13.
PaxDbiQ9JI13.
PeptideAtlasiQ9JI13.
PRIDEiQ9JI13.

PTM databases

iPTMnetiQ9JI13.
PhosphoSiteiQ9JI13.

Expressioni

Tissue specificityi

Detected mainly in subsets of neuronal cells of the brain. In the 17.5 dpc embryo, mainly expressed in the olfactory bulb and cerebral cortex. Postnatally, additionally expressed in the cerebellar cortex, most strongly in the hippocampus.1 Publication

Developmental stagei

Expressed throughout development.1 Publication

Gene expression databases

BgeeiENSMUSG00000070697.
GenevisibleiQ9JI13. MM.

Interactioni

Protein-protein interaction databases

BioGridi211158. 1 interaction.
IntActiQ9JI13. 3 interactions.
MINTiMINT-4133833.
STRINGi10090.ENSMUSP00000087896.

Structurei

3D structure databases

ProteinModelPortaliQ9JI13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi66 – 16095Glu-richAdd
BLAST

Sequence similaritiesi

Belongs to the SAS10 family.Curated

Phylogenomic databases

eggNOGiKOG3118. Eukaryota.
ENOG410XSPX. LUCA.
GeneTreeiENSGT00500000044947.
HOGENOMiHOG000047611.
HOVERGENiHBG074329.
InParanoidiQ9JI13.
KOiK14767.
OMAiEEYIRPQ.
OrthoDBiEOG091G0LB8.
PhylomeDBiQ9JI13.
TreeFamiTF315177.

Family and domain databases

InterProiIPR007146. Sas10/Utp3/C1D.
IPR018972. Sas10_C_dom.
[Graphical view]
PfamiPF09368. Sas10. 1 hit.
PF04000. Sas10_Utp3. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q9JI13-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVKKSRRRGA AQWAAVRAQA GLTATDENED DLGLPPSPGD SSYYQDQVDE
60 70 80 90 100
FHEARSRAVL AKGWNEVESG EEDGDEEEEV LPLDIDDGDD EDGESSEEEE
110 120 130 140 150
VGEDDDGGSS VQSEAEASVD PSLSWGQRKK LYYDTDYGSK SRGRQSQQEV
160 170 180 190 200
EEEEREEEEE AQIIQRRLAQ ALQEDDFGVA WVEAFAKPVP QVDEAETRVV
210 220 230 240 250
KDLAKVSVKE KLKMLKKESP ELLELIEDLQ AKLTEVKDEL EPLLQLVEKG
260 270 280 290 300
VIPTGRGSEY LKTKYNLYLN YCANISFYLI LKARRVPAHG HPVIERLVTY
310 320 330 340 350
RNLINKLSVV DQKLSSEIRH LLTAKDGAVK KEMTPKAKLT KTKPKSVKQA
360 370 380 390 400
AAVALTDEPD FDGAALKYYK EMEDRQELKR KKEENSAEEQ ALEEQNAKRA
410 420 430 440 450
ITYQIAKNRG LTPRRKKIDR NPRVKHREKF RKAKIRRRGQ VREVRREEQR
460
YSGELSGIRA GVKKSIKLK
Length:469
Mass (Da):53,399
Last modified:October 1, 2000 - v1
Checksum:iD469094FF0AB9632
GO
Isoform 21 Publication (identifier: Q9JI13-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     412-412: T → P
     414-469: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:413
Mass (Da):46,544
Checksum:i81B5FEE55C6F53C3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101A → R in AAF80256 (PubMed:11404095).Curated
Sequence conflicti14 – 152AA → RP in AAF80256 (PubMed:11404095).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei412 – 4121T → P in isoform 2. 1 PublicationVSP_051655
Alternative sequencei414 – 46956Missing in isoform 2. 1 PublicationVSP_051656Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155362 mRNA. Translation: AAF80256.2.
AF271213 mRNA. Translation: AAF91409.1.
AK010316 mRNA. Translation: BAB26848.1.
AK145637 mRNA. Translation: BAE26555.1.
BC022994 mRNA. Translation: AAH22994.1.
CCDSiCCDS19402.1. [Q9JI13-1]
RefSeqiNP_075541.1. NM_023054.1. [Q9JI13-1]
UniGeneiMm.490364.

Genome annotation databases

EnsembliENSMUST00000090413; ENSMUSP00000087896; ENSMUSG00000070697. [Q9JI13-1]
GeneIDi65961.
KEGGimmu:65961.
UCSCiuc008xzv.1. mouse. [Q9JI13-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF155362 mRNA. Translation: AAF80256.2.
AF271213 mRNA. Translation: AAF91409.1.
AK010316 mRNA. Translation: BAB26848.1.
AK145637 mRNA. Translation: BAE26555.1.
BC022994 mRNA. Translation: AAH22994.1.
CCDSiCCDS19402.1. [Q9JI13-1]
RefSeqiNP_075541.1. NM_023054.1. [Q9JI13-1]
UniGeneiMm.490364.

3D structure databases

ProteinModelPortaliQ9JI13.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211158. 1 interaction.
IntActiQ9JI13. 3 interactions.
MINTiMINT-4133833.
STRINGi10090.ENSMUSP00000087896.

PTM databases

iPTMnetiQ9JI13.
PhosphoSiteiQ9JI13.

Proteomic databases

EPDiQ9JI13.
MaxQBiQ9JI13.
PaxDbiQ9JI13.
PeptideAtlasiQ9JI13.
PRIDEiQ9JI13.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090413; ENSMUSP00000087896; ENSMUSG00000070697. [Q9JI13-1]
GeneIDi65961.
KEGGimmu:65961.
UCSCiuc008xzv.1. mouse. [Q9JI13-1]

Organism-specific databases

CTDi57050.
MGIiMGI:1919230. Utp3.

Phylogenomic databases

eggNOGiKOG3118. Eukaryota.
ENOG410XSPX. LUCA.
GeneTreeiENSGT00500000044947.
HOGENOMiHOG000047611.
HOVERGENiHBG074329.
InParanoidiQ9JI13.
KOiK14767.
OMAiEEYIRPQ.
OrthoDBiEOG091G0LB8.
PhylomeDBiQ9JI13.
TreeFamiTF315177.

Enzyme and pathway databases

ReactomeiR-MMU-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

PROiQ9JI13.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000070697.
GenevisibleiQ9JI13. MM.

Family and domain databases

InterProiIPR007146. Sas10/Utp3/C1D.
IPR018972. Sas10_C_dom.
[Graphical view]
PfamiPF09368. Sas10. 1 hit.
PF04000. Sas10_Utp3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSAS10_MOUSE
AccessioniPrimary (citable) accession number: Q9JI13
Secondary accession number(s): Q3UL95, Q8R5C6, Q9JJ12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.